Table Of ContentANTIOXIDANT-BASED
THERAPIES FOR DISEASE
PREVENTION AND MANAGEMENT
ANTIOXIDANT-BASED
THERAPIES FOR DISEASE
PREVENTION AND MANAGEMENT
Edited by
Pallavi Singh Chauhan, PhD
Sonia Johri, PhD
First edition published 2022
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Library and Archives Canada Cataloguing in Publication
Title: Antioxidant-based therapies for disease prevention and management / edited by Pallavi Singh Chauhan, PhD, Sonia Johri,
PhD.
Names: Chauhan, Pallavi Singh, editor. | Johri, Sonia, editor.
Description: First edition. | Includes bibliographical references and index.
Identifiers: Canadiana (print) 20210242795 | Canadiana (ebook) 20210242884 | ISBN 9781771889643 (hardcover) |
ISBN 9781774639092 (softcover) | ISBN 9781003129585 (ebook)
Subjects: LCSH: Antioxidants—Therapeutic use.
Classification: LCC RB170 .A55 2022 | DDC 616.07—dc23
Library of Congress Cataloging‑in‑Publication Data
Names: Chauhan, Pallavi Singh, 1989- editor. | Johri, Sonia, 1971- editor.
Title: Antioxidant-based therapies for disease prevention and management / edited by Pallavi Singh Chauhan, PhD, Sonia Johri,
PhD.
Description: First edition. | Palm Bay, FL : Apple Academic Press, 2022. | Includes bibliographical references and index. | Summary:
“This volume, Antioxidant-Based Therapies for Disease Prevention and Management, presents a valuable overview of the
therapeutic aspects as well as applications of antioxidants. This informative book discusses the basic mechanisms of therapy-
based oxidative damage and categorization of nutritional antioxidants. It covers the sources of antioxidants as well as their
extraction and quantification. The volume considers the controversies of the usefulness or disadvantages of antioxidant
supplementation in relation to adaptation and performance and also looks at the effectiveness of bioactives and antioxidant-
based therapies for specific health issues, such as anemia, infectious diseases, urinary tract infections, Parkinson’s diseases, and
diabetes. The book also discusses the sensing of oxidative stress and the effectiveness of antioxidant treatment, followed by
an introduction to several biomarkers to estimate the bioefficacy of dietary/supplemental antioxidants in various forms. Also
discussed are free radicals that can cause oxidative stress, a process that can trigger cell damage, and how antioxidant molecules
have been shown to counteract oxidative stress in laboratory experiments (for example, in cells or animal studies). Several
authors present studies that highlight that high-dose antioxidant supplements may be harmful in some cases. For example,
the results of some studies have linked the use of high-dose beta-carotene supplements to an increased risk of lung cancer
in smokers and use of high-dose vitamin E supplements to increased risks of hemorrhagic stroke (a type of stroke caused by
bleeding in the brain) and prostate cancer. With this book, sports nutrition scientists, nutritionists, food biochemists, advisors,
physiologists, students, and research scholars as well as faculty will find factual information on antioxidative therapies”--
Provided by publisher.
Identifiers: LCCN 2021028092 (print) | LCCN 2021028093 (ebook) | ISBN 9781771889643 (hardback) | ISBN 9781774639092
(paperback) | ISBN 9781003129585 (ebook)
Subjects: LCSH: Antioxidants--Therapeutic use.
Classification: LCC RB170 .A56 2022 (print) | LCC RB170 (ebook) | DDC 613.2/86--dc23
LC record available at https://lccn.loc.gov/2021028092
LC ebook record available at https://lccn.loc.gov/2021028093
ISBN: 978-1-77188-964-3 (hbk)
ISBN: 978-1-77463-909-2 (pbk)
ISBN: 978-1-00312-958-5 (ebk)
About the Editors
Pallavi Singh Chauhan, PhD
Pallavi Singh Chauhan, PhD, is Assistant Professor
at the Amity Institute of Biotechnology, Amity
University Madhya Pradesh, Gwalior, India, as
well as a researcher. Her research focuses on the
synthesis, characterization, and multiple biomedical
application of nanoparticles. The major fields of
science that are relevant to Dr. Chauhan’s work
include nanotechnology, nanobioscience, biomedical
application of nanotechnology, nanotoxicity, magnetic nanostructures,
nanocatalysts, and nanoparticle systems of metals and metal oxides.
Sonia Johri, PhD
Sonia Johri, PhD, is Dean of Academics and an
Associate Professor in the Department of Life
Sciences at ITM University, Gwalior, Madhya
Pradesh, India. She has over 40 papers to her
credit in journals of national and international
repute. She is an external member of the Board
of Studies in Biochemistry at Jiwaji University.
