Alcohol and Cancer: Proceedings of the Third International Conference

274 Pages·2018·5.332 MB·English

by  Vasilis Vasiliou, Samir Zakhari, Lopa Mishra, Helmut K. Seitz

Advances in Experimental Medicine and Biology 1032
Vasilis Vasiliou · Samir Zakhari 
Lopa Mishra · Helmut K. Seitz Editors
Alcohol and
Cancer
Proceedings of the Third International
Conference
Advances in Experimental Medicine
and Biology
Volume 1032
Editorial Board:
IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel
ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research,
Orangeburg, NY, USA
JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA
RODOLFO PAOLETTI, University of Milan, Milan, Italy
NIMA REZAEI, Tehran University of Medical Sciences, Children’s Medical
Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Vasilis Vasiliou • Samir Zakhari • Lopa Mishra
Helmut K. Seitz
Editors
Alcohol and Cancer
Proceedings of the Third International
Conference
Editors
Vasilis Vasiliou Samir Zakhari
Department of Environmental Health Distilled Spirits Council of the US
Sciences Washington, DC, USA
Yale School of Public Health
Yale University Helmut K. Seitz
New Haven, CT, USA Salem Medical Centre
University of Heidelberg
Lopa Mishra Heidelberg, Baden-Württemberg, Germany
Mishra Laboratory
University of Texas
MD Anderson Cancer Center
Houston, TX, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine and Biology
ISBN 978-3-319-98787-3 ISBN 978-3-319-98788-0 (eBook)
https://doi.org/10.1007/978-3-319-98788-0
Library of Congress Control Number: 2018956727
© Springer Nature Switzerland AG 2018
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Preface
Heavy alcohol consumption is a risk factor for disease and mortality worldwide.
According to epidemiological studies, chronic alcohol consumption has also been
associated with a variety of cancers (oral cavity, pharynx, larynx, esophagus, liver,
colorectum, breast). It appears that the risk of developing cancer increases in pro-
portion to the amount of alcohol consumed. Enigmatically, alcohol intake decreases
the risk of thyroid cancer, kidney and lung cancer (with evidence most strongly
supporting lower risk for light and moderate drinkers) and non-Hodgkins lym-
phoma, and does not appear to affect prostate cancer risk. Based upon these epide-
miological data, it is evident that the capacity for alcohol to influence carcinogenesis
varies between tissues or organs. This being the case, it is not unreasonable to pro-
pose that the mechanisms by which alcohol promotes or represses cancer is likely to
be tissue-dependent. In addition, individual risk factors including genetics also
modify ethanol-mediated carcinogenesis. Given the prevalence of alcohol con-
sumption in societies throughout the world and the challenges associated with effec-
tive cancer treatment, a more complete understanding of the risks associated with
alcohol exposure use in relation to cancer is particularly important, as is identifica-
tion of the mechanisms by which alcohol influences cancer development.
Recognizing this, the idea for an international meeting that focused on alcohol and
cancer was born.
In September 2010, the first International Congress on Alcohol and Cancer was
held at the German Cancer Research Center (DKFZ) in Heidelberg, Germany. This
meeting provided a venue for the presentation of research that specifically addressed
alcohol and cancer. Areas of focus included recent advances in epidemiology,
molecular mechanisms and biomarkers of alcohol-induced carcinogenesis, as well
as anticancer therapies.
After the success of the first meeting, additional International Congresses on
Alcohol and Cancer have been held. The second congress took place in May 2013
at Breckenridge, Colorado, USA. Summaries of presentations from this meeting
were published in Advances of Experimental Medicine and Biology 815: 1-436,
2015). In June 2015, the third congress was held in Hersonissos Crete, Greece, in
June 2015.
v
vi Preface
This book comprises papers presented during the third congress. The research
described herein documents the significant progress that has been made in our
understanding of the molecular mechanisms by which alcohol may affect carcino-
genesis, and epidemiological studies examining how alcohol affects the risk of can-
cer development. We anticipate this book will inform the reader about this important
area of alcohol research and stimulate cancer investigators and clinicians to con-
sider how alcohol consumption may affect their research or patient care endeavors.
Finally, it is our intention to continue these congresses; the fourth will be held in
Newport, Rhode Island, USA, on April 14–18, 2019.
New Haven, CT, USA Vasilis Vasiliou
Washington, DC, USA Samir Zakhari
Washington, DC, USA Lopa Mishra
Heidelberg, Germany Helmut K. Seitz
Contents
1 Alcohol Consumption and Risk of Thyroid Cancer:
A Population Based Case-Control Study in Connecticut . . . . . . . . . . 1
Huang Huang, Nan Zhao, Yingtai Chen, Nicole Deziel, Min Dai,
Ni Li, Robert Udelsman, and Yawei Zhang
2 Roles of Cytochrome P450 in Metabolism of Ethanol
and Carcinogens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
F. Peter Guengerich and Narayan G. Avadhani
3 Glutathione and Transsulfuration in Alcohol- Associated
Tissue Injury and Carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
Ying Chen, Ming Han, Akiko Matsumoto, Yewei Wang,
