Anaesthesia and peri-operative Care for Laparoscopic Donor Nephrectomy

138 Pages·2008·23.72 MB·English

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Anaesthesia and
peri-operative Care for
Laparoscopic Donor
Nephrectomy
Ingrid Mertens zur Borg
The studies described in this thesis
were performed at the
Department of Anaesthesiology,
Erasmus University Medical Centre,
Rotterdam, The Netherlands.
Financial support for
printing and celebration of
this thesis was obtained from:
— De Nederlandse Nierstichting
— Arrow Nederland
— Ministerie van Defensie
— Stryker Nederland BV
— KCI Medical BV
— Fresenius Kabi
Aquarel by Oscar van der Linden
Layout, cover design and printing by HollandsGras
Advies Ontwerp Realisatie
Utrecht, the Netherlands
www.hollandsgras.nl

ISBN; 90-809069-1-3
©2008, Copyright by Ingrid R.A.M. Mertens zur Borg
Anaesthesia and peri-operative Care
for Laparoscopic Donor Nephrectomy
Anesthesie en peri-operatieve zorg voor
laparoscopische donor nefrectomie
Proefschrift
ter verkrijging van de graad van doctor aan de
Erasmus Universiteit Rotterdam,
op gezag van de
rector magnificus
Prof.dr. S.W.J. Lamberts
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 28 mei 2008 om 11.45 uur door
Ingrid Roos Agnes Maria Mertens zur Borg
geboren te Nijmegen
Promotiecommissie:
Promotoren : Prof.dr. J. Klein
Prof.dr. J.N.M. IJzermans
Overige leden : Dr. T. van Gelder
Prof.dr. D. Poldermans
Prof.dr. G.J. Scheffer

Copromotor : Dr. D. Gommers
Contents

1 Introduction
11

Original studies

2 The effect of laparoscopic and open donor nephrectomy on the long term renal function in
donor and recipient: a retrospective study
Transplantation 2005 25

3 Comparison of three perioperative fluid regimens for laparoscopic donor nephrectomy:
a dose finding study
Surg. Endosc 2007 33

4 Effect of intra-abdominal pressure elevation and positioning on hemodynamic responses
during carbon dioxide pneumoperitoneum for laparoscopic donor nephrectomy:
a prospective controlled clinical study
Surg. Endosc 2004 45

5 Beneficial effects of a new fluid regime on kidney function of donor and recipient
during laparoscopic versus open donor nephrectomy
Endourology 2007 55

6 Neuroendocrine stress response in laparoscopic and open donor nephrectomy are equal:
propofol ensures more stress response reduction than isoflurane: a randomized
controlled clinical study
Submitted 67

7 Epidural anaesthesia for laparoscopic donor nephrectomy is beneficial for the donor
without affecting kidney function: a randomized controlled clinical study
Submitted 79

8 Effect of epidural analgesia on inflammatory and stress response in
laparoscopic donor nephrectomy: a randomized controlled clinical study
Submitted 93

9 Summary in English, samenvatting in het Nederlands
107
10 General discussion, conclusions and future perspectives
113
Appendices
Abbreviations
Contributing Authors
Acknowledgements, Dankwoord
Nawoord
List of publications
Curriculum Vitae

Een leven in geschonken tijd
André Bek
Voor mijn ouders, Karel, Roos, Jan, Suske, Ben en mijn dierbare vrienden

CHAPTER
CHAPTER
3
1
CHAPTER
4
Introduction