Antibiotic Resistance. Mechanisms and New Antimicrobial Approaches

413 Pages·2016·10.27 MB·English

by  Kateryna Kon

Antibiotic Resistance
Antibiotic Resistance
Mechanisms and
New Antimicrobial Approaches
Kateryna Kon, MD, PhD
Department of Microbiology, Virology, and Immunology
Kharkiv National Medical University
Kharkiv, Ukraine
Mahendra Rai, PhD
Biotechnology Department
SGB Amravati University
Maharashtra, India
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List of Contributors
K.A´cs
Institute ofPharmacognosy,Medical School,University ofPe´cs, Pe´cs, Hungary
C.N. Aguilar
Food ResearchDepartment,School ofChemistry,Universidad Auto´noma de Coahuila, Saltillo,
Coahuila, CP, Mexico
J. Aguirre-Joya
Food ResearchDepartment,School ofChemistry,Universidad Auto´noma de Coahuila, Saltillo,
Coahuila, Mexico
A.Amin
Hospitalist Program, University ofCalifornia, Irvine Medical Center,Irvine, CA, United States
Z.Aumeeruddy-Elalfi
Department ofHealth Sciences, FacultyofScience, University ofMauritius, Re´duit, Mauritius
M. Ballal
EntericDiseasesDivision,Kasturba Medical College, Manipal, Karnataka,India
I. Barbu
Microbiology Immunology Department,FacultyofBiology,University ofBucharest, Bucharest,
Romania
C.Bejenaru
Department ofVegetal& Animal Biology,FacultyofPharmacy,University of Medicine and
Pharmacy ofCraiova, Craiova, Romania
L.E. Bejenaru
Department ofPharmacognosy & Phytotherapy,Faculty ofPharmacy,University ofMedicine
and Pharmacy ofCraiova, Craiova, Romania
T.Bencsik
Institute ofPharmacognosy,Medical School,University ofPe´cs, Pe´cs, Hungary
V.G. Beoletto
Department ofMicrobiologyand Immunology, Universidad Nacional de Rı´oCuarto,Rı´o Cuarto,
Argentina
V.Bhattaram
Department ofAnimalScience, University ofConnecticut,Storrs, CT,United States
C.E. Boucher
Department ofMicrobial, Biochemical and Food Biotechnology,University ofthe Free State,
Bloemfontein, RepublicofSouth Africa
xv
xvi List of Contributors
R.R. Bragg
Department of Microbial,Biochemical and Food Biotechnology,University of theFree State,
Bloemfontein, RepublicofSouthAfrica
M.E. Carezzano
Department of Microbiology and Immunology,Universidad Nacional de Rı´o Cuarto, R´ıo Cuarto,
Argentina
M.L. Cha´vez-Gonza´lez
Food Research Department,School ofChemistry,Universidad Auto´nomade Coahuila, Saltillo,
Coahuila, CP,Mexico
M.C.Chifiriuc
MicrobiologyImmunology Department, Faculty ofBiology, University ofBucharest, Bucharest,
Romania; Research Institute ofthe University ofBucharest, Life, Environmental and Earth
Sciences, Bucharest, Romania
N.B. Cobacho
Centro de Ana´lises Proteoˆmicase Bioquı´micas, Programade Po´s-Graduac¸a˜oem Cieˆncias
Genoˆmicas e Biotecnologia, Universidade Cato´lica de Brası´lia, Brası´lia, DF,Brazil
E. Coetsee
Department of Microbial,Biochemical and Food Biotechnology,University of theFree State,
Bloemfontein, RepublicofSouthAfrica
S.S. daSilva
Department of Biotechnology,School of Engineering ofLorena, University ofSa˜o Paulo, Lorena,
Sa˜oPaulo, Brazil
M. de las Mercedes Oliva
Department of Microbiology and Immunology,Universidad Nacional de Rı´o Cuarto, R´ıo Cuarto,
Argentina
L.A. de Lima
Centro de Ana´lises Proteoˆmicase Bioquı´micas, Programade Po´s-Graduac¸a˜oem Cieˆncias
Genoˆmicas e Biotecnologia, Universidade Cato´lica de Brası´lia, Brası´lia, DF,Brazil
