Table Of Content

UCLA Symposia on Molecular and Cellular Biology Volume XXIV, 1982 BAND T CELL TUMORS EDITEDBY ELLEN S. VITETIA DepartmentofMicrobiology Southwestern Medical&hool UniversityofTexas Dallas, Texas SERIESEDITOR c. FRED FOX DepartmentofMicrobiologyandMolecularBiologyInstitute UniversityofCalifornia, LosAngeles LosAngeles, California ACADEMIC PRESS 1982 A SubsidiaryofHarcourtBraceJovanovich, Publishers NewYork London Paris San Diego San Francisco Sao Paolo Sydney Tokyo Toronto COPYRIGHT © 1982,BY ACADEMIC PRESS, INC. ALLRIGHTSRESERVED. NO PARTOFTHISPUBLICATIONMAYBEREPRODUCEDOR TRANSMITTEDINANYFORMORBYANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, ORANY INFORMATION STORAGEANDRETRIEVAL SYSTEM,WITHOUT PERMISSIONINWRITINGFROM THE PUBLISHER. ACADEMIC PRESS, INC. 111FifthAvenue,NewYork,NewYork10003 UnitedKingdom Edition publishedby ACADEMIC PRESS, INC. (LONDON) LTD. 24/28OvalRoad,LondonNW1 7DX Library of Congress Cataloging in Publication Data Main entry under title: 8 and Tcell tumors. (UCLA symposia on molecular and cellular biology v. 24 (1982» Proceedings of the international conference held in Squaw Valley, Calif., in Mar. 1982. Includes index. 1. Bcells--Tumors--Congresses. 2. Tcells--Tumors- Congresses. I. Vitetta, Ellen S. II. Series: UCLA symposia on molecular and cellular biology; v. 24. [DNLM: 1. B-Lymphocytes--Congresses. 2. T-Lymphocytes- Congresses. 3. Lymphoma--Congresses. W3 IC13 v. 24 / WH 525 8111] RC280.L982 1982 616.99'44 82-13948 ISBN 0-12-722380-0 PRINTEDIN THEUNITED STATES OFAMERICA 82 83 84 85 9 876 5 432 1 Contributors Numbers in parentheses indicate the chapter numbers. AbulK. Abbas(46),DepartmentofPathology, HarvardMedicalSchool, 25Shat tuck Street, Boston, Massachusetts 02115 JoanAbbott(36),SloanKetteringInstituteforCancerResearch,Department6122, Room321K, 425East68th Street, New York, New York10021 Larry W. Arnold (62), Department ofBacteriologyandImmunology, 804FLOB 231H, University ofNorth Carolina Medical School, Chapel Hill, North Carolina27514 Diane C. Arthur (31), Section ofPediatrics, University ofMinnesota, Box 151 University Hospitals, Minneapolis, Minnesota 55455 Y. Asano(13),ImmunologyBranch, Building10,Room4B17, NationalCancerIn stitute, NationalInstitutes ofHealth, Bethesda, Maryland20205 George F. Babcock (59), Surgical Research Laboratory BF4.015, University of TexasSystem CancerCenter, M. D. AndersonHospitalandTumorInstitute, 6723 BertnerAvenue, Houston, Texas 77030 Neal A. Benson (9), Department ofPathology, University ofFlorida College of Medicine, BoxJ-275, Gainesville, Florida32610 E. William Bere, Jr. (5), Biological Research and Therapy Branch, Biological Response Modifiers Program, Division of Cancer Treatment, National CancerInstitute, Frederick, Maryland21701 R. M. Blaese (11), Metabolism Branch, Laboratory of Cellular Immunology, Building 10, Room 4N108, NationalCancerInstitute, NationalInstitutesof Health, Bethesda, Maryland20205 ClaraD. Bloomfield(7, 31, 74), Section ofMedicalOncology, UniversityofMin nesota, Box277University Hospitals, Minneapolis, Minnesota55455 Mortimer M. Bortin (61,) Winter Research Laboratory, Mount Sinai Medical Center, P.O. Box342, Milwaukee, Wisconsin 53201 ScottiBrauer(19), DBL, TheSalkInstitute, P.O. Box85800, SanDiego, Califor nia92138 xiii xiv CONTRIBUTORS Raul C. Braylan (9), Department ofPathology, University ofFlorida College of Medicine, BoxJ-275, Gainesville, Florida32610 Peter R. Brayton(28), DepartmentofNeurology, UniversityofSouthern Califor nia SchoolofMedicine, 2025 