Table Of ContentAngiogenesis
Key Principles - Science - Technology - Medicine
Edited by Rudolf Steiner
Paul B. Weisz
Robert Langer
Birkhauser Verlag
Basel . Boston . Berlin
Editor's addresses:
Dr. R. Steiner Dr. P. B. Weisz
Research Division University of Pennsylvania
Dept. of Surgery Dept. of Chemical and Bioengineering
University Hospital Zurich Room 312, Towne Building/D3
8091 Zurich Philadelphia, PA 19104
Switzerland USA
Dr. R. Langer
Dept. of Chemical Engineering and
Harvard - MIT
Division of Health, Science and Technology
Massachusetts Institute of Technology
Building E 25 Room 342
Cambridge, MA 02139
USA
The use of registered names, trademarks, etc. in this publication does not imply, even in the
absence of a specific statement, that such names are exempt from the relevant protective laws
and regulations and therefore free for general use.
The publisher cannot assume any legal responsibility for given data, especially as far as
directions for the use and the handling of chemicals and drugs are concemed. This informa
tion can be obtained from the manufacturers.
Library of Congress Cataloging-in-Publication Data
Angiogenesis: key principles - science, technology, medicine/edited by R. Steiner, P. B. Weisz,
R. Langer.
(Experientia. Supplementum; v. 61)
Inc1udes bibliographical references and index.
ISBN 978-3-0348-7003-0 ISBN 978-3-0348-7001-6 (eBook)
DOI 10.1007/978-3-0348-7001-6
1. Neovascularization. I. Steiner, R. (RudoIO, 1945- . H. Weisz, Paul B., 1921- . III.
Langer, Robert S. IV. Series.
QPI06.6.A53 1992
612.l'3-dc20
Deutsche Bibliothek Cataloging-in-Publication Data
Angiogenesis: key principles - science - technology - medicine/ed. by R. Steiner ... - Basel;
Boston; Berlin: Birkhäuser, 1992
(Experientia: Supplementum; Vol. 61)
ISBN 978-3-0348-7003-0
NE: Steiner, Rudolf [Hrsg.]; Experientia/Supplementum
This work is subject to copyright. All rights are reserved, whether the whole or part of the
material is concemed, specifically those of translation, reprinting, re-use of illustrations,
broadcasting, reproduction by photocopying machine or similar means, and storage in data
banks. Under §54 of the German Copyright Law, where copies are made for other than
private use, a fee is payable to 'Verwertungsgesellschaft Wort', Munich.
© 1992 Birkhäuser Verlag
Softcover reprint of the hardcover Ist edition 1992
P.O. Box 133
4010 Basel
Switzerland
ISBN 978-3-0348-7003-0
To
Judah Folkman
for his many services
to the experimental physiology and pathology
of angiogenesis
To
Paul Calabresi
in admiration
of his interdisciplinary spirit
Editorial Note
The book on Angiogenesis is a witness to history of the emergence of
new scientific insight of a universally important basic phenomenon, and
the concept of controlling it with respect to health and disease. It is an
initial textbook of current and pertinent knowledge for readers of nearly
all scientific branches providing material background for education and
for research, much of which could easily be considered as obligatory
reading in the study of medicine, molecular biology, chemistry and
engineering. Thus the context of this book does not fit into the narrow
niche of a single compartment. It shouldn't. On the contrary it is
relevant to many.
The most challenging editorial concern was to effectively report major
developments at the forefront of angiogenesis research and to reflect
with short introductories the complex and inextricable interdependence
of key principles in science, technology and medicine.
