Antimicrobial peptides and the interplay between microbes and host

241 Pages·2016·9.92 MB·English

by  Rogier A. Gaiser

Antimicrobial peptides
and the interplay between microbes and host
Towards preventing porcine infections with Streptococcus suis
Rogier A. Gaiser
Thesis committee
Promotor
Prof. Dr Jerry M. Wells
Professor of Host-Microbe Interactomics
Wageningen University
Co-promotor
Dr Peter van Baarlen
Assistant professor, Host-Microbe Interactomics
Wageningen University
Other members
Prof. Elizabeth Wellington, University of Warwick, UK
Dr Stefano Donadio, NAICONS Srl / Ktedogen Srl, Italy
Dr Paul Ross, University College Cork, Ireland
Prof. Dr Hauke Smidt, Wageningen University
This research was conducted under the auspices of the Graduate School of Wageningen
Institute of Animal Sciences (WIAS)
Antimicrobial peptides
and the interplay between microbes and host
Towards preventing porcine infections with Streptococcus suis
Rogier A. Gaiser
Thesis
submitted in fulfilment of the requirement for the degree of doctor
at Wageningen University
by the authority of the Rector Magnificus
Prof. Dr A.P.J. Mol
in the presence of the
Thesis Committee appointed by the Academic Board
to be defended in public
on Friday 7 October 2016
at 1.30 p.m. in the Aula.
Rogier A. Gaiser
Antimicrobial peptides and the interplay between microbes and host:
Towards preventing porcine infections with Streptococcus suis
240 pages.
PhD thesis, Wageningen University, Wageningen, NL (2016)
With references, with summaries in English and Dutch
ISBN: 978-94-6257-891-3
DOI : 10.18174/387767
Voor diegenen die ik liefheb

TABLE OF CONTENTS
Chapter 1 General Introduction 9
Chapter 2 Frog skin host-defense peptides as potential candidates 45
for treatment of topical bacterial infections
Chapter 3 Transcriptome analysis of the generic and adaptive 67
responses by Streptococcus suis to sub-lethal
concentrations of LL-37
Chapter 4 Compositional Profiling of Porcine Microbiota to Identify 95
Bacteria with Strong Positive or Negative Associations
with Streptococcus suis Abundance
Chapter 5 Narrow-spectrum Inhibition of Streptococcus suis by 121
Delta-Lysins of Commensal Staphylococcus pasteuri
Isolated from Porcine Tonsil Microbiota
Chapter 6 Modulation of mucosal barrier function and immunity by 163
valinomycin, an antibiotic ionophore produced by the
mammalian commensal Rothia nasimurium
Chapter 7 General Discussion 203
Appendices Summary 229
Samenvatting
Acknowledgement
Curriculum Vitae
Training Activities
1
C H A P T E R 1
General Introduction