Table Of ContentVOLUME 53 - CONTENTS
No | JANUARY 1998 Page Editorials
] Long acting §, agonists and the risk of life threatening asthma _ P Ernst
3 The failing health care system for adult patients with cystic fibrosis S P Conway, D E Stableforth,
A K Webb
Conference report
Eighth World Conference on Lung Cancer, Dublin, August 1997 R F Fergusson
Original articles
Case-control study of salmeterol and near-fatal attacks of asthma C Williams, L Crossland, ¥ Finnerty,
¥ Crane, S Holgate, N Pearce, R Beasley
Determinants of management errors in acute severe asthma 7 Kolbe,M Vamos, W Fergusson, G Elkind
Expression of growth factors and remodelling of the airway wall in bronchial asthma M Hoshino,
Y Nakamura, ¥ 7 Sim
Family size, childhood infections and atopic diseases C Bodner, D Godden, A Seaton, Aberdeen WHEASE
Group
Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes
A Custovic, A Simpson, H Pahdi, R M Green, M D Chapman, A Woodcock
Influence of excessive weight loss after gastroplasty for morbid obesity on respiratory muscle
performance P Weiner, ¥ Waizman, M Weiner, M Rabner, R Magadle, D Zamir
Comparison of the functional results of single lung transplantation for pulmonary fibrosis and chronic
airway obstruction RA Chacon, P A Corris, } H Dark, G F# Gibson
Review series
Health effects of passive smoking 4: Parental smoking, middle ear disease and adenotonsillectomy in
children DP Strachan, D G Cook
Lung infections: Introduction SL Hill
Lung infections 1: Role of bacteria in the pathogenesis and progression of acute and chronic lung
infection RA Stockle
Occasional review
Allergen avoidance in the treatment of asthma and atopic disorders A Custovic, A Simpson,
M D Chapman, A Woodcock
Case reports
Tracheal botryomycosis in a patient with tracheopathia osteochondroplastica ¥-Y Shih, P-R Hsueh,
¥-L Chang, L-N Lee, Y-C Chen, M-F Chen, K-T Luh
Infection with feline Chlamydia psittaci MM M Cotton, M R Partridge
Letters to the editor
Adrenocortical activity in children J Doull « Fenoterol and asthma deaths ” B Grant * Home
environment and asthma’ R Siebers, P Fitzharris, 7 Crane
Notices + Correction
No 2 FEBRUARY 1998 Editorials
Sputum induction to assess airway inflammation: is it an inflammatory stimulus? ID Pavord
Is the lung important as a privileged site for the human immunodeficiency virus? ¥ R Clarke,
D M Mitchell, R $ Coker, D Israel-Biet
Original articles
Changes in sputum composition between two inductions performed on consecutive days O Holz,
K Richter, R A Forres, P Speckin, M Miicke, H Magnussen
Effect of repeated sputum induction on cell counts in normal volunteers 7% A Nightingale, D F Rogers,
P F Barnes
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients
with mild asthma A Jatakanon, S Lim, S A Kharitonov, K F Chung, P F Barnes
Measurement of sniff nasal and diaphragm twitch mouth pressure in patients PD Hughes,M I Polkey,
D Kyroussis, C-H Hamnegard, ¥ Moxham, M Green
Asthma and airway hyperresponsiveness among Belgian conscripts, 1978-91 P Dubois, E Degrave,
O Vandenplas
Radiofrequency resection of bronchial tumours in combination with cryotherapy: evaluation of a new
technique A Marasso, V Bernardi, R Gai, E Gallo, G M Massaglia, M Onoscuri, S B Cardaci
Short paper
Effect of an inhaled glucocorticosteroid on mast cell and smooth muscle f, adrenergic tolerance in mild
asthma DH Yates, M Worsdell, P ¥ Barnes
Science matters
Secretory leukoprotease inhibitor: a native antimicrobial protein presenting a new therapeutic option?
7 FC Tomee, G H Koéter, P S Hiemstra, H F Kauffman
Review series
Health effects of passive smoking — 5: Parental smoking and allergic sensitisation in children
D P Strachan, D G Cook
Lung infections — 2: Branhamella catarrhalis: epidemiological and clinical aspects of a human respiratory
tract pathogen TJ F Murphy
VOLUME 53 - CONTENTS
No | JANUARY 1998 Page Editorials
] Long acting §, agonists and the risk of life threatening asthma _ P Ernst
3 The failing health care system for adult patients with cystic fibrosis S P Conway, D E Stableforth,
A K Webb
Conference report
Eighth World Conference on Lung Cancer, Dublin, August 1997 R F Fergusson
Original articles
Case-control study of salmeterol and near-fatal attacks of asthma C Williams, L Crossland, ¥ Finnerty,
¥ Crane, S Holgate, N Pearce, R Beasley
Determinants of management errors in acute severe asthma 7 Kolbe,M Vamos, W Fergusson, G Elkind
Expression of growth factors and remodelling of the airway wall in bronchial asthma M Hoshino,
Y Nakamura, ¥ 7 Sim
Family size, childhood infections and atopic diseases C Bodner, D Godden, A Seaton, Aberdeen WHEASE
Group
Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes
A Custovic, A Simpson, H Pahdi, R M Green, M D Chapman, A Woodcock
Influence of excessive weight loss after gastroplasty for morbid obesity on respiratory muscle
performance P Weiner, ¥ Waizman, M Weiner, M Rabner, R Magadle, D Zamir
Comparison of the functional results of single lung transplantation for pulmonary fibrosis and chronic
airway obstruction RA Chacon, P A Corris, } H Dark, G F# Gibson
Review series
