The Human Frontal Lobes, Third Edition: Functions and Disorders (Science and Practice of Neuropsychology)

1076 Pages·2017·9.95 MB·English

by  Bruce L. Miller & Jeffrey L. Cummings

Also Available
Frontal–Subcortical Circuits in Psychiatric and Neurological Disorders
Edited by David G. Lichter and Jeffrey L. Cummings
THE HUMAN FRONTAL LOBES
FUNCTIONS AND DISORDERS
Third Edition
EDITED BY
Bruce L. Miller
Jeffrey L. Cummings
THE GUILFORD PRESS
New York London
Epub Edition ISBN: 9781462531851; Kindle Edition ISBN: 9781462531868
Copyright © 2018 The Guilford Press
A Division of Guilford Publications, Inc.
370 Seventh Avenue, Suite 1200, New York, NY 10001
www.guilford.com
All rights reserved
No part of this book may be reproduced, translated, stored in a retrieval system, or transmitted, in any form
or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without
written permission from the publisher.
Last digit is print number: 9 8 7 6 5 4 3 2 1
Library of Congress Cataloging-in-Publication Data Names: Miller, Bruce L., 1949– editor. | Cummings,
Jeffrey L., 1948– editor.
Title: The human frontal lobes : functions and disorders / edited by Bruce L. Miller, Jeffrey L. Cummings.
Description: Third edition. | New York : The Guilford Press, [2018] | Includes bibliographical references
and index.
Identifiers: LCCN 2017028933 | ISBN 9781462531837 (hardback) Subjects: LCSH: Frontal lobes—
Physiology. | Frontal lobes—Pathophysiology. | BISAC: PSYCHOLOGY / Neuropsychology. | MEDICAL
Psychiatry General. | PSYCHOLOGY Psychopathology General. | MEDICAL / Neuroscience.
Classification: LCC QP382.F7 H85 2018 | DDC 612.8/25—dc23
LC record available at https://lccn.loc.gov/2017028933
About the Editors
Bruce L. Miller, MD, is the A. W. and Mary Margaret Clausen Distinguished
Professor of Neurology at the University of California, San Francisco (UCSF),
and Director of the UCSF Memory and Aging Center. Dr. Miller is a behavioral
neurologist focused on dementia, with special interests in brain–behavior
relationships as well as the genetic and molecular underpinnings of disease. He
currently conducts research on frontotemporal dementia, oversees a program on
healthy aging, and helps lead two privately funded research consortia. Dr. Miller
is a recipient of the Potamkin Prize from the American Academy of Neurology,
the Raymond D. Adams Lectureship from the American Neurological
Association, the J. Elliot Royer Award from the San Francisco Neurological
Society, the UCSF Annual Faculty Research Lectureship in Clinical Science, and
the Gene D. Cohen Research Award in Creativity and Aging from the National
Center for Creative Aging, among many other honors. With more than 700
scientific publications, Dr. Miller has served since 1984 as Scientific Director of
the John Douglas French Alzheimer’s Foundation. He is a member of the
National Academy of Medicine.
Jeffrey L. Cummings, MD, ScD, is Director of the Cleveland Clinic Lou Ruvo
Center for Brain Health in Las Vegas, Nevada, and Cleveland, Ohio. He is the
Camille and Larry Ruvo Chair for Brain Health at the Cleveland Clinic
Neurological Institute and Professor of Medicine at the Cleveland Clinic Lerner
College of Medicine of Case Western Reserve University. A leading authority on
Alzheimer’s disease, Dr. Cummings is interested in clinical trials, developing new
therapies for brain diseases, and the interface of neuroscience and society. He is a
recipient of the Edward Henderson Award from the American Geriatrics Society,
the Research Award from the John Douglas French Alzheimer’s Foundation, the
Ronald and Nancy Reagan Research Institute Award from the Alzheimer’s
Association, the Distinguished Scientist Award from the American Association
for Geriatric Psychiatry, and the Lifetime Achievement Award from the Society
for Behavioral and Cognitive Neurology, among many other honors. Dr.
