Table Of ContentIFMBE Proceedings Volume 28
Series Editor: R. Magjarevic
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Previous Editions:
IFMBE Proceedings BIOMAG2010, “17th International Conference on Biomagnetism Advances in Biomagnetism – Biomag2010”,
Vol. 28, 2010, Dubrovnik, Croatia, CD
IFMBE Proceedings ICDBME 2010, “The Third International Conference on the Development of Biomedical Engineering in
Vietnam”, Vol. 27, 2010, Ho Chi Minh City, Vietnam, CD
IFMBE Proceedings MEDITECH 2009, “International Conference on Advancements of Medicine and Health Care through
Technology”, Vol. 26, 2009, Cluj-Napoca, Romania, CD
IFMBE Proceedings WC 2009, “World Congress on Medical Physics and Biomedical Engineering”,
Vol. 25, 2009, Munich, Germany, CD
IFMBE Proceedings SBEC 2009, “25th Southern Biomedical Engineering Conference 2009”,
Vol. 24, 2009, Miami, FL, USA, CD
IFMBE Proceedings ICBME 2008, “13th International Conference on Biomedical Engineering”
Vol. 23, 2008, Singapore, CD
IFMBE Proceedings ECIFMBE 2008 “4th European Conference of the International Federation for Medical and Biological
Engineering”, Vol. 22, 2008, Antwerp, Belgium, CD
IFMBE Proceedings BIOMED 2008 “4th Kuala Lumpur International Conference on Biomedical Engineering”,
Vol. 21, 2008, Kuala Lumpur, Malaysia, CD
IFMBE Proceedings NBC 2008 “14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics”,
Vol. 20, 2008, Riga, Latvia, CD
IFMBE Proceedings APCMBE 2008 “7th Asian-Pacific Conference on Medical and Biological Engineering”,
Vol. 19, 2008, Beijing, China, CD
IFMBE Proceedings CLAIB 2007 “IV Latin American Congress on Biomedical Engineering 2007, Bioengineering Solution for
Latin America Health”, Vol. 18, 2007, Margarita Island, Venezuela, CD
IFMBE Proceedings ICEBI 2007 “13th International Conference on Electrical Bioimpedance and the 8th Conference on
Electrical Impedance Tomography”, Vol. 17, 2007, Graz, Austria, CD
IFMBE Proceedings MEDICON 2007 “11th Mediterranean Conference on Medical and Biological Engineering and Computing
2007”, Vol. 16, 2007, Ljubljana, Slovenia, CD
IFMBE Proceedings BIOMED 2006 “Kuala Lumpur International Conference on Biomedical Engineering”,
Vol. 15, 2004, Kuala Lumpur, Malaysia, CD
IFMBE Proceedings WC 2006 “World Congress on Medical Physics and Biomedical Engineering”,
Vol. 14, 2006, Seoul, Korea, DVD
IFMBE Proceedings BSN 2007 “4th International Workshop on Wearable and Implantable Body Sensor Networks”,
Vol. 13, 2006, Aachen, Germany
IFMBE Proceedings ICBMEC 2005 “The 12th International Conference on Biomedical Engineering”,
Vol. 12, 2005, Singapore, CD
IFMBE Proceedings Vol. 28
Selma Supek • Ana Sušac (Eds.)
17th International Conference
on Biomagnetism
Advances in Biomagnetism –
Biomag2010
March 28 – April 1, 2010
Dubrovnik, Croatia
123
Editors
Selma Supek
University of Zagreb
Faculty of Science
Dept. of Physics
Bijenicka cesta 32
10000 Zagreb
Croatia
E-mail: [email protected]
Ana Sušac
University of Zagreb
Faculty of Science
Dept. of Physics
Bijenicka cesta 32
10000 Zagreb
Croatia
E-mail: [email protected]
ISSN 1680-0737
ISBN 978-3-642-12196-8 e-ISBN 978-3-642-12197-5
DOI 10.1007/978-3-642-12197-5
Library of Congress Control Number: 2010923826
© International Federation for Medical and Biological Engineering 2010
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Foreword
40th anniversary of "medical uses of SQUID"
It is my great pleasure and honor to invite you to the 17th International Conference on Biomagnetism – Biomag2010 held in
Dubrovnik, Croatia from Sunday, March 28 through Thursday, April 1, 2010.
