Anticancer Potential of Curcumin

144 Pages·2005·4.48 MB·English

by  Bharat Aggarwal

Anticancer Potential of
Curcumin:
An Old Spice With New Targets
Bharat B. Aggarwal, Ph.D.
Cytokine Research Section,
Department of Experimental Therapeutics,
The University of Texas M.D. Anderson Cancer Center,
Houston, Texas, U.S.A.
[email protected]
www.apoptosis2005.org
Oommen V. Oommen, Ph.D.
Bharat B. Aggarwal, Ph.D.
[email protected] or
[email protected]
oommenvo@yahoo.
Golden Triangle
Modern technology
Traditional Knowledge
Modern Knowledge
(Ayurvedic medicine
(Allopathic medicine)
Egypcian medicine
Kampo, TCM)
Inflammation plays a major in development
of most diseases
Cancer
Pulmonary
Cardiovascular
diseases
diseases
Neurological
Inflammation Alzheimer
diseases
Autoimmune
Diabetes II
diseases
Arthritis
Hypothesis!
NF-κB activation is a major
mediator of inflammation in
most diseases & inhibition of
NF-κB activation can
suppresses inflammation
NF-κB has been linked to several diseases
Cancer
Chronic obstructive
Heart failure
pulmonary diseases
Ischemia/Reperfusion
Arthritis
Cardiac hypertrophy
AIDS
Atherosclerosis Asthma
Multiple sclerosis Headache
Muscular dystrophy Diabetes
type 1 and II
NF-κB
Alzheimer’s disease
Aging
Bone resorption
Lupus
Renal disease
Sepsis
Incontinentia pigmenti
Gut disease
Ectodermal dysplasia
Skin disease
Crohn’s disease
Viral infections
Neuropathological
disease
Sleep apnoea
Helicobacter pylori-
Systematic inflammatory
associated gastritis
response syndrome
Hypothesis!
(cid:190) Most carcinogens activate NF- κB
(cid:190) NF-κB activation mediates
carcinogenesis/tumorigenesis
(cid:190) Inhibition of NF-κB activation
suppresses tumorigenesis
Inflammation and cancer:
back to Virchow?
Balkwill F, Mantovani A.
Lancet. 2001;357:539-45.
NF-kappa B: arresting a
major culprit in cancer
Haefner B
Drug Discov Today. 2002;7:653-63
NF-kappaB in cancer:
from innocent bystander
to major culprit
Karin M, Cao Y, Greten FR, Li ZW.
Nat Rev Cancer. 2002;2:301-10.