A Visual Guide to Scleroderma and Approach to Treatment

121 Pages·2014·5.007 MB·English

by  Maureen D. Mayes (eds.)

A Visual Guide to
Scleroderma and
Approach to Treatment
Maureen D. Mayes
Editor
A Visual Guide to Scleroderma and Approach
to Treatment
ThiSisaFMBlankPage
Maureen D. Mayes
Editor
A Visual Guide to
Scleroderma and Approach
to Treatment
Editor
MaureenD.Mayes,MD,MPH
DivisionofRheumatologyandImmunogenetics
UniversityofTexasHealthScienceCenter
Houston,TX,USA
ISBN978-1-4939-0979-7 ISBN978-1-4939-0980-3(eBook)
DOI10.1007/978-1-4939-0980-3
SpringerNewYorkHeidelbergDordrechtLondon
LibraryofCongressControlNumber:2014942076
©SpringerScience+BusinessMediaNewYork2014
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This book is dedicated to our patients in the
hope that it will result in early recognition,
prompt therapy, and better outcomes.
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Preface
Althoughclinicalmanifestationsofsclerodermamakeitavery“visual”disease,the
low prevalence (estimated to be approximately 1 in 4,000 US adults) means that
many physicians, rheumatologists included, may fail to recognize the disease
particularly in its early stages. In addition, scleroderma varies widely in severity
sothatthesometimessubtlefindingsofmilddiseasemaybemissed.
In addition, there is often confusion between localized scleroderma (morphea)
which does not involve internal organs and systemic sclerosis (including limited
anddiffusedisease)whichdoes.Thesimilarterminologyonlyservestocompound
thisconfusion.
This bookisintendedtobeaneasily accessibletoolfor residents,fellows, and
practicing physicians to recognize and accurately categorize scleroderma in its
diverse forms and multiple clinical manifestations. Chapter 4 on nailfold
capillaroscopy is particularly relevant, since this technique is now included in the
2013ACR/EULARclassificationcriteriaforsystemicsclerosis.
Several chapters also include therapeutic approaches. Although a detailed dis-
cussion of treatment is beyond the scope of this book, our goal is to increase
knowledgeofavailabletreatmentoptions.
Houston,TX MaureenD.Mayes
vii
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Contents
1 BriefOverviewofScleroderma:LocalizedScleroderma
andSystemicSclerosis(SSc). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
MaureenD.Mayes
2 LocalizedScleroderma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
CarolynA.Bangert,AndrewKim,andHeidiJacobe
3 SkinManifestationsandMusculoskeletalDiseaseinSSc. . . . . . . . 23
JanetPopeandMaureenD.Mayes
4 NailfoldCapillaroscopy. . .. . . . . . .. . . . . . . .. . . . . . .. . . . . . . .. 37
MichaelHughesandArianeL.Herrick
5 IschemicDigitalUlcers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
FredrickM.Wigley
6 LungInvolvementinSystemicSclerosis. . . . . . . . . . . . . . . . . . . . . 63
JohnT.Huggins,JamesG.Ravenel,andRichardM.Silver
7 GastrointestinalInvolvementinSystemicSclerosis. . . . . . . . . . . . . 77
DineshKhanna,JasonBaker,PhilipJ.Clements,
andChristopherP.Denton
8 CalcinosisCutisinSystemicSclerosis. . . . . . . . . . . . . . . . . . . . . . . 89
GloriaA.SalazarandMaureenD.Mayes
9 SystemicSclerosisMimics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
GloriaA.Salazar,VirginiaD.Steen,andMaureenD.Mayes
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
ix