Table Of ContentAOSpine Maste rs Se rie s
Spinal Co rd Injury and Re g e ne ratio n
AOSpine Mast e rs Se rie s
Spinal Co rd Injury and Re g e ne ratio n
Series Editor:
Luiz Roberto Vialle, MD, PhD
Professor of Orthopedics, School of Medicine
Catholic University of Parana State
Spine Unit
Curitiba, Brazil
Guest Editors:
Michael G. Fehlings, MD, PhD, FRCSC, FACS
Head Spinal Program and Senior Scientist
McEwen Centre for Regenerative Medicine
Toronto Western Hospital
University Health Network
Professor of Neurosurgery
Vice Chair Research
Halbert Chair in Neural Repair and Regeneration
Co-Chairman Spinal Program
Division of Neurosurgery
Department of Surgery
University of Toronto
Toronto, Ontario, Canada
Norbert Weidner, MD
Professor and Chair
Spinal Cord Injury Center
Heidelberg University Hospital
Heidelberg, Germany
With 31 f gures
Thiem e
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Library of Congress Cataloging-in-Publication Data
Names: Vialle, Luiz Roberto, editor. | Fehlings, Michael, editor. | Weidner, Norbert, editor. | AOSpine
International (Firm), sponsoring body.
Title: AOSspine masters series. V. 7, Spinal cord injury and regeneration / editors, Luiz Roberto Vialle,
Michael G. Fehlings, Norbert Weidner.
Other titles: Spinal cord injury and regeneration
Description: New York : Thieme, [2016] | Includes bibliographical references and index.
Identi ers: LCCN 2016021476 (print) | LCCN 2016021669 (ebook) | ISBN 9781626232273 (alk. paper) | ISBN
9781626232280
Subjects: | MESH: Spinal Cord Injuries—therapy | Spinal Cord Regeneration
Classi cation: LCC RA645.S66 (print) | LCC RA645.S66 (ebook) | NLM WL 403 | DDC 617.4/82044—dc23
LC record available at https://lccn.loc.gov/2016021476
Copyright ©2017 by Thieme Medical Publishers, Inc.
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AOSpine Maste rs Se rie s
Luiz Roberto Vialle, MD, PhD
Series Editor
Volume 1 Metastatic Spinal Tumors
Volume 2 Primary Spinal Tumors
Volume 3 Cervical Degenerative Conditions
Volume 4 Adult Spinal Deformities
Volume 5 Cervical Spine Trauma
Volume 6 Thoracolumbar Spine Trauma
Volume 7 Spinal Cord Injury and Regeneration
Volume 8 Back Pain
Volume 9 Pediatric Spinal Deformities
Volume 10 Spinal Infection
Co nte nts
Series Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
Luiz Roberto Vialle
Guest Editors’ Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi
Michael G. Fehlings and Norbert Weidner
1 Pathobiology of Spinal Cord Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1
Hiroaki Nakashima, Narihito Nagoshi, and Michael G. Fehlings
2 Assessment of Functional Status and Outcomes of Individuals with
Traumatic Spinal Cord Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Christian Schuld and Norbert Weidner
3 Serum and CSF Biomarkers to Predict Functional Recovery After Spinal Cord Injury . . . . . 25
Seth S. Tigchelaar and Brian K. Kwon
4 Magnetic Resonance Imaging of the Injured Spinal Cord:
The Present and the Future . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Allan R. Martin, Julien Cohen-Adad, and Michael G. Fehlings
5 Acute Nonoperative Management of Traumatic Spinal Cord Injury:
State of the Art . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
Joshua S. Catapano, Gregory W.J. Haw ryluk, and Michael G. Fehlings
6 Role and Timing of Surgery for Traumatic Spinal Cord Injury:
What Do We Know and What Should We Do? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Christopher D. Witiw and Michael G. Fehlings
7 Methylprednisolone As a Valid Option for Acute Spinal Cord Injury:
A Reassessment of the Literature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80
Michael G. Fehlings and Newton Cho
8 Neuroprotection of the Injured Spinal Cord: What Does the Future Hold? . . . . . . . . . . . . . . . 89
Christopher S. Ahuja and Michael G. Fehlings
9 Hydrogel Biomaterials in Spinal Cord Repair and Regeneration . . . . . . . . . . . . . . . . . . . . . . . . 107
Manuel Ingo Günther, Thomas Schackel, Norbert Weidner, and Armin Blesch
viii
Contents
10 Neural Stem Cell Transplantation for Spinal Cord Repair . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122
Ina K. Simeonova, Beatrice Sandner, and Norbert Weidner
11 Strategies to Overcome the Inhibitory Environment of the Spinal Cord . . . . . . . . . . . . . . . . 132
Elizabeth J. Bradbury and Emily R. Burnside
12 Functional Electrical Stimulation and Neuromodulation Approaches to
Enhance Recovery After Spinal Cord Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
César Márquez-Chin, Emilie Sagripanti, and Milos R. Popovic
13 Advanced Rehabilitation Strategies for Individuals with Traumatic Spinal
Cord Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
William Z. Rymer, Sheila Burt, and Arun Jayaraman
14 Brain–Computer Interfaces to Enhance Function After Spinal Cord Injury . . . . . . . . . . . . . . 179
Rüdiger Rupp
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193