K. de SousaOliveira
Centro de Ana´lises Proteoˆmicase Bioquı´micas, Programade Po´s-Graduac¸a˜oem Cieˆncias
Genoˆmicas e Biotecnologia, Universidade Cato´lica de Brası´lia, Brası´lia, DF,Brazil
M.S.Demo
Department of Microbiology and Immunology,Universidad Nacional de Rı´o Cuarto, R´ıo Cuarto,
Argentina
S.C. Dias
Centro de Ana´lises Proteoˆmicase Bioquı´micas, Programade Po´s-Graduac¸a˜oem Cieˆncias
Genoˆmicas e Biotecnologia, Universidade Cato´lica de Brası´lia, Brası´lia, DF,Brazil
P.F. Seke Etet
Department of Basic Health Sciences, College ofApplied Medical Sciences, QassimUniversity,
Buraydah, SaudiArabia
List of Contributors xvii
M. Farahna
Department ofBasicHealthSciences, College ofApplied Medical Sciences, Qassim University,
Buraydah,SaudiArabia
A.C. Flores-Gallegos
Food ResearchDepartment,School ofChemistry,Universidad Auto´noma de Coahuila, Saltillo,
Coahuila, Mexico
O.L. Franco
Centrode Ana´lises Proteoˆmicas eBioqu´ımicas, Programa de Po´s-Graduac¸a˜o em Cieˆncias
Genoˆmicas eBiotecnologia,Universidade Cato´licade Bras´ılia, Brası´lia, DF,Brazil; S-Inova
Biotech,Po´s-Graduac¸a˜o em Biotecnologia, Universidade Cato´lica Dom Bosco, Campo Grande,
MS, Brazil
A.Gade
Nanobiotechnology Laboratory,Department of Biotechnology,SGB AmravatiUniversity,
Amravati, Maharashtra, India
A.M. Grumezescu
Department ofScience and Engineering ofOxide MaterialsandNanomaterials, Faculty of
Applied Chemistry and Materials Science,University Politehnica ofBucharest, Bucharest,
Romania
V.Grumezescu
LasersDepartment,NationalInstitute for Lasers, Plasmaand Radiation Physics, Bucharest,
Romania;Department of Science andEngineering ofOxide Materialsand Nanomaterials,
FacultyofAppliedChemistry andMaterials Science,University Politehnicaof Bucharest,
Bucharest, Romania
A.Gurib-Fakim
CIDP Research & Innovation, BioPark, Socota Phoenicia, Mauritius
P.S. Haddad
Exact and Earth Sciences Department,Universidade Federal de Sa˜o Paulo, Diadema,SP,Brazil
D.H. Halat
Microbiology Laboratory,School ofPharmacy, Saint-Joseph University,Beirut, Lebanon;
RodolpheMe´rieuxLaboratory, Beirut, Lebanon;Department of Pharmaceutical Sciences,
SchoolofPharmacy,LebaneseInternationalUniversity,Beirut and Bekaa,Lebanon
A.M. Holban
Department ofScience and Engineering ofOxide MaterialsandNanomaterials, Faculty of
Applied Chemistry and Materials Science,University Politehnica ofBucharest, Bucharest,
Romania;Microbiology Immunology Department, Facultyof Biology,University ofBucharest,
Bucharest, Romania
Gy. Horva´th
Institute ofPharmacognosy,Medical School,University ofPe´cs, Pe´cs, Hungary
xviii List of Contributors
L. Hsieh
Hospitalist Programand Division ofInfectious Diseases, University ofCalifornia, Irvine Medical
Center,Irvine, CA,United States
A. Ingle
Nanobiotechnology Laboratory, Department ofBiotechnology,SGB Amravati University,
Amravati, Maharashtra, India
D.P. Karumathil
Department of Animal Science,University of Connecticut,Storrs, CT,UnitedStates
B. Kocsis
InstituteofMedical Microbiology and Immunology,Medical School,University ofPe´cs, Pe´cs,
Hungary
K. Kon
Department of Microbiology,Virology, and Immunology,KharkivNationalMedical University,
Kharkiv,Ukraine
V. Lazar
