A Commemorative Issue in Honor of Professor Nick Hadjiliadis Metal Complex Interactions with Nucleic Acids And/Or DNA

258 Pages·2019·45.237 MB·English

by  Sotiri K Hadjikakou, Christina N Banti

International Journal o f
Molecular Sciences
A Commemorative
Issue in Honor
of Professor
Nick Hadjiliadis
Metal Complex Interactions
with Nucleic Acids and/or DNA
Edited by
Sotiris K. Hadjikakou and Christina N. Banti
Printed Edition of the Special Issue Published in
International Journal of Molecular Sciences
www.mdpi.com/journal/ijms
A Commemorative Issue in Honor of
Professor Nick Hadjiliadis

A Commemorative Issue in Honor of
Professor Nick Hadjiliadis
Metal Complex Interactions with Nucleic
Acids and/or DNA
SpecialIssueEditors
SotirisK.Hadjikakou
ChristinaN.Banti
MDPI•Basel•Beijing•Wuhan•Barcelona•Belgrade
SpecialIssueEditors
SotirisK.Hadjikakou Christina N. Banti
UniversityofIoannina University of Ioannina
Greece Greece
EditorialOffice
MDPI
St.Alban-Anlage66
4052Basel,Switzerland
This is a reprint of articles from the Special Issue published online in the open access journal
InternationalJournalofMolecularSciences(ISSN1422-0067)in2018(availableat: https://www.mdpi.
com/journal/ijms/specialissues/metalnucleicacids)
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Contents
AbouttheSpecialIssueEditors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
Prefaceto”ACommemorativeIssueinHonorofProfessorNickHadjiliadis” . . . . . . . . . . ix
ChristinaN.BantiandSotirisK.Hadjikakou
Prefaceto“ACommemorativeIssueinHonourofProfessorNickHadjiliadis: MetalComplex
InteractionswithNucleicAcidsand/orDNA”
Reprintedfrom:Int.J.Mol.Sci.2018,19,3815,doi:10.3390/ijms19123815 . . . . . . . . . . . . . . 1
Navin C. Sabharwal, Jessica Chen, Joo Hyun (June) Lee, Chiara M. A. Gangemi,
Alessandro D’Urso and Liliya A. Yatsunyk
Interactions Between Spermine-Derivatized Tentacle Porphyrins and The Human Telomeric
DNA G-Quadruplex
Reprintedfrom:Int.J.Mol.Sci.2018,19,3686,doi:10.3390/ijms19113686 . . . . . . . . . . . . . . 4
Yu-Wen Chen, Roshan Satange, Pei-Ching Wu, Cyong-Ru Jhan, Chung-ke Chang,
Kuang-RenChung,MichaelJ.Waring,Sheng-WeiLin,Li-ChingHsiehandMing-HonHou
CoII(Chromomycin)2 Complex Induces a Conformational Change of CCG Repeats from
i-MotiftoBase-ExtrudedDNADuplex
Reprintedfrom:Int.J.Mol.Sci.2018,19,2796,doi:10.3390/ijms19092796 . . . . . . . . . . . . . . 22
GeorgiMomekov,IvaUgrinova,EvdokiaPasheva,DanielaTsekovaandGalinaGencheva
CellularPharmacologyofPalladinum(III)HematoporphyrinIXComplexes: SolutionStability,
AntineoplasticandApoptogenicActivity,DNABinding,andProcessingofDNA-Adducts
Reprintedfrom:Int.J.Mol.Sci.2018,19,2451,doi:10.3390/ijms19082451 . . . . . . . . . . . . . . 37
EskoMakkonen,PatrickRinke,OlgaLopez-AcevadoandXiChen
Optical Properties of Silver-Mediated DNA from Molecular Dynamics and Time Dependent
DensityFunctionalTheory
Reprintedfrom:Int.J.Mol.Sci.2018,19,2346,doi:10.3390/ijms19082346 . . . . . . . . . . . . . . 58
SuyanLiu,AihuaLiang,KuiWu,WenjuanZeng,QunLuoandFuyiWang
BindingofOrganometallicRutheniumAnticancerComplexestoDNA:ThermodynamicBase
andSequenceSelectivity
Reprintedfrom:Int.J.Mol.Sci.2018,19,2137,doi:10.3390/ijms19072137 . . . . . . . . . . . . . . 71
George K. Latsis, Christina N. Banti, Nikolaos Kourkoumelis,
Constantina Papatriantafyllopoulou, Nikos Panagiotou, Anastasios Tasiopoulos,
Alexios Douvalis, Angelos G. Kalampounias, Thomas Bakas and Sotiris K. Hadjikakou
Poly Organotin Acetates against DNA with Possible Implementation on Human Breast Cancer
Reprintedfrom:Int.J.Mol.Sci.2018,19,2055,doi:10.3390/ijms19072055 . . . . . . . . . . . . . . 89
