Table Of ContentShengmai San
Traditional Herbal Medicines for Modern Times
Each volume in this series provides academia, health sciences and the herbal
medicines industry with in-depth coverage of the herbal remedies for infectious
diseases, certain medical conditions or the plant medicines of a particular country.
Edited by Dr Roland Hardman
Volume 1
Shengmai San, edited by Kam-Ming Ko
Shengmai San
Kam-Ming Ko,
Hong Kong University of
Science & Technology, Kowloon, Hong Kong, China
London and New York
First published 2002 by Taylor & Francis
11 New Fetter Lane, London EC4P 4EE
Simultaneously published in the USA and Canada
by Taylor & Francis Inc,
29 West 35th Street, New York, NY 10001
Taylor & Francis is an imprint of the Taylor & Francis Group
This edition published in the Taylor & Francis e-Library, 2004.
© 2002 Taylor & Francis
All rights reserved. No part of this book may be reprinted or reproduced
or utilised in any form or by any electronic, mechanical, or other means,
now known or hereafter invented, including photocopying and recording,
or in any information storage or retrieval system, without permission in
writing from the publishers.
Every effort has been made to ensure that the advice and information in
this book is true and accurate at the time of going to press. However,
neither the publisher nor the authors can accept any legal responsibility or
liability for any errors or omissions that may be made. In the case of drug
administration, any medical procedure or the use of technical equipment
mentioned within this book, you are strongly advised to consult the
manufacturer’s guidelines.
British Library Cataloguing in Publication Data
A catalogue record for this book is available
from the British Library
Library of Congress Cataloging in Publication Data
A catalog record has been requested
ISBN 0-203-21645-8 Master e-book ISBN
ISBN 0-203-27265-X (Adobe eReader Format)
ISBN 0-415-28490-2 (Print Edition)
Contents
Contributors vii
Preface to the series ix
Preface xiii
1 Shengmai San – a renowned traditional Chinese medicinal formula 1
SONG-MING LIANG, SHU-YING CHEN, SI-QIAN LIANG
2 Pharmacological studies on Shengmai San 16
KAM-MING KO, DUNCAN H.F. MAK, TZE-KIN YIM AND YONG-QING YAN
3 Clinical studies on Shengmai San 41
YE-ZHI RONG, MEI-HUA ZHAO, BAO-JING LU, XIANG-YANG ZHU,
SHANG-BIAO LU, YA-CHEN ZHANG, JIE CHEN
4 Side effects of Shengmai San 78
ZHI-MIN XU AND YE-ZHI RONG
5 Phytochemistry and pharmacology of component herbs of
Shengmai San 82
SIU-PO IP, TIMOTHY C.M. TAM AND CHUN-TAO CHE
6 Contemporary applications of a traditional formula:
manufacture of Shengmai San (SMS) preparations and
their applications 112
LIANG-YUAN ZHENG
Glossary 126
Index 132
Contributors
Bao-Jing Lu Liang-Yuan Zheng
Department of Cardiology Livzon Pharmaceutical Group, Inc.
