Table Of ContentAdvances in Experimental Medicine and Biology 928
Subash Chandra Gupta
Sahdeo Prasad
Bharat B. Aggarwal Editors
Anti-inflammatory
Nutraceuticals and
Chronic Diseases
Advances in Experimental Medicine and Biology
Volume 928
Series editors
Irun R. Cohen, Rehovot, Israel
N.S. Abel Lajtha, Orangeburg, USA
Rodolfo Paoletti, Milan, Italy
John D. Lambris, Philadelphia, USA
More information about this series at http://www.springer.com/series/5584
Subash Chandra Gupta Sahdeo Prasad
(cid:129)
Bharat B. Aggarwal
Editors
fl
Anti-in ammatory
Nutraceuticals and Chronic
Diseases
123
Editors
SubashChandra Gupta BharatB. Aggarwal
Banaras HinduUniversity Inflammation Research Institute
Varanasi, Uttar Pradesh SanDiego, CA
India USA
Sahdeo Prasad
University of Texas
MDAnderson Cancer Center
Houston, TX
USA
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine andBiology
ISBN978-3-319-41332-7 ISBN978-3-319-41334-1 (eBook)
DOI 10.1007/978-3-319-41334-1
LibraryofCongressControlNumber:2016947788
©SpringerInternationalPublishingSwitzerland2016
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Contents
1 Curcumin and Its Role in Chronic Diseases .. .... .... ..... .... 1
A. Kunwar and K.I. Priyadarsini
2 Berberine and Its Role in Chronic Disease ... .... .... ..... .... 27
Arrigo F.G. Cicero and Alessandra Baggioni
3 Emodin and Its Role in Chronic Diseases.... .... .... ..... .... 47
B. Anu Monisha, Niraj Kumar and Ashu Bhan Tiku
4 Ursolic Acid and Chronic Disease: An Overview of UA’s Effects
On Prevention and Treatment of Obesity and Cancer.. ..... .... 75
Anna M. Mancha-Ramirez and Thomas J. Slaga
5 Tocotrienol and Its Role in Chronic Diseases . .... .... ..... .... 97
Kok-Yong Chin, Kok-Lun Pang and Ima-Nirwana Soelaiman
6 Indole-3-Carbinol and Its Role in Chronic Diseases.... ..... .... 131
Barbara Licznerska and Wanda Baer-Dubowska
7 Sanguinarine and Its Role in Chronic Diseases.... .... ..... .... 155
Pritha Basu and Gopinatha Suresh Kumar
8 Piperine and Its Role in Chronic Diseases.... .... .... ..... .... 173
Giuseppe Derosa, Pamela Maffioli and Amirhossein Sahebkar
9 Therapeutic Potential and Molecular Targets of Piceatannol
in Chronic Diseases. .... ..... .... .... .... .... .... ..... .... 185
Young-Joon Surh and Hye-Kyung Na
10 Fisetin and Its Role in Chronic Diseases. .... .... .... ..... .... 213
Harish C. Pal, Ross L. Pearlman and Farrukh Afaq
11 Honokiol, an Active Compound of Magnolia Plant, Inhibits
Growth, and Progression of Cancers of Different Organs .... .... 245
Ram Prasad and Santosh K. Katiyar
v
vi Contents
12 Celastrol and Its Role in Controlling Chronic Diseases . ..... .... 267
Shivaprasad H. Venkatesha and Kamal D. Moudgil
13 Boswellic Acids and Their Role in Chronic
Inflammatory Diseases .. ..... .... .... .... .... .... ..... .... 291
H.P.T. Ammon
14 Natural Withanolides in the Treatment of Chronic Diseases.. .... 329
Peter T. White, Chitra Subramanian, Hashim F. Motiwala
and Mark S. Cohen
15 Gambogic Acid and Its Role in Chronic Diseases.. .... ..... .... 375
Manoj K. Pandey, Deepkamal Karelia and Shantu G. Amin
16 Embelin and Its Role in Chronic Diseases.... .... .... ..... .... 397
HongLu,JunWang,YouxueWang,LiangQiaoandYongningZhou
17 Butein and Its Role in Chronic Diseases . .... .... .... ..... .... 419
Ziwei Song, Muthu K. Shanmugam, Hanry Yu and Gautam Sethi
18 Garcinol and Its Role in Chronic Diseases ... .... .... ..... .... 435
Amit K. Behera, Mahadeva M. Swamy, Nagashayana Natesh
and Tapas K. Kundu
19 Morin and Its Role in Chronic Diseases . .... .... .... ..... .... 453
Krishnendu Sinha, Jyotirmoy Ghosh and Parames C. Sil
20 Ellagic Acid and Its Role in Chronic Diseases .... .... ..... .... 473
Giuseppe Derosa, Pamela Maffioli and Amirhossein Sahebkar
Author Index.. .... .... .... ..... .... .... .... .... .... ..... .... 481
About the Editors
Dr. Subash Chandra Gupta is currently Assistant
Professor at Department of Biochemistry, Institute of
Science, Banaras Hindu University, India.