She is also a member of the Institutional Animal
Ethical Committee at ITM University, Gwalior. She has authored a book
entitled Practical Biochemistry, and she is a reviewer for various national
and international journals. She is a life member of the Indian Science
Congress Association. Dr. Johri has 23 years of research experience and
has worked extensively in the diversified fields of metal toxicity, anemia,
hepatoprotection, oxidative stress, and biofuels. Though there is vast
diversification in her field, she holds expertise in toxicological evaluation
of metal toxicants and their therapy in rat models, phytomedicine, oxida
tive stress, physicochemical characterization of natural products as well
as in vitro and in vivo biochemical characterization. She has also worked
on bioethanol production from agro-wastes. Her field of specialization
vi About the Editors
is diagnostic enzymology. She has attended and presented her work at
various international conferences held at Munich, Germany, and Quebec
City, Canada. Dr. Johri is a postgraduate in Biochemistry and was awarded
her doctoral degree from Jiwaji University, Gwalior, India. Her postdoc
toral research was sponsored by the Council of Scientific and Industrial
Research, New Delhi, India.
Contents
Contributors ......................................................................................................... ix
Abbreviations ....................................................................................................... xi
Foreword ............................................................................................................ xiii
Preface .................................................................................................................xv
Introduction ....................................................................................................... xvii
Acknowledgment ................................................................................................ xix
1. Nano‑Antioxidants, A Next‑Generation Therapeutic Strategy ............... 1
Pallavi Singh Chauhan, Shivam Tayal, and Namrata Jha
2. Role of Phytomedicine in the Challenges to Combat Anemia ............... 21
Sonia Johri
3. Role of Free Radicals during Infection and the Advancement of
Antioxidants to Improve the Treatment of Infectious Diseases ............ 53
Manitosh Pandey, Sonia Johri, and Sakshi Talwar
4. Role of Antioxidants in Diabetes .............................................................. 77
Lalita Kushwah, Rupali Dutt, GBKS Prasad, and D. K. Sharma
5. Extraction and Quantification of Antioxidants ...................................... 97
Neha Chauhan and Surbhi Antarkar
6. Comparative Estimation of Antioxidant and Antimicrobial
Activity of Bioactive Components with Special Reference to
Urinary Tract Infection .......................................................................... 127
Pallavi Singh Chauhan, Anuj Dubey, and Sonia Johri
7. Citrus Fruits and Their By‑Products, Power House of
Remedial Antioxidants............................................................................ 145
Hradesh Rajput, Pratistha Srivastava, and Rita Sharma
8. Antioxidative Defense System in Plants ................................................... 183
Renu Yadav, Minerva Sharma, Portia Sharma, and Udita Tiwari
9. Bryophytes, An Extensive Source of Antioxidants ..................................203
Prachi Dixit
viii Contents
10. Natural Antioxidants in the Management of Alzheimer’s Disease ........ 221
Ekta Khare
11. Oxidative Stress and Parkinson’s Diseases,
A Role of Current Therapies ...................................................................... 239
Kavita Singh, Aarshi Vashistha, and GBKS Prasad
12. Solanum lycopersicum, a Reservoir of Antioxidants ............................... 253
Madhu Parmar, Hradesh Rajput, and Sonia Johri
Index ................................................................................................................. 269
Contributors
Surbhi Antarkar
Department of Life Sciences, ITM University, Gwalior, Madhya Pradesh, India
Neha Chauhan
Department of Life Sciences, ITM University, Gwalior, India
Pallavi Singh Chauhan
Department of Life Sciences, ITM University, Gwalior, Madhya Pradesh, India
Prachi Dixit
School of Sciences, ITM University Gwalior, Gwalior, Madhya Pradesh, India
Anuj Dubey
Department of Chemistry, ITM University, Gwalior, Madhya Pradesh, India
Rupali Dutt
School of Studies in Biochemistry, Jiwaji University, Gwalior, India
Namrata Jha
School of Life Sciences, ITM University, Gwalior, Madhya Pradesh, India
Sonia Johri
Department of Life Sciences, ITM University, Gwalior, India
Ekta Khare
School of Pharmacy, ITM University, Gwalior, Madhya Pradesh, India
Lalita Kushwah
School of Studies in Biochemistry, Jiwaji University, Gwalior, India
Madhu Parmar
Department of Life Sciences ITM University Gwalior M.P. India
GBKS Prasad
Centre for Translational Research, School of studies in Biochemistry, Jiwaji University, Gwalior,
Madhya Pradesh, India
Hradesh Rajput
Department of Food Technology, ITM University, Gwalior, India
Sakshi Talwar
Translational Health Science and Technology Institute, Faridabad, India
Shivam Tayal
School of Pharmacy, ITM University, Gwalior, Madhya Pradesh, India
D. K. Sharma
Department of Zoology, Government Model Science College, Gwalior