MicrobiologyImmunology Department, Faculty ofBiology, University ofBucharest, Bucharest,
Romania
J.-Y. Lee
Department of Microbial,Biochemical and Food Biotechnology,University of theFree State,
Bloemfontein, RepublicofSouthAfrica
G.A. Lutzu
KeyLaboratory ofBiofuels, Qingdao Instituteof Bioenergyand Bioprocess Technology, Chinese
Academy ofSciences, Qingdao, Shandong, People’sRepublicofChina
M.F. Mahomoodally
Department of Health Sciences, Faculty ofScience,University of Mauritius,Reduit,Mauritius
J.M. Marioli
Department of Chemistry, Universidad Nacionalde Rı´oCuarto,Rı´o Cuarto,Argentina
L. Meyburgh
Department of Microbial,Biochemical and Food Biotechnology,University of theFree State,
Bloemfontein, RepublicofSouthAfrica
M.M. Michel
Food Research Department,School ofChemistry,Universidad Auto´nomade Coahuila, Saltillo,
Coahuila, Mexico
G.D. Mogos¸anu
Department of Pharmacognosy & Phytotherapy,Facultyof Pharmacy,University ofMedicine
and Pharmacy ofCraiova, Craiova, Romania
List of Contributors xix
J. Morlett-Cha´vez
Food ResearchDepartment,School ofChemistry,Universidad Auto´noma de Coahuila, Saltillo,
Coahuila, Mexico
C.A. Moubareck
Microbiology Laboratory,School ofPharmacy, Saint-Joseph University,Beirut, Lebanon;
RodolpheMe´rieuxLaboratory, Beirut, Lebanon;Department of Natural Science and Public
Health,College ofSustainability Sciences and Humanities, Zayed University,Dubai,
United Arab Emirates
D.Nagaonkar
Nanobiotechnology Laboratory,Department of Biotechnology,SGB AmravatiUniversity,
Amravati, Maharashtra, India
A.H. Nwabo Kamdje
Department ofBiomedical Sciences, Facultyof Sciences, University ofNgaounde´re´,
Ngaounde´re´,Cameroon
A.E. Oprea
Department ofScience and Engineering ofOxide MaterialsandNanomaterials, Faculty of
Applied Chemistry and Materials Science,University Politehnica ofBucharest, Bucharest,
Romania
P.Paralikar
Nanobiotechnology Laboratory,Department of Biotechnology,SGB AmravatiUniversity,
Amravati, Maharashtra, India
A.Parsaeimehr
Laboratory ofBiosystems Engineering,KeyLaboratory ofAgrobiologyof Jiangsu Province,
Institute ofBiotechnology, Jiangsu Academy ofAgricultural Sciences, Nanjing, Jiangsu, People’s
RepublicofChina
M.T. Pelegrino
Exact and Earth Sciences Department,Universidade Federal de Sa˜o Paulo, Diadema,SP,Brazil
R.C. Popescu
Department ofScience and Engineering ofOxide MaterialsandNanomaterials, Faculty of
Applied Chemistry and Materials Science,University Politehnica ofBucharest, Bucharest,
Romania;Department of LifeandEnvironmentalPhysics, Horia HulubeiNationalInstituteof
PhysicsandNuclearEngineering, Bucharest, Romania
G.M. Preciado
Food ResearchDepartment,School ofChemistry,Universidad Auto´noma de Coahuila, Saltillo,
Coahuila, Mexico
M. Rai
Nanobiotechnology Laboratory,Department of Biotechnology,SGB AmravatiUniversity,
Amravati, Maharashtra, India
xx List of Contributors
R. Rodrı´guez-Herrera
Food Research Department,School ofChemistry,Universidad Auto´nomade Coahuila, Saltillo,
Coahuila, CP,Mexico
D.K. Sarkis
MicrobiologyLaboratory,School ofPharmacy,Saint-Joseph University,Beirut, Lebanon;
Rodolphe Me´rieuxLaboratory,Beirut, Lebanon
A.B. Seabra
Exact and Earth Sciences Department, Universidade Federal de Sa˜oPaulo, Diadema, SP,Brazil
M.G.Shurygin
Irkutsk Scientific Centre ofSurgery and Traumatology, Irkutsk,Russia;Irkutsk Scientific Centre
