Basic Disease Mechanisms in Rheumatoid Arthritis

162 Pages·2013·13.59 MB·English

by  Hans Ulrich Scherer

Basic Disease Mechanisms
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HAnS UlRicH ScHeReR
Basic Disease Mechanisms in Rheumatoid Arthritis
Hans Ulrich Scherer
The research described in this thesis was in part supported by an Articulum Fellowship.
The printing of this thesis was financially supported by the Dutch Arthritis Foundation
(het Reumafonds), UCB, Roche, Thermo Fisher Scientific, MSD, AbbVie, Euro Diag-
nostica, Teva, Pfizer.
Cover design: Erwin Timmerman / Hans Ulrich Scherer
Cover photograph: Hans Ulrich Scherer
Layout and printing: Optima Grafische Communicatie, Rotterdam, the Netherlands
ISBN 978-94-6169-375-4
Basic Disease Mechanisms in
Rheumatoid Arthritis
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 25 april 2013
klokke 15.00 uur
door
Hans Ulrich Scherer
geboren te München (Duitsland)
in 1975
PRoMotiecoMMissie
Promotores: Prof. dr. T.W.J. Huizinga
Prof. dr. R.E.M. Toes
Overige leden: Prof. dr. G.R. Burmester (Charité – University Medicine Berlin, Free
and Humboldt University, Duitsland)
Prof. dr. G.A. Schett (University Erlangen-Nuremberg, Duitsland)
Prof. dr. A.M. Deelder
dr. L.A. Trouw
dr. M. Wuhrer
dr. G.J. Wolbink (Reade, Amsterdam)
table of contents
Chapter 1 Introduction 9
Part i t cell control of inflammation
Chapter 2 TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the 31
induction of inflammatory mediators.
J Immunol. 2008 Mar 1;180(5):2747-51.
Part ii characteristics of the immune response to citrullinated
antigens
Chapter 3 Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti- 47
citrullinated peptide antibodies from human serum.
Proteomics Clin Appl. 2009 Jan;3(1):106-15.
Chapter 4 Glycan profiling of anti-citrullinated protein antibodies isolated 65
from human serum and synovial fluid.
Arthritis Rheum. 2010 Jun;62(6):1620-9.
Chapter 5 Anti-citrullinated protein antibodies have a low avidity compared 85
with antibodies against recall antigens.
Ann Rheum Dis. 2011 Feb;70(2):373-9.
Chapter 6 Distinct ACPA fine specificities, formed under the influence of 101
HLA shared epitope alleles, have no effect on radiographic joint
damage in rheumatoid arthritis.
Ann Rheum Dis. 2011 Aug;70(8):1461-4.
Part iii Genetic contribution to joint destruction
Chapter 7 Association of the 6q23 region with the rate of joint destruction in 113
rheumatoid arthritis.
Ann Rheum Dis. 2010 Mar;69(3):567-70.
Chapter 8 Summary and Discussion 127
6 Table of Contents
Chapter 9 Nederlandse Samenvatting 143
Curriculum Vitae 153
List of Publications 155
Dankwoord 159

chapter 1
i ntroduction
Modifi ed from:
Scherer HU and Burmester GR.
New Thoughts on the Pathogenesis of Rheumatoid Arthritis.
Int J Adv Rheumatol. 2008 ; 5(4).
Kvien TK, Scherer HU, Burmester G.
Rheumatoid Arthritis.
In: Bijlsma JW, editor. Eular Compendium on Rheumatic Diseases. 1 ed.
London: BMJ Group; 2009.
Scherer HU, Burmester GR.
A clinical perspective of rheumatoid arthritis.
Eur J Immunol. 2009 Aug;39(8):2044-8.
Scherer HU, Dörner T, Burmester GR.
Patient-tailored therapy in rheumatoid arthritis: an editorial review.
Curr Opin Rheumatol. 2010 May;22(3):237-45.
Scherer HU, Burmester GR.
Adaptive immunity in rheumatic diseases: bystander or pathogenic player?
Best Pract Res Clin Rheumatol. 2011 Dec;25(6):785-800.