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About A Comprehensive Review of Opioid-Induced Hyperalgesia
This document provides a comprehensive review of opioid-induced hyperalgesia (OIH). It begins by defining OIH as a state of nociceptive sensitization caused by exposure to opioids that paradoxically makes patients more sensitive to painful stimuli. The review examines evidence of OIH from observational studies and experimental pain testing in humans. It explores various proposed mechanisms for OIH in the central nervous system. Clinicians are advised to consider OIH when opioid treatment seems ineffective or patients report increased pain with higher doses. Treatment involves reducing the opioid dosage, tapering off opioids, or using NMDA receptor modulators. The review aims to analyze factors related to OIH and identify effective strategies for preventing, reversing or managing this condition.
Detailed Information
| Author: | ['Jose Miguel Arce Romo'] |
|---|---|
| Publication Year: | 2015 |
| Pages: | 18 |
| Language: | English |
| Format: | |
| Price: | FREE |
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