Table Of ContentANTIDIABETIC PLANTS
FOR DRUG DISCOVERY
Pharmacology, Secondary Metabolite
Profiling, and Ingredients with
Insulin Mimetic Activity
Cover photo credits:
Top left: Azadirachta indica. Photo by J.M.Garg. https://en.wikipedia.org/wiki/Azadirachta_indica#/
media/File:Neem_(Azadirachta_indica)_in_Hyderabad_W_IMG_6976.jpg. https://creativecommons.
org/licenses/by/3.0/
Bottom left: Gymnema sylvestre. Photo by Lalithamba from India. https://en.wikipedia.org/
wiki/Gymnema_sylvestre#/media/File:Gymnema_sylvestre_R.Br_-_Flickr_-_lalithamba.jpg.
https://creativecommons.org/licenses/by/2.0/
Top right: Mulberry fruit in Libya. Photo by Tarek Siala from Tripoli, Libya. https://en.wikipedia.org/
wiki/Morus_(plant)#/media/File:Mulberry_in_Libya.jpg. https://creativecommons.org/licenses/by/2.0/
Bottom right: Raw cinnamon bark. Photo by Bertrand Thiry. https://en.wikipedia.org/wiki/Cinnamon#/
media/File:Baton_de_cannelle.jpg. https://creativecommons.org/licenses/by-sa/3.0/
ANTIDIABETIC PLANTS
FOR DRUG DISCOVERY
Pharmacology, Secondary Metabolite
Profiling, and Ingredients with
Insulin Mimetic Activity
Edited by
Deepu Pandita, MPhil
Anu Pandita, MSc
Chander Bhanu, MBBS, PGDDCE
First edition published 2023
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Library and Archives Canada Cataloguing in Publication
Title: Antidiabetic plants for drug discovery : pharmacology, secondary metabolite profiling, and ingredients with insulin
mimetic activity / edited by Deepu Pandita, PhD, Anu Pandita, PhD, Chander Bhanu, PhD.
Names: Pandita, Deepu, 1977- editor. | Pandita, Anu, 1977- editor. | Bhanu, Chander, 1973- editor.
Description: First edition. | Includes bibliographical references and index.
Identifiers: Canadiana (print) 20220282307 | Canadiana (ebook) 20220282374 | ISBN 9781774910061 (hardcover) |
ISBN 9781774910078 (softcover) | ISBN 9781003282938 (ebook)
Subjects: LCSH: Medicinal plants. | LCSH: Botany, Medical. | LCSH: Diabetes—Alternative treatment. |
LCSH: Hypoglycemic agents.
Classification: LCC SB293 .A58 2023 | DDC 633.8/8—dc23
Library of Congress Cataloging-in-Publication Data
CIP data on file with US Library of C o ngress
ISBN: 978-1-77491-006-1 (hbk)
ISBN: 978-1-77491-007-8 (pbk)
ISBN: 978-1-00328-293-8 (ebk)
About the Editors
Deepu Pandita, MPhil
Senior Lecturer, Government Department of School Education, Jammu,
Union Territory of Jammu and Kashmir, India
Deepu Pandita is working as a Senior Lecturer in the Government Depart
ment of School Education, Jammu, Union Territory of Jammu and Kashmir,
India. Deepu Pandita has more than 18 years of teaching experience and
earned her Master of Botany (MSc) at the University of Kashmir, Jammu and
Kashmir, India, and Master of Philosophy (MPhil) in Biotechnology from
the University of Jammu, Jammu and Kashmir, India. Deepu Pandita has a
number of international and national courses to her credit. Deepu Pandita
has qualified fellowships including JRF NET and SRF from the Council of
Scientific & Industrial Research (CSIR), New Delhi, India, Biotechnology
Fellowship, Government Department of Science and Technology, Jammu &
Kashmir, India; and IASC-INSA-NASI Summer Research Teacher Fellow
ship, India. Deepu Pandita has presented her research at work at both the
national and international conferences and was awarded a Best Oral Presen
tation Award in the International Conference on Biotechnology for Better
Tomorrow, a Women Researcher Award, and Research Excellence Award
by two professional associations in India. Deepu Pandita is a life member of
various scientific societies. Deepu Pandita acts as a reviewer (18 journals)
and associate editor and editor of a number of international journals. Deepu
Pandita has published a number of editorials, 25 book chapters (Springer,
Elsevier, CRC, etc.), reviews, and research articles in various journals of
national and international repute like Cells (MDPI) (IF=7.666), Frontiers in
Plant Sciences (IF=6.627), and Frontiers in Physiology (IF=4.566) and has
currently six books in the process of production.