Health effects of passive smoking 4: Parental smoking, middle ear disease and adenotonsillectomy in
children DP Strachan, D G Cook
Lung infections: Introduction SL Hill
Lung infections 1: Role of bacteria in the pathogenesis and progression of acute and chronic lung
infection RA Stockle
Occasional review
Allergen avoidance in the treatment of asthma and atopic disorders A Custovic, A Simpson,
M D Chapman, A Woodcock
Case reports
Tracheal botryomycosis in a patient with tracheopathia osteochondroplastica ¥-Y Shih, P-R Hsueh,
¥-L Chang, L-N Lee, Y-C Chen, M-F Chen, K-T Luh
Infection with feline Chlamydia psittaci MM M Cotton, M R Partridge
Letters to the editor
Adrenocortical activity in children J Doull « Fenoterol and asthma deaths ” B Grant * Home
environment and asthma’ R Siebers, P Fitzharris, 7 Crane
Notices + Correction
No 2 FEBRUARY 1998 Editorials
Sputum induction to assess airway inflammation: is it an inflammatory stimulus? ID Pavord
Is the lung important as a privileged site for the human immunodeficiency virus? ¥ R Clarke,
D M Mitchell, R $ Coker, D Israel-Biet
Original articles
Changes in sputum composition between two inductions performed on consecutive days O Holz,
K Richter, R A Forres, P Speckin, M Miicke, H Magnussen
Effect of repeated sputum induction on cell counts in normal volunteers 7% A Nightingale, D F Rogers,
P F Barnes
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients
with mild asthma A Jatakanon, S Lim, S A Kharitonov, K F Chung, P F Barnes
Measurement of sniff nasal and diaphragm twitch mouth pressure in patients PD Hughes,M I Polkey,
D Kyroussis, C-H Hamnegard, ¥ Moxham, M Green
Asthma and airway hyperresponsiveness among Belgian conscripts, 1978-91 P Dubois, E Degrave,
O Vandenplas
Radiofrequency resection of bronchial tumours in combination with cryotherapy: evaluation of a new
technique A Marasso, V Bernardi, R Gai, E Gallo, G M Massaglia, M Onoscuri, S B Cardaci
Short paper
Effect of an inhaled glucocorticosteroid on mast cell and smooth muscle f, adrenergic tolerance in mild
asthma DH Yates, M Worsdell, P ¥ Barnes
Science matters
Secretory leukoprotease inhibitor: a native antimicrobial protein presenting a new therapeutic option?
7 FC Tomee, G H Koéter, P S Hiemstra, H F Kauffman
Review series
Health effects of passive smoking — 5: Parental smoking and allergic sensitisation in children
D P Strachan, D G Cook
Lung infections — 2: Branhamella catarrhalis: epidemiological and clinical aspects of a human respiratory
tract pathogen TJ F Murphy
Occasional reviews
129 Structural and inflammatory changes in COPD: a comparison with asthma PK Jeffery
137 New therapies for chronic obstructive pulmonary disease P # Barnes
Case reports
148 Commentary FL Raymond
149 Opitz oculo-genito-laryngeal syndrome: a rare cause of recurrent aspiration pneumonia in an adult
D de Silva, A Osborne, S A Simpson, ¥ C S Dean, A Seaton
Familial primary spontaneous pneumothorax consistent with true autosomal dominant inheritance
P ¥ Morrison, RC Lowry, N C Nevin
Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to
“sensitisation” to isocyanates? C Leroyer, L Perfetti, A Cartier, J7-L Malo
Letters to the editor
Atopy phenotype S Thomas, N Morton, S Holgate + Lung volume reduction surgery M D L Morgan,
DA Waller, S ¥ Singh D A Lomas, N Caine, F C Wells
Book review - Notice
No 3 MARCH 1998 Editorials
157 Gene therapy for cystic fibrosis: what message for the recipient? 7A Dodge
159 Pneumococcal serotypes and their clinical relevance M Kalin
Conference report
163 1997 Winter Meeting of the British Thoracic Society 7A Innes
Original articles
166 Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the
MORGEN study __L Grievink, H A Smit, M C Ocké, P van ‘t Veer, D Kromhout
~“ nN Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects M A Sapienza,
S A Kharitonov, I Horvath, K Fan Chung, P F Barnes
Geographical distribution of tuberculosis notifications in national surveys of England and Wales in 1988
and 1993: report of the Public Health Laboratory Service/British Thoracic Society/Department of Health
Collaborative Group L P Ormerod, A Charlett, C Gilham, }H Darbyshire, ?M Watson
182 Non-tuberculous mycobacteria in cystic fibrosis %K Torrens, P Dawkins, S P Conway, E Moya
186 Preventive effect of erythromycin on experimental bleomycin-induced acute lung injury in rats A Azuma,
T Furuta, T Enomoto, Y Hashimoto, K Uematsu, N Nukariya, A Murata, S Kudoh
190 Videothoracoscopic treatment of oesophageal leiomyoma GC Roviaro,M Maciocco, F Varoli, C Rebuffat,
C Vergani, A Scarduelli
Short paper
193 Preferential binding of lysozyme to elastic fibres in pulmonary emphysema _ __B Shteyngart, S Chaiwiriyakul,
+} Wong, ¥ O Cantor
Science matters
197 Gene therapy for cystic fibrosis: which postman, which box? PG Middleton, E W F W Alton
200 New ideas on the pathophysiology and treatment of lung disease D F Rogers, G ¥ Laurent
Review series
Health effects of passive smoking — 6: Parental smoking and childhood asthma: longitudinal and
case-control studies D P Strachan, D G Cook
Lung infections — 3: Pseudomonas aeruginosa and other related species R Wilson, R B Dowling