Cummings has more than 700 scientific publications and is a past president of
the Behavioral Neurology Society and the American Neuropsychiatric
Association.
Contributors
Judith Aharon-Peretz, MD, Cognitive Neurology Unit, Rambam Health Care Campus, Haifa, Israel
Jee Bang, MD, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore,
Maryland
Sarah J. Banks, PhD, Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, Nevada
James R. Bateman, MD, Department of Neurology, University of Colorado School of Medicine, Aurora,
Colorado
Brianne M. Bettcher, PhD, Departments of Neurosurgery and Neurology, University of Colorado School of
Medicine, Aurora, Colorado Antonello Bonci, MD, National Institute on Drug Abuse, Bethesda, Maryland;
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore,
Maryland Kyle Brauer Boone, PhD, California School of Forensic Studies, Alliant International University,
and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los
Angeles, California Nigel J. Cairns, PhD, Department of Neurology, Washington University School of
Medicine, St. Louis, Missouri
Billy T. Chen, PhD, Corporate Development, Ionis Pharmaceuticals, Inc., Carlsbad, California
Winston Chiong, MD, PhD, Memory and Aging Center, Department of Neurology, University of
California, San Francisco, San Francisco, California Helena C. Chui, MD, Department of Neurology, Keck
School of Medicine, University of Southern California, Los Angeles, California Julia Chung, MD,
Department of Psychiatry and Biobehavioral Sciences, Harbor–UCLA Medical Center, Torrance, California
Jeffrey L. Cummings, MD, Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, Nevada
Mary G. De May, MD, Memory and Aging Center, Department of Neurology, University of California, San
Francisco, San Francisco, California Mark D’Esposito, MD, Department of Psychology, University of
California, Berkeley, Berkeley, California
Orrin Devinsky, MD, Department of Neurology, New York University School of Medicine, New York, New
York Nicholas B. Diamond, MA, Department of Psychology, University of Toronto, and Rotman Research
Institute, Baycrest, Toronto, Ontario, Canada Darin D. Dougherty, MD, Department of Psychiatry,
Massachusetts General Hospital and Harvard Medical School, Belmont, Massachusetts Simon Ducharme,
MD, Department of Psychiatry, McGill University Health Centre, McGill University, Montréal, Québec,
Canada Annette L. Ermshar, PhD, Dr. Ermshar and Associates, San Marino, California
Christopher M. Filley, MD, Departments of Neurology and Psychiatry, University of Colorado School of
Medicine, Aurora, Colorado Daniel Fulford, PhD, Department of Psychological and Brain Sciences, Boston
University, Boston, Massachusetts
Adam Gazzaley, MD, Department of Neurology, University of California, San Francisco, San Francisco,
California Daniel H. Geschwind, MD, PhD, Department of Neurology, University of California, Los
Angeles, Los Angeles, California Kelly Gola, PhD, Memory and Aging Center, Department of Neurology,
University of California, San Francisco, San Francisco, California Marlís González-Fernández, MD, PhD,
Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine,
Baltimore, Maryland Maria Luisa Gorno-Tempini, MD, Memory and Aging Center, Department of
Neurology, University of California, San Francisco, San Francisco, California Lea Tenenholz Grinberg,
MD, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San
Francisco, California Helmut Heinsen, MD, Department of Psychiatry, University of Würzburg,
Würzburg, Germany
Argye E. Hillis, MD, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore,
Maryland Sarah M. Hooper, JD, University of California Hastings College of the Law, San Francisco,
California
Alice Y. Hua, BA, Department of Psychology, University of California, Berkeley, Berkeley, California
Marco Iacoboni, MD, PhD, Department of Psychiatry and Biobehavioral Sciences, University of California,
Los Angeles, Los Angeles, California David J. Irwin, MD, Department of Pathology and Laboratory
Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Tracy L. Jerard, PhD,
Memory and Aging Center, Department of Neurology, University of California, San Francisco, San
