Anaerobe 2012 Abstract Book & Program

246 Pages·2012·1.99 MB·English

The 11th Biennial Congress of the
Anaerobe Society of the Americas
Grand Hyatt Hotel
San Francisco, CA USA
June 27-July 1, 2012
Program & Abstract Book

Program & Abstract Book
Contents
Course Directors ii
Welcome Letter iii The 11th Biennial Congress of the
About the Anaerobe Society iv
Anaerobe Society of the Americas
Patrons v
Exhibitors v
Keynote Speaker vi
In Memoriam vii
Lifetime Achievement Awards viii
Grand Hyatt Hotel
Accreditation x
Curricular Goals & Objectives x
San Francisco, CA USA
Presenters & Faculty xi
Congress Program xiv June 27-July 1, 2012
Disclosure Information xx
Abstract Table of Contents 1
Abstracts 3
Poster Index 205
Author Index 215
The 11th Biennial Congress of the
Anaerobe Society of the Americas
Grand Hyatt Hotel
San Francisco, CA USA
June 27-July 1, 2012
The 11th Biennial Congress of the
Anaerobe Society of the Americas
Grand Hyatt Hotel
San Francisco, CA USA
June 27-July 1, 2012
Anaerobe Society of the Americas
PO Box 452058
Los Angeles, CA 90045
Phone: [phone] Fax: [phone]
Web: www.anaerobe.org E-mail: [email protected]
Course Directors
Cynthia L. Sears, M.D. Bennett Lorber, M.D.
ASA President ASA Past President
Johns Hopkins University Temple University
Baltimore, MD USA Philadelphia, PA USA
Organizing Committee
David M. Aronoff, M.D. Purima S. Kumar, D.D.S.
University of Michigan Ohio State University
Ann Arbor, MI USA Columbus, OH USA
Diane M. Citron Jeanne M. Marrazzo, M.D.
R.M. Alden Research Laboratory University of Washington
Culver City, CA USA Seattle, WA USA
Dale N. Gerding, M.D. Carl Erik Nord, M.D.
ASA Vice President Karolinska Institute
Loyola University, Chicago Stockholm, Sweden
Maywood, IL USA
Andrew B. Onderdonk, Ph.D.
Ellie J.C. Goldstein, M.D. Harvard Medical School
ASA Treasurer/ASA Past President Boston, MA USA
R.M. Alden Research Lab / UCLA
Santa Monica, CA USA J. Glenn Songer, Ph.D.
University of Arizona
Stuart Johnson, M.D. Tucson, AZ USA
ASA Past President
Loyola University, Chicago
Maywood, IL USA
Ronald J. Goldman, Ph.D.
ASA Executive Director
Los Angeles, CA USA
۩2012 Anaerobe Society of the Americas
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The 11th Biennial Congress of the
Anaerobe Society of the Americas
Grand Hyatt Hotel
San Francisco, CA USA
June 27-July 1, 2012
Welcome Letter
Welcome to Anaerobe 2012, the 11th biennial Congress of the Anaerobe
Society of the Americas (ASA). This forum brings together clinicians and
scientists from around the world to engage in presentations, dialogues, and
interactions related to the clinical and microbiological aspects of anaerobic
infections. The Congress will explore the role of anaerobes in both health
and disease, while addressing the traditional and emerging technologies for
identification and diagnosis.
Anaerobe 2012 again illustrates the international interest in the field
of anaerobic bacteriology. The 158 papers included in this Abstract Book
represent the work of over 515 scientists from 28 countries.
At this Congress, the Keynote Address will be given by Dr. Peer Bork of the
European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany.
Dr. Bork is a pioneer in novel approaches to the analysis of the microbiome
to decipher its role in health and disease.
Lifetime Achievement Awards will be presented to Dr. Elisabeth Nagy of
University of Szeged in Hungary and Dr. Ian Poxton of the University of
Edinburgh in the United Kingdom. Both have contributed extensively to the
field of anaerobic bacteriology, as researchers, educators, and organizational
leaders.
I would like to thank the members of the Organizing Committee and the
Session Chairs for their assistance in formulating what promises to be an
exciting program. I also would like to thank those from industry—both
patrons and exhibitors—for the financial support that makes this Congress
possible, as well as grants from the U.S. National Institutes of Health,
the European Society of Clinical Microbiology and Infectious Diseases,
Burroughs Wellcome Fund, and the Gut Check Foundation.
In addition, I am grateful for our continued relationship with Anaerobe
Systems for helping organize the expanded Pre-Congress Workshop and
Microbiology Educational Services for providing the continuing education
accreditation for laboratory scientists. And, very special thanks goes to Dr.
Ronald and Pamela Goldman, who again have done an exemplary job in
bringing this meeting together.
Our hope is that Anaerobe 2012 serves to foster stimulating discussions as
well as cultivate personal relationships that continue to invigorate the entire
field beyond the timeframe of this Congress.
Cynthia L. Sears, M.D.
ASA President
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The 11th Biennial Congress of the
Anaerobe Society of the Americas
Grand Hyatt Hotel
San Francisco, CA USA
June 27-July 1, 2012
About the Society
About the AnAerobe Society
Founded in 1992, the Anaerobe Society of the Americas, a non-profit
foundation, serves as a forum for those interested in anaerobes, anaerobic
infections, and related matters. The Society aims: (1) to stimulate interest
in anaerobes and to encourage interchange among anaerobists from all
disciplines, including medical, dental, veterinary, environmental, and
basic sciences; (2) to bring together investigators, clinicians, and laboratory
scientists interested in anaerobic infections for formal and informal
meetings; (3) to review and assess new advances in the field; (4) to discuss
areas of controversy; and (5) to mark future directions.
There are four levels of membership: Doctoral, Non-Doctoral, Verified
Student, and Retired. Details and application form are available on our web
site: www.anaerobe.org.
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The 11th Biennial Congress of the
Anaerobe Society of the Americas
Grand Hyatt Hotel
San Francisco, CA USA
June 27-July 1, 2012
Patrons & Exhibitors
Anaerobe Society of the Americas gratefully acknowledges the following
organizations for their generous support of this congress.
Support for this activity was received in the form of educational grants from:
u National Institute of Allergy and Infectious Diseases
u European Society of Clinical Microbiology and Infectious Diseases
u Burroughs Wellcome Fund
u Gut Check Foundation
Support for this activity from commercial interests include:
PlAtinum PAtronS
u Optimer Pharmaceuticals
u ViroPharma Incorporated
Gold PAtronS
u Anaerobe Systems
u Bruker Daltonics
u Merck & Co., Inc.
Silver PAtronS
u Advanced Instruments, Inc.
u bioMeriuex
u The Dannon Company
bronze PAtronS & exhibitorS
u Anaerobe Journal / Elsevier
u Bio K+ International
u Cepheid
u Co-Action Publishing
u Coy Laboratories
u Cubist Pharmaceuticals
u Hardy Diagnostics
u List Biological Laboratories, Inc.
u Microbiology International
u R.M. Alden Research Laboratory
u Sanofi Pasteur
u Shel Lab
u TechLab
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The 11th Biennial Congress of the
Anaerobe Society of the Americas
Grand Hyatt Hotel
San Francisco, CA USA
June 27-July 1, 2012
Keynote Speaker
Peer bork, Ph.d.
Dr. Peer Bork is senior group leader and joint head
of the Structural and Computational Biology unit
at the European Molecular Biology Laboratory
(EMBL), a European research organization with
headquarters in Heidelberg, Germany. He also
holds an appointment at the Max-Delbrueck-
Center for Molecular Medicine in Berlin.

