Table Of ContentAntimicrobial Resistance in Wastewater
Treatment Processes
Antimicrobial Resistance in Wastewater
Treatment Processes
Edited by Patricia L. Keen and Raphaël Fugère
This edition first published 2018
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Library of Congress Cataloguing‐in‐Publication Data
Names: Keen, Patricia L., editor. | Fugère, Raphaël, editor.
Title: Antimicrobial resistance in wastewater treatment processes / [edited] by Patricia L. Keen,
Raphaël Fugère.
Other titles: Complemented by (work): Antimicrobial resistance in the environment.
Description: Hoboken, NJ : Wiley, 2018. | Designed as a companion volume to Antimicrobial
resistance in the environment / edited by Patricia L. Keen, Mark H.M.M. Montforts. c2012. |
Includes bibliographical references and index. |
Identifiers: LCCN 2017030445 (print) | LCCN 2017034382 (ebook) | ISBN 9781119192442 (pdf) |
ISBN 9781119192459 (epub) | ISBN 9781119192435 (cloth)
Subjects: | MESH: Drug Resistance, Microbial | Water Purification | Anti-Bacterial Agents–analysis |
Water Pollutants | Water Microbiology
Classification: LCC TD196.D78 (ebook) | LCC TD196.D78 (print) | NLM QW 45 | DDC 572.8/44–dc23
LC record available at https://lccn.loc.gov/2017030445
Cover design: Wiley
Cover image: ‘Quick Sands’ 2014 © Philippe Raphanel
Set in 10/12pt Warnock by SPi Global, Pondicherry, India
10 9 8 7 6 5 4 3 2 1
The editors dedicate this book to the memory of Fred Koch.
vii
Contents
List of Contributors ix
Preface xiii
Préface xvii
About the Cover Artist xxi
List of Abbreviations xxiii
1 Antimicrobial Resistance Genes and Wastewater Treatment 1
Mehrnoush Mohammadali and Julian Davies
2 When Pathogens and Environmental Organisms Meet: Consequences
for Antibiotic Resistance 15
Jose Luis Martinez and Fernando Baquero
3 One Health: The Role Wastewater Treatment Plants Play as Reservoirs,
Amplifiers, and Transmitters of Antibiotic Resistance Genes
and Antibiotic Resistant Bacteria 35
Marilyn C. Roberts
4 Assessing the Impact of Wastewater Treatment Plants on Environmental
Levels of Antibiotic Resistance 55
Jessica Williams‐Nguyen, Irene Bueno, and Randall S. Singer
5 Navigating through the Challenges Associated with the Analysis of Antimicrobials
and Their Transformation Products in Wastewater 73
Randolph R. Singh, Rachel A. Mullen, and Diana S. Aga
6 Metagenomic Approaches for Antibiotic Resistance Gene Detection
in Wastewater Treatment Plants 95
Ying Yang and Tong Zhang
7 Antimicrobials and Antimicrobial Resistant Bacteria in Australia 109
Andrew J. Watkinson and Simon D. Costanzo
8 The Mobile Resistome in Wastewater Treatment Facilities
and Downstream Environments 129
Roberto B. M. Marano and Eddie Cytryn
viii Contents
9 Bacterial Diversity and Antibiotic Resistance Genes in Wastewater Treatment
Plant Influents and Effluents 157
Veiko Voolaid, Erica Donner, Sotirios Vasileiadis, and Thomas U. Berendonk
10 The Effect of Advanced Treatment Technologies on the Removal
of Antibiotic Resistance 179
Popi Karaolia, Stella Michael, and Despo Fatta‐Kassinos
11 Antimicrobial Resistance Spread Mediated by Wastewater Irrigation:
The Mezquital Valley Case Study 207
Melanie Broszat and Elisabeth Grohmann
12 Antimicrobial Resistance Related to Agricultural Wastewater and Biosolids 219
Lisa M. Durso and Amy Millmier Schmidt
13 Environmental Antibiotic Resistance Associated with Land
Application of Biosolids 241
Jean E. McLain, Channah M. Rock, and Charles P. Gerba
14 High Throughput Method for Analyzing Antibiotic Resistance Genes
in Wastewater Treatment Plants 253
Johanna Muurinen, Antti Karkman, and Marko Virta
15 Antibiotic Resistance and Wastewater Treatment Process 263
Thi Thuy Do, Sinéad Murphy, and Fiona Walsh
16 Antibiotic Pollution and Occurrence of Bacterial Antibiotic Resistance Genes
in Latin American Developing Countries: Case Study of the Katari Watershed
in the Bolivian Highlands 293
Denisse Archundia, Celine Duwig, Jean M.F. Martins, Frederic Lehembre, Marie‐Christine
Morel, and Gabriela Flores
17 Antimicrobial Resistance in Hospital Wastewaters 309
Judith Isaac‐Renton and Patricia L. Keen
18 Curbing the Resistance Movement: Examining Public Perception of the Spread
of Antibiotic Resistant Organisms 321
Agnes V. MacDonald and Patricia L. Keen
19 Public Health Consequences of Antimicrobial Resistance in the Wastewater
Treatment Process 329
Patricia L. Keen, Raphaël Fugère, and David M. Patrick
Index 339
ix
List of Contributors
Diana S. Aga Irene Bueno
Department of Chemistry College of Veterinary Medicine
University at Buffalo, State University of University of Minnesota
New York St. Paul
Buffalo USA
USA
Simon D. Costanzo
Denisse Archundia
University of Maryland
University Grenoble Alpes, IRD, CNRS
Center for Environmental Science
IGE, Grenoble, France;
Cambridge
Consejo Nacional de Ciencia y
USA
Tecnologia (CONACYT)
México, D.F., Mexico;
Eddie Cytryn
ERNO, Instituto de Geologia
Hermosillo, Son Institute of Soil, Water, and
Mexico Environmental Sciences
Agricultural Research Organization,
Fernando Baquero Volcani Center
Rishon Lezion
