Bioactive Surfaces

235 Pages·2011·6.82 MB·English

by  Erik Wischerhoff

240
Advances in Polymer Science
Editorial Board:
· · ·
A. Abe A.-C. Albertsson K. Dušek J. Genzer
· · ·
W.H. de Jeu S. Kobayashi K.-S. Lee L. Leibler
· · ·
T.E. Long I. Manners M. Möller E.M. Terentjev
· · ·
M. Vicent B. Voit G. Wegner U. Wiesner
Advances in Polymer Science
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Bioactive Surfaces
Volume Editors: Hans G. Börner
Jean-François Lutz
With contributions by
· · ·
N. Badi M. Biesalski H.G. Börner M. Gattermayer
· · ·
R. Gentsch A. Laschewsky J.-F. Lutz H. Möhwald
· · ·
S. Petersen J. Polleux A. Pulsipher A. Skirtach
· · ·
J.C. Tiller D. Volodkin E. Wischerhoff M.N. Yousaf
123
Editors
Prof.Dr.HansG.Börner Prof.Dr.Jean-FrançoisLutz
DepartmentofChemistry InstitutCharlesSadron
LaboratoryofOrganicSynthesis UPR22-CNRS23
ofFunctionalSystems PrecisionMacromolecularChemistryGroup
Humboldt-UniversitätzuBerlin rueduLoessBP8404769
Brook-Taylor-Strasse2 67034Strasbourg
12489Berlin France
Germany jfl[email protected]
[email protected]
ISSN0065-3195 e-ISSN1436-5030
ISBN978-3-642-20154-7 e-ISBN978-3-642-20155-4
DOI10.1007/978-3-642-20155-4
SpringerHeidelbergDordrechtLondonNewYork
LibraryofCongressControlNumber:2011926528
(cid:2)c Springer-VerlagBerlinHeidelberg2011
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Volume Editors
Prof.Dr.HansG.Börner Prof.Dr.Jean-FrançoisLutz
DepartmentofChemistry InstitutCharlesSadron
LaboratoryofOrganicSynthesis UPR22-CNRS23
ofFunctionalSystems PrecisionMacromolecularChemistryGroup
Humboldt-UniversitätzuBerlin rueduLoessBP8404769
Brook-Taylor-Strasse2 67034Strasbourg
12489Berlin France
Germany jfl[email protected]
[email protected]
Editorial Board
Prof.AkihiroAbe Prof.Dr.WimH.deJeu
ProfessorEmeritus DWIanderRWTHAacheneV
TokyoInstituteofTechnology Pauwelsstraße8
6-27-12Hiyoshi-Honcho,Kohoku-ku D-52056Aachen,Germany
Yokohama223-0062,Japan [email protected]
[email protected]
Prof.ShiroKobayashi
Prof.A.-C.Albertsson
R&DCenterforBio-basedMaterials
DepartmentofPolymerTechnology KyotoInstituteofTechnology
TheRoyalInstituteofTechnology Matsugasaki,Sakyo-ku
10044Stockholm,Sweden Kyoto606-8585,Japan
[email protected] [email protected]
Prof.KarelDušek Prof.Kwang-SupLee
InstituteofMacromolecularChemistry DepartmentofAdvancedMaterials
CzechAcademyofSciences HannamUniversity
oftheCzechRepublic 561-6Jeonmin-Dong
HeyrovskýSq.2 Yuseong-Gu305-811
16206Prague6,CzechRepublic Daejeon,SouthKorea
[email protected] [email protected]
Prof.JanGenzer Prof.L.Leibler
DepartmentofChemical& MatièreMolleetChimie
BiomolecularEngineering EcoleSupérieuredePhysique
NorthCarolinaStateUniversity etChimieIndustrielles(ESPCI)
911PartnersWay 10rueVauquelin
27695-7905Raleigh,NorthCarolina 75231ParisCedex05,France
USA [email protected]
vi EditorialBoard
Prof.TimothyE.Long Prof.Dr.MariaJesusVicent
DepartmentofChemistry CentrodeInvestigacionPrincipeFelipe
andResearchInstitute MedicinalChemistryUnit
VirginiaTech PolymerTherapeuticsLaboratory
2110HahnHall(0344) Av.AutopistadelSaler,16
Blacksburg,VA24061,USA 46012Valencia,Spain
[email protected] [email protected]
Prof.BrigitteVoit
Prof.IanManners