Rudolf Steiner
Paul B. Weisz
Robert Langer
Contents
Introductories:
R. Steiner
Angiogenesis - Historical perspective 1
J. Folkman
Angiogenesis - Retrospect and outlook ...................... 4
P. B. Weisz
Angiogenesis - The interdisciplinary challenge 14
L. Sachs
Angiogenesis - Cytokines as part of a network 20
R. Langer
Angiogenesis - Biomedical technology ....................... 23
K. Hellmann
Angiogenesis - Time to review progress ...................... 26
G. K. Uhlschmid
Angiogenesis - A new fascinating enigma for surgeons?! 29
Morphology
P. H. Burri
Intussusceptive microvascular growth, a new mechanism of
capillary network formation .............................. 32
M. A. Konerding, C. van Ackern, F. Steinberg and C. Streffer
Combined morphological approaches in the study of network
formation in tumor angiogenesis .......................... 40
T. Ishibashi and S. J. Ryan
Maturation of newly-formed subretinal vessels ................ 59
H. C. Bauer, M. Steiner and H. Bauer
Embryonic development of the CNS microvasculature in
the mouse: new insights into the structural mechanisms of
early angiogenesis ....................................... 64
D. Virgintino, D. Ribatti, B. Nico, M. Bertossi and L. Roncali
Vascular supply in embryonic neural transplants .............. 69
J. R. Less, T. C. Skalak, E. M. Sevick and R. K. Jain
Microvascular network architecture in a mammary carcinoma 74
I. Freitas, G. F. Baronzio, S. Barni, V. Bertone, O. Griffini,
P. Accossato and P. Pontiggia
Tumor angiogenesis: evidence of new blood vessel channels
from plasma infiltrations ................................... 81
Molecular Biology
J. G. Beitz, I.-S. Kim, P. Calabresi and A. R. Frackelton
Receptors for platelet-derived growth factor on microvascular
endothelial cells ......................................... 85
J. Korhonen, J. Partanen, E. Eerola, S. Vainikka, R. A litalo ,
T. P. Makela, M. Sandberg, H. Hirvonen and K. Alitalo
Five FGF receptors with distinct expression patterns .......... 91
A. Isacchi, L. Bergonzoni, M. Statuto, R. Chiesa, M. Rusnati,
M. Presta, G. Ragnotti and P. Sarmientos
Activation of the tyrosine kinase receptor is not sufficient for
the full biological activity of bFGF ....................... 101
Chemical Engineering
P. B. Weisz, H. C. Hermann, M. M. Joullie, K. Kumor,
E. M. Levine, E. J. Macarak and D. B. Weiner
Angiogenesis and heparin mimics ........................... 107
C. L. Stokes
Endothelial cell migration and chemotaxis in angiogenesis 118
Cell Biology and Dynamics
P. M. Gullino
Microenvironment and angiogenic response 125
R. Montesano, M. S. Pepper, J-D. Vassalli and L. Orci
Modulation of angiogenesis in vitro ......................... 129
M. S. Pepper, J-D. Vassalli, L. Orci and R. Montesano
Proteolytic balance and capillary morphogenesis in vitro ....... 137
M. A. Moses and R. Langer
Metalloproteinase inhibition as a mechanism for the
inhibition of angiogenesis ................................ 146
M. P. Piechocki, S. Kantak and J. M. Onoda
TPA-induced differentiation of rat aortic endothelial cells is
substrate-specific and receptor mediated ...................... 152
A. E. Canfield, A. B. Sutton, S. L. Schor, M. E. Grant and
A. M. Schor
Aortic endothelial cells in culture: factors which modulate their
morphological and biosynthetic phenotypes ................. 158
A. M. Schor, A. E. Canfield, A. B. Sutton, T. D. Allen, P. Sloan
and S. L. Schor
The behaviour of pericytes in vitro: relevance to angiogenesis
and differentiation ...................................... 167
N. Sato, N. Tsuruoka, M. Yamamoto, T. Nishihara, T. Goto
Identification of non heparin-binding endothelial cell growth
factor from rat myofibroblasts ............................ 179
S. M. Albelda
Differential expression of integrin cell-substratum adhesion
receptors on endothelium ................................ 188
P. Defilippi, C. Bozzo, M. Geuna, P. Rossino, L. Silengo and
G. Tarone
Modulation of extracellular matrix receptors (integrins) on
human endothelial cells by cytokines ...................... 193
C. Jackson, K. Jenkins and L. Schrieber
Possible mechanisms of type I collagen-induced vascular
tube formation ......................................... 198
M. Presta, M. Rusnati, C. Urbinati, E. Tanghetti, M. Statuto,
A; Pozzi, A. Gualandris and G. Ragnotti
Basic fibroblast growth factor bound to cell substrate
promotes cell adhesion, proliferation, and protease
production in cultured endothelial cells .................... 205
G. Taraboletti, D. Belotti and R. Giavazzi
Thrombospondin modulates basic fibroblast growth factor
activities on endothelial cells .............................. 210
W. F. Herblin and J. L. Gross
Binding sites for basic fibroblast growth factor on solid
tumors are associated with the vasculature ................. 214
M. Guthridge, J. Schmitt, J. Bertolini, J. Cowling, A. Runting,
S. Katsahambas, A. E. Drummond and M. T. W. Hearn
Studies on basic fibroblast growth factor (FGF-~) gene
expression in the rat and pig ovary using in situ
hybridisation and quantitative reverse transcriptase-
polymerase chain reaction techniques ...................... 219
R. L. Smither and T.-P. D. Fan
Effects of platelet-activating factor on endothelial cells and
fibroblasts in vitro ...................................... 230
J. Badet, F. Soncin and D. Barritault
Angiogenin and endothelial cells ............................ 235
N. Mirsky and E. S. Lindenbaum
