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About Atomic Structure of The Cystic Fibrosis Transmembrane Conductance Regulator 2016 Cell
The structure of zebrafish cystic fibrosis transmembrane conductance regulator (CFTR) was determined by cryo-electron microscopy to 3.7 angstrom resolution. The structure reveals a funnel-shaped ion conduction pathway lined with positively charged residues. A single extracellular gate closes the channel. The dephosphorylated regulatory domain is located between the two nucleotide-binding domains, preventing their dimerization and channel opening. The structure provides insights into how cystic fibrosis-causing mutations disrupt ion conduction, gating, or protein folding.
Detailed Information
| Author: | ['Ed Branco Victor'] |
|---|---|
| Publication Year: | 2016 |
| Pages: | 22 |
| Language: | English |
| Format: | |
| Price: | FREE |
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