ANTIBIOTICS AS ANIMAL-GROWTH STIMULANTS

138 Pages·2002·5.97 MB·English

ANIMAL-GROWTH, STIMULANTS.

FM. WEHER, TD
HOG. LUTHER, BS. M.ChE.
W. M. RESNOLDS, BS,

Aion sets have vse Ly been uid 29 excise not only chert
mat tae seo grostivtinscaing setio, Une row er te auras
Sich a2 peuiley aud goin fave "erm nese! I ikovase thraeah she
Teen lse cowenttines of anebovice ooh 36 eranyein, pes,
survingeiny and ania, Tes snpolntealssotairine ure er oth
ff tana sures are one Se prodaced convey and aes widely
Tees i ly aoulage avd eiseaiiag induc,

Historias

Sour ef tae cay srk wh 2k proscdod ais develymacat was vemcerned
swith che cols cf inestial Eom: in che muciiea no aivuly, Creilershke

Tess is ve el wis peers wh Iie ann HS psaareion
fo sutageanidine by Mershall ard coswerksrs + at the dexcspton of
Tis stseivouess yi ¢ biceinlalie geen tor ym esta “as cian.
Tin romps nha He ikon a wiears whereby there oro
swgarinry avahe Se takebkes fe mas thon possible 10 investigate Ue
purntieael le slyly 10 yes elena. Pralalsy thy a

{So fein thin ee sag that Sy H ack, MEKINGin & Eeefoan+ Te wu
found ie eis eds thee wher swchaguanidce was Red at y Ive! of 0.3%
fea sscUlet et ev sely nied the prs vee af Yoga
1 eas nbsonved hat Usa" exact ahd pannsheracie ald areaponzed
thi Fee

Some ue Kier Mure anil eoacuske's? walended their stn
‘os inastv al spithaes 8 muericoral errs wa istuds suosinglelalbiacle
fund “te andsiot exep-olaiia and suepicmta, Ahiee des ere
Fred engi ants Suaristae’ some ef the ndings ars summasind
in nee |

Tr this Suh sae ser uaerecal ity sane obtaisa i thal
iy done fold lve. stot sialated hs grotherane
oF the ohiske ander Us
50 YM ERRER, HL 6, TITER 2, RUE

Silty. hicks fed | g of suscnylulfetianel per 190 g of Basel
svn al aeite Lok oA ext a eoaeierable ere in gx0Hth
favor he fainted contol. "The ald cok of seeped y the alten
bad xo sgniteant sect aa tho prosnhate. Reading 2 ecmbination af
succicybullubiuccle ame sieplemyein secubed in growtb-raes sightly
leet a es given hy ihe wy eal, Sul ane, Howes
than in the folieacid oot,

1. ss Auten Ube tbe eimalation of gromik vblained sity hese
rugs “tty caine bythe ivliition we Eien teria which lle
Droduce toxic mateial or sends" cera vitanir'® in de let wo Yonge
svuiibie to the crit, 1 e interes (© note tat ix chs esperiment
Ae ae chugs nd sophie sail to tiie fei
‘As a mater of et. thore Ras Le sine change ik the etal count of
intents bates,

Ne fede poston us qae rae of thse nbservations nd several
yomy passed boitre ths groblem sag reineetgatod tirana diferen
ppraach, Many wurkery in the fil ot poly nuaior hid inane
that foe optiniaas germaicrnis » source of sided tint, cal
‘he vnimal protir tector. ad te be ineadod ie aay allsegcable ration.
‘The work POM, Rises & nl” Fakes Ia yrs Jeg as eicive
i promotigg th grow of chick sneiained on an al-vegslahe dit,
Free om he umisl prorin Escar, ‘The rovuls five beer sonimod
ty aetna der

Following the cepon by Ricks at oo-norksts™ the: sitaniy By
sua prodnced in cases benche of <td Simprnpse #poeah and ta
it cold be ioluted in getline fre Sore “he streptosnela formation
bovIh,clner sive: eerertadons were investiga. 8 gs Ex by
Sleiat f. aL that ber tie swe Nergompes serena
Vas used as x sore oF vial Rye gest geet stinnfaton ee
Uhtsinen uw curle he sree Jor By ie emia coun, Sbeequen!
tan stiri? tr gen aneeomcin al sion cin wee
fe reduc anttfoie content of sho fermenaron inthe. 98 reaporiPe
Tor ibe slded yao stimubcion, Ae wus on ehown tha! probably all

aminahis nev art 46 amecalersth simulans Rt wat eniog
Bruce of Cheney eee fin Th It has ges func that 2 lini
Drosably vary in their efecdverase in eiMeceat snimaca: hat inn