SalvatoreSavino,CristinaMarzano,ValentinaGandin,JamesD.Hoeschele,GiovanniNatile
andNicolaMargiotta
Multi-ActingMitochondria-TargetedPlatinum(IV)ProdrugsofKiteplatinwithα-LipoicAcid
intheAxialPositions
Reprintedfrom:Int.J.Mol.Sci.2018,19,2050,doi:10.3390/ijms19072050 . . . . . . . . . . . . . . 107
v
Qi-YuanYang,Qian-QianCao,Qi-PinQin,Cai-XingDeng,HongLiangandZhen-FengChen
Syntheses,CrystalStructures,andAntitumorActivitiesofCopper(II)andNickel(II)Complexes
with2-((2-(Pyridin-2-yl)hydrazono)methyl)
quinolin-8-ol
Reprintedfrom:Int.J.Mol.Sci.2018,19,1874,doi:10.3390/ijms19071874 . . . . . . . . . . . . . . 123
MadhuriHande,SajalMaityandTuomasLo¨nnberg
PalladacyclicConjugateGroupPromotesHybridizationofShortOligonucleotides
Reprintedfrom:Int.J.Mol.Sci.2018,19,1588,doi:10.3390/ijms19061588 . . . . . . . . . . . . . . 140
Mohamed F. AlAjmi, Afzal Hussain, Md. Tabish Rehman, Azmat Ali Khan,
Perwez Alam Shaikh and Rais Ahmad Khan
Design, Synthesis, and Biological Evaluation of Benzimidazole-Derived Biocompatible
Copper(II) and Zinc(II) Complexes as Anticancer Chemotherapeutics
Reprintedfrom:Int.J.Mol.Sci.2018,19,1492,doi:10.3390/ijms19051492 . . . . . . . . . . . . . . 151
TingxiaoQin,KunhuiLiu,DiSong,ChunfanYang,HongmeiZhaoandHongmeiSu
BindingInteractionsofZincCationicPorphyrinwithDuplexDNA:FromB-DNAtoZ-DNA
Reprintedfrom:Int.J.Mol.Sci.2018,19,1071,doi:10.3390/ijms19041071 . . . . . . . . . . . . . . 173
AgnieszkaB.Olejniczak,BarbaraNawrotandZbigniewJ.Les´nikowski
DNA Modified with Boron–Metal Cluster Complexes [M(C2B9H11)2]—Synthesis, Properties,
andApplications
Reprintedfrom:Int.J.Mol.Sci.2018,19,3501,doi:10.3390/ijms19113501 . . . . . . . . . . . . . . 185
Yu-HsuanLai,ChinKuo,MacusTienKuoandHelenH.W.Chen
Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by
TranscriptionalRegulationofCopperHomeostasis
Reprintedfrom:Int.J.Mol.Sci.2018,19,1486,doi:10.3390/ijms19051486 . . . . . . . . . . . . . . 198
VincentMurray,JonK.ChenandLongH.Chung
TheInteractionoftheMetallo-GlycopeptideAnti-TumourDrugBleomycinwithDNA
Reprintedfrom:Int.J.Mol.Sci.2018,19,1372,doi:10.3390/ijms19051372 . . . . . . . . . . . . . . 216
vi
About the Special Issue Editors
Sotiris K. Hadjikakou was born in Famagusta, Cyprus. He graduated from the Chemistry
Department of the Aristotle University of Thessaloniki, Greece. He was awarded a Ph.D. in
chemistry in 1992. He was appointed to the position of Lecturer in Inorganic Chemistry in the
University of Ioannina, Greece, where he is serving as Professor (since 2013). He has worked as
a visiting researcher at the University of Dortmund, Germany and at the University of Essex in
Colchester, UK.Hisresearchinterestsinthefieldofinorganicbiochemistrymainlyfocusondrug
design and development from the modification of NSAIDs, antibiotics, or ingredient of natural
products,fortargetedchemotherapy. HecurrentlycoordinatestheInternationalGraduateProgram
”Biological Inorganic Chemistry” and he is a member of the Editorial Board of the Section of
BioinorganicChemistryinInt.J.Mol.Sci.(IJMS).
Christina N. Banti received her bachelor’s degree in Biological Applications and Technologies,
University of Ioannina, Greece in 2009. She was awarded a M.Sc. in Bioinorganic Chemistry,
University of Ioannina, and obtained her Ph.D. from the Department of Physiology, School of
Medicine,UniversityofIoannina,Greece.SheisnowaPostdoctoralResearcherandAdjunctLecturer
oftheDepartmentofChemistry,UniversityofIoannina. Herresearchinterestsaremainlyfocused
on bioinorganic chemistry and particularly on the evaluation of new anticancer or antibacterial
metallodrugsandtheirstudyoftheirinteractionwithDNAorenzymes.
vii

