Alzheimer's Disease and Related Disorders Annual 5

226 Pages·2005·1.45 MB·English

by  Serge Gauthier

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ALZHEIMER’S
DISEASE AND
RELATED
DISORDERS
5
ANNUAL
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ALZHEIMER’S
DISEASE AND
RELATED
DISORDERS
5
ANNUAL
Edited by
Serge Gauthier,
MD FRCPC
Professor and Director
Alzheimer’s Disease Research Unit
McGill Centre for Studies in Aging
Douglas Hospital
Verdun PQ
CANADA
Philip Scheltens,
MD PhD
Department of Neurology / Alzheimer Center
Academisch Ziekenhuis
Vrije Universiteit
Amsterdam
The Netherlands
Jeffrey L Cummings,
MD
Reed Neurological Research Center
University of California, Los Angeles
Los Angeles, CA
USA
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© 2006 Taylor & Francis, an imprint of the Taylor & Francis Group
First published in the United Kingdom in 2006 by Taylor & Francis, an imprint of the Taylor &
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978 1 84184 561 6
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Contents
List of Contributors vii
1. Neuropathology of mild cognitive impairment 1
in the elderly
Steven T DeKosky, Milos D Ikonomovic, Ronald L Hamilton,
David A Bennett, and Elliot J Mufson
2. Cerebrospinal fluid markers for the diagnosis 17
of Alzheimer’s disease
Niki Schoonenboom, Harald Hampel, Philip Scheltens,
and Mony de Leon
3. Executive control function in ‘mild’ cognitive 35
impairment and Alzheimer’s disease
Donald R Royall
4. Glycosaminoglycan mimetics in Alzheimer’s disease 63
Francine Gervais, Denis Garceau, Paul S Aisen, and
Serge Gauthier
5. Immunotherapy for Alzheimer’s disease 73
David Wilkinson
6. Cholesterol, copper, and statin therapy in 89
Alzheimer’s disease
D Larry Sparks, Suzana Petanceska, Marwan Sabbagh,
Donald Connor, Holly Soares, Charles Adler, Jean Lopez,
Nina Silverberg, Kathryn Davis, Suhair Stipho-Majeed,
Sherry Johnson-Traver, Paul Volodarsky, Chuck Ziolkowski,
Jeff Lochhead, and Patrick Browne
v
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7. Insulin resistance in Alzheimer’s disease – 111
a novel therapeutic target
Suzanne Craft, Mark A Reger, and Laura D Baker
8. Atypical antipsychotics in dementia 135
Lesley M Blake and Jacobo Mintzer
9. Treatment of vascular risk factors to delay 153
Alzheimer’s disease?
Frank-Erik de Leeuw, Raj Kalaria, and Philip Scheltens
10. Cognitive dysfunction in multiple sclerosis 165
Julie A Bobholz and Angela Gleason
11. Cholinesterase inhibitors in the treatment of 181
dementia associated with Parkinson’s disease
Murat Emre
12. Modern applications of electroencephalography 191
in dementia diagnosis
CJ Stam
Index 207
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Contributors
Charles AdlerPhD Julie A BobholzPhD
Mayo Clinic Assistant Professor of Neurology
Scottsdale, AZ Medical College of Wisconsin
USA Milwaukee, WI
USA
Paul S AisenMD
Department of Neurology Patrick Browne MD
Georgetown University Medical Center Center for Chest Disease
Washington, DC Division of Cardiology
USA Boswell Hospital
Sun City, AZ
Laura D BakerPhD USA
Assistant Professor of Psychiatry and
Behavioral Sciences, University of Donald Connor PhD
Washington School of Medicine, Cleo Roberts Clinical Research Center
Geriatric Research, Education and Sun Health Research Institute
Clinical Center, Veterans Affairs Puget Sun City, AZ
Sound Health Care System USA
Seattle, WA
USA Suzanne Craft PhD
Professor of Psychiatry and Behavioral
David A BennettMD Sciences