Occasional review
Pulmonary vasculitis A Burns
Case reports
Non-Hodgkin’s lymphoma arising in cryptogenic fibrosing alveolitis 7 R Orchard, C D Eraut,
A G Davison
A vibrating trachea M # Doherty, D P S Spence, D Graham, B M G Cheetham, X Q Sun,f E Earis
Upper airways sarcoidosis presenting as obstructive sleep apnoea RN H Shah, PR Mills, P ¥ M George,
J A Wedzicha
Letters to the editor
Why are there so few papers or elderly patients in Thorax? M Mamun; A } Knox, ¥ Britton +
Passive smoking in children with asthma T Ashcroft; reply I Crombie, L Irvine
Book review + Notices
No 4 APRIL 1998 Editorials
Brittle asthma: fiend or phantom? M R Hetzel
Improved survival in ARDS: chance, technology or experience? S Baudouin
Lung research funding in the UK: the British Lung Foundation perspective W MacNee, I M Walden
Original articles
Rapid onset asthma: a severe but uncommon manifestation % Kolbe, W Fergusson, ¥G arrett
Airway wall thickness in patients with near fatal asthma and control groups: assessment with high
resolution computed tomographic scanning N Awadh, N L Miiller,C S Park, R T Abboud, ¥M FitzGerald
Chlamydia pneumoniae and asthma _ P # Cook, P Davies, W Tunnicliffe, ?G Ayres, D Honeybourne, R Wise
Induction of IL-8 production in human alveolar macrophages and human bronchial epithelial cells in vitro
by swine dust L Palmberg, B-M Larsson, P Malmberg, K Larsson
Clinical features and prognosis of life time non-smokers with severe a,-antitrypsin deficiency N Seersholm,
A Kok-fensen
Effects of theophylline and ipratropium bromide on exercise performance in patients with stable chronic
obstructive pulmonary disease M Tsukino, K Nishimura, A Ikeda, T Hajiro, H Koyama, T Izumi
Clinical profiles of Chinese patients with diffuse panbronchiolitis K WT Tsang,C GC Oo, M S M Ip,
W-k Lam, H Ngan, E Y T Chan, B Hawkins, C-s Ho, R Amitani, E Tanaka, H Itoh
Medium term results of lung transplantation for end stage pulmonary sarcoidosis S Walker, G Mikhail,
N Banner, } Partridge, A Khaghani, M Burke, M Yacoub
Totally implantable venous access devices in children with cystic fibrosis: incidence and type of
complications ¥ Deerojanawong, S M Sawyer, A M Fink, K B Stokes, C F Robertson
Short papers
Comparison of nose and face mask CPAP therapy for sleep apnoea JIL Mortimore, A T Whittle,
N ¥ Douglas
Reduced mortality in association with the acute respiratory distress syndrome (ARDS) SC Abel,
S F Finney, S ¥ Brett, B F Keogh, C } Morgan, T W Evans
Review series
Health effects of passive smoking — 7: Parental smoking, bronchial reactivity and peak flow variability in
children D G Cook, D P Strachan
Lung infections — 4: Pathogenesis of lower respiratory tract infections due to Chlamydia, Mycoplasma,
Legionella and viruses P Andersen
Occasional reviews
High resolution computed tomography in asthma A N Mclean, M W Sproule, M D Cowan, N C Thomson
Brittle asthma 7 G Ayres, ¥ F Miles, P ¥ Barnes
Case reports
Commentary: “Histiocytosis X” DV Parums
Recurrence of recipient Langerhans’ cell histiocytosis following bilateral lung transplantation SB Habib,
¥ Congleton, D Carr, ¥ Partridge, B Corrin, D M Geddes, N Banner, M Yacoub, M Burke
Recurrence of Langerhans’ cell granulomatosis following lung transplantation E Gabbay, ¥ H Dark,
T Ashcroft, D Milne, G ¥ Gibson, M Healy, P A Corrts
Letters to the editor
Should steroids be first choice for asthma? G Strube; reply M Rudolf + The tobacco epidemic in
Japan H Kawane + Tobacco advertising ban in Europe S G Spiro
Notice
No 5 MAY 1998 Editorials
Typing of mycobacteria using spoligotyping AC Hayward, # M Watson
Bisphosphonates and glucocorticoid-induced osteoporosis: implications for patients with respiratory
diseases S Cowan, S Morin, P Ernst
Burkholderia cepacia: another twist and a further threat A K Webb, 7 R Govan
The new prescription: industrial injuries benefits for smokers? A Seaton
Coal miners’ respiratory disease litigation R Rudd
Rapid communication
Randomised placebo controlled trial of daytime function after continuous positive airway pressure (CPAP)
therapy for the sleep apnoea/hypopnoea syndrome H M Engleman, S E Martin, R N Kingshott,
TW Mackay, I ¥ Deary, N ¥ Douglas
Original articles
Pulmonary tuberculosis in Harare, Zimbabwe: analysis by spoligotyping RS Heyderman, M Goyal,
P Roberts, S Ushewokunze, S Zizhou, B G Marshall, R Makombe, ¥ D A Van Embden, P R Mason, R ¥ Shau
A double blind placebo controlled study to determine the effects of intermittent cyclical etidronate on
bone mineral density in patients on long term oral corticosteroid treatment P Pitt, F Li, P Todd, D Webber,
S Pack, C Moniz
Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and
asthmatic subjects LG Heaney, L ¥ M Cross, L P A McGarvey, K D Buchanan, M Ennis, C Shaw
How long should Atrovent be given in acute asthma? C Brophy, B Ahmed, S Bayston, A Arnold,
D McGivern, M Greenstone
Injury to murine airway epithelial cells by pollen enzymes Z Hassim, S E Maronese, R K Kumar
Diagnosis of pulmonary arteriovenous malformations by colour Doppler ultrasound and amplitude
ultrasound angiography H-C Wang, P-H Kuo, Y-S Liaw, C-} Yu, S-H Kuo, K-T Luh, P-C Yang
