Appendices

428 Pages·2015·8.41 MB·English

by  Michael Heath

Medicines Optimisation

Contents
Appendices
Contents

Appendix A: Guideline Development Group Declarations of Interest ....................... 2
A.1 GDG members ........................................................................................... 2
A.2 NICE Medicines prescribing centre team and additional GDG meeting
attendees ................................................................................................. 11
Appendix B: Scope ................................................................................................ 16
Appendix C: How this guideline was developed ..................................................... 21
C.1 Search strategies for the Medicines Optimisation guideline ..................... 21
C.2 Review questions and review protocols ................................................... 34
C.3 Clinical consort diagrams ......................................................................... 53
C.4 Economic consort diagrams ..................................................................... 58
C.5 Clinical excluded studies .......................................................................... 64
C.6 Economic excluded studies .................................................................... 145
Appendix D: Clinical Evidence Tables and GRADE profiles ................................. 166
D.1 Evidence Tables .................................................................................... 166
D.2 Grade profiles and forest plots ............................................................... 320
D.3 Medicines reconciliation algorithm.......................................................... 399
Appendix E: Economic Evidence Tables .............................................................. 401
Appendix F: ................................................................................................................ 423
F.1 Medication review cost analysis ............................................................. 423
F.2 Full Health Economics Report ................................................................ 428

NICE guideline 5 – Medicines optimisation appendices (March 2015) 1
Medicines Optimisation

Guideline Development Group Declarations of Interest
Appendix A: Guideline Development
Group Declarations of Interest
A.1 GDG members
Weeliat Chong (Chair)
GDG meeting Declaration of interest Action taken
Recruitment/ First None None
GDG meeting (27
November 2013)
Second GDG No changes to record None
meeting (14
January 2014)
Third GDG No changes to record None
meeting (4 March
2014)
Fourth GDG No changes to record None
meeting (2 April
2014)
Fifth GDG No changes to record None
meeting (29 April
2014)
Sixth GDG No changes to record None
meeting (2 July
2014)
Seventh GDG No changes to record None
meeting (5 August
2014)
Eigth GDG No changes to record None
meeting (25
November 2014)
Stephen Dean
GDG meeting Declaration of interest Action taken
Recruitment/ First None None
GDG meeting (27
November 2013)
Second GDG No changes to record None
meeting (14
January 2014)
Third GDG No changes to record None
meeting (4 March
2014)
Fourth GDG No changes to record None
meeting (2 April
2014)
Fifth GDG No changes to record None
meeting (29 April
2014)
Sixth GDG No changes to record None
meeting (2 July
NICE guideline 5 – Medicines optimisation appendices (March 2015) 2
Medicines Optimisation

Guideline Development Group Declarations of Interest
GDG meeting Declaration of interest Action taken
2014)
Seventh GDG No changes to record None
meeting (5 August
2014)
Eigth GDG No changes to record None
meeting (25
November 2014)
David Erskine
GDG meeting Declaration of interest Action taken
Recruitment/ First None None
GDG meeting (27
November 2013)
Second GDG No changes to record None
meeting (14
January 2014)
Third GDG No changes to record None
meeting (4 March
2014)
Fourth GDG No changes to record None
meeting (2 April
2014)
Fifth GDG No changes to record None
meeting (29 April
2014)
Sixth GDG No changes to record None
meeting (2 July
2014)
Seventh GDG No changes to record None
meeting (5 August
2014)
Eigth GDG No changes to record None
meeting (25
November 2014)
Leslie Galloway (member until end May 2014)
GDG Type
meeting Declaration of interest Action taken
Recruitment/ Presents to members of EMIG Advice given regarding Specific personal non-
First GDG and will be asked about speaking about financial
meeting (27 medicines optimisation. medicines optimisation.
November He stated he will not
2013) answer questions
directly relating to
medicines optimisation
while on the GDG
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG No changes to record None
meeting (4
March 2014)
Fourth GDG No changes to record None
NICE guideline 5 – Medicines optimisation appendices (March 2015) 3
Medicines Optimisation

Guideline Development Group Declarations of Interest
GDG Type
meeting Declaration of interest Action taken
meeting (2
April 2014)
Fifth GDG No changes to record None
meeting (29
April 2014)
Withdrew from GDG
Brian Hawkins
GDG Type
meeting Declaration of interest Action taken
Recruitment/ Presentation at training event for None Non-specific personal
First GDG MSD staff - May 2011 non-financial
meeting (27
November
Presentation at training event for Non-specific personal
2013)
Lilly staff – June 2011 non-financial

