Alzheimers Disease: Advances for a New Century

484 Pages·2013·5.42 MB·English

by  George Perry, J. Avila., M. A. Smith, A. Sorensen, X. Zhu

ALZHEIMER’S DISEASE:
ADVANCES FOR A NEW CENTURY
Advances in Alzheimer's Disease

Advances in Alzheimer's Disease brings together the latest insights in Alzheimer’s disease research in specific
areas in which major advances have been made. This book series assembles and builds on work recently
published in the Journal of Alzheimer's Disease (JAD) and also includes further contributions to ensure
comprehensive coverage of the topic. The emphasis is on the development of novel approaches to understanding
and treating Alzheimer’s and related diseases.
Series Editors:
George Perry, Ph.D. and Mark A. Smith, Ph.D.†

Volume 3
Previously published in this series
Vol. 2. J.W. Ashford, A. Rosen, M. Adamson, P. Bayley, O. Sabri, A. Furst, S.E. Black,
M. Weiner (Eds.), Handbook of Imaging The Alzheimer Brain
Vol. 1. G. Casadesus (Ed.), Handbook of Animal Models in Alzheimer’s Disease
ISSN 2210-5727 (print)
ISSN 2210-5735 (online)
Alzheimer’s Disease:
Advances for a New Century
Edited by
George Perry, PhD
University of Texas at San Antonio, USA
Xiongwei Zhu, PhD
Case Western Reserve University, USA
†
Mark A. Smith , PhD
Case Western Reserve University, USA
Aaron Sorensen, MA
Elsevier Science & Technology, USA
and
Jesús Avila, MD
Universidad Autónoma de Madrid, Spain
© 2013 IOS Press and the authors.
All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any
form or by any means, without prior written permission from the publisher.
ISBN 978-1-61499-153-3 (print)
ISBN 978-1-61499-154-0 (online)
Library of Congress Control Number: 20123930413
Publisher
IOS Press BV
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
fax: [phone]
e-mail:
With gratitude for the support
of the Semmes Foundation, Inc.
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Contents
Preface 1
Section 1. Genetics
A Brief History of Alzheimer’s Disease Gene Discovery 5
Rudolph E. Tanzi
AD Gene 3-D: Moving Past Single Layer Genetic Information to Map Novel Loci Involved
in Alzheimer’s Disease 15
Amanda J. Myers
Trait, State, and Mechanism: Looking Back, Looking Forward, and Understanding Why 23
Simon Lovestone
TARDBP Mutation Analysis in TDP-43 Proteinopathies and Deciphering the Toxicity
of Mutant TDP-43 35
Tania F. Gendron, Rosa Rademakers and Leonard Petrucelli
Section 2. Amyloid-β
Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis,
and Treatment of Alzheimer’s Disease? 49
William L. Klein
Molecular Mechanisms of Amyloid Oligomers Toxicity 67
Rakez Kayed and Cristian A. Lasagna-Reeves
Amyloid-β and Cognition in Aging and Alzheimer’s Disease: Molecular
and Neurophysiological Mechanisms 79
Harald Hampel
Neurovascular Defects and Faulty Amyloid-β Vascular Clearance in Alzheimer’s Disease 87
Abhay P. Sagare, Robert D. Bell and Berislav V. Zlokovic
Endothelin-Converting Enzymes and Related Metalloproteases in Alzheimer’s Disease 101
Javier Pacheco-Quinto, Aimee Herdt, Christopher B. Eckman
and Elizabeth A. Eckman
Amyloid-β Peptide: Dr. Jekyll or Mr. Hyde? 111
Daniela Puzzo and Ottavio Arancio
viii
Section 3. Tau
Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism
of Neurofi brillary Degeneration 123
Jian-Zhi Wang, Yi-Yuan Xia, Inge Grundke-Iqbal, and Khalid Iqbal
GSK3 and Tau: Two Convergence Points in Alzheimer’s Disease 141
Felix Hernandez, Jose J. Lucas and Jesus Avila
Tau Triage Decisions Mediated by the Chaperone Network 145
Casey Cook and Leonard Petrucelli
Section 4. Neuropathology
Evolutional Aspects of Alzheimer’s Disease Pathogenesis 155
Heiko Braak and Kelly Del Tredici
Brain Structural and Functional Connectivity and the Progression of Neuropathology
in Alzheimer’s Disease 163
Paul M. Matthews, Nicola Filippini, and Gwenaëlle Douaud
Alzheimer’s Disease-Related Lesions 173
Irina Alafuzoff
Anatomic and Clinical Pathology of Cognitive Impairment and Dementia 181
Kathleen S. Montine and Thomas J. Montine
Alzheimer’s Disease: Recent Advances and Future Perspectives 185
Kiren Ubhi and Eliezer Masliah
