Table Of ContentARTERIAL MESENCHYME
AND ARTERIOSCLEROSIS
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
Nathan Back State University of New York at Buffalo
N. R. Di Luzio Tulane University School of Medicine
Bernard Halpern College de France and Institute of Immuno-Biology
Ephraim Katchalski The Weizmann Institute of Science
David Kritchevsky Wistar Institute
Abel Lajtha New York State Research Institute for Neurochemistry and Drug Addiction
Rodolfo Paoletti University of Milan
Recent Volumes in this Series
Volume 38
HUMAN HYPERLIPOPROTEINEMIAS: Principles and Methods
Edited by R. Fumagalli, G. Ricci, and S. Gorini • 1973
Volume 39
CURRENT TOPICS IN CORONARY RESEARCH
Edited by Colin M. Bloor and Ray A. Olsson' 1973
Volume 40
METAL IONS IN BIOLOGICAL SYSTEMS: Studies of Some Biochemical and
Environmental Problems
Edited by Sanat K. Dahr • 1973
Volume 41A
PURINE METABOLISM IN MAN: Enzymes and Metabolic Pathways
Edited by O. Sperling, A. De Vries, and J. B. Wyngaarden • 1974
Volume 41B
PURINE METABOLISM IN MAN: Biochemistry and Pharmacology of Uric Acid Metabolism
Edited by O. Sperling, A. De Vries, and J. B. Wyngaarden • 1974
Volume 42
IMMOBILIZED BIOCHEMICALS AND AFFINITY CHROMATOGRAPHY
Edited by R. B. Dunlap' 1974
Volume 43
ARTERIAL MESENCHYME AND ARTERIOSCLEROSIS
Edited by William D. Wagner and Thomas B. Clarkson' 1974
Volume 44
CONTROL OF GENE EXPRESSION
Edited by Alexander Kohn and Adam Shatkay • 1974
Volume 45
THE IMMUNOGLOBULIN A SYSTEM
Edited by Jiri Mestecky and Alexander R. Lawton· 1974
Volume 46
PARENTERAL NUTRITION IN INFANCY AND CHILDHOOD
Edited by Hans Henning Bode and Joseph B. Warshaw. 1974
ARTERIAL MESENCHYME
AND ARTERIOSCLEROSIS
Edited by
William D. Wagner and
Thomas B. Clarkson
Department of Comparative Medicine
Arteriosclerosis Research Center
The Bowman Gray School of Medicine
Wake Forest University
Winston-Salem, North Carolina
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
International Workshop on Arterial Mesenchyme and Arteriosclerosis,
New Orleans, 1973.
Arterial mesenchyme and arteriosclerosis.
(Advances in experimental medicine and biology, v. 43)
Includes bibliographies.
1. Arteriosclerosis-Congresses. 2. Mesenchyme-Congresses. I. Wagner, William
D., 1943· ed. II. Clarkson, Thomas B., 1931· ed. III. Title. IV. Series.
[DNLM: 1. Arteries-Congresses. 2. Arteriosclerosis-Physiopathology-Con·
gresses.3. Mesoderm-Congresses. WIAD559 v. 43 1973jWG550 I625a 1973]
RC692.157 1973 616.1'36 74·5207
ISBN-13: 978-1-4684-3245-9 e-ISBN-13: 978-1-4684-3243-5
DOl: 10.1007/978-1-4684-3243-5
Proceedings of an International Workshop on Arterial Mesenchyme and
Arteriosclerosis held in New Orleans, April 2·3, 1973
© 1974 Plenum Press, New York
Softcover reprint of the hardcover 1st edition 1974
A Division of Plenum Publishing Corporation
227 West 17th Street, New York, N.Y. 10011
United Kingdom edition published by Plenum Press, London
A Division of Plenum Publishing Company, Ltd.
4a Lower John Street, London, WIR 3PD, England
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
PREFACE
Presently, and in the past, the predominant investigative
emphasis among research workers in arteriosclerosis has been on
plasma and arterial lipids. Recent data from a number of
laboratories suggest that arterial mesenchyme is of considerable
importance in the pathogenesis and fate of arteriosclerotic lesions.
The significance of some of these observations made it clear that
there was need for intensified research on the connective tissue
components of the arteriosclerotic lesion and that arteriosclerosis
research workers could benefit from a more comprehensive view of the
subject.
Because of their experience in the field of arteriosclerosis
and their interest in stimulating new directions for research
on the lesion, the Committee on Coronary Artery Lesions and
Myocardial Infarctions of the Council on Arteriosclerosis, American
Heart Association, planned an International Workshop on Arterial
Mesenchyme and Arteriosclerosis.
The Workshop brought together scientists expert in connective
tissue research and research on arteriosclerosis who presented the
current status of knowledge in their areas of expertise.
The Workshop was held April 2-3, 1973 at the Royal Orleans
Hotel, New Orleans, Louisiana and was attended by more than 170
people. The twenty papers and discussions presented in this
volume summarize the proceedings of the Workshop and represent a
comprehensive review of the role of arterial mesenchyme in
arteriosclerosis.
The first section of the volume sets the problem in perspec
tive and includes papers by several expert participants who define
the mesenchymal components with respect to the arterial wall and
the arteriosclerotic lesion. The Workshop then addressed itself
to the interaction of lipids with the various connective tissue
components such as collagen, elastin, glycosaminoglycans, and
glycoproteins. The third section of papers is intended to stimu
late interest in tissue culture technology and deals with culture
v
vi PREFACE
techniques applicable in the study of arteriosclerosis. The final
series of papers addresses the pathologic processes resulting
from the interactions of connective tissue components and the
arterial wall.