Dr. Bork received his Ph.D. in Biochemistry (1990)
at the University of Leipzig and his Habilitation in
Theoretical Biophysics (1995). He works in various
areas of computational biology and systems
analysis with a focus on function prediction,
comparative analysis, and data integration. He
says that he chose early on to combine his interest in computers and biology,
because it provided him more room to develop his creativity than was typically
open to a math-oriented student.

His team at EMBL focuses on microbes in two areas: ocean water and the human
body. In the human intestine alone, there are 10,000 species of microbes that are
unknown. Deciphering their behavior could help researchers address conditions
such as diarrhea, which still causes a fifth of child deaths worldwide. “We must
put the puzzle together on how these microbes interact and what risk factors
we can correlate with them, such as diet or obesity. Today, you take antibiotics,
and they kill pretty much everything. That’s not healthy. We need to understand
infections better, so we can come up with more clever ways to treat disease.”

His group has published more than 500 research articles in international peer-
reviewed journals. According to ISI (analyzing the last 10 years), Dr. Bork
is currently the most cited European researcher in Molecular Biology and
Genetics. According to Google Scholar, his most cited peer-reviewed papers are
on the human genome, yeast proteome, mouse genome, and Simple Modular
Architecture Research Tool (SMART). He has published on the human gut
microbiome defining basic enterotypes and an interactive Tree of Life. He also
serves on the editorial board of a number of journals, including Science and PloS
Biology, and functions as senior editor of the journal Molecular Systems Biology.

Dr. Bork cofounded five biotech companies,two of which went public. More
than 25 of his former associates now hold professorships or other group leader
positions in prominent institutions all over the world. He received the Nature
Award for Creative Mentoring for his achievements in nurturing and stimulating
young scientists. He was also the recipient of the prestigious Royal Society
and Academie des Science Microsoft Award for the advancement of science using
computational methods and obtained a competitive ERC Advanced Investigator
Grant.

