Advances in Clinical Science

95 Pages·2016·1.816 MB·English

by  Mieczyslaw Pokorski (eds.)

Advances in Experimental Medicine and Biology 878
Neuroscience and Respiration
Mieczyslaw Pokorski Editor
Advances in
Clinical Science
Advances in Experimental Medicine
and Biology
Neuroscience and Respiration
Volume 878
Editorial Board
Irun R. Cohen, The Weizmann Institute of Science, Rehovot, Israel
N.S.AbelLajtha,KlineInstituteforPsychiatricResearch,Orangeburg,NY,USA
John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA
Rodolfo Paoletti, University of Milan, Milan, Italy
Subseries Editor
Mieczyslaw Pokorski
Moreinformationabout thisseries athttp://www.springer.com/series/13457
Mieczyslaw Pokorski
Editor
Advances in Clinical
Science
Editor
MieczyslawPokorski
PublicHigherMedicalProfessionalSchoolinOpole
InstituteofNursing
Opole,Poland
ISSN0065-2598 ISSN2214-8019 (electronic)
AdvancesinExperimentalMedicineandBiology
ISBN978-3-319-21496-2 ISBN978-3-319-21497-9 (eBook)
DOI10.1007/978-3-319-21497-9
LibraryofCongressControlNumber:2015958794
SpringerChamHeidelbergNewYorkDordrechtLondon
#SpringerInternationalPublishingSwitzerland2016
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Preface
The book series Neuroscience and Respiration presents contributions by
expert researchers and clinicians in the field of pulmonary disorders. The
chapters provide timely overviews of contentious issues or recent advances
in the diagnosis, classification, and treatment of the entire range of pulmo-
narydisorders,bothacuteandchronic.Thetextsarethoughtasamergerof
basic and clinical research dealing with respiratory medicine, neural and
chemical regulation of respiration, and the interactive relationship between
respiration and other neurobiological systems such as cardiovascular func-
tionorthemind-to-bodyconnection.Theauthorsfocusontheleading-edge
therapeutic concepts, methodologies, and innovative treatments. Pharmaco-
therapy is always in the focus of respiratory research. The action and
pharmacology of existing drugs and the development and evaluation of
new agents are the heady area of research. Practical, data-driven options to
manage patients will be considered. New research is presented regarding
older drugs, performed from a modern perspective or from a different
pharmacotherapeutic angle. The introduction of new drugs and treatment
approachesinbothadultsandchildrenalsoisdiscussed.
Lung ventilation is ultimately driven by the brain. However, neuropsy-
chologicalaspectsofrespiratorydisordersarestillmostlyamatterofconjec-
ture. After decades of misunderstanding and neglect, emotions have been
rediscovered as a powerful modifier or even the probable cause of various
somatic disorders. Today, the link between stress and respiratory health is
undeniable. Scientists accept a powerful psychological connection that can
directlyaffectourqualityoflifeandhealthspan.Psychologicalapproaches,
bydecreasingstress,canplayamajorroleinthedevelopmentandtherapyof
respiratorydiseases.
Neuromolecular aspects relating to gene polymorphism and epigenesis,
involvingbothheritablechangesinthenucleotidesequence,andfunctionally
relevantchangestothegenomethatdonotinvolveachangeinthenucleotide
sequence, leading to respiratory disorders will also be tackled. Clinical
advancesstemmingfrommolecularandbiochemicalresearcharebutpossi-
ble if the research findings are translated into diagnostic tools, therapeutic
procedures,andeducation,effectivelyreachingphysiciansandpatients.All
thatcannotbeachievedwithoutamultidisciplinary,collaborative,bench-to-
bedsideapproachinvolvingbothresearchersandclinicians.
v
vi Preface
Thesocietalandeconomicburdenofrespiratoryailmentshasbeenonthe
rise worldwide leading to disabilities and shortening of life span. COPD
alone causes more than three million deaths globally each year. Concerted
efforts are required to improve this situation, and part of those efforts are
gaining insights into the underlying mechanisms of disease and staying
abreast with the latest developments in diagnosis and treatment regimens.
Itishopedthatthebookspublishedinthisserieswillassumealeadingrolein
the field of respiratory medicine and research and will become a source of
referenceandinspirationforfutureresearchideas.
I would like to express my deep gratitude to Mr. Martijn Roelandse and
Ms. Tanja Koppejan from Springer’s Life Sciences Department for their
genuineinterestinmakingthisscientificendeavorcomethroughandinthe
expertmanagementoftheproductionofthisnovelbookseries.
Opole,Poland MieczyslawPokorski
Volume 17: Advances in Clinical Science
Thebookpresentsthelatestdevelopmentsinclinicalmedicine,particularly
involvedwithpulmonarycareanddiseases.Emphasisisplacedontheroleof
childhood obesity, often a result of the ill effects of an unhealthy diet and
nutritional deficits, in shaping propensity for inflammatory pathologies,
allergies,immunedeficiencyandrespiratoryandcardiovascularsequelaein
adult life. Oxidative damage, caused by not full well understood cellular
biochemistry, when unchecked by antioxidative rescue mechanisms, takes
toll on a respiratory health. The book underscores the need to consider the
complexity of mutual interactions of pathophysiological processes, which
calls for tailoring the management strategies depending on the subgroups
which patients belong to, be it obesity, children or elderly. The chapters
also tackle biological diseases with genetic underpinnings. The application
of genetics to identify the molecular alterations or mutations will serve
well both diagnostics and targeted optimization of treatment; the poignant
exemplarbeingthehistologicalsubtypesoflungcancer.Thebookprovides
asourceofcurrentfactsandtrendsinclinicalresearchandpractice.
vii