Leibniz-InstitutfürPolymerforschung
SchoolofChemistry
Dresden
UniversityofBristol
HoheStraße6
Cantock’sClose
01069Dresden,Germany
BS81TSBristol,UK
[email protected]
[email protected]
Prof.GerhardWegner
Prof.MartinMöller
Max-Planck-Institut
DeutschesWollforschungsinstitut
fürPolymerforschung
anderRWTHAachene.V.
Ackermannweg10
Pauwelsstraße8
55128Mainz,Germany
52056Aachen,Germany
[email protected]
[email protected]
Prof.UlrichWiesner
Prof.E.M.Terentjev
MaterialsScience&Engineering
CavendishLaboratory CornellUniversity
MadingleyRoad 329BardHall
CambridgeCB3OHE,UK Ithaca,NY14853,USA
[email protected] [email protected]
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Preface
Biosciencesandmaterialsciencesemergedinitiallyasdistinctdisciplines.However,
recentprogressesinpolymerandmaterialsciencesledtocongruentresearchinter-
ests,thusfusingthefieldsofmaterialandbiosciencesprogressively.Toconcretize
visionary ideas such as adaptive bio-host systems, bio-instructive materials, bio-
integrated functional systems, or regenerative tissue engineering, the interfaces
betweensyntheticmaterialsandbiologicalsystemshavebeenidentifiedasonekey
issue.ThepresentvolumeofAdvancesinPolymerSciencecoversthemostimpor-
tant aspects of the emerging area of “Bioactive Surfaces.” Selected experts in the
fieldofpolymerscience,soft-matterengineering,andbiophysicshavebeeninvited
tohighlighttheirpersonalviewsandperspectivesonthiscrucialfieldofresearch.
Even though molecular biologists developed lately precise analytical tools of
genomics,regulomics,andproteomics,allowingforprogressivelyaccurateinsight
intosystemicfunctionsofcellsandtissues,theinterfacesbetweensyntheticmateri-
alsandbiologicalsystemsarestillfarfrombeingfundamentallyunderstood.Inthe
lastdecade,jointmultidisciplinaryeffortsandintenseexchangebetweenthebiology
andmaterialsresearchcommunitiessetthe focusonsignalingofmaterialstoward
biologicalsystems.Cellsorcellpopulationsatabio-materialinterfaceexperiencea
broadspectrumofchemo-,mechano-physico-,andtopologicalsignals, whichare
interpretedbythebiosystem.Thistriggersdistinctresponses,whichoftenoccuron
allfunctionalbio-hierarchylevelsfromalteringcellmetabolismtochangingcellsta-
tus,regulatingcellproliferation,differentiationormotilitytomacroscopicchanges
ofthecellshape,orientation,migration,oradhesionbehavior.Fundamentalunder-
standing of the eventsand responsespaves the way to activelycommunicatewith
biologicalsystemsviathematerial-interfacetoinfluence,guide,ordirectcellsand
tissues. This promises enormous progress for life science applications, however,
puts challengeson materials design and accurate fabrication, as precisely tailored
materialsandinterfacesaremandatory.
In this exciting context, this volume providesa broad overview on the field of
syntheticbiologicallyactivesurfaces.Inparticular,threeimportantaspectsareem-
phasizedinthisvolume:(1)surfacedesign,(2)interactionsof2Dand3Dsurfaces
withbiosystems,and(3)applications.Regardingsurfacepreparationandmodifica-
tion,thereaderwillfindinthisbookapracticaldescriptionofsynthetictools,which
constitute the state of the art in the field. For instance, surface functionalization
ix