The Cleveland Clinic Foundation Intensive Review of Internal Medicine

428 Pages·2014·6.86 MB·English

by  James K. Stoller MD

(c) 2015 Wolters Kluwer. All Rights Reserved.
The Cleveland Clinic
Foundation Intensive Review
of Internal Medicine
S I X T H E D I T I O N
(c) 2015 Wolters Kluwer. All Rights Reserved.
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The Cleveland Clinic
Foundation Intensive Review
of Internal Medicine
S I X T H E D I T I O N
EDITORS
n JamES K. STOllER, mD, mS, FaCP, FCCP, FaaRC
Jean Wall Bennett Professor of Emphysema Research Respiratory Institute
Samson Global Leadership Academy Endowed Chair
Chairman, Education Institute
Cleveland Clinic
Cleveland, Ohio
n CRaIG NIElSEN, mD, FaCP
Director, Internal Medicine Residency Program
Vice Chairman, Internal Medicine
Medicine Institute
Cleveland Clinic
Cleveland, Ohio
n JaNET BUCCOla, mD
Staff, Department of Hospital Medicine
Medicine Institute
Cleveland Clinic
Cleveland, Ohio
n aNDREI BRaTEaNU, mD, FaCP
Associate Program Director, Internal Medicine Residency Program
Medicine Institute
Cleveland Clinic
Cleveland, Ohio
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Executive Editor: Rebecca Gaertner
Senior Product Development Editor: Kristina Oberle
Production Project Manager: Alicia Jackson
Senior Manufacturing Manager: Beth Welsh
Design Coordinator: Stephen Druding
Production Service: Integra Software Services Pvt. Ltd.
© 2014 Wolters Kluwer Health
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5th edition, © 2009 by Lippincott Williams & Wilkins
4th edition, © 2005 by Lippincott Williams & Wilkins
3rd edition, © 2002 by Lippincott Williams & Wilkins
2nd edition, © 2000 by Lippincott Williams & Wilkins
1st edition, © 1998 by Lippincott Williams & Wilkins
All rights reserved. This book is protected by copyright. No part of this book may be reproduced in
any form by any means, including photocopying, or utilized by any information storage and retrieval
system without written permission from the copyright owner, except for brief quotations embodied
in critical articles and reviews. Materials appearing in this book prepared by individuals as part of
their official duties as U.S. government employees are not covered by the above-mentioned copyright.
Printed in the USA
Library of Congress Cataloging-in-Publication Data
The Cleveland Clinic Foundation intensive review of internal medicine/editors, James K. Stoller,
Craig Nielsen, Janet Buccola, Andrei Brateanu. — Sixth edition.
p. ; cm.
Intensive review of internal medicine
Preceded by: The Cleveland Clinic Foundation intensive review of internal medicine/editors, James
K. Stoller, Franklin A. Michota Jr., Brian F. Mandell. 5th ed. c2009.
Includes bibliographical references and index.
ISBN 978-1-4511-8656-7 (paperback)
I. Stoller, James K., editor of compilation. II. Nielsen, Craig, editor of compilation. III. Buccola,
Janet, editor of compilation. IV. Brateanu, Andrei, editor of compilation. V. Cleveland Clinic Foundation,
issuing body. VI. Title: Intensive review of internal medicine.
[DNLM: 1. Internal Medicine—Examination Questions. WB 18.2]
RC46
616.0076—dc23
2013048360
Care has been taken to confirm the accuracy of the information presented and to describe gener-
ally accepted practices. However, the authors, editors, and publisher are not responsible for errors
or omissions or for any consequences from application of the information in this book and make
no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the
contents of the publication. Application of the information in a particular situation remains the
professional responsibility of the practitioner.
The authors, editors, and publisher have exerted every effort to ensure that drug selection and dos-
age set forth in this text are in accordance with current recommendations and practice at the time
of publication. However, in view of ongoing research, changes in government regulations, and the
constant flow of information relating to drug therapy and drug reactions, the reader is urged to check
the package insert for each drug for any change in indications and dosage and for added warnings
and precautions. This is particularly important when the recommended agent is a new or infrequently
employed drug.
Some drugs and medical devices presented in the publication have Food and Drug Administration
(FDA) clearance for limited use in restricted research settings. It is the responsibility of the health-care
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Dedication
I dedicate this book to the memory of my father, Alfred Stoller (1919–2011),
whose unending love, support, and relentless tenacity have forged his sons; to my
wife, Terry, whose unceasing support and love have allowed all things; and to my
son, Jake, whose huge spirit, energy, and drive light the way forward.
