Table Of ContentMaterials Horizons: From Nature to Nanomaterials
Shrikrishna Nandkishor Joshi
Pranjal Chandra Editors
Advanced
Micro- and Nano-
manufacturing
Technologies
Applications in Biochemical and
Biomedical Engineering
Materials Horizons: From Nature
to Nanomaterials
SeriesEditor
VijayKumarThakur,SchoolofAerospace,TransportandManufacturing,
CranfieldUniversity,Cranfield,UK
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·
Shrikrishna Nandkishor Joshi Pranjal Chandra
Editors
Advanced Micro-
and Nano-manufacturing
Technologies
Applications in Biochemical and Biomedical
Engineering
Editors
ShrikrishnaNandkishorJoshi PranjalChandra
DepartmentofMechanicalEngineering SchoolofBiochemicalEngineering
IndianInstituteofTechnologyGuwahati IndianInstituteofTechnology(BHU)
Guwahati,Assam,India Varanasi
Varanasi,UttarPradesh,India
ISSN2524-5384 ISSN2524-5392 (electronic)
MaterialsHorizons:FromNaturetoNanomaterials
ISBN978-981-16-3644-8 ISBN978-981-16-3645-5 (eBook)
https://doi.org/10.1007/978-981-16-3645-5
©TheEditor(s)(ifapplicable)andTheAuthor(s),underexclusivelicensetoSpringerNature
SingaporePteLtd.2022
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Preface
Micro- and nano-manufacturing technologies deal with miniaturized fabrication
techniquesthatcreatefeatures,products,systems,anddeviceshavingdimensionsin
therangeofnanometerstomillimeters.Thesedevicesincludefunctionalsegments,
immobileassemblies,orboth.Intoday’sdate,micro–nano-fabricationandmanufac-
turinghavebecomeanintegralpartofapplicationsinbiochemicalandbiomedical
disciplines.Theseapplicationscanbemajorlycategorizedintofourdomains:appli-
cationinmolecularbiologyandbiochemicalscience,applicationfocusingoncellular
systems,prototypingofmedicaldevices,anddevelopmentofbiosensors.
Micro-andnano-manufacturingstructuresprovideaconsiderablyimprovedfunc-
tionforconventionaldevices.Thesefabricationtechniquesalwaysoffergreatpoten-
tials.Suchenhancedandimprovedpotentialsaredeliberatedwhenthesetechniques
are exploited appropriately to address the right types of problems. Considering
the massive advancement of micro–nano-manufacturing technologies, this book
attempts to provide an illustrative knowledge regarding these techniques between
itstwocovers.Itdiscussesvividlytheprinciplesofvariousadvancedmanufacturing
technologiesappliedtodevelopdifferentbiomedicaldevices.Techniquesincluding
advancedmicrochannelfabrication,advancedfinishingprocesses,andrapidmanu-
facturing for configuring biomedical devices have been accounted for. The novel
areas of interest considering the mediators like nanomaterials, piezoelectric nano-
generators,localizedsurfaceplasmonresonanceforsensordevelopment,andfabri-
cation have also been discussed thoroughly. This book also collectively detailed
the varying advantages presented by these techniques and how these advantages
have been explored to date. We believe the chapters presented in the book cover
various new dimensions of micro- and nano-manufacturing technologies and their
mostrecentapplicationsinbiochemicalandbiomedicalengineering.Thisbooknot
only will be helpful for the students, scholars, and faculty members, but will also
helpthenewcomersinthefieldandtheindustryexperts.
