Antiepileptic Drugs - Combination Therapy and Interactions - J. Majkowski, et al., (Cambridge, 2005) WW

516 Pages·2005·4.87 MB·English

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Antiepileptic Drugs
Combination Therapy and Interactions

This book reviews the use of antiepileptic drugs focussing on the interactions between these
drugs, and between antiepileptics and other drugs. These interactions can be beneficial or can
cause harm. The aim of this book is to increase awareness of the possible impact of combination
pharmacotherapies. Pharmacokinetic and pharmacodynamic interactions are discussed sup-
ported by clinical and experimental data. The book consists of five parts covering the general
concepts and advantages of combination therapies, the principles of drug interactions, the
mechanisms of interactions, drug interactions in specific populations or in patients with co-mor-
bid health conditions, concluding with a look at the future directions for this field of research.
The book will be of interest to all who prescribe antiepileptics to epileptic and non-epileptic
patients, including epileptologists, neurologists, neuropediatricians, psychiatrists and general
practitioners.

Antiepileptic Drugs

Combination Therapy and Interactions

Edited by

Jerzy Majkowski

The Foundation of Epileptology, Warsaw

Blaise F. D. Bourgeois

Harvard Medical School, USA

Philip N. Patsalos

Institute of Neurology, UK

and

Richard H. Mattson

Yale University School of Medicine, USA

cambridge university press
Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo

Cambridge University Press
The Edinburgh Building, Cambridge cb2 2ru, UK

First published in print format

isbn-13
978-0-521-82219-0

isbn-13
978-0-511-12593-5

© Cambridge University Press 2005

2005

Information on this title: www.cambridge.org/9780521822190

This publication is in copyright. Subject to statutory exception and to the provision of
relevant collective licensing agreements, no reproduction of any part may take place
without the written permission of Cambridge University Press.

isbn-10
0-511-12593-3

isbn-10
0-521-82219-x

Cambridge University Press has no responsibility for the persistence or accuracy of urls
for external or third-party internet websites referred to in this publication, and does not
guarantee that any content on such websites is, or will remain, accurate or appropriate.

Published in the United States of America by Cambridge University Press, New York
www.cambridge.org

hardback

eBook (NetLibrary)

eBook (NetLibrary)

hardback

Contents

List of contributors
Page
ix

Foreword Giuliano Avanzini
xiii

Foreword Torbjörn Tomson
xv

Acknowledgements
xvii

Part I
Introduction
1

1
Combination therapy of diseases: general concepts
3

Emma Mason and Philip A. Routledge

2
Combination therapy with antiepileptic drugs: potential
advantages and problems
16

Richard H. Mattson

3
Pharmacogenetic aspects
26

Matthew C. Walker, Michael R. Johnson and Philip N. Patsalos

Part II
Pharmacokinetic interactions
45

4
Pharmacokinetic principles and mechanisms of drug interactions
47

Philip N. Patsalos

5
Predictability of metabolic antiepileptic drug interactions
57

Edoardo Spina, Emilio Perucca and Rene Levy

6
Influence of food and drugs on the bioavailability of antiepileptic drugs
93

Carlos A. Fontes Ribeiro

7
Interactions between antiepileptic drugs
111

Bernhard Rambeck and Theodor W. May

8
Interactions between antiepileptic and non-antiepileptic drugs
139

Jerzy Majkowski and Philip N. Patsalos

v

Part III
Pharmacodynamic interactions
179

9
Pharmacodynamic principles and mechanisms of drug interactions
181

Blaise F. D. Bourgeois

10
Methods for assessing pharmacodynamic interactions
193

Blaise F. D. Bourgeois

11
Experimental studies of pharmacodynamic interactions
208

Stanislaw J. Czuczwar

12
Clinical studies of pharmacodynamic interactions
228

John R. Pollard and Jacqueline French

13
Clinical studies of pharmacodynamic interactions
between antiepileptic drugs and other drugs
241

Gaetano Zaccara, Andrea Messori and Massimo Cincotta

Part IV
Drug interactions in specific patient populations
and special conditions
255

14
Antiepileptic drug interactions in children
257

Olivier Dulac, Elizabeth Rey and Catherine Chiron

15
Antiepileptic drug interactions in the elderly
273

Jeannine M. Conway and James C. Cloyd

16
Antiepileptic drug interactions in pregnancy
294

Mark S. Yerby

17
Antiepileptic drug interactions in handicapped and
mentally retarded patients
325

Matti Sillanpää

18
Antiepileptic drugs and sex steroids
341

Richard H. Mattson

19
Antiepileptic drug interactions in patients requiring
psychiatric drug treatment
350

Michael R. Trimble and Marco Mula

20
Antiepileptic drugs in non-epileptic health conditions:
possible interactions
369

Jerzy Majkowski

21
Drug monitoring in combination therapy
392

Walter Fröscher

vi
Contents

22
Cognitive side-effects due to antiepileptic drug
combinations and interactions
403

Albert P. Aldenkamp, Mark de Krom, Irene Kotsopoulos and Jan Vermeulen

Part V
Conclusions and future perspectives
419

23
Selection of drug combinations in clinical practice:
current and future perspectives
421

Jerzy Majkowski

24
Future research: an experimental perspective
441

Rob A. Voskuyl, Daniel M. Jonker and Fernando H. Lopes da Silva

25
Future research: a clinical prospective
458

Carlos A. Fontes Ribeiro

Index
475

vii
Contents

List of contributors

Professor Albert P. Aldencamp
Department of Neurology, University
Hospital of Maastricht, PO Box 21, NL 2100
AB, Heeze, The Netherlands

Professor Blaise F. D. Bourgeois
Children’s Hospital – HU2, Harvard Medical
School, 300 Longwood Avenue, Boston,
MA 02115, USA

Dr Catherine Chiron
Hospital Necker-Enfants Malades, 149 Rue
de Sevres, Paris 75015, France

Dr Massimo Cincotta
Unit of Neurology, Santa Maria Nuova
Hospital, Florence, Italy

Dr James C. Cloyd
College of Pharmacy, University of
Minnesota, Room 7101, Weaver Densford
Hall, 308 Harvard St SE, Minneapolis,
MN 55455 0353, USA

Dr Jeannine M. Conway
College of Pharmacy, University of
Minnesota, 7-170 WDH, 308 Harvard St SE,
Minneapolis, MN 55455, USA

Professor Stanislaw J. Czuczwar
Department of Pathophysiology, Medical
Academy, Jaczewskiego 8, 820-090 Lublin,
Poland

Dr Mark de Krom
Department of Neurology, University
Hospital of Maastricht, PO Box 21, NL 2100
AB, Heeze, The Netherlands

Professor Olivier Dulac
Hospital Necker-Enfants Malades, 149 Rue
de Sevres, Paris 75015, France

Professor Carlos A. Fontes Ribeiro
Department of Pharmacology,
Faculty of Medicine, 3000 Coimbra,
Portugal

Professor Jacqueline French
Department of Neurology, 3 West Gates,
Hospital of the University of Pennsylvania,
3400 Spruce St, PA 19104, USA

Professor Walter Fröscher
Department of Neurology and Epileptology,
Die Weissenau (Department of Psychiatry I),
University of Ulm, D-88214 Ravensburg,
Germany

Dr Michael R. Johnson
Division of Neurosciences and Psychological
Medicine, Imperial College London,
Charing Cross Hospital, London,
W6 8RP, UK

Dr Daniel M. Jonker
Epilepsy Institute of the Netherlands (SEIN),
Achterweg 5, NL 21 03 SW,
Heemstede, The Netherlands

ix