Dr. Sahdeo Prasad iscurrently at the Department of
Experimental Therapeutics, The University of
Texas MD Anderson Cancer Center, USA.
vii
viii AbouttheEditors
Dr.BharatAggarwal iscurrentlyFoundingDirector
of Inflammation Research Institute, San Diego, CA,
USA. He was a Ransom Horne, Jr., Distinguished
Professor of Experimental Therapeutics, Cancer
Medicine and Immunology, The University of
Texas MD Anderson Cancer Center, USA.
Chapter 1
Curcumin and Its Role in Chronic
Diseases
A. Kunwar and K.I. Priyadarsini
Abstract Curcumin, a yellow pigment from the spice turmeric, is used in Indian
and Chinese medicine since ancient times for wide range of diseases. Extensive
scientific research on this molecule performed over the last 3 to 4 decades has
proved its potential as an important pharmacological agent. The antioxidant,
anti-inflammatory, antimicrobial and chemopreventive activities of curcumin have
been extended to explore this molecule against many chronic diseases with
promisingresults.Further,itsmultitargetingabilityandnontoxicnaturetohumans
evenupto12 g/dayhaveattractedscientiststoexplorethisasananticanceragentin
the clinic, which is in different phases of trials. With much more scope to be
investigated and understood, curcumin becomes one of the very few inexpensive
botanical molecules with potent therapeutic abilities.
(cid:1) (cid:1) (cid:1) (cid:1)
Keywords Curcumin Antioxidant Anti-inflammatory Anticancer
(cid:1)
Turmeric Polyphenol
1.1 Introduction
Curcumin,anaturalpolyphenol,isoneofthemostinvestigatedbiomoleculesfrom
Mother Nature. Its natural source, Curcuma longa or turmeric is used in Indian
AyurvedicandSiddhamedicinesandalsoinChinesemedicinessincethousandsof
years[3,6,22,107].Turmericisaperennialplantofthegingerfamily,cultivatedin
tropical and subtropical regions of South Asia, and India is one of the largest
producers of turmeric [35]. In Ayurveda, turmeric is used to treat ailments like
arthritis,sprains, openwounds, acnes, stomach upset,flatulence,dysentery,ulcers,
A.Kunwar(cid:1)K.I.Priyadarsini(&)
RadiationandPhotochemistryDivision,BhabhaAtomicResearchCentre,
Trombay,Mumbai400085,India
e-mail:[email protected]
A.Kunwar
e-mail:[email protected]
©SpringerInternationalPublishingSwitzerland2016 1
S.C.Guptaetal.(eds.),Anti-inflammatoryNutraceuticalsandChronicDiseases,
AdvancesinExperimentalMedicineandBiology928,
DOI10.1007/978-3-319-41334-1_1