WSOURLMENTAL
Gronth Responee to Tereumysia

Touemysis ca he ees £5 an example ofc atisitc abil le
been four ce peslicukely eetive us an aniqu-e-ovth sti:reane

©

le the soe chiskets (ae experimsntal den hier fa tube Uf are
‘isi of Ue resulls obama ken this ancdoiotic is Ineerporated
is eM, UFR, Th THER eM. KEYROUE

teri aequere in azote gronth faster,

238%) ard in all know:

fckiding stauno By, "az Cie was somipseed tala
She Bln So Fane tesnmocte “60

Hal wrig tbe alien of 6 g of tovietysin pos on of base clon
(9 raga, inroass i Nolet all grow:h index wore cbseree, a ell
su diauien in she prtily ales Hf of lane thes wwe a 1 days
Thane i gond evidence tht teeangein i etorciing ¢ postive inbusooe
on ths growebrats a: 57 day te arnblosotrsta birds show ar over
[33g ott over tne conta gene The wiasion of ences tals
ie spi aed of res. practical importenos

orks

The sepa of guy of 125 turkeys «10 ang of levemytin per
keg of asi non i suo ie able AL, Foo: Mase rsa Ica be eer
Rt Lae rel spn akg in a High a8 20% in 3 dope ne
low Teel af 10 mg of seeariyi. pe” Ag OF rabca is use. pir: Bom
the growth espunve, ake loner asia ate of tho acne gran
Moould be considered, tay ele > putkvlalle sits the case
OC Linke whi nly ages quits 39h ome af merle
le a

Foss

Tee gpoit popes of igs & euaangels fe ewe3 moro deme
Fires geo Barn fond want hen the 9 eel fl ony of
himsin ss added to ca mite thon, kg avsags gale oF 19%
reskzo! iq the gpring sce dtseen AC Te 8 29) ad 399 I PL Ke
Nov esrate inatane of zee dy roe a ernie sie eH
prowtnrate perio’ ete dt (16 egy and 125 8457 to). Meeks ower
(oh te oy eve 128 Te 57 RB) £38 200 oD] kA, te sme
ih proativate ie Sm. Tbe 19h! teriee seen ine weight onde Ey
angen 26 th DH ba 1F hg and 14 Th G6 a eee fo
These Ihrem pv

Gown Response to Other Anubis

J: was iniiscted preooie'y div all sien ll ped sie
‘orne sell onal proth osponae ‘9 apral, 3eC with varva deyress OL
Thacg. Esporiscea wore ee op I Ue velo a ier aes

aos aves fa wit 28 ng of aii go bse
1 Lo, EMRE, a TARE WL M ReNOEDS

‘twkee

The eiderencsa in grovah respanee wt Rrkeyy he fe ble 1, ae
worthy ot mole: abu the sigiliean:Feduotion in peraaage ert nt
fhe irae hon le level, nf arisalcy ee sled 0 Th eats,

oes

Table ¥ stows grosch indioss for hogy tal va Menor data sl
inisatag the advaniiges of ineorperadag inthe dit Tow wie of att
ivi,

Gna Response wo Mised Antibia

One of the qustion® necwaly asked is Whol ips of respomee
busied i's wiatuce of srtbises is used PAs eppers roe tao WU,
tu conitmaion of euiibiots ws found to exert a signreane eras
romain deel, te our ond dolls were mu reore eEtS
AS EMEETECS As BONE Gow SLL LAOS bs

shes sal sambisoron than whe oie sony, Lbs is uP interes, ence
if catibiotis fnetiog rows contol of the insane! fava, sue would
taraly feel thar alsin tayzae oth devon eallbaessial apse
as pure Tir ord stesraayia slew’ show ative cit Ben wed
io combination,

se

Withdramal af Anthines

Um the eeomeas Poin: of SIS iL was ern eter 20%
nrg artic snpotereniuion rans be maltesined 1, in her irl,
te lig at sheer inl be wile oeiaia bids oa ates
Toe wale # Les wosks ead shoe wer’ te helene ev lbh
ifsive gies,

"Tao noad for ceria ssppleanealution using Wis eetive gitar hte
sf he Bird is odisatce be the data fs able WIL © sarypgmson oF the
anion youep ees both the S and I wess3 knee wih thowe
fer Patods af erly four iy and phe wes, si cat al i acowthe
Fale ilo iuareiately ape Che vatdrawal of Fy art atk

