Atlas of differential diagnosis in neoplastic hematopathology

908 Pages·2014·489.81 MB·English

by  Gorczyca

Clinical Medicine Gorczyca
Atlas of
Differential Diagnosis in
Third Edition
A
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Atlas of Differential Diagnosis in l
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s Neoplastic Hematopathology

Neoplastic Hematopathology o
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Management of tumor patients now relies on new individualized approaches to f
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treatment, requiring extensive knowledge of the molecular makeup of tumors.
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Updated and expanded, the third edition of Atlas of Differential Diagnosis in e T h i rd E d i t i o n
Neoplastic Hematopathology examines not only the differential diagnosis but also n
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the detailed morphologic, immunophenotypic, and especially genetic characteris- i
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tics of the majority of hematolymphoid malignancies.
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Featuring a new structure and including new chapters, the third edition updates all
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content and presents considerable expansion on many topics, including: a
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• Metaphase cytogenetic and FISH n
• Flow cytometry (overview and detailed analysis of specific tumors) o
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• Acute myeloid leukemia and new classification schemes
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• MDS, AML, and B- and T-cell lymphoproliferations s

• Abnormal patterns in the lymph node and bone marrow with detail i
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differential diagnosis based on histologic features and cellular composition

• Detailed differential diagnosis based on the expression of broad list of N
antigenic markers (flow cytometry and immunohistochemistry) e
• Extranodal lymphomas o
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• Diagnosis of MDS and myeloproliferative neoplasm and their
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differential diagnosis based on the morphologic, flow cytometric, a
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and chromosomal features
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The book also provides expanded differential diagnosis of the most common as

well as most difficult and rare entities, including morphologic, immunophenotypic, H
and karyotypic/molecular features. This edition includes updated algorithms for e
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most common diagnoses as well as several new algorithms. The majority of
figures have been revised and are in full color. a
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About the Author:
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Dr. Wojciech Gorczyca is a noted authority in clinical flow cytometry and hemato- a
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pathology. He earned his medical degree and doctorate in pathology from Pomera-
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nian Medical University in Szczecin, Poland. A well-respected lecturer and author, o
he has published numerous peer-reviewed journal articles and six textbooks. l
o
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y Wojciech Gorczyca

K21710 Third Edition
Atlas of
Differential Diagnosis in
Neoplastic Hematopathology

T h i rd E d i t i o n
TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk
Atlas of
Differential Diagnosis in
Neoplastic Hematopathology

T h i rd E d i t i o n
Wojciech Gorczyca
Boca Raton London New York
CRC Press is an imprint of the
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Version Date: 20131217
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Dedication
To my wife, Elżbieta, and my daughters, Marta, Ewa, and Małgorzata.
TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk
Contents
Prefacexi
Abbreviations xiii
SECTION I General Histologic and Cytologic Features
Chapter 1 Lymph Node 1
Chapter 2 Bone Marrow21
SECTION II Immunophenotyping
Chapter 3 Flow Cytometry 49
Chapter 4 Immunohistochemistry 105
Chapter 5 Immunophenotypic Markers: Differential Diagnosis 119
SECTION III Introduction to Cytogenetics, FISH, and Molecular Testing
Chapter 6 Cytogenetics 155
Chapter 7 Fluorescence In Situ Hybridization and Polymerase Chain Reaction189
SECTION IV Mature B-Cell Neoplasms
Chapter 8 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and B-Cell Prolymphocytic Leukemia 211
Chapter 9 Mantle Cell Lymphoma 235
Chapter 10 Marginal Zone Lymphoma 251
Chapter 11 Follicular Lymphoma 267
Chapter 12 Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia 297
Chapter 13 Diffuse Large B-Cell Lymphoma and its Variants 307
Chapter 14 Hairy Cell Leukemia 335
vii
viii Contents
Chapter 15 Burkitt Lymphoma and B-Cell Lymphoma, Unclassifiable (with Features Intermediate between Burkitt
Lymphoma and DLBCL) 345
Chapter 16 Plasma Cell Neoplasms 359
Chapter 17 B-Cell Lymphomas with Plasmablastic Morphology and/or EBV Expression383
SECTION V Mature T-Cell Neoplasms
Chapter 18 Adult T-Cell Leukemia/Lymphoma 395
Chapter 19 T-Cell Prolymphocytic Leukemia and T-Cell Large Granular Lymphocyte Leukemia 401
Chapter 20 Peripheral T-Cell Lymphoma 417
Chapter 21 Angioimmunoblastic T-Cell Lymphoma 433
Chapter 22 Anaplastic Large Cell Lymphoma 447
Chapter 23 Extranodal Natural Killer/T- Cell Lymphoma, Nasal Type 465
SECTION VI Hodgkin Lymphoma
Chapter 24 Classical Hodgkin Lymphoma 473
Chapter 25 Nodular Lymphocyte Predominant Hodgkin Lymphoma 491
SECTION VII Myeloproliferative Neoplasms
Chapter 26 Introduction to Myeloproliferative Neoplasms 503
Chapter 27 Chronic Myeloid Leukemia 517
Chapter 28 Polycythemia Vera 533
Chapter 29 Essential Thrombocythemia 539
Chapter 30 Primary Myelofibrosis 545
Chapter 31 Other Myeloproliferative Neoplasms 551
Contents ix
SECTION VIII M yelodysplastic Syndromes and Mixed Myelodysplastic/
Myeloproliferative Neoplasms
Chapter 32 Myelodysplastic Syndromes 565
Chapter 33 Mixed Myelodysplastic–Myeloproliferative Neoplasms 597
SECTION IX Acute Myeloid Leukemia: An Introduction
Chapter 34 Acute Myeloid Leukemia: An Introduction 611
Chapter 35 Acute Myeloid Leukemia without Specific Genetic Changes 645
Chapter 36 Acute Myeloid Leukemia with Recurrent Genetic Abnormalities 675
SECTION X Acute Lymphoblastic Leukemia and Other Hematopoietic Tumors
Chapter 37 B-Lymphoblastic Leukemia/Lymphoma 695
Chapter 38 T-Lymphoblastic Leukemia/Lymphoma 715
Chapter 39 Other Tumors 729
SECTION XI Extranodal Lymphomas and Their Differential Diagnosis
Chapter 40 Body Cavities 751
Chapter 41 Liver 759
Chapter 42 Lung and Mediastinum 771
Chapter 43 Salivary Glands 783
Chapter 44 Skin 789
Chapter 45 Spleen 831
Chapter 46 Stomach and Gastrointestinal Tract 853
Chapter 47 Testis 881
Index 891