Francisco, California Daniel I. Kaufer, MD, Department of Neurology, University of North Carolina
School of Medicine, Chapel Hill, North Carolina Eun-Joo Kim, MD, Department of Neurology, Pusan
National University Hospital, Pusan, South Korea
Joel H. Kramer, PsyD, Memory and Aging Center, Department of Neurology, University of California, San
Francisco, San Francisco, California Anthony E. Lang, MD, Toronto Western Hospital and Division of
Neurology, University of Toronto, Toronto, Ontario, Canada Taraz G. Lee, PhD, Department of
Psychology, University of Michigan, Ann Arbor, Michigan
Virginia M.-Y. Lee, PhD, Department of Pathology and Laboratory Medicine, University of Pennsylvania
School of Medicine, Philadelphia, Pennsylvania Gabriel C. Léger, MD, Lou Ruvo Center for Brain Health,
Cleveland Clinic, Las Vegas, Nevada
Ira Lesser, MD, Department of Psychiatry and Biobehavioral Sciences, Harbor–UCLA Medical Center,
Torrance, California Brian Levine, PhD, Department of Psychology, University of Toronto, and Rotman
Research Institute, Baycrest, Toronto, Ontario, Canada Anli Liu, MD, Department of Neurology, New York
University School of Medicine, New York, New York
Carol A. Mathews, MD, Department of Psychiatry, University of Florida College of Medicine, Gainesville,
Florida Bruce L. Miller, MD, Memory and Aging Center, Department of Neurology, University of
California, San Francisco, San Francisco, California Georges Naasan, MD, Memory and Aging Center,
Department of Neurology, University of California, San Francisco, San Francisco, California Jennifer Ogar,
MD, Center for Aphasia and Related Disorders, Veterans Affairs Northern Health Care System, Martinez,
California David C. Perry, MD, Memory and Aging Center, Department of Neurology, University of
California, San Francisco, San Francisco, California Katherine L. Possin, PhD, Memory and Aging Center,
Department of Neurology, University of California, San Francisco, San Francisco, California Bruce H.
Price, MD, Department of Neurology, McLean Hospital, Harvard Medical School, Belmont, Massachusetts
Liliana Ramirez-Gomez, MD, Department of Neurology, University of California, San Francisco, San
Francisco, California Katherine P. Rankin, PhD, Memory and Aging Center, Department of Neurology,
University of California, San Francisco, San Francisco, California Edwin H. Rodriguez, PhD, Biophysics
Graduate Program, School of Medicine, University of California, San Francisco, San Francisco, California
Howard J. Rosen, MD, Memory and Aging Center, Department of Neurology, University of California, San
Francisco, San Francisco, California Sharon J. Sha, MD, Department of Neurology and Neuropsychological
Sciences, Stanford University School of Medicine, Stanford, California Adam M. Staffaroni, MS, Memory
and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco,
California Melanie L. Stephens, PhD, Memory and Aging Center, Department of Neurology, University of
California, San Francisco, San Francisco, California Virginia E. Sturm, PhD, Memory and Aging Center,
Department of Neurology, University of California, San Francisco, San Francisco, California Leonel Tadao
Takada, MD, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil
Maria Carmela Tartaglia, MD, Tanz Center for Research in Neurodegenerative Disease, University of
Toronto, Toronto, Ontario, Canada John Q. Trojanowski, MD, Department of Pathology and Laboratory
Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Vivianna M. Van
Deerlin, MD, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of
Medicine, Philadelphia, Pennsylvania Anne-Catherine Vijverman, MD, Toronto Western Hospital and
Division of Neurology, University of Toronto, Toronto, Ontario, Canada Sophia Vinogradov, MD,
Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota Joshua D.
Woolley, MD, Department of Psychiatry, University of California, San Francisco, and San Francisco
Veterans Affairs Medical Center, San Francisco, California Weiguo Zhu, MD, PhD, Department of
Psychiatry and Biobehavioral Sciences, Harbor–UCLA Medical Center, Torrance, California