Treatment of early puberty in adopted and non-adopted children: when, why and how. Auxo! ogica ...

240 Pages·2010·5.1 MB·English

Treatment of early puberty in adopted and non-adopted children:
when, why and how.
Auxo!ogica[, psychological and ethical aspects of growth promoting treatment around puberty
Dick Mul
GIP-data Koninklijke Bibliotheek, Den Haag
ISBN: 90-9014107-3
Treatment of early puberty in adopted and non~adopted children: when, why and how.
Auxological, psychological and ethical aspects of growth promoting treatment around puberty
© D. Mul, 2000
Thesis Erasmus University Rotterdam, The Netherlands
No part of this thesis may be reproduced, stored in a relrieval system or transmitted in any
form or by any means, without permission of the author or, when appropriate, of the
publisher of the publication
Printed by: Optima Grafische Communicalie, Rotterdam
Treatment of early puberty in adopted and non-adopted children:
when, why and how.
Behandeling van vroege puberteit bij geadopteerde en niet -geadopteerde kinderen:
wanneer, waarom en hoe.
Auxological, psychological and ethical aspects of growth promoting treatment around puberty
PROEFSCHRIFT
Ter verkrijging van de graad van doctor aan de
Erasmus Universiteit Rotterdam op gezag van de
Rector Magnificus
Prof. dr. if. J.H. van Semmel
en volgens het besluit van het College voor Promoties.
De openbare verdediging zal plaatsYinden op
woensdag 20 december 2000 om 09.45 uur
door
Dick Mul
geboren Ie Barneveld
PROMOTIECOMMISSIE
Promotor: Prof. dr. S.L.S. Drop
Overige leden: Prof. dr. B.C.J.M. Fauser
Prof. dr. F.C. Verhulst
Prof. dr. J.M. Wit
Co-promotor: Dr. W. Oostdijk
Today is a gift,
that's why we call it present
Voor jOlt, Auuemiek
The printing of this thesis was financially supported by Pharmacia & Upjohn BV, Woerden ,
Ferring BV, Hoofddorp and Abbott BV, Hoofddorp.
Contents
INTRODUCTION
Chapter 1
General introduction 11
Chapter 2: Normal puberty
2.1 Pubertal development in The Netherlands 1965 - 1997 41
2.2 Trends in pubertal development in Europe 65
II
EARLY AND PRECOCIOUS PUBERTY
Chapter 3 77
Pituitary and gonadal responsiveness in 2 different Gonadotropin
Releasing Hormone (GnRH) stimulation tests in girls with precocious
or early puberty
Chapter 4 91
Auxologica[ and biochemical evaluation of pubertal suppression with
the GnRH agonist Leuprolide acetate in early and precocious puberty
Horm Res 1999;51:270-76
Chapter 5: Final height after CPP
5.1 Final height after Gonadotrophin Releasing Hormone agonist 103
treatment for central precocious puberty: the Dutch experience
J Ped Endocrinol Metab 2000;13:765-72
5.2 Effect of Gonadotrophin Releasing Hormone agonist (GnRHa) 117
treatment in boys with central precocious puberty: Final height results
III
TREATMENT WITH GNRHA AND GH
Chapter 6: Study of the effect of treatment with GnRH-agonist (Decapeptyl)
alone or in combination with biosynthetic human growth hormone (Genotropin)
in adopted children with early puberty.
6.1 Gonadotrophin Releasing Hormone agonist (GnRHa) treatment with 131
or without recombinant human growth hormone (GH) in adopted children
with early puberty
6.2 Study of the effect of treatment with GnRH (GnRH)-agonist alone or in 147
combination with recombinant human growth hormone in adopted Children
with early puberty: Psychological assessments before and after treatment
6,3 Motivation for treatment and psychological evaluation in adoptive families 163
when a child presents with early puberty
Chapter 7 177
A randomized controlled trial of three years of growth hormone (GH) and GnRH
agonist treatment in children with Idiopathic Short Stature and Intra-Uterine Growth
Retardation.
J elin Endocrinol Metab (in press)
Chapter 8 195
The effect of pubertal delay by GnRH agonist in Growth Hormone Deficient (GHD)
children on final height
Acta Paediatrica (in press)
IV
ETHICS OF GROWTH PROMOTING TREATMENT
Chapter 9 201
Growth hormone in short children: beyond medicine?
V
GENERAL DISCUSSION AND RECOMMENDATIONS
Chapter 10 211
General discussion and recommendations
Summary in English 223
Samenvatting vaor de niet-medicus 227
Abbreviations 231
Dankwoord 233
CUrriculum Vitae 237
List of publications 239
INTRODUCTION
Chapter 1
General introduction
Chapter? Normal puberly
2.1 Pubertal development in The Netherlands 1965 -1997
2.?' Trends in pubertal development in Europe