James K. Stoller, MD, MS
I would like to dedicate this edition to my lovely wife Simone for her continued support and
encouragement and to my Father, Earl Nielsen, MD, for consistently role-modeling excellence.
Craig Nielsen, MD, FACP
To my daughters, my family, and my residents, who motivate and inspire me every day.
Andrei Brateanu, MD, FACP
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Contributors
Abby Abelson, MD Aaron Brzezinksi, MD
Chair Staff
Department of Rheumatic and Immunologic Diseases Center for Inflammatory Bowel Disease
Orthopedic and Rheumatology Institute Digestive Disease Institute
Cleveland Clinic Cleveland Clinic
Cleveland, Ohio Cleveland, Ohio
Abraham D. Abernethy, MD Janet Buccola, MD
Resident Physician Staff
Department of Internal Medicine/Pediatrics Department of Hospital Medicine
Case Western Reserve University Medicine Institute
Cleveland, Ohio Cleveland Clinic
Loutfi S. Aboussouan, MD Cleveland, Ohio
Staff
Matthew P. Bunyard, MD
Respiratory Institute
Staff
Cleveland Clinic
Department of Rheumatic and
Cleveland, Ohio
Immunologic Disease
M. Chadi Alraies, MD, FACP Orthopedic and Rheumatology Institute
Staff Cleveland Clinic
Department of Hospital Medicine Cleveland, Ohio
Medicine Institute
Carol A. Burke, MD
Cleveland Clinic
Director
Cleveland, Ohio
Center for Colon Polyp and Cancer Prevention
Gerald B. Appel, MD
Department of Gastroenterology and Hepatology
Professor of Clinical Medicine
Digestive Disease Institute
Department of Medicine
Cleveland Clinic
Columbia University College of Physicians and Surgeons
Cleveland, Ohio
Director of Clinical Nephrology
Columbia University Medical Center David B. Chaiffetz, MD
New York, New York Resident, Adult Psychiatry
Department of Psychiatry
Charles J. Bae, MD
Neurological Institute
Staff
Cleveland Clinic
Department of Sleep Medicine
Cleveland, Ohio
Neurological Institute
Cleveland Clinic Leslie Cho, MD
Cleveland, Ohio Director
Gerald J. Beck, PhD Women’s Cardiovascular Center
Head, Section of Clinical Trials Section Head and Medial Director, Preventive
Department of Health Sciences Cardiology and Rehabilitation
Lerner Research Institute Heart and Vascular Institute
Cleveland Clinic Cleveland Clinic
Cleveland, Ohio Cleveland, Ohio
Andrei Brateanu, MD, FACP Humberto Kukhyun Choi, MD
Associate Program Director Staff
Internal Medicine Residency Program Department of Pulmonary and Critical Care Medicine
Medicine Institute Respiratory Institute
Cleveland Clinic Cleveland Clinic
Cleveland, Ohio Cleveland, Ohio
vii
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viii Contributors
Mina K. Chung, MD Michael D. Faulx, MD
Staff Staff
Department of Cardiovascular Medicine Department of Cardiology
Heart and Vascular Institute Heart and Vascular Institute
Cleveland Clinic Associate Program Director
Cleveland, Ohio Department of Internal Medicine
Cleveland Clinic
Patrick H. Collier, MD, PhD
Fellow Cleveland, Ohio
Advanced Cardiac Imaging Jeffery A. Fowler, DO
Heart and Vascular Institute Chief Medical Resident
Cleveland Clinic Clinical Associate
Cleveland, Ohio Medicine Institute
Steven R. Deitcher, MD Cleveland Clinic
President, CEO, and Board Member Cleveland, Ohio
Talon Therapeutics, Inc.