Short paper
Detection of IgG and IgA against the mycobacterial antigen A60 in patients with extrapulmonary
tuberculosis M Alifano, R De Pascalis, M Sofia, S Faraone, M Del Pezzo, I Covelli
Review series
Health effects of passive smoking — 8: Passive smoking and risk of adult asthma and COPD: an update
D B Coultas
Genetics and pulmonary medicine: Introduction 7 Britton, }H opkin
Genetics and pulmonary medicine — 1: The genetics of cystic fibrosis lung disease D ¥ Davidson,
D F Porteous
Occasional reviews
Coal mining and chronic obstructive pulmonary disease: a review of the evidence D Coggon,A N Taylor
Public health aspects of obstructive sleep apnoea G ¥ Gibson
Sleep apnoea and its impact on public health ¥% Wright, T Sheldon
Systematic review of the efficacy of nasal CPAP N F Douglas
Cardiovascular aspects of obstructive sleep apnoea and their relevance to the assessment of the efficacy of
nasal continuous positive airway pressure therapy RF O Davies
Measurement of airway hyperresponsiveness: new considerations 4 Létvall, M Inman, P O’Byrne
Clinical impact of bone and calcium metabolism changes in sarcoidosis G Rizzato
Case reports
Chronic Burkholderia cepacia bronchiectasis in a non-cystic fibrosis individual M ¥ Ledson, M ¥ Gallagher,
M F Walshaw
Cross infection between cystic fibrosis patients colonised with Burkholderia cepacia M # Ledson,
M F Gallagher, ¥ E Corkill, CA Hart, M ¥ Walshaw
Letters to the editor
Inhibition of T cell proliferation by human alveolar macrophages ¥M Grange; reply P G Holt,
JF W Upham + Adenosine and adenosine antagonism in asthma _ C Persson; reply S T Holgate
Book reviews + Notice
No 6 JUNE 1998 Editorials
Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme
(SACE) activity in patients with sarcoidosis BG Marshall, R ¥ Shaw
Surgery for lung cancer S W Fountain
Severity of chronic asthma A # Woolcock, D Dusser, I Fajac
Original articles
Improving surgical resection rate in lung cancer C Laroche, F Wells, R Coulden, S Stewart, M Goddard,
E Lowry, A Price, D Gilligan
Surgery for combined type small cell lung carcinoma R Hage, ¥ R F Elbers, A Brutel de la Riviere,
¥M M van den Bosch
Cross sectional study of exhaled nitric oxide levels following lung transplantation <A 7 Fisher, E Gabbay,
T Small, S Doig, ¥H Dark, P A Corris
Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme
(SACE) activity in patients with sarcoidosis Y Takemoto, M Sakatani, S Takami, T Tachibana, ¥ Higaki,
T Ogihara, T Miki, T Katsuya, T Tsuchiyama, A Yoshida, H Yu, Y Tanio, E Ueda
IgG subclasses in the serum and sputum from patients with bronchiectasis SL Hill, # L Mitchell,
D Burnett, R A Stockley
Idiopathic pulmonary fibrosis: survival in population based and hospital based cohorts D W Mapel,
W C Hunt, R Utton, K B Baumgartner, } M Samet, D B Coultas
Randomised controlled trial of inhaled corticosteroids in patients with chronic obstructive pulmonary
disease ¥ Bourbeau,M Y Rouleau, S Boucher
Effect of endogenous nitric oxide inhibition on airway responsiveness to histamine and adenosine-5'-
monophosphate in asthma DA Taylor, 7 L McGrath, L M Orr, P F Barnes, B ¥ O’Connor
Differences in asthma management between white European and Indian subcontinent ethnic groups living
in socioeconomically deprived areas in the Birmingham (UK) conurbation H Moudgil, D Honeybourne
Short papers
Domiciliary nocturnal intermittent positive pressure ventilation in patients with respiratory failure due to
severe COPD: long term follow up and effect on survival S E Jones, S Packham, M Hebden, A P Smith
Evidence for eosinophil activation in bronchiectasis unrelated to cystic fibrosis and bronchopulmonary
aspergillosis: discrepancy between blood eosinophil counts and serum eosinophil cationic protein levels
C Kroegel, M Schiiler, M Férster, R Braun, P R Grahmann
Review series
Genetics and respiratory disease 2: Alpha,-antitrypsin deficiency, cirrhosis and emphysema
R Mahadeva, D A Lomas
Occasional reviews
The donor lung: conservation of a precious resource CA Keller
Pathophysiology and treatment of Cheyne-Stokes respiration M T Naughton
Psychosocial aspects of asthma in adults BD W Harrison
Case reports
Commentary: bronchiectasis and inflammatory bowel disease RA Stockley
Bronchiectasis in association with coeliac disease R Mahadeva, C Flower, ¥ Shneerson
Bronchiectasis following colectomy for Crohn’s disease 7 E Eaton, N Lambie, A U Wells
Letter to the editor
Evolution of OSA _S F Quan, P Lévy, F L Pépin
Book review + Notice
No 7 JULY 1998 Editorial
Regulation of granulocyte apoptosis and implications for anti-inflammatory therapy FE R Chilvers,
A G Rossi, ¥ Murray, C Haslett
Occasional note
Lump sum compensation for asbestos related lung disease JT Williams, P Slade, ¥R aeburn
BTS guidelines
Chemotherapy and management of tuberculosis in the United Kingdom: recommendations 1998
Joint Tuberculosis Committee of the British Thoracic Society
Original articles
Birth weight, childhood lower respiratory tract infection, and adult lung function SO Shaheen,
4A C Sterne, $S Tucker, C du V Florey
