Table Of ContentTHE PHYSIOLOGICAL GENOMICS
OF THE CRITICALLY ILL MOUSE
BASIC SCIENCE FOR THE CARDIOLOGIST
1. B. Swynghedauw (ed.): Molecular Cardiology for the Cardiologist. Second
Edition. 1998 ISBN 0-7923-8323-0
2. B. Levy, A. Tedgui (eds.): Biology of the Arterial Wall 1999
ISBN 0-7923-8458-X
3. M.R. Sanders, J.B. Kostis (eds.): Molecular Cardiology in Clinical
Practice. 1999 ISBN 0-7923-8602-7
4. B.Ostadal, F. Kolar (eds.): Cardiac Ischemia: From Injury to Protection. 1999
ISBN 0-7923-8642-6
5. H. Schunkert, G.A.J. Riegger (eds.): Apoptosis in Cardiac Biology. 1999
ISBN 0-7923-8648-5
6. A. Mälliani, (ed.): Principles of Cardiovascular Neural Regulation in Health
and Disease. 2000 ISBN 0-7923-7775-3
7. P. Benlian: Genetics of Dyslipidemia. 2001 ISBN 0-7923-7362-6
8. D. Young: Role of Potassium in Preventive Cardiovascular Medicine. 2001
ISBN 0-7923-7376-6
9. E. Carmeliet, J. Vereecke: Cardiac Cellular Electrophysiology. 2002
ISBN 0-7923-7544-0
10. C. Holubarsch: Mechanics and Energetics of the Myocardium. 2002
ISBN 0-7923-7570-X
11. J.S. Ingwall: ATP and the Heart. 2002 ISBN 1-4020-7093-4
12. W.C. De Mello, M.J. Janse: Heart Cell Coupling andImpuse Propagation in
Health and Disease. 2002 ISBN 1 -4020-7182-5
13. P.P.-Dimitrow: Coronary Flow Reserve - Measurement and Application: Focus
on transthoracic Doppler echocardiography. 2002 ISBN 1 -4020-7213-9
14. G.A. Danieli: Genetics and Genomics for the Cardiologist. 2002
ISBN 1-4020-7309-7
15. F.A. Schneider, LR. Siska, J. A. Avram: Clinical Physiology of the Venous System.
2003 ISBN 1-4020-7411-5
16. Can Ince: Physiological Genomics of the Critically III Mouse. 2004
ISBN 1-4020-7641-X
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
THE PHYSIOLOGICAL GENOMICS
OF THE CRITICALLY ILL MOUSE
edited by
CAN INCE
Department of Physiology
Academic Medical Center
University of Amsterdam
The Netherlands
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publieation Data
A CLP. Catalogue record for this book is available
from the Library of Congress.
The Physiological Genomics of the Critically 111 Mouse edited by Can Ince
ISBN 978-1-4613-5099-6 ISBN 978-1-4615-0483-2 (eBook)
DOI 10.1007/978-1-4615-0483-2
Copyright © 2004 by Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers in 2004
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Content
Contributing Authors IX
Foreword xvii
Section I: Physiological Monitoring of the Mouse
Assessment of quality in commercially supplied genetically modified
animals
ADRIAN A. DEENY 3
Cannulation techniques for multiple blood withdrawal in mice
EDWIN SPOELSTRA AND RENE REMIE II
Mouse anesthesia in relation to optimal hemodynamics
COERT J. ZUURBIER, VANESSA M. EMONS, ANNEKE KOEMAN AND
CAN INCE 23
Mechanical ventilation of mice
LOTHAR A. SCHWARTE AND CAN INCE 35
Mouse echocardiography
A TTILA KOVACS AND MICHAEL COURTOIS 53
Optical Spectroscopy in mice
EGBERT G. MIK AND CAN INCE 73
vi Physiological Genomics of the Critically III Mouse
ECG monitoring and analyses in mice
Ivo AMENDE, J. MATTHEW DUBACH, KATRINA PISKORSKI,JAMES P.
MORGAN, AND THOMAS G. HAMPTON 89
High-definition magnetic resonance of genetically modified mice
KLAAS NICOLAY, GUSTAV J. STRUKERS, JEANINE J. PROMPERS, AND
MAARTEN R. DROST 101
Pet studies in the mouse
ADRIAAN A. LAMMERTSMA 119
Mouse telemetry for long-term monitoring
KLAAS KRAMER AND STEVE HACHTMAN 127
Section II: Cardiovascular Pathophysiology of the Mouse 143
Physiological genomics of reperfusion injury
THORSTEN VOWINKEL AND D. NEIL GRANGER 145
iNOS-deficient mice in the study of resuscitated sepsis
STEVEN M. HOLLENBERG. 159
The microcirulation in hypercholesterolemic mice
ALINA CONSTANTINESCU AND HANS VINK 179
The mouse in shock
MARTIN G. SCHWACHA AND IRS HAD H. CHAUDRY 187
Expression systems to analyze trans genes in the heart
PETRA E.M.H. HABETS, ANTOON F.M. MOORMAN AND VINCENT M.
CHRISTOFFELS 201
Structural and functional adaptations of the heart after coronary artery
ligation in the Mouse
BEN JANSSEN, TUL DE CELLE, JOS PAQUAY, Jos SMITS, AND
MATTHIJS BLANKESTEIJN 211
Mouse models of sepsis
GERD ALBUSZIES 225
Physiological Genomics oft he Critically III Mouse vii
Mouse models for arterial thrombosis: does clotting make a difference in
human cardiovascular disease?
