Tight Junctions

234 Pages·2006·5.7 MB·English

by  Lorenza Gonzalez-Mariscal Ph.D. (auth.)

MOLECULAR BIOLOGY
INTELUGENCE
UNIT
Tight Junctions
Lorenza Gonzalez-Mariscal, Ph.D.
Department of Physiology, Biophysics and Neuroscience
Center for Research and Advanced Studies (CINVESTAV)
Mexico D.F., Mexico
LANDES BIOSCIENCE / EUREKAH.COM SPRINGER SCIENCE+BUSINESS MEDIA
GEORGETOWN, TEKAS NEW YORK, NEW YORK
USA U.S.A.
TIGHT JUNCTIONS
Molecular Biology Intelligence Unit
Landes Bioscience
Springer Science+Business Media, LLC
ISBN: 0-387-33201 -4 Printed on acid-free paper.
Copyright ©2006 Landes Bioscience and Springer Science+Business Media, LLC
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9 8 7 6 5 4 3 21
Library of Congress Cataloging-in-Publication Data
Tight junctions / [edited by] Lorenza Gonzdlez-Mariscal.
p.; cm. ~ (Molecular biology intelligence unit)
Includes bibliographical references and index.
ISBN 0-387-33201-4
1. Tight junctions (Cell biology) I. Gonzilez-Mariscal, Lorenza. II. Tide. III. Series: Molecular biology
intelligence unit (Unnumbered)
[DNLM:1. Tight Junctions. QU 350 T566 2006]
QH603.C4T56 2006
571.6~dc22
2006007715
CONTENTS
Preface xi
1. Evolution of the Transporting Epidielium Phenotype 1
Marcelino Cereijido, Maria del Refugio Garcia-Villegas, Liora Shoshani
and Rubin Gerardo Contreras
Experimental Approaches 4
The Development of Tight Junctions 4
The Development of Polarity: The Role of the P-Subunit
of the Na%K"-ATPase 5
a/p-Subunit Interactions 6
Na%K*-ATPase, Cell Attachment and the Position of the TJ 6
Evolution of the Epithelial Vectorially Transporting Phenotype 8
Evolution of the Na%K^-ATPase 8
Evolution of Junction Proteins 9
The Dawn of Metazoans and Transporting Epithelia 11
Na%K^-ATPase and Cell Adhesion: Role of the P-Subunit
in Cell Attachment 12
2. Occludin, a Constituent of Tight Junctions 19
Yan-Hua Chen, Daniel A. Goodenough and Qun Lu
Identification of Occludin from Different Species 19
Localization of Occludin at TJs 20
Expression of Occludin in Vitro 21
Functional Analysis of Occludin Domains 22
Occludin Interacting Proteins 24
Roles of Occludin Phosphorylation 26
Regulation of Occludin by Signaling Molecules 27
Phenotypes of Occludin-Deficient Mice 28
Occludin in Cancer Cells 28
3. Tight Junction Channels 33
James Melvin Anderson and Christina M. Van Itallie
Channel-Like Properties of Tight Junctions 33
The Claudin Family and Its Extended Relatives 34
Lessons from Cell Culture Models 37
Lessons from Heritable Human Diseases 38
Lessons from Mutant Mice 39
4. JAM Family Proteins: Tight Junction Proteins That Belong
to the Immunoglobulin Superfeunily 43
Susumu Hirabayashi and Yutaka Hata
General Features of JAM Family Proteins 44
Functions of JAM Family Proteins 48
5. Cingulin, a Cytoskeleton-Associated Protein of the Tight Junction 54
Laurent Guillemot and Sandra Citi
Identification of Cingulin as a Tight Junction-Associated Protein 54
Molecular Structure and Evolution of Cingulin 55
Interaction of Cingulin with the Actomyosin Cytoskeleton 57
Cingulin Associates with Several Tight J unction Proteins 57
The Head Domain of Cingulin Is Essential
for Its Junctional Recruitment 57
Cingulin Is Maternally Expressed and Is an Early Component
of Cell-Cell Junctions in Developing Vertebrate Embryos 58
Cingulin as a Marker for Differentiated Epithelial Cells 60
