Table Of Content

Antibody Expression and Production Cell Engineering Volume7 SeriesEditor ProfessorMohamedAl-Rubeai UCDSchoolofChemicalandBioprocessEngineering UniversityCollegeDublin Dublin,Ireland EditorialBoard DrHansjorgHauser HelmholtzCentreforInfectionResearch Braunschweig Germany ProfessorMichaelBetenbaugh JohnsHopkinsUniversity Baltimore,USA ProfessorMartinFussenegger SwissFederalInstituteofTechnology Zurich,Switzerland ProfessorNigelJenkins NationalInstituteforBioprocessingResearchandTraining Dublin,Ireland DrOtto-WilhelmMerten A.F.M.-Genethon11 GeneTherapyProgram Evry,France Forothertitlespublishedinthisseries,goto http://www.springer.com/series/5728 CELL ENGINEERING Vol. 7: Antibody Expression and Production Editedby MohamedAl-Rubeai UniversityCollegeDublin,Ireland 123 Editor Prof.MohamedAl-Rubeai SchoolofChemicalandBioprocess Engineering UniversityCollegeDublin Dublin Ireland [email protected] ISSN1389-6946 ISBN978-94-007-1256-0 e-ISBN978-94-007-1257-7 DOI10.1007/978-94-007-1257-7 SpringerDordrechtHeidelbergLondonNewYork LibraryofCongressControlNumber:2011928367 ©SpringerScience+BusinessMediaB.V.2011 Nopartofthisworkmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorby anymeans,electronic,mechanical,photocopying,microfilming,recordingorotherwise,withoutwritten permissionfromthePublisher,withtheexceptionofanymaterialsuppliedspecificallyforthepurpose ofbeingenteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Contents 1 ExpressionofAntibodyinMammalianCells. . . . . . . . . . . . . 1 ThomasJostock 2 Bioreactor Systems for Producing Antibody from MammalianCells . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 DarrinKuystermansandMohamedAl-Rubeai 3 ProductionofAntibodyinInsectCells . . . . . . . . . . . . . . . . 53 HidekiYamaji 4 ProductionofMonoclonalAntibodiesinGlycoengineered Pichiapastoris . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 DongxingZha,ThomasLinden,andThomasPotgieter 5 ProductionofAntibodiesinHansenulapolymorpha . . . . . . . . . 99 GeorgMelmer,StephanHellwig,GritHehmann,andUlrikeDahlems 6 ProductionofAntibodybyTransgenicAvians . . . . . . . . . . . . 121 YoshinoriKawabeandMasamichiKamihira 7 ProductionofAntibodiesinPlants . . . . . . . . . . . . . . . . . . 143 AlejandroSarrion-Perdigones,PalomaJuarez, AntonioGranell,andDiegoOrzaez 8 Production of Antibody Fab Fragments inEscherichiacoli . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 HiroshiTachibanaandMasatakaTakekoshi 9 IntrabodyExpressioninMammalianCells. . . . . . . . . . . . . . 179 SilviaBiocca 10 EngineeringAntibodiesforCancerTherapy . . . . . . . . . . . . . 197 LisaE.GoldsmithandMatthewK.Robinson 11 Recombinant Bispecific Antibodies forCancerTherapy . . . . . . . . . . . . . . . . . . . . . . . . . . 235 DafneMüllerandRolandE.Kontermann v vi Contents 12 TheRoleofGlycosylationinTherapeuticAntibodies . . . . . . . . 251 MaureenSpearman,BenDionne,andMichaelButler 13 QualityIssuesArisingfromPost-translationalModification ofRecombinantAntibodies . . . . . . . . . . . . . . . . . . . . . . 293 RaymondTytherandNigelJenkins 14 RecoveryandPurificationofAntibody . . . . . . . . . . . . . . . . 