The interdisciplinary field of biomagnetism includes dynamic and evolving SQUID-based technologies offering advanced
real-time methods for noninvasive assessments of magnetic signals from the brain, heart and other organs as well as a range
of modeling, mathematical and computational methods for functional source localization approaches. Excellent spatial
resolution and unique, millisecond, temporal resolution of biomagnetic techniques allow insights into cortical
neurodynamics and neurobiological basis of the human brain as well as assessment of heart and other organs functions in
health and disease. Biomag2010 will be a great opportunity for an exchange of ideas and presentation of the latest
developments in instrumentation, modeling approaches, basic and clinical biomedical studies. We are particularly proud to
announce the celebration of the 40th anniversary of the first SQUID-based MCG measurements published on April 1, 1970.
Since then ''medical uses of SQUID'' were dynamic and growing, including the most recent developments, in combination
with a low field MRI, toward a ''direct neuronal imaging''.
Dubrovnik, the host city of the Biomag2010, a jewel on the Adriatic, will be a superb and stimulating setting for both
scientific and social aspects of this meeting.
I am looking forward to hosting you in Dubrovnik, Croatia in spring of 2010.
Selma Supek
Conference Chair
Organization
Proceedings Editors
Selma Supek
Ana Sušac
Organizer
University of Zagreb, Faculty of Science, Department of Physics
Sponsor
Croatian Ministry of Science and Technology
Endoursed By
Croatian Biophysical Society
Croatian Cardiac Society
International Federation for Medical and Biological Engineering
Croatian Institute for Brain Research
Croatian Neurological Society
Croatian Physical Society
Croatian Society for Medical and Biological Engineering
Croatian Society for Neuroscience
Zagreb Epilepsy Center
Croatian Academy of Sciences and Arts
Conference Chair
Selma Supek
Secretary General
Ana Sušac
International Advisory Board
Shinya Kuriki, Chair (Japan)
Kazuhiko Atsumi (Japan)
Douglas Cheyne (Canada)
David Cohen (USA)
Luder Decke (Austria)
Sergio Erne (Germany)
Eric Halgren (USA)
Jens Haueisen (Germany)
VIII Organization
Toivo Katila (Finland)
Makoto Kotani (Japan)
Gian Luca Romani (Italy)
Selma Supek (Croatia)
Shoogo Ueno (Japan)
Harold Weinberg (Canada)
Chris Wood (USA)
Scientific Program Committee
Selma Supek, Chair (Croatia)
Jens Haueisen, Co-chair (Germany)
Robert Kraus, Co-chair (USA)
Cheryl J. Aine (USA)
Sylvain Baillet (USA)
Susan Bowyer (USA)
Line Garnero† (France)
Matti Hämäläinen (USA)
Riitta Hari (Finland)
Risto Ilmoniemi (Finland)
Ole Jensen (The Netherlands)
Shinya Kuriki (Japan)
Sari Levänen (USA)
Markku Mäkijärvi (Finland)
Ksenija Marinkovic (USA)
Maria Mody (USA)
Nobukazu Nakasato (Japan)
Yoshio Okada (USA)
Christo Pantev (Germany)
Andrew Papanicolaou (USA)
Gian Luca Romani (Italy)
Kensuke Sekihara (Japan)
Yoshinori Uchikawa (Japan)
Peter Van Leeuwen (Germany)
Local Organizing Committee
Hrvoje Hećimović
Sanja Josef-Golubić
Veljko Grilj
Ratko Magjarević
Marko Miljević
Sandra Požar
Ana Sušac
Nikolina Wolf
Marko Banušić, IT Manager
Branko Đurđević, IT Manager