We are hopeful that the Workshop and the published proceedings
will stimulate investigators to undertake specific new directions
in investigating the pathogenesis of arteriosclerosis, including
progression and regression of lesions, based on new knowledge of
mesenchymal tissues.
One of our aims was to publish and disseminate to other
investigators in arteriosclerosis and connective tissue research
the information presented at the workshop as soon as possible.
In this regard we apologize for any unavoidable form and stylistic
imperfections. During the printing process for the book all
illustrations were reduced 10% in addition to any reductions
listed for figures. Certain remarks of some of the participants
were not recorded clearly at the meeting; therefore, to those
discussants omitted we apologize.
We should like to acknowledge the following support provided
for the workshop and the preparation of the proceedings.
National Heart and Lung Institute (HL 15707), National
Institutes of Health
Committee on International Program, American Heart
Association
Committee on Coronary Artery Lesions and Myocardial
Infarction, American Heart Association
The local arrangements for the meeting were gratefully
provided by the staff of the L.S.D. SCOR in Arteriosclerosis
under the direction of Dr. Gerald Berenson.
The editors thank the efficient assistance of Mrs. Shirley
Pegram, Ms. Suzanne Pickett, and Ms. Martha Van Noppen in the
technical preparation of the manuscripts for publication.
William D. Wagner
Thomas B. Clarkson
ORGANIZING COMMITIEE
CIARKSON, THOMAS B. Department of Comparative Medicine
Chairman Bowman Gray School of Medicine
Wake Forest University
Winston-Salem, North Carolina
WAGNER, WILLIAM D. Department of Comparative Medicine
(ad hoc as Assistant Bowman Gray School of Medicine
to Chairman) Wake Forest University
Winston-Salem, North Carolina
BERENSON, GERALD S. Departments of Medicine and
(ad hoc for Local Biochemistry
Arrangements) Louisiana State University
Medical Center
New Orleans, Louisiana
ARMSTRONG, MARK L. Department of Internal Medicine
The University of Iowa
Iowa City, Iowa
CHOBANIAN, ARAM VAN Department of Medicine
Boston University Medical School
Boston, Massachusetts
DAOUD, ASSAAD S. Department of Pathology
Veterans Administration Hospital and
Albany Medical College
Albany, New York
FRANTZ, IVAN D., JR. Department of Medicine
University of Minnesota
Medical School
Minneapolis, Minnesota
vii
viii ORGANlllNG COMMITIEE
GORE, IRA Department of Pathology
University of Alabama
Medical School
Birmin~ham, Alabama
MCGILL, HENRY C. Department of Pathology
University of Texas
Medical School
San Antonio, Texas
STRONG, JACK P. Department of Pathology
Louisiana State University
Medical Center
New Orleans, Louisiana
WISSLER, ROBERT W. Department of Pathology
University of Chicago
Chicago, Illinois
WORKSHOP PARTICIPANTS
BERENSON, GERALD S. Department of Medicine
and Biochemistry
Louisiana State University
Medical Center
New Orleans, Louisiana
DAOUD, ASSAAD S. Department of Pathology
Veterans Administration
Hospital and Albany Medical College
Albany, New York
DORFMAN, ALBERT Department of Pediatrics
The University of Chicago
Chicago, Illinois
FEDOROFF, SERGEY Department of Anatomy
University of Saskatchewan
Saskatoon
Saskatchewan, Canada
FISHER-DZOGA, KATTI Department of Pathology
The University of Chicago
Chicago, Illinois
GEER, JACK C. Department of Pathology
College of Medicine
The Ohio State University
Columbus, Ohio
GROSS, JEROME Developmental Biology Laboratory
Harvard Medical School
Massachusetts General Hospital
Boston, Massachusetts
HAUST, M. DARIA Department of Pathology
The University of Western Ontario
London, Ontario, Canada
ix
x WORKSHOP PARTICIPANTS
KRAMSCH, DIETER M. Department of Medicine
University Hospital
Boston University Medical Center
Boston, Massachusetts
LABELLA, FRANK S. Department of Pharmacology and
Therapeutics
University of Manitoba
Faculty of Medicine
Winnipeg 3, Canada
MCMILLAN, GARDNER C. National Heart and Lung Institute
National Institutes of Health
Bethesda, Maryland
MINICK, C. RICHARD Department of Pathology
MURPHY, GEORGE E. The New York Hospital
Cornell Medical Center
New York, New York
MUIR, HELEN Kennedy Institute of Rheumatology
Bute Gardens, Hammersmith
London, England
PARTRIDGE, S. M. Agricultural Research Council
Meat Research Institute
Langford, Bristol
RENAIS, J. Centre de Recherches Cardiologiques
Hospital Boucicaut
Paris, France
ROBERT, LADISLAS Laboratoire de Biochimie du Tissu
Conjonctif
Faculte de Medecine
Universite Paris-Val de Marne
Creteil, France
ROSS, RUSSELL Department of Pathology and
Medicine
University of Washington
School of Medicine
Seattle, Washington
STARY, HERBERT C. Department of Pathology
Louisiana State University
Medical Center
New Orleans, Louisiana
Description:Presently, and in the past, the predominant investigative emphasis among research workers in arteriosclerosis has been on plasma and arterial lipids. Recent data from a number of laboratories suggest that arterial mesenchyme is of considerable importance in the pathogenesis and fate of arteriosclero
