Table Of ContentBacterial Membranes
Structural and Molecular Biology
Edited by
Han Remaut
Structural Biology Brussels
Vrije Universiteit Brussel and VIB
Brussels
Belgium
and
Rémi Fronzes
Groupe à 5 ans ‘Biologie Structurale de la Sécretion
Bactérienne’
Institut Pasteur
Paris
France
Caister Academic Press
Copyright © 2014
Caister Academic Press
Norfolk, UK
www.caister.com
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library
ISBN: 978-1-908230-27-0
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Cover design adapted from Figures 8.1 and 8.3.
Printed and bound in Great Britain
Contents
Contributors v
Preface xi
Part I Membrane Composition and Synthesis 1
1 Bacterial Cell Wall Growth, Shape and Division 3
Adeline Derouaux, Mohammed Terrak, Tanneke den Blaauwen and
Waldemar Vollmer
2 The Outer Membrane of Gram-negative Bacteria:
Lipopolysaccharide Biogenesis and Transport 55
Paola Sperandeo, Riccardo Villa, Gianni Dehò and Alessandra
Polissi
3 Outer Membrane Protein Biosynthesis: Transport and
Incorporation of Outer Membrane Proteins (in)to the
Outer Membrane Bilayer 91
Kelly H. Kim, Suraaj Aulakh and Mark Paetzel
4 Bacterial Lipoproteins: Biogenesis, Virulence/
Pathogenicity and Trafficking 133
Hajime Tokuda, Peter Sander, Bok Luel Lee, Suguru Okuda,
Thomas Grau, Andreas Tschumi, Juliane K. Brülle, Kenji Kurokawa
and Hiroshi Nakayama
5 The Fascinating Coat Surrounding Mycobacteria 179
Mamadou Daffé and Benoît Zuber
Part II Protein–Lipid Interactions 193
6 The Role of Lipid Composition on Bacterial Membrane
Protein Conformation and Function 195
Vinciane Grimard, Marc Lensink, Fabien Debailleul, Jean-Marie
Ruysschaert and Cédric Govaerts
iv | Contents
Part III Transport Across Bacterial Membranes 225
7 Bacterial ABC Transporters: Structure and Function 227
Anthony M. George and Peter M. Jones
8 Energy-coupled Transport Across the Outer Membrane
of Gram-negative Bacteria 249
Volkmar Braun
9 The Permeability Barrier: Passive and Active Drug
Passage Across Membranes 283
Kozhinjampara R. Mahendran, Robert Schulz, Helge Weingart,
Ulrich Kleinekathöfer and Mathias Winterhalter
10 Targeting and Integration of Bacterial Membrane Proteins 303
Patrick Kuhn, Renuka Kudva, Thomas Welte, Lukas Sturm and
Hans-Georg Koch
11 Envelope-spanning Secretion Systems in Gram-negative Bacteria 343
Matthias J. Brunner, Rémi Fronzes and Thomas C. Marlovits
Part IV Signal Transduction Across Bacterial Membranes 385
12 Signalling Mechanisms in Prokaryotes 387
Mariano Martinez, Pedro M. Alzari and Gwénaëlle André-Leroux
Part V Bacterial Membranes in Pathogenesis 413
13 Outer Membrane-embedded and -associated Proteins
and their Role in Adhesion and Pathogenesis 415
Vincent van Dam, Virginie Roussel-Jazédé, Jesús Arenas, Martine
P. Bos and Jan Tommassen
14 Bacterial Membranes as Drug Targets 449
Alvin Lo, Gaetano Castaldo and Han Remaut
Index 491
Contributors
Pedro M. Alzari Tanneke den Blaauwen
Unite de Microbiologie Structurale and CNRS Bacterial Cell Biology
UMR 3528 Swammerdam Institute for Life Sciences
Institut Pasteur University of Amsterdam
Paris Amsterdam
France The Netherlands
[email protected] [email protected]
Gwénaëlle André-Leroux Martine P. Bos
Unite de Microbiologie Structurale and CNRS Department of Molecular Microbiology and
UMR 3528 Institute of Biomembranes
Institut Pasteur Utrecht University
Paris Utrecht
France The Netherlands
[email protected] [email protected]
