Table Of ContentTAURINE 6
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IRUN R. COHEN, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research
RODOLFO PAOLETTI, University of Milan
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TAURINE 6
Edited by Simo S. Oja and Pirjo Saransaari
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TAURINE 6
Edited by
Simo S. Oja
Tampere University Hospital
Tampere, Finland
and
Pirjo Saransaari
University of Tampere
Tampere, Finland
Simo S. Oja Pirjo Saransaari
The Center for Laboratory Me dicine Brain Research Center
Tampere University Hospital Medical School
PO Box 2000 FI-33014 University of Tampere, Finland
FI-33521 Tampere, Finland [email protected]
[email protected]
Proceedings of the 15th International Taurine Meeting, “Taurine Today,” held in Tampere,
Finland, June 12–15, 2005
A CIP record for this book is available from the Library of Congress.
ISSN: 0065 2598
ISBN-10: 0-387-32356-2 e-ISBN 0-387-33504-8
ISBN-13: 978-0387-32356-5
Printed on acid-free paper.
(cid:164) 2006 Springer Science+Business Media, LLC
All rights reserved. This work may not be translated or copied in whole or in part without the
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PREFACE
The 15th Taurine Meeting, “Taurine Today,” was held June 12–15, 2005, in
Tampere, Finland. Tampere is the third largest city (200,000 inhabitants) in Finland and
the largest inland city in Scandinavia, located 109 miles north of Helsinki, capital of
Finland. The meeting venue was the Scandic Hotel Rosendahl on the shores of the Lake
Pyhäjärvi, located about two miles from the city center on a hillside of the highest sand
ridge in the world. This narrow ridge was formed by the Ice Age between two large lakes,
embracing the present-day city of Tampere.
Approximately 80 individuals attended this meeting from twenty-one countries and
four continents. The present meeting continued the prestigious series of taurine meetings,
regularly gathering together most of the prominent investigators in the field. The
scientific program consisted of thirty-three platform and forty-seven poster presentations.
This volume is based on these presentations given at the meeting. The topics range from
the presence and metabolism of taurine in microorganisms to the applicability of taurine
derivatives in clinical medicine. Characterization of the significance of taurine in
nutrition and of the putative functions in the organisms was also emphasized, among
several other aspects of taurine.
The Finnish Physiological Society and Tampere University Brain Research Center
were the official organizations sponsoring the meeting. The Program Committee,
Professors Junichi Azuma, Laura Della Corte, J. Barry Lombardini, Stephen W. Schaffer,
Simo S. Oja, and Pirjo Saransaari, cooperated in composing the meeting program. The
heaviest burden of all practical matters was on the shoulders of the Organizing
Committee, including Prof. Simo S. Oja, Prof. Pirjo Saransaari, Assoc. Prof. Kirsi-Marja
Marnela, Assoc. Prof. Vince Varga, Dr. Satoshi Abe, Dr. Sirpa Rainesalo, and Ms.
Svetlana Molchanova, MSci.
The organizers of the meeting are indebted to the Academy of Finland; Tampere
University Research Fund; Taisho Pharmaceutical Company, Ltd., Japan; Red Bull
GmBh, Austria; Korean Taurine Society; Dong-A Pharmaceutical Company, Korea; and
the organizer of the previous taurine meeting, Prof. Stephen Schaffer, for their generous
financial support. The organizers likewise thank Ms. Svetlana Molchanova, MSci; Mr.
Pasi Puumala, BMed; and Mr. Róbert Dohovics, MSci, for their skilful technical help
with computers, Power Point shows, and microphones during the meeting. The excellent
professional competence of the staff of the TAVI Congress Bureau, in particular that of,
the managingdirector, Ms.Anja Hakkarainen, and the kind cooperation of the personnel
of the Scandic Hotel Rosendahl, were greatly appreciated. Ms. Sari Luokkala gave us
expert advice and technical help in editing the manuscripts.
v
v i PREFACE
Finally, the organizers wish to thank all the participants of the meeting and the
authors of the papers in this volume. Their invaluable contributions made everything
worth our efforts. The presentations at the meeting and the articles in this volume shed
bright light on the various aspects of the significance and role of taurine, although many
questions still remain unanswered. This calls for the next taurine meeting to be organized
in about two years’ time.