Putative Functions and Regulation of Cingulin 60
Paracingulin 61
6. ZO Proteins and Tight Junction Assembly 64
Alan S. Fanning
Role as Molecular Scaffold of Tight Junction Proteins 65
ZO Proteins as Cytoskeletal Linkers G7
Organization of Signal Transduction Pathways
and Transcription Factor Complexes That Regulate
Junction Structure and Function 68
Extension of the Paradigm: ZO Proteins and Global
Organization of Cell-Cell Junctions 70
7. TJ Proteins That Make Round Trips to the Nucleus 7G
Esther LopeZ'Bayghen, Blanca Estela Jaramilloy Miriam Huerta,
Abigail Betanzos andLorenza Gonzalez-Mariscal
TJ Proteins Participate in Maintaining the Equilibrium
between Proliferation and Differentiation IG
Conditions Upon Which TJ Proteins Are Found at the Nucleus 11
Signals Contained in the Sequence of TJ Proteins That Facilitate
Membrane-Nuclear Shutding 80
A Protein Involved in Chromatin Remodeling Colocalizes
widi ZO-1 at the TJ 86
Nuclear Matrix and TJ Proteins 89
Interaction of TJ Cortical Proteins with Molecules Involved
in RNA Processing and Transcriptosome Assembly 92
TJ Proteins Associate with Transcription Factors at the Nucleus
and the Plasma Membrane 93
8. Tight Junctions and the Regulation of EpitheUal
Cell Proliferation and Gene Expression 101
Emma Kavanaghy Anna Tsapara, Karl Matter and Maria S. Balda
Junctional Membrane Proteins 102
Junctional Plaque Proteins 102
ZO-1 and ZONAE in the Regulation of Cell Proliferation 105
ZONAE and the Regulation of Gene Expression 107
Tight Junctions and the Ras Pathway in the Regulation
of Cell Proliferation 108
9. Tight Junction Proteins and Cancer 116
Isabel]. Latorre, Kristopher K. Frese and Ronald T. Javier
TJ Proteins 117
TJ Proteins and Cancer 118
The TJ and Viral Oncoproteins 124
10. Regulation of Paracellular Transport across Tight Junctions
by the Actin Cytoskeleton 135
Matthias Bruewer andAsma Nusrat
Modulation of Myosin Light Chain-Phosphorylation
in the Perijunctional F-Actin Ring Influences TJ Function 136
Modulation of Earrier Function by Rho GTPases 137
Modulation of Earrier Function by Cytokines 139
11. Regulation of Tight Junctions' Functional Integrity:
Role of a Urinary Factor, Lipids and Ouabain 146
Liora Shoshaniy David Flores-Benitez, Lorenza Gonzalez-Mariscal
and Rubin Gerardo Contreras
Regulatory Factors of the Tight Junctions 147
Urinary Factors 149
Lipids 152
Ouabain 155
12. Tight Junctions during Development 164
Bhavwanti Sheth, Judith Eckert, Fay Thomas and Tom P. Fleming
Epithelial Differentiation in the Mouse Embryo 165
Compaction: A Prerequisite for Tight Junction Formation 166
Three Phases of Tight Junction Eiogenesis 166
Cell Adhesion and Regulation of Tight Junction Assembly 169
Tight Junctions in Other Mammalian Preimplantation Embryos 170
13. Tight Junctions and the Blood-Brain Barrier 175
Hartwig Wolhurg, Andrea Lippoldt and Klaus Ebnet
Structure of Blood-Brain Barrier Tight Junctions 176
Molecular Composition of Blood-Brain Barrier Tight Junctions 178
Regulatory Mechanisms in the Blood-Brain Barrier 184
14. Tight Junctions in CNS Myelin 196
JeffM. Bronstein and Seema Tiwari-Woodruff
The Radial Component of CNS Myelin Are Tight Junctions 196
OSP/Claudin-11 Is Essential for the Formation
of CNS Myelin TJs 197
Myelin Compaction Is Dependent on Both OSP/Claudin-11
and PLP/DM20 199
Regulation of Migration and Proliferation; OSP/Claudin-11