Rush Alzheimer’s Disease Center University of Washington School of
Rush university Medical Center Medicine
Chicago, IL Associate Director,
USA Geriatric Research, Education and
Clinical Center
Lesley M BlakeMD Veterans Affairs Puget Sound Health
Division of Geriatric Psychiatry Care System
Northwestern University Medical Seattle, WA
School USA
Chicago, IL
USA
vii
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viii ALZHEIMER’SDISEASEANDRELATEDDISORDERSANNUAL
Jeffrey L CummingsMD
Department of Neurology Serge Gauthier MD FRCPC
David Geffen School of Medicine at Professor and Director
UCLA Alzheimer’s Disease Research Unit
Los Angeles, CA McGill Centre for Studies in Aging
USA Douglas Hospital
Verdun PQ
Kathryn DavisBA Canada
Sun Health Research Institute
Sun City, AZ Francine GervaisPhD
USA Vice-President, R&D
Neurochem
Steven T DeKoskyMD Laval
Department of Neurology Quebec
University of Pittsburgh School of Canada
Medicine
Pittsburgh, PA Angela Gleason PhD
USA Postdoctoral Fellow
Department of Neurology
FE De Leeuw MD PhD
Medical College of Wisconsin
Department of Neurology
Milwauke, WI
University Medical Center St. Radboud
USA
Nijmegen
The Netherlands Ronald L HamiltonMD
Division of Neuropathology
Mony de LeonPhD
Department of Pathology
New York University School of
University of Pittsburgh School of
Medicine
Medicine
Center for Brain Health
Pittsburgh, PA
New York, NY
USA
USA
Murat EmreMD Harald Hampel PhD
Department of Psychiatry
Professor of Neurology
University of Munich
Head, Behavioral Neurology and
Nussbaumstr. 7
Movement Disorders Unit
Munich
Department of Neurology
Germany
Istanbul Faculty of Medicine
Çapa, Istanbul
Milos D Ikonomovic MD
Turkey
Alzheimer’s Disease Research Center
Denis GarceauPhD University of Pittsburgh School of
Drug Development Medicine
Neurochem Pittsburgh, PA
Laval, Quebec USA
Canada
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CONTRIBUTORS ix
Sherry Johnson-Traver Mark A RegerPhD
Sun Health Research Institute Acting Assistant Professor of Psychiatry
Sun City, AZ and Behavioral Sciences
USA University of Washington School of
Medicine
Raj N KalariaMD Geriatric Research, Education and
Wolfson Research Centre Clinical Center
Institute for Ageing and Health Veterans Affairs Puget Sound Health
Newcastle General Hospital Care System
Westgate Road Seattle, WA
Newcastle upon Tyne USA
UK
Donald R Royall MD
Jeff Lochhead BS Julia and Van Buren Parr Professor
Sun Health Research Institute for Alzheimer’s research in psychiatry
Sun City, AZ Chief: Geriatric Psychiatry Division
USA The University of Texas Health Sciences
Center at San Antonio
Jean LopezRN MSN San Antonio, TX
Cleo Roberts Clinical Research Center USA
Sun Health Research Institute
Sun City, AZ Marwan Sabbagh MD
USA Cleo Roberts Clinical Research Center
Sun Health Research Institute
Jacobo E MintzerMD Sun City, AZ
Medical University of South Carolina USA
Charleston, SC
USA Philip Scheltens MD PhD
Department of Neurology/Alzheimer
Elliot J MufsonPhD Center
Division of Neuroscience VU University Medical Center
Rush University Amsterdam
Rush Presbyterian St Luke’s Medical The Netherlands
Center
Chicago, IL Niki Schoonenboom MD
USA Department of Neurology/Alzheimer
Center
Suzana PetanceskaPhD VU University Medical Center
Nathan Kline Institute and Amsterdam
Deptartments of Psychiatry and The Netherlands
Pharmmacology
New York University Medical Center Nina Silverberg PhD
Orangeburg, NY Sun Health Research Institute
USA Sun City, AZ
USA