305 XueJunHan,ArthurHewig,andGaneshVedantham SubjectIndex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341 Contributors MohamedAl-Rubeai SchoolofChemicalandBioprocessEngineering,and ConwayInstituteofBiomolecularandBiomedicalResearch,UniversityCollege Dublin,Dublin,Ireland,[email protected] SilviaBiocca DepartmentofNeuroscience,UniversityofRome“TorVergata”, 00133Rome,Italy,[email protected] MichaelButler DepartmentofMicrobiology,UniversityofManitoba,Winnipeg, MB,CanadaR3T2N2,[email protected] UlrikeDahlems PharmedArtisGmbH,Forckenbeckstr.6,D-52074Aachen, Germany,[email protected] BenDionne DepartmentofMicrobiology,UniversityofManitoba,Winnipeg, MB,CanadaR3T2N2,[email protected] LisaE.Goldsmith DevelopmentalTherapeuticsProgram,FoxChaseCancer Center,Philadelphia,PA19111,USA,[email protected] AntonioGranell InstitutodeBiologíaMolecularyCelulardePlantas(IBMCP), UPV-CSIC,46022Valencia,Spain,[email protected] XueJunHan AmgenInc.,Seattle,WA98119,USA,[email protected] GritHehmann PharmedArtisGmbH,Forckenbeckstr.6,D-52074Aachen, Germany,[email protected] StephanHellwig PharmedArtisGmbH,Forckenbeckstr.6,D-52074Aachen, Germany,[email protected] ArthurHewig AmgenInc.,Seattle,WA98119,USA,[email protected] NigelJenkins NationalInstituteforBioprocessingReasearchandTraining, UniversityCollegeDublin,Dublin,Ireland,[email protected] ThomasJostock NovartisPharmaAG,CH-4002Basel,Switzerland, [email protected] PalomaJuarez InstitutodeBiologíaMolecularyCelulardePlantas(IBMCP), UPV-CSIC,46022Valencia,Spain,[email protected] vii viii Contributors MasamichiKamihira DepartmentofChemicalEngineering,Facultyof Engineering,KyushuUniversity,Fukuoka819-0395,Japan, [email protected] YoshinoriKawabe DepartmentofChemicalEngineering,Facultyof Engineering,KyushuUniversity,Fukuoka819-0395,Japan, [email protected] RolandE.Kontermann InstitutfürZellbiologieundImmunologie,Universität Stuttgart,70569Stuttgart,Germany,[email protected] DarrinKuystermans SchoolofChemicalandBioprocessEngineering,and ConwayInstituteofBiomolecularandBiomedicalResearch,UniversityCollege Dublin,Dublin,Ireland,[email protected] ThomasLinden BioprocessDevelopment,Merck&Co,Rahway,NJ07065, USA,[email protected] GeorgMelmer PharmedArtisGmbH,Forckenbeckstr.6,D-52074Aachen, Germany,[email protected] DafneMüller InstitutfürZellbiologieundImmunologie,UniversitätStuttgart, 70569Stuttgart,Germany,[email protected] DiegoOrzaez InstitutodeBiologíaMolecularyCelulardePlantas(IBMCP), UPV-CSIC,46022Valencia,Spain,[email protected] ThomasPotgieter BioprocessDevelopment,Merck&Co,Rahway,NJ07065, USA,[email protected] MatthewK.Robinson DevelopmentalTherapeuticsProgram,FoxChaseCancer Center,Philadelphia,PA19111,USA,[email protected] AlejandroSarrion-Perdigones InstitutodeBiologíaMolecularyCelularde Plantas(IBMCP),UPV-CSIC,46022Valencia,Spain,[email protected] MaureenSpearman DepartmentofMicrobiology,UniversityofManitoba, Winnipeg,MB,CanadaR3T2N2,[email protected] HiroshiTachibana DepartmentofInfectiousDiseases,TokaiUniversitySchool ofMedicine,Isehara,Kanagawa259-1193,Japan,[email protected] MasatakaTakekoshi DepartmentofMolecularLifeScience,TokaiUniversity SchoolofMedicine,Isehara,Kanagawa259-1193,Japan, [email protected] RaymondTyther NationalInstituteforBioprocessingReasearchandTraining, UniversityCollegeDublin,Dublin,Ireland,[email protected] GaneshVedantham AmgenInc.,Seattle,WA98119,USA, [email protected] Contributors ix HidekiYamaji DepartmentofChemicalScienceandEngineering,Graduate SchoolofEngineering,KobeUniversity,Kobe657-8501,Japan, [email protected] DongxingZha GlycoFiInc.(Awholly-ownedsubsidiaryofMerck&CoInc.), Lebanon,NH03766,USA,[email protected]

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Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression
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Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression

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