ZonalAvenue, LosAngeles, California 90033 Colin G. Brooks (21), Program in Basic Immunology, Fred Hutchinson Cancer Research Center, 1124Columbia Street, Seattle, Washington 98104 Jean-Claude Brouet (10), Laboratoired'Immunochimie et d'Immunopathologie, INSERM U 108, Hopital SaintLouis, 75474Paris, Cedex 10, France Yuri Bushkin (34), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021 Robert Carter (46), Department ofPathology, HarvardMedicalSchool, 25 Shat tuck Street, Boston, Massachusetts 02115 Richard Ciavarra(65), BiologicalSciencesGroup, Genetics/CellBiologySection, The University ofConnecticut, Storrs, Connecticut 06268 DavidI.Cohen(29),LaboratoryofImmunology, NationalInstituteofAllergyand InfectiousDiseases, Building10, Room 11N311, NationalInstitutesofHealth, Bethesda, Maryland20205 MelvinCohn(19), TheSalkInstitute, P.O. Box85800, SanDiego, California92138 JohnLeslieCollins(19), TheSalkInstitute, P.O. Box85800, SanDiego, California 92138 Andreas Conzelmann (15), Swiss Institute for Experimental Cancer Research, CH-1066Epalinges, Switzerland PatriciaCorthesy(15),SwissInstituteforExperimentalCancerResearch, CH-1066 Epalinges, Switzerland Jeffrey Cossman (33), Laboratory ofPathology, Hematopathology Section, Na tional Cancer Institute, National Institutes ofHealth, Bethesda, Maryland 20205 GeraldR. Crabtree(33),LaboratoryofPathology, HematopathologySection, Na tional Cancer Institute, National Institutes ofHealth, Bethesda, Maryland 20205 Carlo Croce(73), The WistarInstitute, 36thStreetatSpruce, Philadelphia, Penn sylvania 19104 Antero Danersund (52), Department of Tumor Biology, The Wallenberg Laboratory, P.O. Box562, S-75122 Uppsala, Sweden MarkM. Davis(29,55), LaboratoryofImmunology, NationalInstituteofAllergy and Infectious Diseases, Building 10, Room 11N311, National Institutes of Health, Bethesda, Maryland20205 Patrick DeBaetselier(32), DepartmentofMolecularBiology, TheFree University ofBrussels, St. GenesiusRode, Belgium Anthony L. DeFranco(29, 55), Laboratory ofImmunology, NationalInstituteof Allergy and Infectious Diseases, Building 10, Room 11N311, National In stitutes ofHealth, Bethesda, Maryland20205 Koussay Dellagi (10), Laboratoired'Immunochimie et d'Immunopathologie, IN SERM U108, Hopital SaintLouis, 75474Paris, Cedex 10, France CONTRIBUTORS xv Alfred C. Denn III (5), Biological Research and Therapy Branch, Biological Response Modifiers Program, Division of Cancer Treatment, National CancerInstitute, Frederick, Maryland21701 Thomas M. Dexter (17), The Paterson Laboratories, Christie HospitalandHolt Radium Institute, Whithington, ManchesterM20 9BX, England Jeffrey A. Drebin (30, 46), Department ofPathology, HarvardMedical School, Boston, Massachusetts 02115 Michel Dy (14), INSERM U25, CNRS 122, HopitalNecker, 161 Rue de Sevres, F-75730Paris, Cedex15, France Herman Eisen (22, 75), Department of Biology, Center for Cancer Research, E17-128, Massachusetts Institute ofTechnology, 77Massachusetts Avenue, Cambridge, Massachusetts 02139 ZeligEshhar(43), DepartmentofChemicalImmunology, The Weizmann Institute ofScience, Rehovot 76100, Israel John L. Fahey(39), DepartmentofMicrobiologyandImmunology, Universityof California SchoolofIYfedicine, LosAngeles, California90024 Werner Falk (14), Institute for Immunology and Genetics, German Cancer Research Center, 1m Neuenheimer Feld 280, D-6900 Heidelberg, Federal RepublicofGermany John Farrar (27), National Institute Diabetes Research, Building 30, Room 326, NationalInstitutes ofHealth, Bethesda, Maryland20205 C. Garrison Fathman (13), Department ofMedicine, Division ofImmunology, Stanford University Medical Center, Stanford, California94305 Anthony S. Fauci (33), Laboratory ofImmunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20205 AnnJ. Feeney(24), InstituteforCancerResearch, FoxChaseCancerCenter, 7701 BurholmeAvenue, Philadelphia, Pennsylvania 19111 Michael Feldman (32), Department ofCell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel StuartFeldman(34),MemorialSloanKetteringCancerCenter, 1275 YorkAvenue, New York, New York 10021 A. C. Feller (2), Institute of Pathology, Klinikum der CAU, Hospitalstr. 42, D-2300Kiel1, FederalRepublicofGermany PhilipJ. Fialkow(1),DepartmentofMedicine, RG-20, Universityof Washington SchoolofMedicine, Seattle, Washington 98195 Robert Finberg(46),DepartmentofPathology, HarvardMedicalSchool,25Shat tuck Street, Boston, Massachusetts 02115 Richard Ford (26), Department ofPathology, Section ofPathobiology, M. D. Anderson Hospitaland Tumor Institute, Houston, Texas 77030 James Forman (18, 65, 75), Department ofMicrobiology, University of Texas Science CenteratDallas. 5323 Harry Hines Boulevard, Dallas, Texas 75235 Jeffrey A. Frelinger (28),DepartmentofMicrobiology, HMR 405. University qf Southern California School ofMedicine, 2025 ZonalAvenue, LosAngeles, California90033 xvi CONTRIBUTORS John Frelinger(13), DepartmentofMedicine, Division ofImmunology (SI02A), Stanford University MedicalCenter, Stanford, California94305 GlaucoFrizzera(7,31),SectionofLaboratoryMedicineandPathology, University ofMinnesota, Box198University Hospitals, Minneapolis, Minnesota55455 Shu Man Fu (50), The Cancer Research Program, The Oklahoma Medical ResearchFoundation, 825NorthEast13thStreet, OklahomaCity, Oklahoma 73104 Shigeyoshi Fujimoto (44), Department ofImmunology, Kochi Medical School, Kohasu, Okoh-Cho, Nankoku-Shi, Kochi 781-51, Japan HiromiFujiwara(35), DepartmentofOncogenesis, InstituteforCancerResearch, Osaka University MedicalSchool, 1-1-50, Fukishima, Osaka 553, Japan Kazimiera J. Gajl-Peczalska (7, 31), Section of Laboratory Medicine and Pathology, University ofMinnesota, Box 609 University Hospitals, Min neapolis, Minnesota 55455 Robert Peter Gale (39, 72), Department ofMedicine, Division ofHematology/ Oncology, UniversityofCaliforniaSchoolofMedicine, LosAngeles, Califor nia90024 Diethard Gemsa (14), Institute for Immunology and Serology, University of Heidelberg, 1mNeuenheimerFeld305, D-6900Heidelberg, FederalRepublic ofGermany JohannesGerdes (2), InstituteofPathology, Klinikum derCAU, Hospitalstr. 42, D-2300Kiell, FederalRepublicofGermany RichardK. Gershon(37), DepartmentofPathology/HowardHughesMedicalIn stitute, Brady Memorial Laboratories, Yale University School ofMedicine, 310CedarStreet, NewHaven, Connecticut 06510 MagnusGidlund(52),DepartmentofImmunology, BiomedicalCenter, University ofUppsala, P.O. Box582, S-751 23 Uppsala, Sweden M. J.Glennie(57),AgriculturalResearchCouncil, InstituteofAnimalPhysiology, Babraham, Cambridge, England ToreGoda!(8,68), DepartmentofPathology, NorskHydro'sInstituteforCancer Research, TheNorwegian Radium Hospital, Montebello, Oslo3, Norway Robert S. Goodenow (28), Department of Biology, California Institute of Technology, Pasadena, California91106 J. Gordon (57), Department ofTumorBiology, Karolinska Institute, Box60400, S-101 01, Stockholm, Sweden Mark I. Greene (30, 46), Department ofPathology, Harvard Medical School, Boston, Massachusetts 02115 Toshiyuki Hamaoka (20, 35), Department ofOncogenesis, Institutefor Cancer Research, Osaka