and Associated Proteins 201
15. Tight Junction Modulation and Its Relationship to Drug Delivery.... 206
Noha N. Salama, Natalie D. Eddington andAlessio Fasano
The Paracellular Route 207
Structural Characteristics of Tight Junctions 207
Enhancing Drug Delivery via Modulation of the TJs 209
Discovery of Zonula Occludens Toxin 210
Insights into the Zonulin System 211
Identification of the Zot Receptors 211
Zot as a TJ Modulator for Improved Drug Delivery 212
Index 221
EDITOR
Lorenza Gonzalez-Mariscal
Department of Physiology, Biophysics and Neuroscience
Center for Research and Advanced Studies (CINVESTAV)
Mexico D.F., Mexico
Email: [email protected]
Chapters 7, 11
CONTRIBUTORS
James Melvin Anderson Matthias Bruewer
Departments of Cell and Molecular Department of General Surgery
Physiology and Medicine University of Muenster
University of North Carolina Muenster, Germany
at Chapel Hill Email: [email protected]
Chapel Hill, North Carolina, U.S A. Chapter 10
Email: [email protected]
Chapter 3 Marcelino Cereijido
Department of Physiology,
Maria S. Balda Biophysics and Neuroscience
Division of Cell Biology Center for Research and Advanced
Institute of Ophthalmology Studies (CINVESTAV)
University College London Mexico D.F., Mexico
London, U.K. Email: [email protected]
Email: [email protected] Chapter 1
Chapter 8
Yan-Hua Chen
Abigail Betanzos Department of Anatomy and Cell Biology
Department of Pathology East Carolina University Brody
Center for Research and Advanced School of Medicine
Studies (CINVESTAV) Greenville, North Carolina, U.S.A.
Mexico D.F., Mexico Email: [email protected]
Email: [email protected] Chapter 2
Chapter 7
Sandra Citi
JefFM. Bronstein Department of Molecular Biology
Department of Neurology, RNRC University of Geneva
David Geffen School of Medicine Geneva, Switzerland
at UCLA Email: [email protected]
Los Angeles, California, U.S.A. Chapter 5
Email: [email protected]
Chapter 14
Rub^n Gerardo Contreras Alan S. Fanning
Department of Physiology, Department of Cell
Biophysics and Neuroscience and Molecidar Physiology
Center for Research and Advanced University of North Carolina
Studies (CINVESTAV) at Chapel Hill
Mexico D.F., Mexico Chapel Hill, North Carolina, U.S A.
Email: [email protected] Email: [email protected]
Chapters 1, 11 Chapter 6
Marfa del Refugio Garcfa-Villegas Alessio Fasano
Department of Physiology, Mucosal Biology Research Center
Biophysics and Neuroscience University of Maryland
Center for Research and Advanced School of Medicine
Studies (CINVESTAV) Baltimore, Maryland, U.S.A.
Mexico D.F., Mexico Email: [email protected]
Email: [email protected] Chapter 15
Chapter 1
Tom P. Fleming
Klaus Ebnet School of Biological Sciences
Institute of Cell Biology University of Southampton
ZMBE Southampton, U.K.
University of Munster Email: [email protected]
Munster, Germany Chapter 12
Chapter 13
David Flores-Benftez
Judith Eckert Department of Physiology,
Developmental Origins of Health Biophysics and Neuroscience
and Disease Center for Research and Advanced
School of Medicine Studies (CINVESTAV)
University of Southampton Mexico D.F., Mexico
Southampton, U.K. Email: [email protected]
Email: [email protected] Chapter 11
Chapter 12
Kristopher K. Frese
Natalie D. Eddington Abramson Family Center
Department of Pharmaceutical Sciences Research Institute
Pharmacokinetics-Biopharmaceutics Philadelphia, Pennsylvania, U.S.A.