Anu Pandita, MSc
Dietician, Vatsalya Clinic, New Delhi, India
Anu Pandita is working as a Senior Dietician at Vatsalya Clinic, E-5/11,
Krishna Nagar, New Delhi, India. Previously she worked as a Lecturer at
the Bee Enn College of Nursing, Talab Tillo, Jammu, India, and Dietician
vi About the Editors
at the Ahinsa Dham Bhagwan Mahavir Charitable Health Centre, New
Delhi, India. Anu Pandita has done her MSc internship and a course in the
Dietetics Department of PGI, Chandigarh, India. Anu Pandita has taken
a case study at the Pediatric Gastroenterology Ward at ‘‘Nehru Hospital’’
PGI, Chandigarh, India, on a patient suffering from chronic liver disease.
She earned a certificate for a course in food and nutrition as well. She has
a number of training sessions, refresher courses, and workshops to her
credit. Anu Pandita is a life-time member of the Indian Dietetic Associa
tion and Indian Science Congress Association, Kolkata, India. Anu Pandita
has presented her research at work at both the national and international
conferences. Anu Pandita has published various book chapters in Springer,
CRC, etc. publications and has a number of review and research articles
in various journals of national and international repute, including Cells
(MDPI) (IF=7.666) and Frontiers in Physiology (IF=4.566). She currently
has six books in the process of production.
Chander Bhanu, MBBS, PGDDCE
Senior Consultant Physician, Vatsalya Clinic; Dr. Kailash Chander Jain
Memorial Clinic; Ahinsa Dham Bhagwan Mahavir Medical Center,
New Delhi, India
Chander Bhanu, MBBS, PGDDCE, is working as a Senior Consultant
Physician at Vatsalya Clinic, Krishna Nagar, New Delhi, Dr. Kailash
Chander Jain Memorial Clinic, and Ahinsa Dham Bhagwan Mahavir
Medical Center, Madhu Vihar, New Delhi, India. Dr. Bhanu earned his
MBBS (Bachelor of Medicine and Bachelor of Surgery) from Govt.
Medical College, Calicut, Kerala, and PGDDCE (Post Graduate Diploma
in Diabetes and Clinical Endocrinology) from the Royal College of
Physicians, United Kingdom. Dr. Bhanu has a certification in diabetes
mellitus accredited by the Royal Liverpool Academy, United Kingdom.
Previously he has worked as a neuro associate in the Institute of Brain and
Spine; resident medical officer at the VIMHANS (Vidya Sagar Institute
of Mental Health and Neurosciences) Hospital, New Delhi; and a chief
medical officer in Primus Hospital; and Medical Officer in Neurology
and Neurosurgery Departments in Fortis Hospital. He has expertise and
experience in various clinical procedures such as pleural tapping, ascitic
tapping, lumbar puncture, suturing, and other procedures both in pediatrics
and adult groups and also deals with stroke and accident cases as well.