UniversityMedicalSchool, 1-1-50, Fukushima, Osaka 553, Japan Terence J. Hamblin (63), Lymphoma Research Group, Tenovus Laboratory, Southampton General Hospital, Tremona Road, Shirley, Southampton, Hampshire S094Xl-: England CONTRIBUTORS xvii Andrew J. Hapel (53), Biological Carcinogenesis Program, Frederick Cancer ResearchFacility, P.O. BoxB, Building560, NationalCancerInstitute, Na tionalInstitutes ofHealth, Frederick, Maryland21701 Richard C. Harmon (28), DepartmentofMicrobiology, HMR 405, University of Southern California School ofMedicine, 2025 ZonalAvenue, LosAngeles, California90033 Noboru Hashimoto (20), Department of Oncogenesis, Institute for Cancer Research, OsakaUniversityMedicalSchool, 1-1-50,Fukushima, Osaka 553, Japan Yasuhiro Hashimoto (20), Department of Oncogenesis, Institute for Cancer Research, OsakaUniversityMedicalSchool, 1-1-50,Fukushima, Osaka 553, Japan Geoffrey Haughton (62, 71), Department ofBacteriology andImmunology, 804 FLOB 231H, University ofNorth Carolina Medical School, Chapel Hill, North Carolina27514 Lee Henderson (65), Department ofMicrobiology, University of Texas Health Science CenteratDallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235 ChristopherS. Henney(21, 69),Program inBasicImmunology, FredHutchinson CancerResearch Center, 1124Columbia Street, Seattle, Washington 98104 KishiHiroyuki(48), The ThirdDepartmentofInternalMedicine, OsakaUniversi tyMedicalSchool, Fukushima-ku, Osaka553, Japan Richard Hodes (13), Immunology Branch, Building 10, Room 4B17, National CancerInstitute, NationalInstitutes ofHealth, Bethesda, Maryland20205 Leroy Hood (28), Department ofBiology, California Institute of Technology, Pasadena, California91106 Richard G. Hoover(45), DepartmentofPathology, UniversityofIowaCollegeof Medicine, Iowa City, Iowa52242 Andre vanderHoven(47),DepartmentofBiochemistry, UniversityofNatal, P.O. Box375, Pietermaritzburg3201, Natal, South Africa Maureen Howard (27), National Institute ofAllergy and Infectious Diseases, Building10,Room11D14,NationalInstitutesofHealth, Bethesda,Maryland 20205 LotharHultner(14), InstituteofHematology, Landwehrstr. 61, D-8000Miinchen 2, FederalRepublicofGermany JamesN. Ihle(53),BiologicalCarcinogenesisProgram,FrederickCancerResearch Facility, P.O. BoxB, Building 560, National CancerInstitute, National In stitutesofHealth, Frederick, Maryland21701 A. J. Infante (13), Department ofMedicine, Division ofImmunology (S102A), Stanford University MedicalCenter, Stanford, California94305 Peter C. Isakson (14, 49), Department ofMicrobiology, University of Texas Health Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 ElaineS. Jaffe(12, 33, 70), HematopathologySection, LaboratoryofPathology, Building 10, Room 2N110, National CancerInstitute, NationalInstitutes of Health, Bethesda, Maryland20205 xviii CONTRIBUTORS Denise L. Johnson(41), DepartmentofAlicrobiology, University ofTexasHealth Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 Dieter Kabelitz (52), Department ofImmunology, BiomedicalCenter, University ofUppsala, P.O. Box582, S-751 23 Uppsala, Sweden Shulamit Katzav (32), Department ofCell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel Jo-Ann Keene (18), Department of Microbiology, University of Texas Health Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 Ursula Kees (14), Institute for Immunology and Genetics, German Cancer Research Center, 1m Neuenheimer Feld 280, D-6900 Heidelberg, Federal RepublicofGermany JohnD.Kemp(37),DepartmentofPathology, BradyMemorialLaboratories, Yale University School