David C. Thompson, and Vasilis Vasiliou
4 Fatty Liver Disease and Hepatocellular Carcinoma:
The Pathologist’s View . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
Dina G. Tiniakos, João Maurício, and Helen L. Reeves
5 Alcoholic Liver Disease Accelerates Early Hepatocellular
Cancer in a Mouse Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Gyongyi Szabo
6 Chronic Ethanol Consumption and Generation
of Etheno-DNA Adducts in Cancer-Prone Tissues . . . . . . . . . . . . . . . . 81
Teresa Peccerella, Tatjana Arslic-Schmitt, Sebastian Mueller,
Kirstin- Berit Linhart, Devanshi Seth, Helmut Bartsch,
and Helmut K. Seitz
7 Role of TGF-β in Alcohol-Induced Liver Disease . . . . . . . . . . . . . . . . 93
Wilma Jogunoori and Lopa Mishra
vii
viii Contents
8 NANOG-Dependent Metabolic Reprogramming
and Symmetric Division in Tumor-Initiating Stem-like Cells . . . . . . . 105
Keigo Machida
9 Diet Supplementation with Soy Protein Isolate,
but Not the Isoflavone Genistein, Protects Against
Alcohol-Induced Tumor Progression
in DEN-Treated Male Mice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115
K. E. Mercer, C. F. Pulliam, L. Hennings, M. A. Cleves,
E. E. Jones, R. R. Drake, and M. J. J. Ronis
10 ALDH1L1 and ALDH1L2 Folate Regulatory
Enzymes in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127
Sergey A. Krupenko and Natalia I. Krupenko
11 Developmental Morphogens & Recovery from Alcoholic
Liver Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145
Anna Mae Diehl
12 Suppressed Fat Mobilization Due to PNPLA3
rs738409 -Associated Liver Damage in Heavy Drinkers:
The Liver Damage Feedback Hypothesis . . . . . . . . . . . . . . . . . . . . . . 153
Vanessa Rausch and Sebastian Mueller
13 Aldo-Keto Reductases: Multifunctional Proteins
as Therapeutic Targets in Diabetes and Inflammatory Disease . . . . . 173
Kun-Che Chang and J. Mark Petrash
14 Engineered Animal Models Designed for Investigating Ethanol
Metabolism, Toxicity and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
Stephanie Marshall, Ying Chen, Surendra Singh,
Pablo Berrios-Carcamo, Claire Heit, Nicholas Apostolopoulos,
Jaya Prakash Golla, David C. Thompson, and Vasilis Vasiliou
Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265
Contributors
Nicholas Apostolopoulos Department of Environmental Health Sciences, Yale
School of Public Health, Yale University, New Haven, CT, USA
Tatjana  Arslic-Schmitt Department of Medicine, Salem Medical Centre,
Heidelberg, Germany
Narayan  D.  Avadhani Department of Biomedical Sciences, University of
Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
Helmut Bartsch Division of Toxicology and Cancer Risk Factors, German Cancer
Research Centre (DKFZ), Heidelberg, Germany
Pablo Berrios-Carcamo Department of Environmental Health Sciences, Yale
School of Public Health, Yale University, New Haven, CT, USA
Program of Molecular and Clinical Pharmacology, Institute of Biomedical Sciences,
Faculty of Medicine, University of Chile, Santiago, Chile
Kun-Che Chang Department of Ophthalmology, School of Medicine, University
of Colorado, Aurora, CO, USA
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and
Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA
Ying Chen Department of Environmental Health Sciences, Yale School of Public
Health, Yale University, New Haven, CT, USA
Yingtai Chen Department of Environmental Health Sciences, Yale School of
Public Health, New Haven, CT, USA
Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing, China
M. A. Cleves Department of Pediatrics, University of Arkansas for Medical
Sciences, Little Rock, AR, USA
Arkansas Children’s Nutrition Center, Little Rock, AR, USA
ix
x Contributors
Min Dai Cancer Institute & Hospital, Chinese Academy of Medical Sciences,
Beijing, China
Nicole Deziel Department of Environmental Health Sciences, Yale School of
Public Health, New Haven, CT, USA
Anna Mae Diehl Department of Medicine, Duke University School of Medicine,
Durham, NC, USA
R. R. Drake Medical University of South Carolina Proteomic Center, Charleston,
SC, USA
Jaya Prakash Golla Department of Environmental Health Sciences, Yale School
of Public Health, Yale University, New Haven, CT, USA
Ming Han Department of Environmental Health Sciences, Yale School of Public
Health, New Haven, CT, USA
College of Environment and Resource, Shanxi University, Taiyuan, Shanxi, China
Claire Heit Department of Pharmaceutical Sciences, Skaggs School of Pharmacy,
University of Colorado, Aurora, CO, USA
L.  Hennings Department of Pathology, University of Arkansas for Medical
Sciences, Little Rock, AR, USA
Huang Huang Department of Surgery, Yale School of Medicine, New Haven, CT,
USA
Wilma Jogunoori Center for Translational Medicine, Department of Surgery and
George Washington Cancer Center, George Washington University, Washington,
DC, USA
Veterans Affairs Medical Center, Washington, DC, USA
E. E. Jones Medical University of South Carolina Proteomic Center, Charleston,
SC, USA
Natalia I. Krupenko Department of Nutrition, University of North Carolina at
Chapel Hill, Chapel Hill, NC, USA
UNC Nutrition Research Institute, Chapel Hill, NC, USA
Sergey A. Krupenko Department of Nutrition, University of North Carolina at
Chapel Hill, Chapel Hill, NC, USA
UNC Nutrition Research Institute, Chapel Hill, NC, USA
Kirstin-Berit  Linhart Department of Medicine, Salem Medical Centre,
Heidelberg, Germany
Ni Li Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,
China