Cryptococcosis in HIV negative patients: findings on chest radiography LD ¥ Roebuck, D A Fisher,
B F Currie
Risk of non-fatal cardiac failure and ischaemic heart disease with long acting 8, agonists RM Martin,
N R Dunn, S N Freemantle, R D Mann
Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects
¥ A Nightingale, D F Rogers, L A Hart, S A Kharitonov, K F Chung, P # Barnes
Effect of exercise induced hypoxaemia on myocardial repolarisation in severe chronic obstructive
pulmonary disease RP Smith, M K Johnson,f Ashley, S T Rudkin, R ¥ White
Glucocorticoids decrease c-fos expression in human nasal polyps in vivo ¥~ N Baraniuk, G Wong, M Ah,
M Sabol, T Troost
Short papers
Inhaled corticosteroids reduce neutrophilic bronchial inflammation in patients with chronic obstructive
pulmonary disease M Confalonieri, E Mainardi, R Della Porta, S Bernorio, L Gandola, B Beghée,
A Spanevello
Pituitary adenylate cyclase activating peptides relax human pulmonary arteries by opening of K,,,. and K
channels L Bruch, S Rubel, A Kastner, K Gellert, M Gollasch, C Witt
Review series
Genetics and pulmonary medicine 3: Genetic susceptibility to tuberculosis in human populations
R Bellamy
Occasional reviews
Iron metabolism in the lower respiratory tract F Mateos, ¥ H Brock, 7 L Pérez-Arellano
Role of transcription factors in inflammatory lung diseases JI Rahman, W MacNee
Pulmonary neuronal M. muscarinic receptor function in asthma and animal models of hyperreactivity
8 W Costello, D B Jacoby, A D Fryer
Case reports
Commentary PA Corris
Single lung transplantation for adult respiratory distress syndrome after paraquat poisoning M Licker,
A Schweizer, L Hohn, D R Morel, A Spiliopoulos
Heart lung transplantation in a patient with end stage lung disease due to common variable
immunodeficiency A T Hill, R A Thompson, ¥ Wallwork, D E Stableforth
Letters to the editor
COPD Guidelines M Perry;reply M G Pearson, P M A Calverley * COPD Guidelines R Jones * Travel
by air for patients with COPD R K Sinha; reply M G Pearson, P M A Calverley + Guidelines on
pulmonary embolism C WH Davies; reply A Miller «+M alignant neoplasms in pulmonary sarcoidosis
¥ M Reich; reply N Seersholm, ¥ Vestbo, K Viskum
Book review + Notices
No 8 AUGUST 1998 Editorials
Is sleep disordered breathing associated with increased mortality? ¥A Fleetham
Small airways: a time to revisit? D ¥ Evans, M Green
Original articles
Increased mortality among sleepy snorers: a prospective population based study E Lindberg, C Janson,
K Svdardsudd, T Gislason, } Hetta, G Boman
The prevalence of clinically significant sleep apnoea syndrome in the Netherlands A Knuistingh Neven,
H A M Middelkoop, B Kemp, H A C Kamphuisen, M P Springer
Evaluation of an auto-CPAP device for treatment of obstructive sleep apnoea 7H Ficker,G H Wiest,
G Lehnert, B Wiest, EG Hahn
Association of years of occupational quartz exposure with spirometric airflow limitation in Norwegian men
aged 30-46 years S Humerfelt,G E Eide, A Gulsvik
Fluticasone propionate 750 yg/day versus beclomethasone dipropionate 1500 pg/day: comparison of
efficacy and adrenal function in paediatric asthma D Fitzgerald, P Van Asperen, C Mellis, M Honner,
L Smith, G Ambler
Individual allergens as risk factors for bronchial responsiveness in young adults S Chinn, D Farvis,
C Luczynska, P Burney
Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1
in airway macrophages in asthma: a new marker of oxidative stress JI Horvath, L E Donnelly, A Kiss,
P Paredi, S A Kharitonov, P ¥ Barnes
Influence of atmospheric nitric oxide concentration on the measurement of nitric oxide in exhaled air
M Corradi, A Pelizzoni, M Majori, A Cuomo, E de’ Munari, A Pesci
Acute inhalation of cigarette smoke increases lower respiratory tract nitric oxide concentrations
D C Chambers, W S Tunnicliffe, 7 G Ayres
680 Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric
oxide LP Ho, FA Innes, A P Greening
685 Increases in CD4+ T lymphocytes, macrophages, neutrophils and interleukin 8 positive cells in the airways
of patients with bronchiectasis M Gaga, A M Bentley, M Humbert, ¥}B arkans, F O’Brien, C G Wathen,
A B Kay, S R Durham
Interstitial laser photocoagulation of normal lung parenchyma in rats D / Fielding, G Buonaccorsi,
A Hanby, M R Hetzel, S G Bown
Review series
Genetics and pulmonary medicine 4: Pulmonary embolism M Laffan
Occasional reviews
Current role of positron emission tomography in thoracic oncology V ¥ Lowe, K S Naunheim
Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists Y Amrani,
RA Panettieri Fr
Case report
Human syngamosis: the first case in Korea H Y Kim, S M Lee, J-E Foo, M 7 Na, M H Ahn, D Y Min
Letters to the editor
Cyclo-oxygenase A Sampson, S Holgate, K F Austen, A Szczeklik; reply 7 A Mitchell,
M G Belvisi + Intrapleural streptokinase 7% Porter, A P Banning
Notice
No 9 SEPTEMBER 1998 | Pz Editorials
Quality of life in cystic fibrosis D ¥ French
Management of persistent dry cough F O’Connell
Respiratory intensive care in Europe: lessons forthe UK M W Elliott, S V Baudouin
Original articles
Quality of life in patients with cystic fibrosis and their parents: what is important besides disease severity?