Elucidating the Triggers, Progression, and Effects of Alzheimer’s Disease 195
Rodrigo Medeiros, Meredith A. Chabrier and Frank M. LaFerla
Alzheimer’s Disease and the Frontotemporal Dementias: Contributions to Clinico-Pathological
Studies, Diagnosis, and Cognitive Neuroscience 211
John R. Hodges
Alzheimer’s Disease and the “Valley of Death”: Not Enough Guidance from Human Brain Tissue? 219
Thomas G. Beach
Section 5. Oxidative Stress, Metabolism, Metals, and Infl ammation
Alzheimer’s Disease and the Quest for its Biological Measures 237
Domenico Praticò
ix
Oxidative Modifi cation of Brain Proteins in Alzheimer’s Disease: Perspective on Future
Studies Based on Results of Redox Proteomics Studies 243
Rukhsana Sultana and D. Allan Butterfi eld
Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer’s Disease 253
Xiongwei Zhu, George Perry, Mark A. Smith and Xinglong Wang
Insulin and Alzheimer’s Disease: Untangling the Web 263
Suzanne Craft, Brenna Cholerton, and Laura D. Baker
The Metal Theory of Alzheimer’s Disease 277
Ashley I. Bush
Metals, Membranes, and Amyloid-β Oligomers: Key Pieces in the Alzheimer’s Disease Puzzle? 283
Andrew D. Watt, Victor L. Villemagne and Kevin J. Barnham
The NeuroImmune System in Alzheimer’s Disease: The Glass is Half Full 295
Suzanne E. Hickman and Joseph El Khoury
Section 6. Imaging and Biomarkers
Imaging the Onset and Progression of Alzheimer’s Disease: Implications for Prevention Trials 305
Yuying Liang, Natalie S. Ryan, Jonathan M. Schott and Nick C. Fox
Recent Advances in Imaging Alzheimer’s Disease 313
Meredith N. Braskie, Arthur W. Toga and Paul M. Thompson
Perspectives for Multimodal Neurochemical and Imaging Biomarkers in Alzheimer’s Disease 329
Stefan J. Teipel, Osama Sabri, Michel Grothe, Henryk Barthel, David Prvulovic,
Katharina Buerger, Arun L.W. Bokde, Michael Ewers, Wolfgang Hoffmann and Harald Hampel
Long Night’s Journey into the Day: Amyloid-β Imaging in Alzheimer’s Disease 349
Victor L. Villemagne and Christopher C. Rowe
Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: More to Come? 361
Henrik Zetterberg and Kaj Blennow
Biomarkers for Alzheimer’s Disease: Showing the Way or Leading Us Astray? 371
Joseph F. Quinn
Section 7. Diagnosis and Epidemiology
Multimodal Comparative Studies of Neurodegenerative Diseases 379
Murray Grossman
x
From Molecule to Clinic and Community for Neurodegeneration: Research
to Bridge Translational Gaps 385
C arol Brayne, Roger A. Barker, Denise Harold, Paul G. Ince, George M. Savva,
Julie Williams, Caroline H. Williams-Gray and Stephen B. Wharton
Selected Findings from the Religious Orders Study and Rush Memory and Aging Project 397
D avid A. Bennett, Robert S. Wilson, Zoe Arvanitakis, Patricia A. Boyle,
Leyla de Toledo-Morrell and Julie A. Schneider
Characterizing the Preclinical Stages of Alzheimer’s Disease and the Prospect
of Presymptomatic Intervention 405
Richard J. Caselli and Eric M. Reiman
Clinically Asymptomatic Vascular Brain Injury: A Potent Cause of Cognitive Impairment
Among Older Individuals 417
Charles DeCarli
Patterns of Compensation and Vulnerability in Normal Subjects at Risk of Alzheimer’s Disease 427
Oscar L. Lopez, James T. Becker and Lewis H. Kuller
Risk Estimations, Risk Factors, and Genetic Variants Associated with Alzheimer’s Disease
in Selected Publications from the Framingham Heart Study 439
Galit Weinstein, Philip A. Wolf, Alexa S. Beiser, Rhoda Au and Sudha Seshadri
Lessons from Epidemiologic Research about Risk Factors, Modifi ers, and Progression
of Late Onset Alzheimer’s Disease in New York City at Columbia University Medical Center 447
D evangere Devanand, Joseph Lee, Jose Luchsinger, Jennifer Manly, Karen Marder,
Richard Mayeux, Nikolaos Scarmeas, Nicole Schupf and Yaakov Stern
From Genetics to Dietetics: The Contribution of Epidemiology to Understanding
Alzheimer’s Disease 457
P ascale Barberger-Gateau, Jean-Charles Lambert, Catherine Féart, Karine Pérès,
Karen Ritchie, Jean-François Dartigues and Annick Alpérovitch
Prevention of Alzheimer’s Disease: Moving Backward through the Lifespan 465
Alina Solomon, Miia Kivipelto and Hilkka Soininen
Subject Index 471
Author Index 473