HJALMAR HANSEN AND HUGO TEN CATE 239
Identification of mouse models of cardiovascular disease using
mutagenesis
KAREN L. SVENSON 257
Acute lung injury and pneumonia in mice
MARCUS J. SCHULTZ AND TOM V AN DER POLL 275
Section III: Treating the Critically III Mouse 289
Endothelial nitric oxide synthase in cardiovascular homeostasis and disease
DIRK J. DUNCKER, RIEN VAN HAPEREN, ELZA VAN DEEL, MONIQUE
DE W AARD, BAREND MEES, RINI DE CROM 291
Arteriogenesis in mice
IMO E HOEFER, MICHIEL V OSKUIL AND NIELS VAN ROYEN. 311
Mouse models to study pro- and anti-angiogenic potential: novel roles for
PIGF and Fltl
LIEVE MOONS, AERNOUT LUTTUN, PETER CARMELIET AND ED
CONWAY 329
Stem cell therapy in the mouse heart
DOUWE E. ATSMA 349
Gene therapy for the critically ill mouse
PHILIP A. EFRON AND LYLE L. MOLDA WER 363
Index 383
Contributing Authors
Gerd Albuszies
Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung
Universitatsklinik fUr Anasthesiologie Universitat Ulm, Ulm, Germany.
IvoAmende
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston,
Massachusetts USA.
DouweAtsma
Department of Cardiology, Leiden University Medical Center, P.O.Box
9600,2300 RC Leiden, the Netherlands.
Matthijs B1ankesteijn
Department of Pharmacology &Toxicology, Cardiovascular Research
Institute Maastricht (CARIM), University of Maastricht, Maastricht, the
Netherlands.
Peter Carmeliet
The Center for Transgene Technology and Gene Therapy, Flanders
Interuniversity Institute for Biotechnology, KU Leuven, Leuven, B-3000,
Belgium.
Hugo ten Cate
Laboratory for Clinical Thrombosis and Hemostasis, Cardiovascular
Research Institute Maastricht, University of Maastricht, the Netherlands.
Irshad H. Chaudry
Center for Surgical Research and Department of Surgery, University of
Alabama at Birmingham, Birmingham, Alabama, USA.
Vincent M. Christoffels
Experimental and Molecular Cardiology Group, Academic Medical Center,
University of Amsterdam, Meibergdreef9, 1105 AZ Amsterdam, the
Netherlands.
x Physiological Genomics oft he Critically III Mouse
Alina Constantinescu
Department of Medical Physics, Academic Medical Center, University of
Amsterdam, Meibergdreef9, 1105 AZ Amsterdam the Netherlands.
Michael Courtois
Center for Cardiovascular Research, Washington University School of
Medicine,660 South Euclid Avenue, POBox 8086, 63110, St. Louis,
Missouri, USA.
Tijl De Celie
Department of Pharmacology &Toxicology, Cardiovascular Research
Institute Maastricht (CARIM), University of Maastricht, Maastricht, the
Netherlands.
Ed Conway
The Center for Transgene Technology and Gene Therapy, Flanders
Interuniversity Institute for Biotechnology, KU Leuven, Leuven, B-3000,
Belgium.
Rini de Crom
Departments of Cell Biology & Genetics and Vascular Surgery" Erasmus
Medical Center, University Medical Center Rotterdam, Rotterdam, the
Netherlands.
Elza van Deel
Division of Experimental Cardiology, Cardiology, Thoraxcenter, Erasmus
Medical Center, University Medical Center Rotterdam, Rotterdam, the
Netherlands.
Adrian A. Deeny
Harlan UK Ltd, Hillcrest, Dodgeford Lane, Belton, Nr Loughborough,
Leicestershire, United Kingdom.
Maarten R. Drost
Department of Movement Sciences, Maastricht University, Maastricht, the
Netherlands.
J. M. Dubach
Mouse Specifics, Inc. 28 State Street, Suite 1110
Boston, Massachusetts 02109, USA.
Physiological Genomics oft he Critically III Mouse xi
Dirk J. Duncker
Division of Experimental Cardiology, Cardiology, Thoraxcenter, Erasmus
Medical Center, University Medical Center Rotterdam, Rotterdam, the
Netherlands.
Philip A. Efron
Surgical Research Laboratory, Department of Surgery, University of Florida
College of Medicine Shands Hospital, 1600 SW Archer Road PO Box
100286 Gainesville, Florida, 32610-0286 USA.
Vanessa M. Emons
Department of Anesthesiology and Physiology, Academic Medical Center,
University of Amsterdam, Meibergdreef9, 1105 AZ Amsterdam, the
Netherlands.
D. Neil Granger
Department of Molecular and Cellular Physiology, Louisiana State
University Health Sciences Center, Shreveport, Louisiana, USA.
Petra E.M.H. Habets
Experimental and Molecular Cardiology Group, Academic Medical Center,
University of Amsterdam, Meibergdreef9, 1105 AZ Amsterdam, the
Netherlands.
Steve Hachtman
Data Sciences International 4358 West Round Lake Road, St. Paul,
Minnesota 55126, USA.
Thomas G. Hampton
Beth Israel Deaconess Medical Center, Harvard Medical School,
and Mouse Specifics, Inc. 28 State Street, Suite 1 I 10
Boston, Massachusetts 02109, USA.
Hjalmar Hansen
Laboratory for Experimental Internal Medicine' Academic Medical Center,
University of Amsterdam, Meibergdreef9, 1105 AZ Amsterdam, the
Netherlands.
Rien van Haperen
Departments of Cell Biology & Genetics, Erasmus Medical Center,
University Medical Center Rotterdam, Rotterdam, the Netherlands.