Guwahati,India ShrikrishnaNandkishorJoshi
Varanasi,India PranjalChandra
v
Contents
1 Nanomaterials BasedBiosensing: Methods andPrinciple
ofDetection ................................................... 1
NirmalKumarKatiyar,GauravGoel,andSauravGoel
2 PathwaystoTranslatetheBiomedicalPrototypes ................ 29
TamannaBhuyan, SurjenduMaity, DeviRupaSaha,
NayanManiDas,andDipankarBandyopadhyay
3 AccuracyofBiosensorsasRapidDiagnosticandBiochemical
Monitoring Tools for Non-communicable Diseases
Management .................................................. 57
NorhafizahMuhammad, LimTiongHoo,
AfiqahNabihahAhmad, AzureenMohamad,
andSyazanaAbdullahLim
4 Rapid Manufacturing of Biomedical Devices: Process
Alternatives,SelectionandPlanning ............................ 77
SanchitJhunjhunwalaandSajanKapil
5 AdvancedFinishingProcessesforBiomedicalApplications ........ 105
TalwinderSinghBedi,RaviKant,andHemaGurung
6 Advanced Microchannel Fabrication Technologies
forBiomedicalDevices ......................................... 127
UpasanaSarma,PranjalChandra,andShrikrishnaN.Joshi
7 Droplet Microfluidics—A Tool for Biosensing
andBioengineeringApplications ................................ 145
U.Banerjee,R.Iqbal,S.Hazra,N.Satpathi,andA.K.Sen
8 Advances in Microfluidic Techniques for Detection
andIsolationofCirculatingTumorCells ........................ 173
K.Mirkale,R.Gaikwad,B.Majhy,G.Narendran,andA.K.Sen
vii
viii Contents
9 LocalizedSurfacePlasmonResonanceSensorsforBiomarker
DetectionwithOn-ChipMicrofluidicDevicesinPoint-of-Care
Diagnostics ................................................... 199
S.Z.Hoque, L.Somasundaram, R.A.Samy, A.Dawane,
andA.K.Sen
10 Development of Piezoelectric Nanogenerator Based
onMicro/NanofabricationTechniquesandItsApplication
onMedicalDevices ............................................ 225
AparnaZagabathuniandSubramaniKanagaraj
11 OpticalBiosensorsTowardsPointofCareTestingofVarious
Biochemicals .................................................. 245
VinothEdalJosephandArchanaRamadoss
12 Blood Coagulation System and Carbon-Based
NanoengineeringforBiomedicalApplication ..................... 279
AbhishekR.Panigrahi, PoojaYadav, SamirK.Beura,
andSunilK.Singh
13 OpportunitiesandChallengesinMedicalRoboticDevice
Development .................................................. 299
NehaKhatri,MukeshKumar,andRanjanJha
14 Flexible Organic Field-Effect Transistors for Biomimetic
Applications .................................................. 315
VivekRaghuwanshiandShreePrakashTiwari
15 MethodsforSurfaceSuperfinishingofProsthesis ................. 335
AtulSinghRajput,SajanKapil,andManasDas
16 Principles of Advanced Manufacturing Technologies
forBiomedicalDevices ......................................... 361
G.L.Samuel,LingxueKong,Y.Arcot,andPavanPandit
About the Editors
Prof.ShrikrishnaNandkishorJoshi isaProfessorof
MechanicalEngineeringattheIndianInstituteofTech-
nology(IIT)Guwahati,India.HewasaVisitingFaculty
attheAsianInstituteofTechnology,Thailandin2015.
His research interests include micro, nano, and preci-
sionmanufacturingprocesseswithafocusonapplica-
tions of lasers in manufacturing, thin-wall machining,
single point diamond turning, CAD/CAM, and manu-
facturing automation. Prof. Joshi published more than
seventy research articles in journals of international
reputeandconferences.Hehaspublishedtwobookson
Laser-basedManufacturingandauthoredmorethanten
bookchapters.HehasdevelopedaMassiveOpenOnline
Course on “Automation in Manufacturing” and a web
course on “Mechatronics and Manufacturing Automa-
tion” as part of the Government of India’s flagship
projectNationalProgrammeonTechnologyEnhanced
Learning(NPTEL).
Prof.PranjalChandra is an Assistant Professor at
the School of Biochemical Engineering, Indian Insti-
tuteofTechnology (BHU),Varanasi,India.Heearned
his Ph.D. from Pusan National University, South
Koreaanddidpost-doctoraltrainingatTechnion-Israel
Institute of Technology, Israel. His research focus
is highly interdisciplinary, spanning a wide range in
biotechnology, nanobiosensors, material engineering,
and nanomedicine. He has designed several commer-
cially viable biosensing prototypes that can be oper-
atedforonsiteanalysisforbiomedicaldiagnostics.He
is a guest editor and an editorial board member of
variousinternationaljournals.Heisauthorofover100
ix
x AbouttheEditors
high impact publications including research/reviews
papers and invited book chapter. He has published
11 books on various aspects of biosensors/medical
diagnostics. Dr. Chandra is the recipient of many
prestigious awards, coveted honors, and fellowships
such as: DST Ramanujan fellowship (Government
of India); Early Career Research Award (ECRA)
(DST, Government of India); BK-21 and NRF fellow-
ship,SouthKorea;TechnionPost-DoctoralFellowship,
Israel; Nano Molecular Society India Young Scien-
tist Award; Biotech Research Society India (BRSI)
YoungScientistAward;YoungEngineersAward2018;
Highly Cited Corresponding authors in The Royal
SocietyofChemistry(RSC),Cambridge,London;Top
10% cited article in the General Chemistry Section
RSC Journal, Cambridge, London, Gandhian Young
Technology Innovation Award (GYTI) 2020, etc. Dr.
Chandraisalsolistedamongtheworld’stop2%scientist
inareportbyStanfordUniversity,USA.