Employer, Cwm Taf LHB, has Non-specific non-
received funding for project from personal financial
TEVA UK ltd and GSK.
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG No changes to record None
meeting (4
March 2014)
Fourth GDG No changes to record None
meeting (2
April 2014)
Fifth GDG No changes to record None
meeting (29
April 2014)
Sixth GDG No changes to record None
meeting (2
July 2014)
Seventh Asked to be a speaker at the Advised he needs to be Specific personal non-
GDG hospital pharmacy Europe very careful of the financial
meeting (5 conference in Birmingham on 9 content of the
August 2014) September 2014 on the subject of presentation and not
“Optimising medicines discuss the guideline.
management”.
Eigth GDG No changes to record None
meeting (25
November
2014)
John Holden
GDG meeting Declaration of interest Action taken
Recruitment/ First None None
GDG meeting (27
November 2013)
Second GDG No changes to record None
meeting (14
NICE guideline 5 – Medicines optimisation appendices (March 2015) 4
Medicines Optimisation

Guideline Development Group Declarations of Interest
GDG meeting Declaration of interest Action taken
January 2014)
Third GDG No changes to record None
meeting (4 March
2014)
Fourth GDG No changes to record None
meeting (2 April
2014)
Fifth GDG No changes to record None
meeting (29 April
2014)
Sixth GDG No changes to record None
meeting (2 July
2014)
Seventh GDG No changes to record None
meeting (5 August
2014)
Eigth GDG No changes to record None
meeting (25
November 2014)

Tessa Lewis
GDG
meeting Declaration of interest Action taken
Recruitment/ None None
First GDG
meeting (27
November
2013)
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG Wrote an article on medication None at present. Specific personal non-
meeting (4 review. financial
March 2014)
Fourth GDG No changes to record None
meeting (2
April 2014)
Fifth GDG No changes to record None
meeting (29
April 2014)
Sixth GDG No changes to record None
meeting (2
July 2014)
Seventh No changes to record None
GDG
meeting (5
August 2014)
Eigth GDG No changes to record None
meeting (25
November
2014)
NICE guideline 5 – Medicines optimisation appendices (March 2015) 5
Medicines Optimisation

Guideline Development Group Declarations of Interest
Harriet Lewis
GDG Type
meeting Declaration of interest Action taken
Recruitment/ Employee of Association of None Non-specific personal
First GDG British Pharmaceutical Industry financial
meeting (27 (ABPI)
November
2013)
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG No changes to record None
meeting (4
March 2014)
Fourth GDG No changes to record None
meeting (2
April 2014)
Fifth GDG No changes to record None
meeting (29
April 2014)
Sixth GDG No changes to record None
meeting (2
July 2014)
Seventh No changes to record None
GDG
meeting (5
August 2014)
Eigth GDG No changes to record None
meeting (25
November
2014)
Margaret Ogden
GDG Type
meeting Declaration of interest Action taken
Recruitment/ Sits on a voluntary patient Advised not to discuss Non-specific personal
First GDG advisory group with a the guideline. non-financial
meeting (27 pharmaceutical company
November Attended a one-to-one meeting Non-specific personal
2013) with a small pharmaceutical non-financial
company.
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG No changes to record None
meeting (4
March 2014)
Fourth GDG Working with Alzheimer’s Society None at present Non-specific personal
meeting (2 on patient reported outcomes non-financial
April 2014)
Fifth GDG No changes to record None
meeting (29
April 2014)
Sixth GDG Attending a medication safety None at present Non-specific personal
NICE guideline 5 – Medicines optimisation appendices (March 2015) 6
Medicines Optimisation

Guideline Development Group Declarations of Interest
GDG Type
meeting Declaration of interest Action taken
meeting (2 focus group on 11 July for NIHR non-financial
July 2014) Greater Manchester Primary
Care Patient Safety Translational
Research Centre
Seventh No changes to record None
GDG
meeting (5
August 2014)
Eigth GDG No changes to record None
meeting (25
November
2014)
Bunis Packham
GDG Type
meeting Declaration of interest Action taken
Recruitment/ Previously work involved None Non-specific personal
First GDG medicines adherence non-financial
meeting (27
November
2013)
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG No changes to record None
meeting (4
March 2014)
Fourth GDG No changes to record None
meeting (2
April 2014)
Fifth GDG No changes to record None
meeting (29
April 2014)
Sixth GDG No changes to record None
meeting (2
July 2014)
Seventh No changes to record None
GDG
meeting (5
August 2014)
Eigth GDG No changes to record None
meeting (25
November
2014)
Richard Seal
GDG Type
meeting Declaration of interest Action taken
Recruitment/ Wife is a practice support Advised to be careful Non-specific personal
First GDG pharmacist employed by Arden when discussing financial
meeting (27 Commissioning Support Unit and medicines optimisation
November also employed as a practice and to not discuss the

2013) pharmacist by a GP practice. guideline.
NICE guideline 5 – Medicines optimisation appendices (March 2015) 7
Medicines Optimisation

Guideline Development Group Declarations of Interest
GDG Type
meeting Declaration of interest Action taken

Provides advisory support for Non-specific personal
pharmaceutical journal for which non-financial
he receives no recompense.