Contents
PrevalenceofOlfactoryImpairmentinGranulomatosis
withPolyangiitis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
K.Zycinska,M.Straburzynski,A.Nitsch-Osuch,R.Krupa,
M.Hadzik-Błaszczyk,M.Cieplak,andK.Wardyn
BiochemistryofOxidativeStress. . . . . . . . . . . . . . . . . . . . . . . . . . 9
MichałP.Pruchniak,MagdalenaAraz´na,andUrszulaDemkow
UsageofOver-the-CounterandHerbalProductsinCommon
ColdinPoland:FindingsfromConsumerSurvey. . . . . . . . . . . . . . 21
K.Karlowicz-Bodalska,K.Mis´kiewicz,D.Kurpas,S.Han,
A.Kowalczyk,D.Marciniak,A.Drys´,T.Glomb,S.Cedzich,
U.Broniecka,andE.Kuchar
RARβ PromoterMethylationasanEpigeneticMechanism
ofGeneSilencinginNon-smallCellLungCancer. . . . . . . . . . . . . 29
A.Dutkowska,A.Antczak,D.Pastuszak-Lewandoska,
M.Migdalska-Se˛k,K.H.Czarnecka,P.G(cid:1)orski,J.Kordiak,
E.Nawrot,andE.Brzezian´ska-Lasota
CardiovascularRiskFactorsinObeseChildren
andAdolescents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
MałgorzataRumin´ska,AnnaMajcher,BeataPyrz˙ak,
AnetaCzerwonogrodzka-Senczyna,MichałBrzewski,
andUrszulaDemkow
NutritionandImmuneSysteminChildren
withSimpleObesity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
AnetaCzerwonogrodzka-Senczyna,MalgorzataJanusz,
AnnaJeznach-Steinhagen,UrszulaDemkow,andBeataPyrzak
TheInfluenceofShockwaveTherapyonOrthodontic
ToothMovementInducedintheRat. . . . . . . . . . . . . . . . . . . . . . . 57
HagaiHazan-Molina,ItayAizenbud,HanaKaufman,
SorinTeich,andDrorAizenbud
ThyroidHormoneLevelsandTSHActivityinPatients
withObstructiveSleepApneaSyndrome. . . . . . . . . . . . . . . . . . . . 67
P.Bielicki,T.Przybyłowski,M.Kumor,M.Barnas´,
M.Wiercioch,andR.Chazan
ix