Cultured endothelial cell mobilization induced by partially
purified human uterine angiogenic factor ................... 239
A. Amberger, U. Tontsch, O. Lemykin, G. Gabbiani and
H. C. Bauer
Two cloned cerebral endothelial cell phenotypes: an in vitro
model for angiogenesis? .................................. 244
M. L. Brandi
Bone endothelial cells: A tool for analyzing cell to cell
interactions in the skeletal tissue .......................... 250
H. S. Sharma, M. Wunsch, M. Schmidt, R. J. Schott,
R. Kandolf and W. Schaper
Expression of angiogenic growth factors in the collateralized
swine myocardium ...................................... 255
H. C. Lichtenbeld and G. H. Blijham
Tumor cell spheroids induce a mitogenic response in
endothelial cells ......................................... 261
J. M. Wang, R. D. Hunter and S. Kumar
A Monoclonal antibody (E-9) binds preferentially to
the vasculatures of human tumours, embryonic and
regenerating tissues ...................................... 266
D. Rusciano, P. Lorenzoni and M. M. Burger
Liver or lung colonization by F9 teratocarcinoma cells follows
specific interactions with the target organ .................. 272
St. Riedl, P. Moller, A. Faissner and P. Schlag
Induction and altered distribution of tenascin in the basal
lamina of colorectal adenomas and carcinomas ............. 277
Assays and Models
K. Norrby
On the quantitative rat mesenteric-window angiogenesis
assay .................................................. 282
D. A. Cox, S. Kunz, N. Cerletti, G. K. McMaster and R. R. Burk
Wound healing in aged animals - effects of locally applied
transforming growth factor beta in different model systems ... 287
G. Weckbecker, R. Liu and L. Tolcsvai
Intradermal angiogenesis in nude mice induced by human tumor
cells or b-FGF ......................................... 296
L. B. G. B. Vieira, J. A. A. Rodriques, V. H. R. Leite and
S. P. Andrade
Angiogenic activity of PAF and inhibition of blood flow by
Bothrops Jararaca venom in a mouse sponge model ......... 302
T-P. D. Fan, D-E. Hu, R. L. Smither and G. A. Gresham
Furher studies on angiogenesis in a rat sponge model .......... 308
T-P. D. Fan, E. E. Frost and A. D. Wren
A multichannel wounding device for the study of vascular
repair in vitro .......................................... 315
R. Adatia, L. Poggi, E. W. Thompson, R. C. Gallo,
G. F. Fassina, and A. Albini
Assessment of angiogenic potential - the use of AIDS-KS cell
supernatants as an in vitro model ......................... 321
Biomedical Technology
R. Langer
Delivery systems for angiogenesis stimulators and inhibitors .... 327
E. Wintermantel, L. Cima, B. Schloo and R. Langer
Angiopolarity of cell carriers: directional angiogenesis in
resorbable liver cell transplantation devices ................. 331
A. I. Skene, R. J. L. Williams, R. D. Goldin and R. D. Rosin
Angiogenic vessels as a potential for targeted therapy in
human liver metastases .................................. 335
D. J. Kerr, J. A. Goldberg, J.R. Anderson, N. Wilmott,
A. T. Whatelely, C. S. McArdle and J. McKillop
The effect of angiotensin II on tumor blood flow and the
delivery of microparticulate cytotoxic drugs ................ 339
T. M. Lam, N. E. Whereat, S. C. Henderson, W. H. Burgess,
A. Shaheen and H. P. Greisler
Effects of hypercholesterolemia on mono kine induced
smooth muscle cell proliferation .......................... 346
I. A. Burney, R. J. Maxwell, J. R. Griffiths and S. B. Field
Deuterium nuclear magnetic resonance imaging of the
developmental pattern of tumour blood flow ............... 357
C. Thomas, C. Counsell, J. Sansom, P. Wood,1. Stratford
and G. Adams
The perfluorocarbon emulsion PFOB: potential indicator
of change in blood volume using fluorine 19 NMR
spectroscopy ........................................... 362
M. Molls, H. J. Feldman and K. Sievers
Clinical investigations on blood perfusion in human malignancies
of the pelvis and abdomen: significance for tumor therapy 368
E. G. Salerud and S. Hellem
A bone tissue integrated single fibre laser Doppler
flowmeter probe ........................................ 373
Pharmacology and Medicine
J. 1. Stagner and E. Samols
Induction of angiogenesis by growth factors: relevance to
pancreatic islet transplantation ............................ 381
v. Lindner and M. A. Reidy
Role of basic fibroblast growth factor in proliferation of
endothelium and smooth muscle after denuding
injury in vivo ........................................... 386
M. D. Brown and O. Hudlicka
Capillary growth in the heart ............................... 389
G. Imre and E. Csonka
Angiogenic role of lactic acid in the mechanism of
neovascularization ......................................... 395
D. G. S. Thilo-Korner, U. Marre, N. Savion, F. W. Hehrlein,
and R. H. Bodecker
Hyperoxia (145 mmHg p02) and tissue normoxia
(20-40 mmHg p02) modulate human vascular cell functions .. 400
M. Kamler, H.-A. Lehr, J. H. Barker, R. K. Saetzler, E. Uhl
and K. Messmer
Impact of basic fibroblast growth factor (bFGF) on wound
healing in chronically ischemic tissue ...................... 405
C. Mothersill, C. B. Semour, D. Mulvin and T. P. Hennessy
Endothelial cell proliferation is induced by radiation in cultured
explants of human urothelium and oesophageal mucosa 407
L. Ghali and M. Dyson
The direct effect of light therapy on endothelial cell
proliferation in vitro .................................... 411
