Behavioral Neurobiology of Eating Disorders

320 Pages·2011·2.18 MB·English

by  Lisa Rachelle Riso Lilenfeld (auth.)

Current Topics in Behavioral Neurosciences
Series Editors:
Mark Geyer, La Jolla, CA, USA
Bart Ellenbroek, Hamburg, Germany
Charles Marsden, Nottingham, UK
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Roger A.H. Adan Walter H. Kaye
l
Editors
Behavioral Neurobiology
of Eating Disorders
Editors
Prof.Dr.RogerA.H.Adan Prof.Dr.WalterH.Kaye
RudolfMagnusInstituteofNeuroscience UniversityofCalifornia,SanDiego
DepartmentofNeuroscienceand DepartmentofPsychiatry
Pharmacology LaJollaDrive8950
Universiteitsweg100 LaJolla,CA92037
3508ABUtrecht SuiteC207
Netherlands USA
[email protected] [email protected]
ISSN1866-3370 e-ISSN1866-3389
ISBN978-3-642-15130-9 e-ISBN978-3-642-15131-6
DOI10.1007/978-3-642-15131-6
SpringerHeidelbergDordrechtLondonNewYork
#Springer-VerlagBerlinHeidelberg2011
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Preface
This book describes the current state of the art of the neurobiology of eating
disorders and provides the latest insights and ideas in the eating disorders field.
Importantbreakthroughsinthelastdecadehaveimprovedourunderstandingofthe
etiologyofeatingdisorders.Duetoneuropsychologicalstudies,wenowunderstand
betterwhichalterationsunderliedisturbedcognitiveprocessinginanorexianervosa
and now that these are being combined with imaging and genetics we start to
understand the underlying neural circuitry and genetic pathways. Interestingly
when combining the novel insights from the different chapters in the book, it
emerges,forinstance,thatanorexianervosaisaccompaniedbyadeficitinreward
processingandimpairedbehavioralflexibilitywhichisdrivenbyahighdegreeof
cognitive control. Clearly, alterations in the dopamine system and an overactive
dorsalneurocircuit(includingforinstancethedorsolateralprefrontalcortex)med-
iatingcognitiveprocessingareimplicated,whichmayalsounderliepoordecision
making. A new concept arises that anorexia nervosa is a neurodevelopmental
striatocortical disorder. Because there are animal models that mimic traits of
pathologicaleatingbehavior,itispossiblethatsuchmodels,whencombinedwith
advances in genetic research, will further contribute to unraveling the molecular
pathways underlying eating disorders. That is, studies using animals and the
application of genetic variation to explain different responses in human imaging
studiesmaygiveusabetterunderstandingofwhatgoeswrongwhereinthebrainof
eating disorder patients. Finally, the treatments currently available for eating dis-
orders in general, and anorexia nervosa in particular, are inadequate. Perhaps the
mostimportantaspectofnewinsightsintohowsymptomsarecodedinthebrainis
thatthisprovidesnewtargetsfordevelopingmoreeffective therapies.Becauseof
the critical need to advance treatment, we have included several chapters from
pioneersinthisfield.Insummary,basedontheknowledgedescribedinthisbook,
wehopethatpeopleintheeatingdisorderfieldgetinspiredtoexplorenewhorizons
fortherapeuticinterventionsthatarebasedonthenewinsights.
Utrecht,TheNetherlands RogerA.H.Adan
LaJolla,CA,USA WalterH.Kaye
v
.
Contents
PartICognitionandEmotionsinEatingDisorders
PersonalityandTemperament .................................................. 3
LisaRachelleRisoLilenfeld
CognitionsandEmotionsinEatingDisorders ................................ 17
NicoletteSiep,AnitaJansen,RemcoHavermans,andAnneRoefs