SB RAS, Irkutsk,Russia
I.A.Shurygina
Irkutsk Scientific Centre ofSurgery and Traumatology, Irkutsk,Russia;Irkutsk Scientific Centre
SB RAS, Irkutsk,Russia
B.G. Sukhov
A. E.Favorsky Irkutsk Institute ofChemistry SB RAS, Irkutsk,Russia
C. Theron
Department of Microbial,Biochemical and Food Biotechnology,University of theFree State,
Bloemfontein, RepublicofSouthAfrica
A. Upadhyay
Department of Animal Science,University of Connecticut,Storrs, CT,UnitedStates
I. Upadhyaya
Department of Animal Science,University of Connecticut,Storrs, CT,UnitedStates
W.A.van derWesthuizen
Department of Microbial,Biochemical and Food Biotechnology,University of theFree State,
Bloemfontein, RepublicofSouthAfrica
L. Vecchio
Department of Basic Health Sciences, College ofApplied Medical Sciences, QassimUniversity,
Buraydah, SaudiArabia
K. Venkitanarayanan
Department of Animal Science,University of Connecticut,Storrs, CT,UnitedStates
S.L. Villarreal-Morales
Food Research Department,School ofChemistry,Universidad Auto´nomade Coahuila, Saltillo,
Coahuila, Mexico
Preface
Resistance to antimicrobials has been described involving all types of infectious agents and con-
tinues tobe agrowing challenge inmodernmedicine. A common problem inacutecare hospitals is
the use of potent, broad-spectrum antibiotics, as well as inappropriate or suboptimal therapy, all of
which contribute to the development of antibiotic resistance. One of the solutions to this issue,
which may prolong the effectiveness of currently available antibiotics is antimicrobial stewardship
strategies that encourage the judicious use of these antibiotics. Moreover, the potential of emerging
and enabling technologies like nanotechnology should be harnessed to tackle the global problem of
multidrug-resistance (MDR).These issues are discussedin thisbook.
Understanding the fundamental mechanisms of antibiotic resistance is a key step for the discov-
ery of effective methods to cope with the resistance. This book discusses up-to-date knowledge
about the mechanisms of antibiotic resistance in different types of bacteria and application of this
knowledge into developing new and optimal treatment strategies. In addition, it explores alternative
antimicrobialapproachesinfightingmicrobialresistance.Severalchaptersaredevotedtothepoten-
tial of nanotechnology in combating MDR bacteria, to the role of magnetite-based nanomaterials in
developing alternative therapeutic and preventive approaches against pathogens, to different
polymer-containing metal nanocomposites as promising antimicrobial agents, and to the role of
nanooxides and nitric oxides in fighting antibiotic-resistant bacteria. Alternative natural sources of
antimicrobial agents are also discussed in detail, including plant-derived products, such as essential
oils (EOs) and plant extracts, bacteriophages, bacteriocin-producing bacteria, marine-derived bacte-
ria, fungi, sponges,algae,corals, mollusks, and otherinvertebrates.
The potential audience for the book include researchers in microbiology, biotechnology,
pharmacology, nanotechnology, and infection control; students of medical, pharmaceutical, and
biological faculties; andclinicians dealing with infectionsinvarious locations.
xxi