Preface to ”A Commemorative Issue in Honor of
Professor Nick Hadjiliadis”
ThisSpecialIssueoftheInternationalJournalofMolecularSciencecomprisesacomprehensive
studyon“MetalComplexInteractionswithNucleicAcidsand/orDNA”.ThisSpecialIssuehasbeen
inspiredbytheimportantcontributionofProf. NickHadjiliadistothefieldofpalladiumor/and
platinum/nucleicacidinteractions. Itcoversaselectionofrecentresearchandreviewarticlesinthe
fieldofmetalcomplexinteractionswithnucleicacidsand/orDNA.
Metalcomplexeshavelongbeenrecognizedascriticallyimportantcomponentsofnucleicacid
chemistry,bothintheregulationofgeneexpressionandaspromisingtherapeuticagents.Theability
torecognize,tounderstandatthemolecularlevelofhowmetalcomplexesinteractwithDNAhas
become an active research area at the interface between biological inorganic chemistry, molecular
biology,andmedicine.
Arguably,themostprominentdrugwhichcontainsametaliscisplatin,themostwidelyused
anti-cancerdrug. Thesuccessofcisplatininchemotherapyandtheclarificationofitsmechanismof
actionthroughinteractionwithDNAhasmotivatedalargenumberofstudiesonmetalcomplexes
interactionwithnucleicacidsor/andDNA.FromtheforegoingthatthereaderofthisSpecialIssue
willgainanappreciationoftherealroleoftheinteractionsofmetalcomplexeswithnucleicacids
or/andDNAinmodernmedicine.
ThisSpecialIssueonthe”MetalcomplexesinteractionswithNucleicacidsand/orDNA”aims
toprovideanoverviewofthisincreasinglydiversefield,presentingrecentdevelopments,andthe
latestresearchwithparticularemphasisonmetal-baseddrugsandmetaliontoxicity.
SotirisK.Hadjikakou,ChristinaN.Banti
SpecialIssueEditors
ix