Simo S. Oja
Pirjo Saransaari
University of Tampere
PARTICIPANTS
Satoshi Abe John Browne
Taurine Project Team Department of Surgery
Taisho Pharmaceutical Co, Ltd Royal College of Surgeons
Tokyo, Japan Beaumont Hospital
[email protected] Dublin, Ireland
[email protected]
Elmira Anderzhanova
University of Athens Medical School Marie-Louise Bülow
Athens, Greece Institute of Molecular Biology
[email protected] University of Copenhagen,
Copenhagen, Denmark
Junichi Azuma [email protected]
Clinical Evaluation of
Medicines and Therapeutics Kyung Ja Chang
Graduate School of Pharmaceutical Department of Food and Nutrition
Sciences Inha University
Osaka University Incheon, South Korea
Osaka, Japan [email protected]
[email protected]
Aisa Chepkova
Laura Bianchi Institute of Neurophysiology
Dipartimento di Farmakologia Heinrich-Heine University
Preclinica e Clinica Düsseldorf, Germany
Università degli Studi di Firenze [email protected]
Florence, Italy
[email protected] Russel W. Chesney
Department of Pediatrics
David Brouchier-Hayes University of Tennessee
Department of Surgery Health Sciences Center
Royal College of Surgeons Le Bonheur Children’s Medical Center
Beaumont Hospital Memphis, TN, USA
Dublin, Ireland [email protected]
[email protected]
vii
v i i i PARTICIPANTS
Alasdair Cook Jingchun Guo
Department of Biological Sciences Department of Integrative Medicine
University of Constance Shanghai Medical College
Constance, Germany Fudan University
[email protected] Shanghai, China
[email protected]
Robért Dohovics
Brain Research Center Ramesh Gupta
Medical School SASRD
University of Tampere Nagaland University
Tampere, Finland Medziphema, India
[email protected] [email protected]
John Dominy Xiaobin Han
Division of Nutritional Sciences Department of Pediatrics
Cornell University University of Tennessee
Ithaca, NY, USA Health Sciences Center
[email protected] Le Bonheur Children’s Medical Center
Memphis, TN, USA
Abdeslem El Idrissi [email protected]
Department of Biology and Center for
Development Svend H. Hansen
College of Staten Island/CUNY Department of Clinical Biochemistry
Staten Island, NY, USA Rigshospitalet
[email protected] Copenhagen University Hospital
Copenhagen, Denmark
Mario Fontana [email protected]
Dipartimento di Scienze Biochimiche,
Università di Roma “La Sapienza” Antonio Herranz
Rome, Italy Servicio de Neurobiología
[email protected] Hospital Ramón y Cajal
Madrid, Spain
Kjell Fugelli [email protected]
Department of Molecular Biosciences
University of Oslo Wojciech Hilgier
Oslo, Norway Department of Neurotoxicology
[email protected] Medical Research Centre
Polish Academy of Sciences
Ludmila Gavrovskaya Warsaw, Poland
Research Institute of Experimental [email protected]
Medicine
Russian Academyof Medical Sciences Tuomas Huttunen
St. Petersburg, Russia Brain Research Center
[email protected] Medical School
University of Tampere
Tampere, Finland
[email protected]
PARTICIPANTS ix
Takashi Ito Ewa Kontny
Clinical Evaluation of Medicines and Department of Pathophysiology &
Therapeutics Immunology
Graduate School of Pharmaceutical Institute of Rheumatology
Sciences Warsaw, Poland
Osaka University [email protected]
Osaka, Japan
[email protected]_u.ac.jp Irina B. Krylova
Research Institute of Experimental
Réka Janáky Medicine
Brain Research Center Russian Academy of Medical Sciences
Medical School St. Petersburg, Russia
University of Tampere [email protected]
Tampere, Finland
[email protected] Nien Vinh Lam
School of Food and Nutritional
Young-Sook Kang Sciences
College of Pharmacy University of Shizuoka
Sookmyung Women’s University, Shizuoka, Japan
Seoul, Korea [email protected]
[email protected]
Ian Henry Lambert
Tomie Kawada Department of Biochemistry
Pharmacy Division Institute for Molecular Biology and
Niigata University Hospital Physiology
Niigata, Japan Copenhagen, Denmark
[email protected] [email protected]
Chaekyun Kim Cesar Lau-Cam
Center for Advanced Medical Department of Pharmaceutical Sciences,
Education by BK21 Project College of Pharmacy and Allied Health
Inha University College of Medicine Professions
Incheon, 400-712, Korea St. John’s University
[email protected] Jamaica, NY, USA
[email protected]
Ha Won Kim
Department of Life Sciences Robert Law
University of Seoul Department of Preclinical Sciences
Seoul, South Korea University of Leicester
[email protected] Leicester, UK
[email protected]
Vija Kluša
Department of Pharmacology Florence Ledeque
Faculty of Medicine Unite de Biochimie
University of Latvia Universitè Catholique de Louvain
Riga, Latvia Louvain-la-Neuve, Belgium
[email protected] [email protected]
Description:Taurine (2-aminoethanesulfonic acid) is an enigmatic compound abounding in animal tissues. It is present at relatively high concentrations in all electrically excitable tissues such as the brain, sensory organs, the heart, and in certain endocrine glands. Some of its physiological functions are alre