Jesús Arenas Volkmar Braun
Department of Molecular Microbiology and Max Planck Institute for Developmental
Institute of Biomembranes Biology
Utrecht University Tübingen
Utrecht Germany
The Netherlands
[email protected]
[email protected]
Juliane K. Brülle
Suraaj Aulakh Institut für Medizinische Mikrobiologie
Department of Molecular Biology and Universität Zürich
Biochemistry Zurich
Simon Fraser University Switzerland
Burnaby
[email protected]
Canada
[email protected]
vi | Contributors
Matthias J. Brunner Gianni Dehò
Research Institute of Molecular Biotechnology Dipartimento di Scienze Biomolecolari e
(IMBA) Biotecnologie
Austrian Academy of Sciences; Università di Milano
Research Institute of Molecular Pathology Milan
(IMP) Italy
Vienna
[email protected]
Austria
[email protected] Adeline Derouaux
Centre d´ingénierie des protéines
Gaetano Castaldo Institut de Chimie
Structural and Molecular Microbiology; Université de Liège
Structural Biology Brussels Sart-Tilman
VIB Department of Structural Biology Belgium
Vrije Universiteit Brussel
[email protected]
Brussels
Belgium
Rémi Fronzes
[email protected] Groupe à 5 ans ‘Biologie Structurale de la
Sécretion Bactérienne’
Mamadou Daffé Institut Pasteur
Department of Molecular Mechanisms of Paris
Mycobacterial Infections France
Institut de Pharmacologie et Biologie
[email protected]
Structurale du Centre National de la
Recherche Scientifique (CNRS)
Anthony M. George
Université Paul Sabatier
School of Medical and Molecular Biosciences
Toulouse
and iThree Institute
France
University of Technology Sydney
[email protected] Broadway
Australia
Vincent van Dam
[email protected]
Department of Molecular Microbiology and
Institute of Biomembranes
Cédric Govaerts
Utrecht University
Department of Structure and Function of
Utrecht
Biological Membranes
The Netherlands
Structural Biology and Bioinformatics Center
[email protected] Université Libre de Bruxelles
Brussels
Fabien Debailleul Belgium
Department of Structure and Function of
[email protected]
Biological Membranes
Structural Biology and Bioinformatics Center
Thomas Grau
Université Libre de Bruxelles
Roche Diagnostics Ltd
Brussels
Rotkreuz
Belgium
Switzerland
[email protected]
[email protected]
Contributors | vii
Vinciane Grimard Patrick Kuhn
Department of Structure and Function of Institut für Biochemie und Molekularbiologie
Biological Membranes ZBMZ
Structural Biology and Bioinformatics Center Albert-Ludwigs-Universität Freiburg
Université Libre de Bruxelles Freiburg
Brussels Germany
Belgium
[email protected]
[email protected]
Kenji Kurokawa
Peter M. Jones Division of Phamaceutical Cell Biology
School of Medical and Molecular Biosciences Faculty of Pharmaceutical Sciences
and iThree Institute Nagasaki International University
University of Technology Sydney Nagasaki
Broadway Japan
Australia
[email protected]
[email protected]
Bok Luel Lee
Kelly H. Kim National Research Laboratory of Defense
Department of Molecular Biology and Proteins
Biochemistry College of Pharmacy
Simon Fraser University Pusan National University
Burnaby Busan
Canada Korea
[email protected] [email protected]
Ulrich Kleinekathöfer Marc Lensink
School of Engineering and Science Interdisciplinary Research Institute (IRI) –
Jacobs University Bremen Computational Biology
Bremen USR3078 CNRS
Germany Villeneuve d’Ascq
France
[email protected]
[email protected]
Hans-Georg Koch
