Table Of Content4 E
TH DITION
SHERRIS
M
EDICAL
M
ICROBIOLOGY
A I I D
N NTRODUCTIONTO NFECTIOUS ISEASES
i
EDITORS
KENNETHJ.RYAN,MD C.GEORGERAY,MD
Dean,Academic Affairs Clinical Professor of Pathology
Professor of Pathology College of Medicine
Professor of Microbiology and Immunology University of Arizona
College of Medicine Tucson,Arizona
University of Arizona
Tucson,Arizona
CONSULTING EDITOR
JOHNC.SHERRIS,MD,FRCPATH
Professor Emeritus
Department of Microbiology
School of Medicine
University of Washington
Seattle,Washington
AUTHORS
JAMESJ.CHAMPOUX,PHD FREDERICKC.NEIDHARDT,PHD
Professor and Interim Chair Frederick G. Novy Distinguished University Professor of
Department of Microbiology Microbiology and Immunology,Emeritus
School of Medicine University of Michigan
University of Washington Medical School
Seattle,Washington Ann Arbor,Michigan
W.LAWRENCEDREW,MD,PHD JAMESJ.PLORDE,MD
Professor of Laboratory Medicine Professor Emeritus
Professor of Medicine Department of Medicine and
School of Medicine Department of Laboratory Medicine
University of California,San Francisco School of Medicine
Mount Zion Medical Center University of Washington
San Francisco,California Seattle,Washington
CONTRIBUTORS
JOHNJ.MARCHALONIS,PHD STANLEYFALKOW,PHD
Professor and Head Professor of Microbiology and Immunology
Department of Microbiology and Professor of Medicine
Immunology School of Medicine
College of Medicine Stanford University
University of Arizona Stanford,California
Tucson,Arizona
MURRAYR.ROBINOVITCH,DDS,PHD
Professor and Chairman
Department of Oral Biology
School of Dentistry
University of Washington
Seattle,Washington
4 E
TH DITION
SHERRIS
M
EDICAL
M
ICROBIOLOGY
A I I D
N NTRODUCTIONTO NFECTIOUS ISEASES
K J. R , MD
ENNETH YAN
C. G R , MD
EORGE AY
E
DITORS
MCGRAW-HILL
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DOI: 10.1036/0838585299
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C O N T E N T S
Preface xi P A R T I V
Acknowledgments xiii
SPREADANDCONTROLOFINFECTION 173
Overview 1
CHAPTER 1 Sterilization and Disinfection 175
CHAPTER 11
Kenneth J.Ryan
Kenneth J.Ryan
P A R T I CHAPTER 12 Epidemiology ofInfectious
Diseases 185
THEBACTERIALCELL 9
W.Lawrence Drew
Bacterial Structures 11
CHAPTER 2 Antibacterial and Antiviral
CHAPTER 13
Frederick C.Neidhardt
Agents 193
Kenneth J.Ryan and W.Lawrence Drew
Bacterial Processes 27
CHAPTER 3
Frederick C.Neidhardt
Antimicrobial Resistance 215
CHAPTER 14
Kenneth J.Ryan
Bacterial Genetics 53
CHAPTER 4
Frederick C.Neidhardt
Principles ofLaboratory
CHAPTER 15
Diagnosis ofInfectious Diseases 229
P A R T I I
Kenneth J.Ryan and C.George Ray
BIOLOGYOFVIRUSES 77
Virus Structure 79
CHAPTER 5 P A R T V
James J.Champoux
PATHOGENICBACTERIA 259
Virus Multiplication 87
CHAPTER 6
Staphylococci 261
James J.Champoux CHAPTER 16
Kenneth J.Ryan
Viral Genetics 105
CHAPTER 7
Streptococci and Enterococci 273
James J.Champoux CHAPTER 17
Kenneth J.Ryan
P A R T I I I
Corynebacterium,Listeria,
CHAPTER 18
HOST-PARASITEINTERACTIONS 113 andBacillus 297
Kenneth J.Ryan
Immune Response to Infection 115
CHAPTER 8
John J.Marchalonis CHAPTER 19 Clostridium,Peptostreptococcus,
Bacteroides,and Other
Normal Microbial Flora 141 Anaerobes 309
CHAPTER 9
Kenneth J.Ryan Kenneth J.Ryan
Host-Parasite Relationships 149 Neisseria 327
CHAPTER 10 CHAPTER 20
Stanley Falkow Kenneth J.Ryan
viii Contents
Enterobacteriaceae 343 Enteroviruses 531
CHAPTER 21 CHAPTER 36
Kenneth J.Ryan C.George Ray
Vibrio,Campylobacter, Hepatitis Viruses 541
CHAPTER 22 CHAPTER 37
andHelicobacter 373 W.Lawrence Drew
Kenneth J.Ryan
Herpesviruses 555
CHAPTER 38
CHAPTER 23 Pseudomonasand Other W.Lawrence Drew
Opportunistic Gram-negative
Bacilli 385 Viruses ofDiarrhea 577
CHAPTER 39
Kenneth J.Ryan C.George Ray
HaemophilusandBordetella 395 Arthropod-Borne and Other
CHAPTER 24 CHAPTER 40
Kenneth J.Ryan Zoonotic Viruses 585
C.George Ray
MycoplasmaandUreaplasma 409
CHAPTER 25
W.Lawrence Drew CHAPTER 41 Rabies 597
W.Lawrence Drew
Legionella 415
CHAPTER 26
Kenneth J.Ryan CHAPTER 42 Retroviruses,Human
Immunodeficiency Virus,and
Spirochetes 421 Acquired Immunodeficiency
CHAPTER 27
Kenneth J.Ryan Syndrome 601
James J.Champoux and W.Lawrence Drew
Mycobacteria 439
CHAPTER 28
James J.Plorde CHAPTER 43 Papovaviruses 617
W.Lawrence Drew
ActinomycesandNocardia 457
CHAPTER 29
Kenneth J.Ryan CHAPTER 44 Persistent Viral Infections ofthe
Central Nervous System 623
CHAPTER 30 Chlamydia 463 W.Lawrence Drew
W.Lawrence Drew
P A R T V I I
Rickettsia,Coxiella,Ehrlichia,
CHAPTER 31
andBartonella 471 PATHOGENICFUNGI 629
W.Lawrence Drew
Characteristics ofFungi 631
CHAPTER 45
CHAPTER 32 Plague and Other Bacterial Kenneth J.Ryan
Zoonotic Diseases 481
Pathogenesis,Immunity,and
Kenneth J.Ryan CHAPTER 46
Chemotherapy ofFungal
Infections 639
P A R T V I
Kenneth J.Ryan
PATHOGENICVIRUSES 493
Dermatophytes,Sporothrix,
CHAPTER 47
Influenza,Respiratory Syncytial and Other Superficial and
CHAPTER 33
Virus,Adenovirus,and Other Subcutaneous Fungi 649
Respiratory Viruses 495 Kenneth J.Ryan
C.George Ray
Candida,Aspergillus,and Other
CHAPTER 48
Mumps Virus,Measles,Rubella, Opportunistic Fungi 659
CHAPTER 34
and Other Childhood Kenneth J.Ryan
Exanthems 513
C.George Ray CHAPTER 49 Cryptococcus,Histoplasma,
Coccidioides,and Other
Poxviruses 525 Systemic Fungal Pathogens 669
CHAPTER 35
C.George Ray Kenneth J.Ryan
