Aromatic Hydroxyketones: Preparation and Physical Properties

2935 Pages·2011·11.6 MB·English

by  Robert Martin (auth.)

Aromatic Hydroxyketones:
Preparation and Physical Properties

Robert Martin
Aromatic Hydroxyketones:
Preparation and Physical
Properties
Robert Martin
Emeritus Professor
Formerly Curie Institute
Paris, France
[email protected]
ISBN 978-1-4020-9786-7 e-ISBN 978-1-4020-9787-4
DOI 10.1007/978-1-4020-9787-4
Springer Dordrecht Heidelberg London New York
© Springer Science+Business Media B.V. 2011
No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any
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Printed on acid-free paper
Springer is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to Canon Joseph
Clerc priest at Montmorot (Jura, France,
1899-1985) who in 1944 gave a home to the
Martin brothers, young Parisians refugees.
Robert Martin

Foreword
It is my great pleasure to write a foreword for Dr. R. Martin’s handbook on Fries
rearrangement and their aromatic hydroxyketones products. The present work is the
result of numerous years of experience in compiling and editing data.
I have known Dr. Martin since my arrival at the Curie Institute in the 1990s and
his enthusiasm was most encouraging, setting a good example of passion for chem-
istry. Although being retired from industry, he deliberately came to work in our
team, not only for bibliographical work but also for working at the bench.
In this work, special effort has been made to select material suitable to meet the
needs of chemists who do not benefit from unlimited time for specialized research
in the field of hydroxyacetophenones and hydroxybenzophenones. These com-
pounds are precursors of substituted aromatic derivatives which are often not
straightforwardly obtained but have many potential applications in fine and medicinal
chemistry.
I recognize that it represented a huge effort for Dr. Martin to produce such an
exhaustive compilation within the limits set to him by the economy of space. This
work will primarily be of great value to professional chemists, from physicists to
pharmacists, who are often called upon to solve problems about the synthesis of this
kind of aromatic compounds.
In this handbook set, the reader will find four independent parts which succes-
sively cover the topics of monoaroyl and polyaroylphenols in Volume 1, hydroxy-
acetophenones in Volume 2, substituted hydroxyacetophenones in Volume 3 and
hydroxypropiophenones, hydroxyisobutyrophenones and hydroxypivalophenones
in Volume 4.
For such needs as described above, this compilation will supply helpful and
easy-to-read information, even in our computerized era.
Dr. Jean-Claude Florent
Director of the CNRS/Institut Curie Research Unit “Conception,
Synthesis and Targeting of Biomolecules”
Institut Curie, Paris
vii

Preface
Aromatic hydroxyketones are widely used as starting materials in organic synthesis
to obtain medicines, dyes, perfumes, plastics, explosives, preservatives, etc. and,
what is more, many of them also offer very specific uses.
This Handbook contains information on Hydroxybenzophenones,
Hydroxyacetophenones, Hydroxypropiophenones, Hydroxyisobutyrophenones,
Hydroxypivalophenones and numerous methylethers, collecting more than 6,000
ketones of which an indicated preparation as well as their physico-chemical and
spectrochemical data are presented. This updated study now also covers the litera-
ture from 1890 until December 2008, including circa 8,500 references.
Aromatic Hydroxyketones: Preparation and Physical Properties is presented in
dictionary style, with a logical classification of the ketones, which makes the infor-
mation easily available for consultation. Ketones are classified methodically. As a
result, they are easily accessible to the reader from three tables provided at the end
of Volume 4: the molecular formula index, the Chemical Abstracts Registry
Numbers and the usual names index.
This is the reason why it seemed interesting to update the contents of the four
previous volumes and regroup them into one big handbook set. In this format, it
will be more convenient for its main users, academics and industrial chemists.
Robert Martin
Institute Curie, France
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