D Staab, K Wenninger, N Gebert, K Rupprath, S Bisson, M Trettin, K D Paul, K M Keller, U Wahn
Long term follow up of changes in FEV, and treatment intensity during Pseudomonas aeruginosa
colonisation in patients with cystic fibrosis M Ballmann, P Rabsch, H von der Hardt
Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic
protocol LL PA McGarvey, L G Heaney, } T Lawson, B T Fohnston, C M Scally, M Ennis, D R T Shepherd,
b MacMahon
Asthma control during long term treatment with regular inhaled salbutamol and salmeterol D R Taylor,
G I Town, G P Herbison, D Boothman-Burrell, E M Flannery, B Hancox, E Harré, K Laubscher, V Linscott,
C M Ramsay, G Richards, with the technical assistance of ¥ Cowan, N Holbrook, C McLachlan, S Rigby
Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time
F L Faul, C T Leonard, C M Burke, V ¥ Tormey, L W Poulter
Core guidelines for the discharge home of the child on long term assisted ventilation in the United
Kingdom = E Fardine, C Wallis
Exertional dyspnoea in patients with airway obstruction, with and without CO, retention
S G M Cloosterman, I D Hofland, C P van Schayck, H Th M Folgering
Exhalation flow and pressure-controlled reservoir collection of exhaled nitric oxide for remote and delayed
analysis P Paredi, S Loukides, S Ward, D Cramer, M Spicer, S A Kharitonov, P ¥ Barnes
Influence of nasal obstruction on auto-CPAP behaviour during sleep in sleep apnoea/hypopnoea syndrome
C Lafond, F Sériés
Prospective study on the effect of smoking and nicotine substitution on leucocyte blood counts and
relation between blood leucocytes and lung function E ¥ Fensen, B Pedersen, R Frederiksen, R Dahl
Short paper
Effect of the number of peak expiratory flow readings per day on the estimation of diurnal variation
P F G Gannon, D T Newton, C F A Pantin, P S Burge
Review series
Genetics and pulmonary medicine — 5: Genetics of drug resistant tuberculosis A Telenti
Occasional reviews
Intermediate respiratory intensive care units in Europe: a European perspective S Nava, M Confalonieri,
C Rampulla
Similarities and discrepancies between exacerbations of asthma and chronic obstructive pulmonary disease
L Fabbri, B Beghé, G Caramori, A Papi, M Saetta
Case reports
809 Serum KL-6 level as a monitoring marker in a patient with pulmonary alveolar proteinosis M Nakajima,
T Manabe, Y Niki, T Matsushima
Reactivation of coccidioidomycosis in a fit American visitor FM K Williams, V Markides, ¥E dgeworth,
A F Williams
Letters to the editor
Comparison of outcome measures in patients with COPD M Ferrer, ¥ Alonso, L Prieto, ¥ M Anto; reply
R Harper, ¥ Brazier, ¥ Waterhouse * CFA with preserved lung volumes WN Strickland, ¥M B Hughes; reply
M F Doherty, P M A Calverley * Serum adenosine deaminase activity in pleural effusion V Singh, S Kharb,
P S Ghalaut, A Fanmeja
814 Book reviews + Notice
No 10 OCTOBER 1998 Page
Editorials
815
The acute respiratory distress syndrome: fibrosis in the fast lane R Marshall, G Bellingan, G Laurent
818
Improving donor lung evaluation: a new approach to increase organ supply for lung transplantation
A F Fisher, ¥}H Dark, P A Corris
A fresh look at p-dimer in suspected pulmonary embolism A C Miller
Original articles
Fibroproliferation and mast cells in the acute respiratory distress syndrome 7 M Liebler, Z Qu, B Buckner,
M R Powers, ¥ T Rosenbaum
Usefulness of p-dimer, blood gas, and respiratory rate measurements for excluding pulmonary embolism
P Egermayer, G I Town, ¥G Turner, D C Heaton, A L Mee, M E F Beard
Effect of the leukotriene receptor antagonist pranlukast on cellular infiltration in the bronchial mucosa of
patients with asthma Y Nakamura, M Hoshino, ¥ ¥ Sim, K Ishu, K Hosaka, T Sakamoto
Air pollution, pollens, and daily admissions for asthma in London 1987-92 H R Anderson,
A Ponce de Leon, ¥#M Bland, ¥ S Bower, } Emberlin, D P Strachan
An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased
methacholine responsiveness following chronic exposure to aerosolised allergen ¥ Temelkovski, S P Hogan,
D P Shepherd, P S Foster, R K Kumar
Pulmonary artery pressure variation in patients with connective tissue disease: 24 hour ambulatory
pulmonary artery pressure monitoring DA Raeside,G Chalmers, ¥C lelland, R Madhok, A F Peacock
Survey of non-invasive ventilation (NIPPV) in patients with acute exacerbations of chronic obstructive
pulmonary disease (COPD) inthe UK M # Doherty, M A Greenstone
Increased levels of exhaled carbon monoxide in bronchiectasis: a new marker of oxidative stress
I Horvath, S Loukides, T Wodehouse, S A Kharitonov, P ¥ Cole, P ¥ Barnes
Mycobacterium tuberculosis DNA in tissues affected by sarcoidosis M L Wilsher, R E Menzies, M C Croxson
Short papers
Updating UK estimates of age, sex and period specific cumulative constant tar cigarette consumption per
adult BA Forey, P N Lee, ¥ S Fry
Silver/silver chloride electrodes for measurement of potential difference in human bronchi I Fayac,
¥ Lacronique, A Lockhart, ¥ Dall’Ava-Santucci, D ¥ Dusser
Endogenous nitric oxide in patients with stable COPD: correlates with severity of disease E Chm,
L Bianchi, M Pagani, N Ambrosino
Review series
Health effects of passive smoking — 9: Parental smoking and spirometric indices in children D G Cook,
D P Strachan, I M Carey