Spoken on medicine optimisation Specific personal non-
at the Pharmacy Management financial
National Seminar.
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG Notified the GDG that he is no None NA
meeting (4 longer a member of Pharmacy
March 2014) Management
Fourth GDG No changes to record None
meeting (2
April 2014)
Fifth GDG No changes to record None
meeting (29
April 2014)
Sixth GDG No changes to record None
meeting (2
July 2014)
Seventh No changes to record None
GDG
meeting (5
August 2014)
Eigth GDG No changes to record None
meeting (25
November
2014)
David Terry
GDG Type
meeting Declaration of interest Action taken
Recruitment/ Presenting at a conference in Advised not to discuss Non-specific personal
First GDG March 2014. the guideline and be non-financial
meeting (27 careful of presentation
November content.
2013)
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG Co-ownership of NuCo R&D Ltd. None at present but Non-specific personal
meeting (4 NuCo was incorporated as a may review at future financial
March 2014) company on 26th February 2014. meetings.
It is a research company but may
in the future also distribute and or
sell medicines. At present does
not believe there is anything on
NuCo’s agenda / portfolio that
causes concern with this
NICE guideline 5 – Medicines optimisation appendices (March 2015) 8
Medicines Optimisation

Guideline Development Group Declarations of Interest
GDG Type
meeting Declaration of interest Action taken
guideline. NuCo is not currently
trading.
Fourth GDG No changes to record None
meeting (2
April 2014)
Fifth GDG Accepted an invitation to take None Non-specific personal
meeting (29 part in The Clinical Pharmacy non-financial
April 2014) Congress 2014, 25 – 26 April
2014. He joined a panel,
sponsored by Sanofi-Aventis to
discuss the subject: The wider
role of pharmacists in delivering
outcomes in diabetes
Sixth GDG No changes to record None
meeting (2
July 2014)
Seventh No changes to record None
GDG
meeting (5
August 2014)
Eigth GDG No changes to record None
meeting (25
November
2014)
Katrina Vout
GDG meeting Declaration of interest Action taken
Recruitment/ First None None
GDG meeting (27
November 2013)
Second GDG No changes to record None
meeting (14
January 2014)
Third GDG No changes to record None
meeting (4 March
2014)
Fourth GDG No changes to record None
meeting (2 April
2014)
Fifth GDG No changes to record None
meeting (29 April
2014)
Sixth GDG No changes to record None
meeting (2 July
2014)
Seventh GDG No changes to record None
meeting (5 August
2014)
Eigth GDG No changes to record None
meeting (25
November 2014)
NICE guideline 5 – Medicines optimisation appendices (March 2015) 9
Medicines Optimisation

Guideline Development Group Declarations of Interest
Mary Weatherstone
GDG Type
meeting Declaration of interest Action taken
Recruitment/ Member of an NHS England Advised not to discuss Specific personal non-
First GDG clinical reference group on the guideline at the financial
meeting (27 Medicines Optimisation. reference group.
November
2013)
Is a NICE MPC Associate
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG No changes to record None
meeting (4
March 2014)
Fourth GDG No changes to record None
meeting (2
April 2014)
Fifth GDG No changes to record None
meeting (29
April 2014)
Sixth GDG No changes to record None
meeting (2
July 2014)
Seventh No changes to record None
GDG
meeting (5
August 2014)
Eigth GDG No changes to record None
meeting (25
November
2014)
Nigel Westwood
GDG Type
meeting Declaration of interest Action taken
Recruitment/ Received travel expenses and Advised not to discuss Non-specific personal
First GDG attendance fees from a number of the guideline. financial
meeting (27 pharmaceutical companies when
November attending meetings (Abbott,
2013) Proctor and Gamble, Kinetic
Concepts Inc., UCB and Warner
Chillcott) as a speaker on patient
experience to pharmaceutical
staff, trainee medical
professionals and specialist
registrars.
Second GDG No changes to record None
meeting (14
January
2014)
Third GDG No changes to record None
meeting (4
March 2014)
Fourth GDG No changes to record None
meeting (2
NICE guideline 5 – Medicines optimisation appendices (March 2015) 10