Laboratory Email: [email protected]
School of Pharmacy Chapter 9
University of Maryland at Baltimore
Baltimore, Maryland, U.S.A. Daniel A. Goodenough
Email: [email protected] Department of Cell Biology
Chapter 15 Harvard Medical School
Boston, Massachusetts, U.S.A.
Email:
[email protected]
Chapter 2
Laurent Guillemot Ronald T. Javier
Department of Molecular Biology Department of Molecular Virology
University of Geneva and Microbiology
Geneva, Switzerland Baylor College of Medicine
Email: Houston, Texas, U.S.A.
[email protected] Email: [email protected]
Chapter 5 Chapter 9
Yutaka Hata Emma Kavanagh
Department of Medical Biochemistry Division of Cell Biology
Graduate School of Medicine Institute of Ophthalmology
Tokyo Medical and Dental University University College London
Tokyo, Japan London, U.K.
Email: [email protected] Email: [email protected]
Chapter 4 Chapter 8
Susumu Hirabayashi Isabel J. Latorre
Department of Medical Biochemistry Abramson Family Center
Graduate School of Medicine Research Institute
Tokyo Medical and Dental University Philadelphia, Pennsylvania, U.S.A.
Tokyo, Japan Email: [email protected]
Email: [email protected] Chapter 9
Chapter 4
Andrea Lippoldt
Miriam Huerta Max Delbriick-Center Berlin-Buch
Department of Genetics Department of Neurology
and Molecular Biology Schering AG Berlin
Center for Research and Advanced Berlin, Germany
Studies (CINVESTAV) Email:
Mexico D.F., Mexico [email protected]
Email: [email protected] Chapter 13
Chapter 7
Esther Lopez-Bayghen
Blanca Estela Jaramillo Department of Genetics
Department of Physiology, and Molecular Biology
Biophysics and Neuroscience Center for Research and Advanced
Center for Research and Advanced Studies (CINVESTAV)
Studies (CINVESTAV) Mexico D. F., Mexico
Mexico D. F., Mexico Email: [email protected]
Email: [email protected] Chapter 7
Chapter 7
Qun Lu Liora Shoshani
Department of Anatomy Center for Research and Advanced
and Cell Biology Studies (CINVESTAV)
East Carolina University Mexico, D.F, Mexico
Brody School of Medicine Email: [email protected]
Greenville, North Carolina, U.S.A. Chapters 1, 11
Email: [email protected]
Chapter 2 Fay Thomas
School of Biological Sciences
Karl Matter University of Southampton
Division of Cell Biology Southampton, U.K.
Institute of Ophthalmology Email: [email protected]
University College London Chapter 12
London, U.K.
Email: [email protected] Seema Tiwari-Woodruff
Chapter 8 Department of Neurology
Geffen School of Medicine at UCLA
Asma Nusrat Los Angeles, California, U.S.A.
Department of Pathology Email: [email protected]
and Laboratory Medicine Chapter 14
Emory University
Whitehead Research Building Anna Tsapara
Adanta, Georgia, U.S A. Division of Cell Biology
Email: [email protected] Institute of Ophthalmology
Chapter 10 University College London
London, U.K.
Noha N. Salama Email: [email protected]
Department of Pharmaceutical Sciences Chapter 8
Pharmacokinetics-Biopharmaceutics
Laboratory Christina M. Van Itallie
School of Pharmacy Department of Medicine
University of Maryland at Baltimore University of North Carolina
Baltimore, Maryland, U.S.A. at Chapel Hill
Email: [email protected] Chapel Hill, North Carolina, U.S A.
or [email protected] Email: christina [email protected]
Chapter 15 Chapter 3
Bhavwanti Sheth Hartwig Wolburg
School of Biological Sciences Institute of Pathology
University of Southampton University of Tubingen
Southampton, U.K. Tubingen, Germany
Email: [email protected] Email:
Chapter 12 [email protected]
Chapter 13