Genetics and pulmonary medicine — 6: Immotile cilia syndrome: past, present, and prospects for the
future BA Afzelius
Occasional review
Respiratory illness: a complementary perspective G T Lewith
Case reports
905 Disseminated Penicillium marneffei infection presenting as a right upper lobe mass in an HIV positive
patien H McShane, C M Tang, C P Conlon
906 Flitting radiographic shadows: an unusual presentation of cancer in the lungs WM Edmondstone
908 Book reviews - Notices
No 11 NOVEMBER 1998 Page Editorials
909 Asthma in African cities P Cullinan
911 Infections in asthma and allergy SA Lewrs
913 Viruses and asthma exacerbations N G Papadopoulos, S L Fohnston
Rapid communication
Telomerase activity in human pleural mesothelioma K Dhaene, R Hiibner, S Kumar-Singh, B Weyn,
E Van Marck
Original articles
Prevalence of exercise induced bronchospasm in Kenyan school children: an urban-rural comparison
L W Ne’ang’a, ¥ A Odhiambo, M W Mungai, C M Gicheha, P Nderitu, B Maingi, P T Macklem,
M R Becklake
Early childhood infection and atopic disorder JIS Faroogi, 7 M Hopkin
Repeatability of lung function tests during methacholine challenge in wheezy infants C Delacourt,
M-R Benoist, S Waernessyckle, P Rufin, J-¥ Brouard, F de Blic, P Scheinmann
Environmental correlates of impaired lung function in non-smokers with severe a,-antitrypsin deficiency
PiZZ E Putulainen, G Tornling, S Eriksson
Effect of breathing circuit resistance on the measurement of ventilatory function D P Fohns,CM Ingram,
S Khov, P D Rochford, E H Walters
Impact of nasal ventilation on survival in hypercapnic Duchenne muscular dystrophy A K Simonds,
F Muntoni, S Heather, S Fielding
Comparison of spontaneous and induced sputum for investigation of airway inflammation in chronic
obstructive pulmonary disease A Bhowmik, TA R Seemungal, R F Sapsford, 7 L Devalia, } A Wedzicha
Efficacy of nasal continuous positive airway pressure therapy in chronic heart failure: importance of
underlying cardiac rhythm 7 UL Kiely, P Deegan, A Buckley, P Shiels, B Maurer, W T McNicholas
Gastro-oesophageal reflux related cough and its response to laparoscopic fundoplication C # Allen,
M Anvari
Detection of anti-cytokeratin 8 antibody in the serum of patients with cryptogenic fibrosing alveolitis and
pulmonary fibrosis associated with collagen vascular disorders N Dobashi, ¥#F ujita, Y Ohtsuki, I Yamadori,
T Yoshinouchi, T Kamei, M Tokuda, S Hojo, H Okada, ¥ Takahara
Effects of Aspergillus fumigatus culture filtrate on antifungal activity of human phagocytes in vitro
T Murayama, R Amitani, Y Ikegami, R Kawanami, W F Lee, R Nawada
Review series
Genetics and pulmonary medicine 7: Somatic mutations in the development of lung cancer
M Roland, R M Rudd
Occasional reviews
Methodology of bronchial responsiveness S Chinn
Renal and hormonal abnormalities in chronic obstructive pulmonary disease (COPD) P Palange
Airway hyperresponsiveness in asthma: not just a matter of airway inflammation V Brusasco, E Crimi,
R Pellegrino
Case report
999 Commentary: Retransplantation in a patient with cystic fibrosis D Geddes
1000 Retransplantation in a patient with cystic fibrosis M McCloskey, A P Maxwell, V Hall, A O B Redmond,
7 S Elborn
Letter to the editor
Rifampicin containing antituberculosis medication GF Cavell, D C S Hutchison, B C Whiteman
Book review +« Notice
No 12 DECEMBER 1998 Page Editorials
1003 DNase in cystic fibrosis: the challenge of assessing response and maximising benefit 7A Innes
1005 Societal and health care benefits of early use of inhaled steroids T Haahtela, T Klaukka
1007 Augmentation therapy for severe @,-antitrypsin deficiency: is the jury still out on atrial? 7 K Stoller
Rapid communication
1010 Effects of formoterol on histamine induced plasma exudation in induced sputum from normal subjects
L Greiff, P Wollmer, M Andersson, C Svensson, C G A Persson
Original articles
Long term effects of aerosolised rhDNase on pulmonary disease progression in patients with cystic fibrosis
C E Milla
Contribution of genetic factors other than CFTR to disease severity in cystic fibrosis ¥ Hull,
A H Thomson
Alpha-1 antitrypsin deficiency alleles and severe cystic fibrosis lung disease R Mahadeva, S Stewart,
D Bilton, D A Lomas
First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthma
L Blais, S Suissa, J-F Boivin, P Ernst
Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and
disease severity despite treatment with oral and inhaled corticosteroids RG Stirling, S A Kharitonov,
D Campbell, D S Robinson, S R Durham, K F Chung, P ¥ Barnes for the Asthma and Allergy Group
Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence T Nicolai, S Illi,
E von Mutius
Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D.,,
and bronchial responsiveness to methacholine S O’Sullivan, S-E Dahlen, K Larsson, B-M Larsson,
P Malmberg, M Kumlin, L Palmberg
Inflammatory response after inhalation of bacterial endotoxin assessed by the induced sputum technique
¥ Thorn, R Rylander
Cross-colonisation with Pseudomonas aeruginosa of patients in an intensive care unit DC ¥ ¥ Bergmans,
M # M Bonten, F H van Tiel, C A Gaillard, S van der Geest, R M Wilting, P W de Leeuw, E E Stobberingh
Urinary cGMP concentrations in severe primary pulmonary hypertension M Bogdan, M Humbert,