Departamento de Microbiología
Israel
Hospital Universitario Ramón y Cajal
Instituto Ramón y Cajal de Investigación
Sanitaria (IRYCIS) Julian Davies
Madrid Department of Microbiology and
Spain Immunology
University of British Columbia
Thomas U. Berendonk Vancouver
Institute for Hydrobiology Canada
Technische Universität Dresden
Dresden, Germany Thi Thuy Do
Antimicrobial Resistance and
Melanie Broszat Microbiome Research Group
Division of Infectious Diseases Department of Biology
University Medical Centre Freiburg National University of Ireland Maynooth
Freiburg County Kildare
Germany Ireland
x List of Contributors
Erica Donner Elisabeth Grohmann
Future Industries Institute Division of Infectious Diseases
University of South Australia University Medical Centre Freiburg
Mawson Lakes Freiburg
Australia Germany
Lisa M. Durso
Judith Isaac‐Renton
Agroecosystem Management
Research Unit University of British Columbia
Agricultural Research Service Vancouver
U.S. Department of Agriculture Canada
Lincoln, Nebraska
USA Popi Karaolia
Celine Duwig Department of Civil and Environmental
University Grenoble Alpes Engineering and
IRD, CNRS, IGE Nireas International Water
Grenoble Research Centre
France School of Engineering
University of Cyprus
Despo Fatta‐Kassinos
Nicosia
Department of Civil and Environmental Cyprus
Engineering and
Nireas International Water Antti Karkman
Research Centre
University of Gothenburg
School of Engineering
Göteborg
University of Cyprus
Sweden
Nicosia
Cyprus
Patricia L. Keen
Gabriela Flores
Department of Civil Engineering
University Grenoble Alpes, IRD, CNRS, University of British Columbia
IGE, Grenoble, France; Vancouver
MMAyA, Ministerio de Medio New York Institute of Technology
Ambiente y Agua (Ministry of Water and Vancouver
Environment of Bolivia) Canada
La Paz
Bolivia
Frederic Lehembre
Raphaël Fugère
University Grenoble Alpes, IRD,
Raphaël Fugère and Associates CNRS, IGE
Lévis, Québec Grenoble
Canada France
Charles P. Gerba
Agnes V. MacDonald
University of Arizona
Department of Soil, Water, and Department of Sociology
Environmental Science Simon Fraser University
Tucson Burnaby, British Columbia
USA Canada
List of Contributors xi
Roberto B. M. Marano Mehrnoush Mohammadali
Institute of Soil, Water, and Department of Civil Engineering
Environmental Sciences University of British Columbia
Agricultural Research Organization, Vancouver
Volcani Center Canada
Rishon Lezion, Israel
Department of Agroecology and Plant Marie‐Christine Morel
Health University Grenoble Alpes, IRD,
Robert H. Smith Faculty of Agriculture, CNRS, IGE, Grenoble, France;
Food, and Environment CNAM, Laboratoire d’analyses chimiques
The Hebrew University of Jerusalem et bio analyses
Rehovot Paris
Israel France
Jose Luis Martinez Rachel A. Mullen
Departamento de Biotecnología Department of Chemistry
Microbiana University at Buffalo, State University of
Centro Nacional de Biotecnología New York
Consejo Superior de Investigaciones Buffalo
Científicas USA
Madrid
Sinéad Murphy
Spain
Antimicrobial Resistance and
Microbiome Research Group
Jean M.F. Martins
Department of Biology
University Grenoble Alpes
National University of Ireland Maynooth
IRD, CNRS, IGE
County Kildare
Grenoble
Ireland
France
Johanna Muurinen
Jean E. McLain
University of Helsinki
University of Arizona Helsinki
Water Resources Research Center Finland
Department of Soil, Water, and
Environmental Science David M. Patrick
Tucson School of Population and Public Health
USA University of British Columbia
Vancouver
Stella Michael Canada
Department of Civil and Environmental
Engineering and Marilyn C. Roberts
Nireas International Water Department of Environmental and
Research Centre Occupational Health Sciences
School of Engineering School of Public Health
University of Cyprus University of Washington
Nicosia Seattle
Cyprus USA
xii List of Contributors
Channah M. Rock Veiko Voolaid
University of Arizona Institute for Hydrobiology
Department of Soil, Water, and Technische Universität Dresden
Environmental Science Dresden
Tucson Germany
USA
Fiona Walsh
Antimicrobial Resistance and
Amy Millmier Schmidt
Microbiome Research Group
Biological Systems Engineering and
Department of Biology
Animal Science
National University of Ireland Maynooth
University of Nebraska
County Kildare
Lincoln
Ireland
USA
Andrew J. Watkinson
Randall S. Singer University of Queensland
College of Veterinary Medicine St. Lucia
University of Minnesota Australia
St. Paul
Jessica Williams‐Nguyen
USA
Department of Epidemiology
School of Public Health
Randolph R. Singh
University of Washington
Department of Chemistry Seattle
University at Buffalo, State University USA
of New York
Buffalo Ying Yang
USA Guangdong Provincial Key Laboratory of
Marine Resources and Coastal Engineering
Sotirios Vasileiadis School of Marine Sciences
Sun Yat‐sen University
Future Industries Institute
Guangzhou
University of South Australia
China
Mawson Lakes
Australia Tong Zhang
Environmental Biotechnology Laboratory
Marko Virta Department of Civil Engineering
University of Helsinki University of Hong Kong
Helsinki Hong Kong
Finland China