Kathleen Franco-Bronson, MD, MS
South San Francisco, California
Associate Dean
Sevag Demirjian, MD Cleveland Clinic Lerner College of Medicine
Associate Staff Staff
Department of Hypertension and Nephrology Psychiatry and Education Institute
Glickman Urologic and Kidney Institute Cleveland Clinic
Cleveland Clinic Cleveland, Ohio
Cleveland, Ohio
Jorge A. Garcia, MD
Krupa B. Doshi, MD Staff
Staff Department of Solid Tumor
Department of Endocrinology, Diabetes, and Metabolism Oncology/Urology
Endocrinology and Metabolism Institute Taussig Cancer Institute
Cleveland Clinic Cleveland Clinic
Cleveland, Ohio Cleveland, Ohio
Raed A. Dweik, MD, FACP, FRCP(C), FCCP, FSSC, FAHA
Steven M. Gordon, MD
Director
Chairman
Pulmonary Vascular Program
Department of Infectious Disease
Staff
Medicine Institute
Respiratory Institute
Cleveland Clinic
Cleveland Clinic
Cleveland, Ohio
Cleveland, Ohio
Brian P. Griffin, MD, FACC
Kristin A. Englund, MD
Staff
Staff
Department of Cardiovascular Medicine
Department of Infectious Disease
Heart and Vascular Institute
Medicine Institute
Cleveland Clinic
Cleveland Clinic
Cleveland, Ohio
Cleveland, Ohio
Ronan Factora, MD Vedant Gupta, MD
Staff Chief Medical Resident
Center for Geriatric Medicine Clinical Associate
Medicine Institute Medicine Institute
Cleveland Clinic Cleveland Clinic
Cleveland, Ohio Cleveland, Ohio
Charles Faiman, MD Jorge A. Guzman, MD
Consultant Head, Section of Critical Care
Department of Endocrinology, Diabetes, and Metabolism Director, Medical Intensive Care Unit
Endocrinology and Metabolism Institute Respiratory Institute
Cleveland Clinic Cleveland Clinic
Cleveland, Ohio Cleveland, Ohio
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Contributors ix
Aaron C. Hamilton, MD, MBA Vidyasagar Kalahasti, MD
Associate Staff Staff, Section of Cardiovascular Imaging
Department of Hospital Medicine Heart and Vascular Institute
Medicine Institute Cleveland Clinic
Cleveland Clinic Cleveland, Ohio
Cleveland, Ohio
Subramanian Kannan, MD
Amir H. Hamrahian, MD Chief Clinical Fellow
Staff Department of Endocrinology, Diabetes, and Metabolism
Department of Endocrinology Endocrinology and Metabolism Institute
Endocrinology and Metabolism Institute Cleveland Clinic
Cleveland Clinic Cleveland, Ohio
Cleveland, Ohio
Samir Kapadia, MD
Robert E. Hobbs, MD Director
Staff Sones Cardiac Catheterization Laboratory
Department of Cardiovascular Medicine Department of Cardiovascular Medicine
Heart and Vascular Institute Heart and Vascular Institute
Cleveland Clinic Cleveland Clinic
Cleveland, Ohio Cleveland, Ohio
Edward P. Horvath, Jr., MD Aanchal Kapoor, MD
Department of Veterans Affairs Medical Center Associate Program Director, Critical Care
Cleveland, Ohio Staff
Erik H. Howell, MD Department of Critical Care Medicine
Resident, Internal Medicine Respiratory Institute
Medicine Institute Cleveland Clinic
Cleveland Clinic Cleveland, Ohio
Cleveland, Ohio Michael Kenneth Keng, MD
Carlos M. Isada, MD Fellow, Hematology-Oncology
Vice Chairman Taussig Cancer Institute
Department of Infectious Disease Cleveland Clinic
Medicine Institute Cleveland, Ohio
Program Director Leila Khan, MD
Infectious Disease Fellowship Associate Staff
Cleveland Clinic Department of Endocrinology
Cleveland, Ohio Endocrinology and Metabolism Institute
Sunguk Jang, MD Cleveland Clinic
Staff Cleveland, Ohio
Department of Gastroenterology Sumita B. Khatri, MD
Digestive Disease Institute Co-Director, Asthma Center
Cleveland Clinic Staff
Cleveland, Ohio Respiratory Institute
Hani Jneid, MD, FACC, FAHA, FSCAI Cleveland Clinic
Assistant Professor Cleveland, Ohio
Department of Medicine Christopher S. Kovacs, Jr., MD
Baylor College of Medicine Chief Medical Resident
Director of Interventional Cardiology Research Clinical Associate
Division of Cardiology Medicine Institute
The Michael E. DeBakey VA Medical Hospital Cleveland Clinic
Houston, Texas Cleveland, Ohio
Seby John, MD Richard Krasuski, MD
Chief Resident Director of Adult Heart Services
Department of Neurology Department of Cardiovascular Medicine
Neurological Institute Heart and Vascular Institute
Cleveland Clinic Cleveland Clinic
Cleveland, Ohio Cleveland, Ohio
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