Contents
Contributors ......................................................................................................... ix
Abbreviations .....................................................................................................xiii
Preface .............................................................................................................. xvii
1. Azadirachta indica: Its Biological, Pharmacological,
Antidiabetic Potential, and Omics Applications ...................................... 1
Vincent Ezin1 and Ifagbemi Bienvenue Chabi
2. Gymnema sylvestre (Asclepiadaceae): Multi-Potent Medicinal
Plant with Potential for Antidiabetes and Obesity ................................. 23
Ramachandra Reddy Pamuru, Ambedkar Yarrapalle, and D. Vijaya Lakshmi
3. Perspectives of Syzygium cumini (L.) Skeels, as a Potential
Rational Herbal Medicine for Diabetes .................................................. 55
Lepakshi Md. Bhakshu, K. Venkata Ratnam, Deepu Pandita, Anu Pandita,
Pulala Raghuveer Yadav, and R. R. Venkata Raju
4. Cinnamomum zeylanicum: Nature’s Wonder Plant with
Antidiabetic Prominence ..........................................................................83
Sasireka Rajendran, Anu Pandita, Vinoth Rathinam, Sugumari Vallinayagam,
Deepu Pandita, and Madheswaran Muthusamy
5. Antidiabetic Potential of the Insulin Plant (Costus pictus) .................. 105
Kavita Rani, Swati Priya, Narender Singh, and Ruchi Bansal
6. Health Benefits of Trigonella foenum-graecum with Regard to
Metabolomics of Antidiabetic Efficiency .............................................. 147
Neha Sharma, Rajesh Singh Tomar, and Shuchi Kaushik
7. Mulberry: From Root to Fruit with Antidiabetic Properties ............. 171
Masarat Bashir and Ashraf Dar
8. The Antidiabetic Effect of Nigella sativa L. with Respect to
Its Phytochemicals and the Mechanism of Action ............................... 193
Iffat Zareen Ahmad
viii Contents
9. Aegle marmelos (L.) as a Functional Food for Managing
Diabetes Mellitus .....................................................................................221
Khyatie Anjaria, Himanshu Dawda, Karishma Rajbhar, and Usha Mukundan
10. Garlic (Allium sativum): A Potential Antidiabetic Agent ..................... 247
Prabhash Kumar Pandey, Jayant Dewangan, Shambhoo Sharan Tripathi,
Ranjan Singh, Farrukh Jamal, and Srikanta Kumar Rath
11. Antidiabetic Potential of Ficus benghalensis ........................................ 277
Diksha Kapoor and Tabassum Khan
Index ................................................................................................................. 303
Contributors
Iffat Zareen Ahmad
Natural Products Laboratory, Department of Bioengineering, Integral University, Dasauli,
Kursi Road, Lucknow – 226026, Uttar Pradesh, India, E-mail: [email protected]
Khyatie Anjaria
Department of Botany, Ramniranjan Jhunjhunwala College, Ghatkopar (W), Mumbai – 400 086,
Maharashtra, India
Ruchi Bansal
Division of Germplasm Evaluation, ICAR-National Bureau of Plant Genetic Resources,
New Delhi – 110012, India, E-mail: [email protected]
Masarat Bashir
College of Temperate Sericulture, Sheri-Kashmir University of Agricultural Sciences and
Technology, Srinagar, Jammu and Kashmir, India, E-mail: [email protected]
Lepakshi Md. Bhakshu
Department of Botany, PVKN Government College (Autonomous), Chittoor – 517 002,
Andhra Pradesh, India, E-mails: [email protected]; [email protected]
Ifagbemi Bienvenue Chabi
Department of Nutrition and Food Sciences, Faculty of Agricultural Science,
University of Abomey-Calavi, 01 BP 526 Cotonou, Benin
Ashraf Dar
Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir – 190006, India,
E-mail: [email protected]
Himanshu Dawda
Department of Botany, Ramniranjan Jhunjhunwala College, Ghatkopar (W), Mumbai – 400 086,
Maharashtra, India
Jayant Dewangan
Genotoxicity Lab, Division of Toxicology and Experimental Medicine,
CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Vincent Ezin
Department of Crop Production, Faculty of Agricultural Science, University of Abomey-Calavi,
01 BP 526 Cotonou, Benin, E-mails: [email protected]; [email protected]
Farrukh Jamal
Department of Biochemistry, Dr. Rammanohar Lohia Avadh University, Ayodhya,
Uttar Pradesh, India
Diksha Kapoor
Department of Pharmaceutical Chemistry and Quality Assurance,
SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India