Institut für Biochemie und Molekularbiologie Alvin Lo
ZBMZ Structural and Molecular Microbiology,
Albert-Ludwigs-Universität Freiburg Structural Biology Brussels
Freiburg VIB Department of Structural Biology
Germany Vrije Universiteit Brussel
Brussels
[email protected]
Belgium
Renuka Kudva [email protected]
Institut für Biochemie und Molekularbiologie
ZBMZ
Albert-Ludwigs-Universität Freiburg
Freiburg
Germany
[email protected]
viii | Contributors
Kozhinjampara R. Mahendran Mark Paetzel
Jacobs University Bremen Department of Molecular Biology and
School of Engineering and Science Biochemistry
Bremen Simon Fraser University
Germany Burnaby
British Columbia
mahendran.kozhinjampararadhakrishnan@
Canada
chem.ox.ac.uk
[email protected]
Thomas C. Marlovits
Research Institute of Molecular Biotechnology Alessandra Polissi
(IMBA) Dipartimento di Biotecnologie e Bioscienze
Austrian Academy of Sciences Università di Milano-Bicocca
Research Institute of Molecular Pathology Milan
(IMP) Italy
Vienna
[email protected]
Austria
[email protected] Han Remaut
Structural Biology Brussels
Mariano Martinez Vrije Universiteit Brussel and VIB
Unite de Microbiologie Structurale and CNRS Brussels
UMR 3528 Belgium
Institut Pasteur
[email protected]
Paris
France
Virginie Roussel-Jazédé
[email protected] Department of Molecular Microbiology and
Institute of Biomembranes
Hiroshi Nakayama Utrecht University
Biomolecular Characterization Team Utrecht
RIKEN The Netherlands
Wako
[email protected]
Japan
[email protected] Jean-Marie Ruysschaert
Department of Structure and Function of
Suguru Okuda Biological Membranes
Department of Chemistry and Chemical Structural Biology and Bioinformatics Center
Biology Université Libre de Bruxelles
Harvard University Brussels
Cambridge, MA Belgium
USA
[email protected]
[email protected]
Peter Sander
Institut für Medizinische Mikrobiologie
Universität Zürich
Zurich
Switzerland
[email protected]
Contributors | ix
Robert Schulz Andreas Tschumi
Jacobs University Bremen Institut für Medizinische Mikrobiologie
School of Engineering and Science Universität Zürich
Bremen Zurich
Germany Switzerland
[email protected] [email protected]
Paola Sperandeo Riccardo Villa
Dipartimento di Biotecnologie e Bioscienze Dipartimento di Biotecnologie e Bioscienze
Università di Milano-Bicocca Università di Milano-Bicocca
Milan Milan
Italy Italy
[email protected] [email protected]
Lukas Sturm Waldemar Vollmer
Institut für Biochemie und Molekularbiologie Centre for Bacterial Cell Biology
ZBMZ Institute for Cell and Molecular Biosciences
Albert-Ludwigs-Universität Freiburg Newcastle University
Freiburg Newcastle upon Tyne
Germany UK
[email protected] [email protected]
Mohammed Terrak Helge Weingart
Centre d’ingénierie des protéines School of Engineering and Science
Institut de Chimie Jacobs University Bremen
Université de Liège Bremen
Sart-Tilman Germany
Belgium
[email protected]
[email protected]
Thomas Welte
Hajime Tokuda Institut für Biochemie und Molekularbiologie
Faculty of Nutritional Sciences ZBMZ
University of Morioka Albert-Ludwigs-Universität Freiburg
Takizawa Freiburg
Iwate Germany
Japan
[email protected]
[email protected]
Mathias Winterhalter
Jan Tommassen School of Engineering and Science
Department of Molecular Microbiology and Jacobs University Bremen
Institute of Biomembranes Bremen
Utrecht University Germany
Utrecht
[email protected]
The Netherlands
[email protected]