Bovina! mowtirirs ace fad to doped on bie Histol ol
psbioes, sili Ihg, me be protein deve: cf he sation teed. Te et
revogaized vary eany i he ook rv anion pri emt thal
in cider iv pis ke muniavara gran vespnie Hut snes
Adecpor ssa Uy Be sup ied in THe Et
136 2M WERK, 1, LEAKE a 6 RECT NG

itu th, Svadag Acttls

Wh aes Sno hat Pers exo a anodes» degree olin It
soaring activey. Ia older unl lie eNotes ve ineapfated Ir he
fit, the masinin zh alecan heohsned an everewleofvcamin By
lone fg, A feshoula he parce wt thatthe wee edstiva of tits
Fr noc sofiiens to mals, rue lion al fa poor cts. Adequare preva,
nell alse lem, mak o presemcin arder ts Enduce us mene

anscussiey

‘tut possible reshanians or mechenisms tan be sPonsible or the
smonounesd gioith mimicition in animals by aisle saeels ) Mb y
Reaves uve sree peupnsn vf us aRsevimentl eidsaee 10 aupport
‘hem is ealeevely tnesgre. Mur worker tn Lae Held tral ibe
he efsetivonsre af uacbiolcy Wir eallveetia ative Suto sL2*
postdzte the “urninmn vf took pokced By anseroses, nani, the
Clstiy. In a similar soi Growehh™ and lene ave

etiney fr €us vo uke Eurpate clive fron oe festa rat of
Undearyble bic etie SII stor ncchanism is poss, Tat oF the
Ulin often baer hich nem carapee wil thesia
oration. Sora sell eadeace for Us ise Pays sarng ation
of antibitin. Tee eso Uy mua wechers tos yrived i tilted
because the satbielics ounirn try svete subsea! ens. An the
voy she overall disse Lose Held down ard rhe aniral devises rae

Tega howell Gal ainine it ble ly atk soge Las and ore
"Wher. tbe problea: oF corsclling Intstiaa: Aora. and chelr vole i
sings ruilsnis sorte, ie york whl Perper dicks By Reyaice

AM! oosvorhsre™ aheald be wersmed, Te as found hy Reyes Met
“oneal fori ew otic rear cor periods of tour 19 eigat seeks <n
Pxpertental Zn euaw end Ceelopel oe wel som so erick fe the
fatce diet, Tee addition of sources of nidsntitiod glewlvfaco a
‘iloses il nel spill Seezese th promttrates cf serates chive.
ry Fisting ofeval.re ne that Inge cunion ne u.b5
vee found in be soosal ssnronce of gormetese a 21 a8 sorta cits
Shon the Vee silane ape aor necevely af scala eo

Since te bacterclageal study af possible sei orflor chen
ToLewing tat wi of vtitisdss, Bas oct yield whar are balled to by
Sigua sats, tie prsblen as ltachal homo ileert nope in oth
Taboraaves, If she mate of fete ontiol ware anit spay he
frerilurbmerabil epecno were taken inte cearderntina f anght be
pusibe Io éelezmine Wht eae types of microorgcaizm we afkted
Thaw I's reson te unlfli,rvvuilin os fet fo sky ce deter
136 few MHARR, BL UTHER. mua RoLD

hai gro veporse mighe reat ate table VAUD, The amt
Wiswibiet acter or thie able limite tons. caps? 19 Ee
Fargh, bosb pacborame mlz: mv auton ety wou
haus an escumely side range 2? akco-orgpans i emoen one
tor ay high a3 399 pg 19 etacr onl riwdein esevualy
Fungal in acts,

Howser, cable VILL dukes emsidenasle growl aimulation in
cicks by rirgln,_Testiald be veoaTod that giowerstizmating. ant
biotin mich ae pon Sia ad ‘erraajen show Atle or ue seul et
igy thee action being ere sky sya Pas hacer a the 12
coments mal

‘Us: Wide ferences in he atinicrobiel spectro wersanve ma a
rimostain auggened iat a amin, of the Io antibiotoe iat sa
tuned tales ers found Sovmone, thee when cbese suetansee
tree ised in dfeest repecatioss wb ola zaibiodc evel 1 we
There Was no videoue of setecysri J) weg es somme en eon Saabs
te ah sv hy single ee,

vrs thege Wut ond ia the Hmiony 9 the expeimealy, i
is iia to ase how anes Ja prea em meta anette
Stieunats by spe vad asst val seahial en, Wi thas the
Irecharies enusisvahhy mere omplex in mata, tbereore, Lm
Setvky eiuply involving intestinal ars

‘One very Tntsteting abeeration zie by Cand se Hhat hops fed
sid an annibigtc srplemert consuried, 4 An average tries a AGH
Trofer # conta groans We Rave ade @ eeily controled check om