Xin-Hua Hospital North Guihua Road, Gongbei
Shanghai Second Medical University Zhuhai, Guangdong 519020
1665 Kong-Jiang Road China
Shanghai 200092
China Mei-Hua Zhao
Department of Cardiology
Chun-Tao Che Xin-Hua Hospital
School of Chinese Medicine Shanghai Second Medical University
The Chinese University of Hong Kong 1665 Kong-Jiang Road
Shatin, N.T. Shanghai 200092
Hong Kong China
China
Shang-Biao Lu
Duncan H.F. Mak
Department of Cardiology
Department of Biochemistry
Xin-Hua Hospital
Hong Kong University of Science
Shanghai Second Medical University
& Technology
1665 Kong-Jiang Road
Clear Water Bay
Shanghai 200092
Hong Kong
China
China
Shu-Ying Chen
Jie Chen
School of Materia Medica
Department of Cardiology
Guangzhou University of Traditional
Xin-Hua Hospital
Chinese Medicine
Shanghai Second Medical University
12 Jichang Road, Guangzhou
1665 Kong-Jiang Road
519020
Shanghai 200092
China
China
Kam-Ming Ko Si-Qian Liang
Department of Biochemistry Department of Applied Science
Hong Kong University of Science Hong Kong Institute of Vocational
& Technology Education (CW)
Clear Water Bay Chai Wan
Hong Kong Hong Kong
China China
viii Contributors
Siu-Po Ip Ya-Chen Zhang
School of Chinese Medicine Department of Cardiology
The Chinese University of Hong Kong Xin-Hua Hospital
Shatin, N.T. Shanghai Second Medical University
Hong Kong 1665 Kong-Jiang Road
China Shanghai 200092
China
Song-Ming Liang
School of Chinese Medicine Ye-Zhi Rong
The Chinese University of Hong Kong Dept. of Medicine, Xin-Hua Hospital
Shatin, N.T. Shanghai Second Medical University
Hong Kong 1665 Kong-Jiang Road
China Shanghai 200092
China
Timothy C.M. Tam
School of Pharmacy Yong-Qing Yan
The Chinese University of Hong Kong The China Pharmaceutical University
Shatin, N.T. 24 Tong Jia Xiang, Nanjin
Hong Kong Jiangsu 210009
China China
Tze-Kin Yim Zhi-Min Xu
Department of Biochemistry Department of Cardiology
Hong Kong University of Science & Xin-Hua Hospital
Technology Shanghai Second Medical University
Clear Water Bay 1665 Kong-Jiang Road
Hong Kong Shanghai 200092
China China
Xiang-Yang Zhu
Department of Cardiology
Xin-Hua Hospital
Shanghai Second Medical University
1665 Kong-Jiang Road
Shanghai 200092
China
Preface to the series
Global warming and global travel are among the factors resulting in the spread of
such infectious diseases as malaria, tuberculosis, hepatitis B and HIV. All these are not
well controlled by the present drug regimes. Antibiotics too are failing because of
bacterial resistance. Formerly less well known tropical diseases are reaching new shores.
A whole range of illnesses, for example cancer, occur worldwide. Advances inmolecular
biology, including methods of in vitro testing for a required medical activity give
new opportunities to draw judiciously upon the use and research of traditional herbal
remedies from around the world. The re-examining of the herbal medicines must be
done in a multidisciplinary manner.
Since 1997 twenty volumes have been published in the Book Series Medicinal and
Aromatic Plants – Industrial Profiles. The series continues, and is characterised bya
single plant genus per volume. With the same Series Editor, this new seriesTraditional
Herbal Medicines for Modern Times, covers multi genera per volume. It accom-
modates for example, the Traditional Chinese Medicines (TCM), the Japanese Kampo
versions of this and the Ayurvedic formulations of India. Collections of plants are also
brought together because they have been re-evaluated for the treatment of specific
diseases, such as malaria, tuberculosis, cancer, diabetes, etc. Yet other collections are of
the most recent investigations of the endemic medicinal plants of a particular country,
e.g. of India, South Africa, Mexico, Brazil (with its vast flora), or of Malaysia with its
rainforests said to be the oldest in the world.
Each volume reports on the latest developments and discusses key topics relevant
to interdisciplinary health science research by ethnobiologists, taxonomists, conserva-
tionists, agronomists, chemists, pharmacologists, clinicians and toxicologists. TheSeries
is relevant to all these scientists and will enable them to guide business, government
agencies and commerce in the complexities of these matters. The background to the
subject is outlined below.
Over many centuries, the safety and limitations of herbal medicines have been
established by their empirical use by the ‘healers’ who also took a holistic approach.
The ‘healers’ are aware of the infrequent adverse affects and know how to correct these
when they occur. Consequently and ideally, the pre-clinical and clinical studies of
a herbal medicine need to be carried out with the full cooperation of the traditional
healer. The plant composition of the medicine, the stage of the development of the
plant material, when it is to be collected from the wild or when from cultivation, its
post-harvest treatment, the preparation of the medicine, the dosage and frequency
and much other essential information is required. A consideration of the intellectual
property rights and appropriate models of benefit sharing may also be necessary.