¥ Francoual, C Claise, P Duroux,G Simonneau, A Lindenbaum
Short paper
Glucocorticoid insensitive asthma: a one year clinical follow up pilot study P Demoly, DF affuel,
M Mathieu, H Sahla, P Godard, F-B Michel, ¥} Bousquet
Occasional reviews
1066 Review of psychosocial stress and asthma: an integrated biopsychosocial approach R # Wright,
M Rodriguez, S Cohen
1075 Cellular responses to hypoxia in the pulmonary circulation SO Brij, A ¥ Peacock
1080 Clinical usefulness of high resolution computed tomography in cryptogenic fibrosing alveolitis A Wells
Case reports
1088 Commentary DM Hansell
1089 Diagnosis of pulmonary sequestration by spiral CT angiography 7 Franco, R Aliaga, M L Domingo,
P Plaza
1092 Interventricular septal shift due to massive pulmonary embolism shown by CT pulmonary angiography: an
old sign revisited 7B Oliver, 7H Reid, ¥ T Murchison
Letters to the editor
1094 Cardiac risks with § agonists B Lindmark; R M Martin, N R Dunn, R D Mann, S N Freemantle +
Genetics and tuberculosis GH Bothamley * Chlamydia pneumoniae and asthma F Blasi, L Allegra,
P Tarsia; D L Hahn + Non-Hodgkin’s lymphoma with CFA — A Nicholson, B Corrin; T R Orchard,
C D Eraut, A G Davison
1096 Book reviews * Correction
Supplement No 1 BTS Recommendations to Respiratory Physicians for Organising the Care of Patients with Lung
JUNE 1998 Cancer
Introduction
Recommendations
Treatment
Organisation of cancer units in the UK
Appendix 1: Grading scheme for recommendations in the guidelines
References
Supplement No 2 1998 Year in Review
AUGUST 1998 Introduction D # Hendrick, DM Mitchell
In search of a cause of cryptogenic fibrosing alveolitis (CFA): one initiating factor or many?
M Turner-Warwick
Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease H Koyama, D M Geddes
Update on the “Dutch hypothesis” for chronic respiratory disease 7 Véestbo, E Prescott
Diving and the risk of barotrauma E W Russi
Spiral computed tomographic scanning and magnetic resonance angiography for the diagnosis of
pulmonary embolism PA Grenier, C Beigelman
Strategy and cost in investigating solitary pulmonary nodules M K Gould, G A Lillington
The cost to society of smoking cesstion D Cohen, G Barton
Persistent respiratory effects in survivors of the Bhopal disaster WS Beckett
Role of the indoor environment in determining the severity of asthma A Woodcock, A Custovic
Effects of anti-IgE in asthmatic subjects A ¥ Frew
Oral appliances for the management of snoring and obstructive sleep apnoea _ L S Bennett, R ¥ O Davies,
F R Stradling
Use of fibrinolytic agents in the management of complicated parapneumonic effusions and empyemas
S A Sahn
Supplement No 3 The Cardiovascular Implications of Sleep Disordered Breathing
OCTOBER 1998 Introduction 3¥A Fleetham
“he study of human sleep: a historical perspective WC Dement
Sleep apnoea and snoring: potential links with vascular disease C E Sullivan, SG McNamara
Sleep apnoeain women WN Edwards, I Wilcox, C E Sullivan
Epidemiological insights into the public health burden of sleep disordered breathing: sex differences in sur-
vival among sleep clinic patients 7 Young, L Finn
Sleep apnoea and autonomic function C W Zwillich
“Syndrome Z”: the interaction of sleep apnoea, vascular risk factors and heart disease I Wilcox,
S G McNamara, F L Collins, R R Grunstein, C E Sullivan
Heart block in patients with sleep apnoea H F Becker, U Koehler, A Stammnitz, ¥H Peter
Prognosis and sleep disordered breathing in heart failure J Wilcox, S G McNamara, T Wessendorf,
GN Willson, A F Piper, C E Sullivan
Impact of treatment of sleep apnoea on left ventricular function in congestive heart failure
M T Naughton
Treatment of central sleep apnoea in congestive heart failure with nasal ventilation GN Willson,
I Wilcox, A‘¥ Piper, W E Flynn, R R Grunstein, C E Sullivan
CPAP therapy: outcomes and patient use N ¥ Douglas, H M Engleman
Intelligent CPAP systems: clinical experience H Teschler,M Berthon-fFones
Supplement No 4 British Thoracic Society Winter Meeting 1998 Programme and Abstracts
DECEMBER 1998
Supplement No 5 Smoking Cessation Guidelines and their Cost Effectiveness
DECEMBER 1998 Part 1: Smoking Cessation Guidelines for Health Professionals
About these guidelines
Recommendations
Section 1: Introduction
Section 2: Recommendations for the primary care team
Section 3: Recommendations for all health professionals
Section 4: Recommendations for smoking cessation specialists
Section 5: Nicotine replacement therapy
Section 6 Other populations and topics
$13 Hospital patients
$13 Pregnant smokers
S13 Young people
S13 Low income smokers
$14 Sex
$14 Weight gain
$14 Other treatments
$14 No Smoking Day
$14 Telephone help lines
$14 Training
Section 7: Recommendations for health commissioners
References
Part 2: Guidance for Commissioners on the Cost Effectiveness of
Smoking Cessation Interventions
About this guidance
Section 1: Introduction
Section 2: The case for smoking cessation
Section 3: Effectiveness
Section 4: Cost
Section 5: Cost effectiveness
Section 6: Conclusions
Appendices
Appendix 1: Key cost effectiveness studies
Appendix 2: A review of smoking cessation cost effectiveness studies
Appendix 3: An introduction to discounting
Appendix 4: Incremental cost effectiveness
References
