Arsenicals containing quinoline and quinazoline nuclei

49 Pages·06.583 MB·English

by  Wu, Yao Hua

NOTE TO USERS
This reproduction is the best copy available.
UMI®
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
UNIVERSITY OF NEBRASKA UERARIES
MANUSCRIPT THESIS
Permission to use this thesis has been given by the
author or department under "whose direction it is written.
Approved by author
Approved by department .... .
It is expected that proper credit will be given for any
quotations taken from this work. Extensive copying or pub­
lication of the thesis in whole or in part requires the
written consent of the author or department.
This thesis has been used by the following person, whose
signatures attest their acceptance of the above restrictions.
A library which borrows this thesis for use by its patrons
is expected to secure the signature of each user,
■— ™ '"-“pate" ‘
i
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
AMfMEWATEJt fJGKTAXHXIKi
$nofQbxss km kxjglei
W
tm Huft Wu
A THESIS
Presented to Hi* Faculty of
Hi® Gratuat# College la tb« Wa&yoratty #f
In Partial ftilflllaetoS of B»cpi 2j*siassS® feo* t&©
' ©*gr©e of ©00/tea? of Pliilosopliy
Ifed*** Wm 8ap*rriai*» *f Or* #*. S* laalltoa
»• •
• «• <!
Limooln, Helaraska
81, 1851
M u r
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
UMI Number: DP14025
INFORMATION TO USERS
The quality of this reproduction is dependent upon the quality of the copy
submitted. Broken or indistinct print, colored or poor quality illustrations and
photographs, print bleed-through, substandard margins, and improper
alignment can adversely affect reproduction.
In the unlikely event that the author did not send a complete manuscript
and there are missing pages, these will be noted. Also, if unauthorized
copyright material had to be removed, a note will indicate the deletion.
UMI®
UMI Microform DP14025
Copyright 2006 by ProQuest Information and Learning Company.
All rights reserved. This microform edition is protected against
unauthorized copying under Title 17, United States Code.
ProQuest Information and Learning Company
300 North Zeeb Road
P.O. Box 1346
Ann Arbor, Ml 48106-1346
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
writer ®Fafc«fally aelsaoirltdg*#
M * t» Bv« 0 . 3*. ttw & tlN !
who directed $fet« i»T«afcigati0m# and
to the University of lf«hr&8ie& feap
. iTnhitan'n JtsttkiWr BtaXXowslii'DS *
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
tu fts w m m m xm
?ag«
X* X8S8®I^®SX0S* ■•* #■ * * * *. « # #■ *■ * . . X
* *
XX* £XS0t3S$X0B* * * * ■*• ♦ * *. .* * ■*• •# * * * ♦ * * .» 8
xxx* w m w rn m * m m m i * * . * * .* . * * *■■*.*..# *• .■ :m
XS* SKEBRXKfflFSMEi* ■ * * * * # # * « * * *■ * * > * * 10
A* of 4-*lxdx»©jgrquiaolin« A r««tiftalc
jfcffiai M islz Xtt%«iwi53sSss « • • * * • • « • • X®
X* 4-Hydh*©xy<pte®Xliy*. . . 16
Cn| D iethyl AnilinoaethyleneaSLlonate. . 16
(h | ®-*Garh®«io*y**4^hydp©3Ey<pljaoXia« * * X#
(©J ®»0&i»h@ j^«^^y^<s3Ey<|tiia©Xiat* « * • 1?
£tj 4*% ^ « 0^ |iiX ii» lla » . * * * • * * , * I f
$» 4*% droa^-®*iiiti?©<ittiiielim o, * ♦ * . * # . $0
S« @*Amiiio»4*hy<lpoxy<|ttto©lia« • . . . . . . 18
4* 4-% <iroxyquinoliJie-6-arsoiiio Acid * , * 19
1* ®*Ai»s©ii#s®-4»hyd3?©xycplmolia« « . * . . 20
i* 4»Qhl®rcnp im oliao * * * . * * * ♦ . . . 20
f * * *. * * * * * . 'M
8 . 8«Aaiao*»4 '*0hl^fo<|iiiholia# * « . « * * # 21
i* jw ts *• * * ■ i t
If * 4-i^rtJ*oaEy-S««i#8iyl<|ala©llA# * • « * * * 08
(AJ Ith y l @ »«iiilia0#i*ot©aat® . . * . ♦ , 23
fill • *..*♦> ■ 88
11* 4»HydJ*o3sy'-2-a®^.yl-6«^ltp@gttlnolte# * *r 24
1®# 6-telao»4*hyd^o3qr-8'-«®^ylqm laollm » » *- ■ 88.
38 • 4*Hyd3*o3qr»2^m#tliyl{|alaollii®-6*ai*soaie A elt 80
i
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
14. 26
XI* 4»Clil©j?o**t»m©«iyXQMim©lla#. * * * * • * 2?
XI# 4-0toX©ro•i^ao tbyl^^tr oqplMllaui. * * .If
I* fi?®p«a%lm of Arsenicals
and Haoii? X2t©n*4iatos* * * * • * . . . . . if
Xf. 4*^di*®3ty^itisiag@Xiafi. * * * * » * * * * if
XS# 4H$yir «xy ^^tv*qalAft*»ll&*• * * « * -*■ 28
If* M & %p o*&1far*alll « Aoi# * *. * * * * * * H
■ (a) 3-Nltrophthftllmid©. «. * » « . . * * 28
{%) I"4T11*« a&lfegtt&ili* Acid . . . * . . 28
2#* 4*%di»o^-I-Nai%3«»futa&fJoXla«. * * * # * SI
21* 4klTltF0*&tfaipMillle A®id * * * * * * * * 4HI
US* 4-%dr^*7-iy(.%i?@qmimz©XX^ * * * *..« *. S§
21. Amino-4**liy<fe*©3qrq|uinaE©liae® , ♦ . . . . 31
(a) 6*iliaiao-*4-ii7droxrqttlaaa@lia«* * * * SI
( I) iii* u p l£ a s * * * * 'IX
.
(c) T^AiiXao-A-^ydFcsKjrfuijaazollaa. * * * .-IX
■ 'Si*; AsiH# * * IS:
| a) 4-%di*<«yQttimajs#lia««I-ar®oalo Aeid $H-
{fe| A«il .1$
C@) Ailft ' -IP'
21# f~Ax*»®aoa o-4-hyIra£yfttimaa@Xii*§ . . . • 33
21* 4*#toX^ri^pii»sw@Xii^.-* * * * * * .#• « *'-*■ 1$
I* Condensation of 4**I&l©li»t®F©§y<iX«a witfa *»
Arsanillc Acid . . . . . . . . . . . . . . . 34
if* 4* C 4 *«&x>a«i&Mi&ill&oItaroeyaloa * * * #4.
i
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
(a) 4-{4*-»4i*»oaoaallim9}*8^ t*oqalaaXlxk» it
C%| 4~<4 * -Arseaaoaaillae) th^uiaolfe* .19
C@) 4~(4 »-Ars<moanilino)-£-a* thyl-6- ■
nitroqulnoline. * * « * « * • * • # 35
|4 ) 4 -{4 *-A j*s o iio ira illn o )» ^ te a s© iiia® * * . i§
©* Analytical Methods . . . . . . . . . . . . . 35
? * srowiAwr# * ♦ » # * * * * # * #■ • * • #• * * ■* *■ # w
*JU BmiOGMFHT . , * » * * , ♦ * * * * * * * * * * I t
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.