ofMedicine, 310 Cedar Street, New Haven, Connecticut 06510 John H. Kersey(7), Section ofLaboratoryMedicineandPathology, Universityof Minnesota, Box609 University Hospitals, Minneapolis, Minnesota 55455 John R. Kettman (41, 78), Department oJ~ Microbiology, University of Texas Health Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 MasaoKimoto(13), The ThirdDepartmentofInternalMedicine, OsakaUniversi ty Hospital, Fukushima-ku, Osaka553, Japan Paul W. Kincade (6, 17, 74), Sloan Kettering Institutefor Cancer Research, 145 Boston PostRoad, Rye, New York 10580 ThomasJ. Kindt(11), LaboratoryofImmunogenetics, Building5, Room100, Na tional Institute ofAllergy and Infectious Diseases, National Institutes of Health, 9000RockvillePike, Bethesda, Maryland20205 Mary E. Kirch (36), Sloan Kettering Institutefor Cancer Research, Department 6122, Room 321K, 425East 68th Street, New York, New York 10021 HolgerKirchner(14), Institutefor Virology, German CancerResearch Center, 1m NeuenheimerFeld280, D-6900Heidelberg, FederalRepublicofGermany TadamitsuKishimoto(48,76), The ThirdDepartmentofInternalMedicine, Osaka University Medical School, Fukushima-ku, Osaka553, Japan Peter H. Krammer (14, 49), Institute for Immunology and Genetics, German Cancer Research Center, 1m Neuenheimer Feld 280, D-6900 Heidelberg, FederalRepublicofGermany KeithA. Krolick(58,77),DepartmentofMicrobiology, UniversityofTexasHealth Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 Lawrence Lachman (26), Immunex Corporation, 51 University Building, Seattle, Washington 98101 Kenneth S. Landreth (6), Sloan Kettering Institute for Cancer Research, 145 Boston PostRoad, Rye, New York 10580 Lewis L. Lanier(3,53,54), BectonDickinsonMonoclonalCenter, 1500-CSalado Drive, Mountain View, California 94043 Judith E. Layton (47), Department ofMicrobiology, University of Texas Health Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 CONTRIBUTORS xix TuckerW. LeBien(7), Section ofLaboratoryMedicineandPathology, University ofMinnesota, Box609 University Hospitals, Minneapolis, Minnesota 55455 JohnC. Lee(53), BiologicalCarcinogenesisProgram, FrederickCancerResearch Facility, P.O. Box B, Building 560, National Cancer Institute, National In stitutes ofHealth, Frederick, Maryland21701 TheresaLee(36), SloanKetteringInstituteforCancerResearch, Department6122, Room 321K, 425East68th Street, New York, New York 10021 K. Lennert(2),InstituteofPathology, KlinikumderCAU, Hospitalstr. 42, D-2300 Kiel1, FederalRepublicofGermany PeterE. Lipsky(79),DepartmentofInternalMedicine, UniversityofTexasHealth Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 N. J. LoCascio (62), Department ofBacteriology and Immunology, 804 FLOB 231H, University ofNorth Carolina Medical School, Chapel Hill, North Carolina27514 Marie-Luise Lohmann-Matthes (14), Max-Planck-Institute for Immunobiology, Stubeweg51, D-7800Freiburg, FederalRepublicofGermany Richard G. Lynch (45), Department ofPathology, University ofIowa College of Medicine, Iowa City, Iowa 52242 Abby Maizel (26), Department ofPathology, Section ofPathobiology, M. D. Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, Houston, Texas 77030 RayaMandler(43),DepartmentofPharmacology, Case WesternReserveUniversi ty Medical School, Cleveland, Ohio 44106 Fabrizio Marcucci (14), Institutefor Virology, German CancerResearch Center, 1mNeuenheimerFeld280, D-6900Heidelberg, FederalRepublicofGermany GeraldE. Marti (11), LaboratoryofImmunogenetics, Building5, Room 100, Na tional Institute ofAllergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20205 Elizabeth McLaughlin-Taylor (28), Department ofMicrobiology, University of Southern California School ofMedicine, 2025 ZonalAvenue, LosAngeles, California 90033 ShashikantMehta(26), DepartmentofPathology, SectionofPathobiology, M. D. Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, Houston, Texas 77030 Roland Mertelsmann (34), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021 Stefan Meuer (16), Department ofMedicine, Division of Tumor Immunology, Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115 Yoshitsugu Miki (48), The ThirdDepartmentofInternalMedicine, Osaka Unive sityMedical School, Fukushima-ku, Osaka553, Japan Gary L. Milburn (45), Department ofPathology, University ofIowa College of Medicine, Iowa City, Iowa 52242 Malcolm A. S. Moore (34), Memorial Sloan Kettering CancerCenter, 1275 York Avenue, New York, New York 10021 xx CONTRIBUTORS Shoshana Morecki (64), Department of Medicine A, Hadassah University Hospital, P.O. Box1200, KiriatHadassah, Jerusalem, Israel John Morgan (26), Department ofPathology, Section ofPathobiology, M. D. Anderson Hospitaland Tumor Institute, Houston, Texas 77030 D. E.Mosier(24,25,79),InstituteforCancerResearch,FoxChaseCancerCenter, 7701 BurholmeAvenue, Philadelphia, Pennsylvania 19111 Markus Nabholz (15), Genetics Unit, Swiss Institute for Experimental Cancer Research, CH-1066Epalinges, Switzerland Lee M. Nadler (11), Division ofTumor Immunology, Sidney Farber Cancer In stitute, 44BinneyStreet, Boston, Massachusetts 02115 Toshimasa Nakagawa (48), The Third Department ofInternal Medicine, Osaka University Medical School, Fukushima-ku, Osaka553, Japan Kenji Nakanishi (27), National Institute of Allergy and Infectious Diseases, Building10,Room11D14,NationalInstitutesofHealth, Bethesda,Maryland 20205 PatriciaNelson(13), DepartmentofMedicine, Division ofImmunology(S102A), Stanford University Medical Center, Stanford, California94305 Ellen A. Nielsen (29), Laboratory ofImmunology, National Institute ofAllergy and Infectious Diseases, Building 10, Room 11N311, National Institutes of Health, Bethesda, Maryland20205 Kenneth Nilsson (52, 67), Department of Tumor Biology, The Wallenberg Laboratory, P.O. Box562, S-75122 Uppsala, Sweden Kenji Nishioka (59), Surgical Research Laboratory BF4.017, M. D. Anderson Hospital and Tumor Institute, 6723 BertnerAvenue, Houston, Texas 77030 VirginiaA. Nourse(9), DepartmentofPathology, UniversityofFloridaCollegeof Medicine, BoxJ-275, Gainesville, Florida32610 MasajiOkada(48), The ThirdDepartmentofInternalMedicine, OsakaUniversity Medical School, Fukushima-ku, Osaka553, Japan Anders Orn (28), Department of Biology, California Institute of Technology, Pasadena, California 91106 JohnOrtaldo(69), NationalCancerInstitute, Building10, Room8B-02, National Institutes ofHealth, Bethesda, Maryland20205 ChristopherJ. Paige(23, 51, 76), BaselInstituteforImmunology, Grenzacherstra 487, Postfach CH-4005, Basel, Switzerland Mark S. Pasternack (22), Massachusetts Institute of Technology, E17-128, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139 Paul Q. Patek (19), The Salk Institute, P.O. Box 85800, San Diego, California 92138 WilliamE. Paul(27, 29, 55),NationalInstituteofAllergyandInfectiousDiseases, Building 10, Room 11N311, National Institutes of Health, Bethesda, Maryland20205 Christopher A. Pennell (62), Department ofBacteriology and Immunology, 804 FLOB 231H, University ofNorth Carolina Medical School, Chapel Hill, North Carolina27514

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