Table Of Content

Antimalarial combination therapy: lessons from mitochondrial physiology Akhil B. Vaidya Drexel University College of Medicine The Challenge of Feeding the Pipeline • Resistance to currently used combination therapies will arise • Development of new drugs is a long process with many failures on the way (90%?; 99%?) • Need to have a strategy that will feed the pipeline for a long period (50 years?; 100 years?) • Basic understanding of parasite physiology and mechanisms of drug action is essential for an informed strategy for drug development pipeline • Drugs that work but for which MOAs are unknown should be subjected to in depth basic research to make informed decisions about their use in combination therapy The Story of Weird Mitochondria of Malaria Parasites Plasmodium spp. Abbreviated Electron Transport Chain in Plasmodium Mitochondrion Dihydroorotate dehydrogenase Five Mitochondrial NADH dehydrogenase (rotenone insensitive) Dehydrogenases Succinate dehydrogenase Malate-quinone oxidoreductase Located in the Glycerol 3-phosphate dehydrogenase Inner Membrane Electrons Atovaquone Ubiquinone Ubiquinol H+ translocated Cytochrome bc complex 1 Cytochrome c (ox.) Cytochrome c (red.) H+ pumped Cytochrome c oxidase O H O 2 2 O CH 3 O H H C 9 3 H C 3 O CH 3 O Ubiquinone The Q Cycle of Complex III O CH 3 O H H C 9 3 H C 3 O CH 3 O Ubiquinone Cl O OH O Atovaquone MMMiiitttoooccchhhooonnndddrrriiiaaalll FFFuuunnnccctttiiiooonnnsss iiinnn MMMaaalllaaarrriiiaaa PPPaaarrraaasssiiittteeesss Q NADH UUbbiiqquuiinnoonnee ssyynntthheessiiss NAD+ PPyyrriimmiiddiinnee Dihydroorotate bbiioossyynntthheessiiss [[FFee--SS]] cclluusstteerr RReepplliiccaattiioonn Orotate aasssseemmbbllyy RReeccoommbbiinnaattiioonn RReeppaaiirr Malate Porin mtDNA Oxaloacetate Succinate TTrraannssccrriippttiioonn PPrroocceessssiinngg Fumarate QH 2 mRNA c bc rRNA co1mplex H+ HHeemmee Porin c bbiioossyynntthheessiiss Cytc H+ PPrrootteeiinn oxidase Cyt b ssyynntthheessiiss c ATP synthase? Cox1 3 proteins Cox3 Proteins tRNAs Metabolites Outer Inner Cytoplasm Matrix membrane membrane

Description:
Antimalarial combination therapy: Drugs that work but for which MOAs are unknown should be subjected to in Mitochondria of Malaria. Parasites
ebook img

Antimalarial combination therapy: lessons from mitochondrial physiology PDF

35 Pages·2007·1.52 MB·English
by  Akhil B. Vaidya
Save to my drive
Quick download
Download

Download Antimalarial combination therapy: lessons from mitochondrial physiology PDF Free - Full Version

by Akhil B. Vaidya| 2007| 35 pages| 1.52| English

Download Antimalarial combination therapy: lessons from mitochondrial physiology by Akhil B. Vaidya in PDF format completely FREE. No registration required, no payment needed. Get instant access to this valuable resource on PDFdrive.to!

Free Download PDF

About Antimalarial combination therapy: lessons from mitochondrial physiology

Antimalarial combination therapy: Drugs that work but for which MOAs are unknown should be subjected to in Mitochondria of Malaria. Parasites

Detailed Information

Author:Akhil B. Vaidya
Publication Year:2007
Pages:35
Language:English
File Size:1.52
Format:PDF
Price:FREE
Download Free PDF

Safe & Secure Download - No registration required

Why Choose PDFdrive for Your Free Antimalarial combination therapy: lessons from mitochondrial physiology Download?

  • 100% Free: No hidden fees or subscriptions required for one book every day.
  • No Registration: Immediate access is available without creating accounts for one book every day.
  • Safe and Secure: Clean downloads without malware or viruses
  • Multiple Formats: PDF, MOBI, Mpub,... optimized for all devices
  • Educational Resource: Supporting knowledge sharing and learning

Free Books Similar to Antimalarial combination therapy: lessons from mitochondrial physiology

Frequently Asked Questions

Is it really free to download Antimalarial combination therapy: lessons from mitochondrial physiology PDF?

Yes, on https://PDFdrive.to you can download Antimalarial combination therapy: lessons from mitochondrial physiology by Akhil B. Vaidya completely free. We don't require any payment, subscription, or registration to access this PDF file. For 3 books every day.

How can I read Antimalarial combination therapy: lessons from mitochondrial physiology on my mobile device?

After downloading Antimalarial combination therapy: lessons from mitochondrial physiology PDF, you can open it with any PDF reader app on your phone or tablet. We recommend using Adobe Acrobat Reader, Apple Books, or Google Play Books for the best reading experience.

Is this the full version of Antimalarial combination therapy: lessons from mitochondrial physiology?

Yes, this is the complete PDF version of Antimalarial combination therapy: lessons from mitochondrial physiology by Akhil B. Vaidya. You will be able to read the entire content as in the printed version without missing any pages.

Is it legal to download Antimalarial combination therapy: lessons from mitochondrial physiology PDF for free?

https://PDFdrive.to provides links to free educational resources available online. We do not store any files on our servers. Please be aware of copyright laws in your country before downloading.

The materials shared are intended for research, educational, and personal use in accordance with fair use principles.

We use cookies

We use cookies to ensure you get the best browsing experience on our website. By clicking "Accept Cookies", you agree that we can store cookies on your device in accordance with our Terms and Privacy.