PartIINeuralCircuits,Neurotransmitters,andBehavior
NeurocircuityofEatingDisorders ............................................. 37
WalterH.Kaye,AngelaWagner,JulieL.Fudge,andMartinPaulus
Serotonin:ImagingFindingsinEatingDisorders ............................ 59
UrsulaF.BailerandWalterH.Kaye
Dopamine-BasedRewardCircuitryResponsivity,Genetics,
andOvereating .................................................................. 81
EricStice,SonjaYokum,DavidZald,andAlainDagher
RewardandNeurocomputationalProcesses .................................. 95
GuidoK.W.Frank
Cognitive-BehavioralFlexibilityinAnorexiaNervosa ..................... 111
Hans-ChristophFriederichandWolfgangHerzog
NeuralCircuits,Neurotransmitters,andBehavior ........................ 125
HowardSteiger,KennethR.Bruce,andPatriciaGroleau
vii
viii Contents
PartIIIGenetics,GenderandHeritability
TheHeritabilityofEatingDisorders:MethodsandCurrentFindings .. 141
LauraM.Thornton,SuzanneE.Mazzeo,andCynthiaM.Bulik
TheGeneticsofEatingDisorders ............................................ 157
SietskeG.HelderandDavidA.Collier
TheInfluenceofGenderandPubertyontheHeritability
ofDisorderedEatingSymptoms ............................................. 177
KristenM.Culbert,SarahE.Racine,andKellyL.Klump
PartIVNeuroendocrinologyandAnimalResearch
NewFrontiersinEndocrinologyofEatingDisorders ...................... 189
PalmieroMonteleone
AnimalModelsofEatingDisorderTraits .................................. 209
MartienJ.H.KasandRogerA.H.Adan
NeurobiologyDrivingHyperactivityinActivity-BasedAnorexia ......... 229
R.A.H.Adan,J.J.G.Hillebrand,U.N.Danner,S.CardonaCano,
M.J.H.Kas,andL.A.W.Verhagen
PartVTranslationalApproachtoTreatment
TranslatingExperimentalNeuroscienceintoTreatmentofEating
Disorders:TwoExamples .................................................... 253
UlrikeSchmidt,AnnaOldershaw,andAnnemarievanElburg
CognitiveRemediationTherapyforEatingDisorders:Development,
RefinementandFutureDirections ........................................... 269
KateTchanturiaandJamesLock
IncorporatingDispositionalTraitsintotheTreatment
ofAnorexiaNervosa .......................................................... 289
NancyL.Zucker,DavidHerzog,AshleyMoskovich,RhondaMerwin,
andTammyLin
Index ........................................................................... 315
Contributors
RogerA.H.Adan
DepartmentofNeuroscienceandPharmacology,RudolfMagnusInstituteofNeu-
roscience, University Medical Centre Utrecht, Str. 5.203, P.O.B. 85060 3508 AB
Utrecht,TheNetherlandsandAltrechtEatingDisordersRintveld,AltrechtMental
HealthInstitute,Zeist,TheNetherlands,[email protected]
UrsulaF.Bailer
Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy,
MedicalUniversityofVienna,Vienna,AustriaandEatingDisorderTreatmentand
ResearchProgram,DepartmentofPsychiatry,UniversityofCalifornia,SanDiego,
LaJolla,CA,USA
KennethR.Bruce
Eating Disorders Program, Douglas University Institute, 6875 LaSalle Blvd,
Montreal(Verdun),QC, Canada H4H 1R3 and Department ofPsychiatry,McGill
University,Montreal,QC,CanadaandDepartmentofPsychology,McGillUniver-
sity,Montreal,QC,Canada
CynthiaM.Bulik
Department ofPsychiatry,UniversityofNorth Carolina at Chapel Hill,101Man-
ningDrive,CB#7160,ChapelHill,NC27599-7160,USA,[email protected]
S.CardonaCano
DepartmentofNeuroscienceandPharmacology,RudolfMagnusInstituteofNeu-
roscience, UniversityMedical Centre Utrecht,Str. 5.203, P.O.B. 85060,3508 AB
Utrecht,TheNetherlands
ix