Mia Vucic, Visual identity
Organization IX
National MEG Initiative Board – CroMEGin
Anto Bagić, Coordinator (USA)
Igor Antončić (Rijeka)
Vedran Deletis (Split)
Vida Demarin (Zagreb)
Dražen Domijan (Rijeka)
Sanja Hajnšek (Zagreb)
Hrvoje Hećimović (Zagreb)
Ivica Kostović (Zagreb)
Ratko Magjarević (Zagreb)
Joško Paladino (Zagreb)
Selma Supek (Zagreb)
Dinko Štimac (Osijek)
Reviewers
Cheryl J. Aine (USA) Markku Mäkijärvi (Finland)
Sylvain Baillet (USA) Ksenija Marinkovic (USA)
Susan Bowyer (USA) Maria Mody (USA)
Markus Butz (Germany) John C. Mosher (USA)
Chun Kee Chung (South Korea) Nobukazu Nakasato (Japan)
Maureen Clerc (France) Yoshio Okada (USA)
Paulo R. Fonseca (Italy) Christo Pantev (Germany)
Michael Funke (USA) Christos Papadelis (Italy)
Matti Hämäläinen (USA) Andrew Papanicolaou (USA)
Riitta Hari (Finland) Hubert Preissl (Germany)
Richard Henson (UK) Gian Luca Romani (Italy)
Jens Haueisen (Germany) Kensuke Sekihara (Japan)
Risto Ilmoniemi (Finland) Peter Soros (USA)
Sunao Iwaki (Japan) Selma Supek (Croatia)
Ole Jensen (The Netherlands) Ana Sušac (Croatia)
Blake Johnson (Australia) Norman Tepley (USA)
Sung Chan Jun (South Korea) Yoshinori Uchikawa (Japan)
Robert Kraus (USA) Peter Van Leeuwen (Germany)
Shinya Kuriki (Japan) Tony W. Wilson (USA)
Sari Levänen (USA) Filippo Zappasodi (Italy)
Jo-Fu Lotus Lin (USA) Johanna Zumer (UK)
Burkhard Maess (Germany)
Table of Contents
40 Years of SQUIDs in Biomagnetism: Highlights of Heart and Brain Research
Forty Years of Magnetocardiology ............................................................ 1
Gerhard Stroink
Highlights of 40 Years of SQUID-Based Brain Research and Clinical Applications ............ 9
Cheryl J. Aine
Instrumentation: MEG
Development of a Whole-Head Child MEG System ........................................... 35
Y. Adachi, M. Miyamoto, J. Kawai, M. Kawabata, M. Higuchi, D. Oyama, G. Uehara, H. Ogata,
H. Kado, Y. Haruta, G. Tesan, S. Crain
Characteristics of the Helium Circulation System on the 440 CH Vector Type MEG ......... 39
Tsunehiro Takeda, Masayoshi Okamoto, Keishi Katagiri
Correction of Disturbances Caused by Temporary and Continuous Head Movements ......... 43
J. Nenonen, J. Nurminen, D. Kiˇci´c, R. Bikmullina, P. Lioumis, V. Jousma¨ki, S. Taulu, L. Parkkonen,
M. Putaala, S. Ka¨hk¨onen
Video-MEG: Integration of Digital Video to MEG Epilepsy Recordings....................... 47
Juha Wilenius, Andrey Zhdanov, Erik Larismaa, Lauri Parkkonen, Matti Kajola, Jaakko Lyytinen,
Antti Ahonen, Ossi Miikkulainen, Jyrki P. Ma¨kela¨, Ritva Paetau
Demodulated Effect of SQUID to Magnetic Signal Outside Frequency Bandwidth ............ 50
Daisuke Oyama, Masanori Higuchi, Jun Kawai, Yoshiaki Adachi, Gen Uehara, Hisashi Kado
Asymmetric Three-Dimensional Finite Element Analysis of a Magnetically Shielded Room
with Access Ports ............................................................................ 54
Broc A. Burke, Solomon G. Diamond
Instrumentation: MCG
Mapping the Cardiomagnetic Field with 19 Room Temperature Second-Order
Gradiometers................................................................................. 58
A. Weis, G. Bison, N. Castagna, S. Cook, A. Hofer, M. Kasprzak, P. Knowles, J.-L. Schenker