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The 11th Biennial Congress of the
Anaerobe Society of the Americas
Grand Hyatt Hotel
San Francisco, CA USA
June 27-July 1, 2012
In Memoriam
SuSAn kinder hAAke, d.m.d., Ph.d.
Dr. Susan Kinder Haake was a respected
member of the UCLA School of Dentistry
faculty in the sections of Periodontics and Oral
Biology and Medicine, as well as a leading
researcher on the role of oral bacteria in human
health.
Born in Bath, ME, Dr. Haake earned her
under-graduate degree from Hamilton College
and a D.M.D. in 1979 from the Tufts School
of Dental Medicine. She went on to pursue
periodontal specialty training at the University
of Connecticut, where she worked with Dr.
Kenneth Kornman to pursue research on fastidious anaerobic bacteria and
complete an M.S. degree in dental science in 1985.
When Dr. Kornman moved to the University of Texas Health Science Center in
San Antonio, he recruited Dr. Haake to pursue graduate studies in microbiology.
Earning a Ph.D. in 1993, she made a series of key discoveries about interbacterial
adherence that underlie our current understanding about the central role of
Fusobacterium nucleatum in the formation of dental plaque.
In 1991, Dr. Haake joined the faculty of UCLA’s School of Dentistry. After
establishing her own laboratory, she discovered a family of unique endogenous
plasmids that she developed into the first shuttle vectors and other molecular
tools for genetic manipulation of F. nucleatum. This work led to the identification
of the outer membrane proteins that mediate the coaggregation of F. nucleatum
with other oral bacteria.
Reflecting her broad perspective as both a microbiologist and periodontologist,
she made a number of keen insights into the roles of periodontal bacteria
in human health and disease. In recent years, Dr. Haake became a leading
investigator in the NIH Human Microbiome Initiative. At the time of her death,
she was heading an innovative, multidisciplinary project to elucidate the role of
the periodontal microflora in gum disease.
Dr. Haake’s numerous awards included the National Institutes of Health–
National Institute of Dental Research Physician-Scientist Award (1987-1992);
the Robert B. Wolcott Award of the Omicrom Kappa Upsilon Society (2004) for
distinguished service to the dental profession; and diplomate status from the
American Board of Periodontology (2007). In recognition for outstanding
teaching and mentoring in periodontics, she received the American Academy of
Periodontology’s Educator Award (2008, 2012).
She died of pancreatic cancer at age 58 and is survived by her husband, Dr.
David Haake; her children, Christine and Erik; two sisters; and two brothers.
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The 11th Biennial Congress of the
Anaerobe Society of the Americas
Grand Hyatt Hotel
San Francisco, CA USA
June 27-July 1, 2012
Lifetime Lifetime
Achievement Award Achievement Award
eliSAbeth nAGy, m.d., Ph.d., d.Sc.
Dr. Nagy is Professor of Clinical Microbiology
at the University of Szeged Institute of Clinical
Microbiology in Szeged Hungary. Born in
Budapest in 1944, she received her M.D. from
Albert Szent-Györgyi Medical University in
1968, as well as a Ph.D. (1983) and D.Sc. (1994)
in clinical microbiology. She has taught Clinical
Microbiology at University of Szeged for 41 years,
including 14 years as Department Head.
Her current research interest is clinical
bacteriology with particular emphasis on the
clinically-significant anaerobic bacteria. Focus has
been on Clostridium difficile infections, resistance
mechanisms of Bacteroides strains against beta-
lactam antibiotics, plasmid profile analysis of Bacteroides strains, antibiosis
studies in connection with the ecological balance of the vagina and the small
intestine, diagnostic problems of systemic fungal infections, and investigation
of antifungal drugs. She has also been evaluating new diagnostic methods,
such as sequencing and MALDI-TOF MS, in the routine diagnostics of anaerobic
bacteria.
Dr. Nagy has been active in a variety of national and international organizations.
She has been a Board Member of the Hungarian Society for Microbiology, the
Hungarian Society for Chemotherapy, and Hungarian Society for Infectious
Diseases and Clinical Microbiology, as well as serving as President of the
Hungarian College of Clinical Microbiology. Over the past nine years, she has
served the European Society for Clinical Microbiology and Infectious Diseases
as member of the Executive Committee, Professional Affairs for Clinical
Microbiology, and Chair of the ESCMID Study Group on Anaerobic Infections,
since 2010.
She has authored 278 publications, with a cumulative impact factor of 197.471.
She also has served as an editor of such journals as Journal of Medical Microbiology
and Clinical Microbiology and Infections. Her awards include the Hungarian
Society for Microbiology’s Manninger Medallion (1995), the American Society for
Microbiology’s Morrison Award (1996), the Hungarian Society for Laboratory
Medicine’s Pandy Medallion (1997), and the Hungarian Society for Infectious
Diseases and Clinical Microbiology’s Gerloczy Award (2012).
Dr. Nagy is married, with three children and seven grandchildren. She has
recently stepped down as Head of the Institute of Clinical Microbiology, but
continues to work on research projects, including international collaborations.
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