Towards Clinical MCG with Room-Temperature Sensors ..................................... 62
Gertrud Lembke, Markus Stumpf, Sergio Nicola Ern´e, Georg Bison
Improvement of Small-Channel MCG System for Unshielded Environment ................... 66
Mykola M. Budnyk, Oleksandr V. Zakorcheny, Vitaly C. Koshelnyk, Vitaly M. Budnyk,
Volodymyr V. Lukashyk, Yuriy D. Minov, Pavlo G. Sutkovyi, Tetyana M. Ryzhenko
XII Table of Contents
Instrumentation: Multi-modal Integration - MEG, Low-Field MRI, EEG, fMRI,
TMS, NIRS
Magnetoresistive Hybrid Sensors for Simultaneous Low-Field MRI and Biomagnetic
Measurements ................................................................................ 70
Natalia Sergeeva-Chollet, Hadrien Dyvorne, Hedwige Polovy, Myriam Pannetier-Lecoeur, Claude Fermon
Safety in Simultaneous Ultra-Low-Field MRI and MEG: Forces Exerted on Magnetizable
Objects by Magnetic Fields................................................................... 74
Juhani Dabek, Fredrik Sannholm, Jaakko O. Nieminen, Panu T. Vesanen, Risto J. Ilmoniemi
Hybrid MEG-MRI: Geometry and Time Course of Magnetic Fields Inside a Magnetically
Shielded Room ............................................................................... 78
P.T. Vesanen, J.O. Nieminen, J. Dabek, R.J. Ilmoniemi
Magnetic Resonance Relaxometry at Low and Ultra Low Fields .............................. 82
P. Volegov, M. Flynn, R. Kraus, P. Magnelind, A. Matlashov, P. Nath, T. Owens, H. Sandin, I. Savukov,
L. Schultz, A. Urbaitis, V. Zotev, M. Espy
Characterizing Cerebral and Extracerebral Components in TMS-Evoked Near-Infrared
Spectroscopy Signals.......................................................................... 88
Hanna M¨aki, Tiina Na¨si, Kalle Kotilahti, Ilkka Nissila¨, Pekka Merila¨inen, Risto J. Ilmoniemi
Real-Time Spatial Localization System of Brain Regions for TMS Application by
Co-registration with fMRI.................................................................... 92
A.S.C. Peres, V.H.O. Souza, E.M. Rodrigues, C.E.G. Salmon, D.B. de Araujo, O. Baffa
Multimodal Integration: Constraining MEG Localization with EEG and fMRI................ 97
Richard N.A. Henson
MEG Modeling and Spatio-temporal Source Localization
Academic Software Toolboxes for the Analysis of MEG Data ................................. 101
S. Baillet, F. Tadel, R.M. Leahy, J.C. Mosher, A. Delorme, S. Makeig, R. Oostenveld, M. Ha¨ma¨la¨inen,
S.S. Dalal, J. Zumer, M. Clerc, C.H. Wolters, S. Kiebel, O. Jensen
The Adjoint Method for General EEG and MEG Sensor-Based Lead Field Equations......... 105
Th´eodore Papadopoulo, Sylvain Vallagh´e, Maureen Clerc
The Symmetric BEM: Bringing in More Variables for Better Accuracy ....................... 109
Maureen Clerc, Alexandre Gramfort, Emmanuel Olivi, Theo Papadopoulo
From Classical to Bayesian Estimators in the Interpretation of MEG and EEG ............... 113
Jukka Sarvas, Risto J. Ilmoniemi
Skull Thickness versus Mesh Density — A Study on BEM Discretization Error............... 117
Pascal Werner, Matti Stenroos
Domain Decomposition for Coupling Finite and Boundary Element Methods in EEG......... 120
Emmanuel Olivi, Maureen Clerc, Th´eodore Papadopoulo
