Table Of ContentAPPLIED BIOLOGICAL
ENGINEERING – PRINCIPLES
AND PRACTICE
Edited by Ganesh R. Naik
Applied Biological Engineering – Principles and Practice
Edited by Ganesh R. Naik
Published by InTech
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Copyright © 2012 InTech
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First published March, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]
Applied Biological Engineering – Principles and Practice, Edited by Ganesh R. Naik
p. cm.
ISBN 978-953-51-0412-4
Contents
Preface IX
Part 1 Computational Methods in Bioengineering 1
Chapter 1 Efficient Computational
Techniques in Bioimpedance Spectroscopy 3
Aleksander Paterno,
Lucas Hermann Negri and Pedro Bertemes-Filho
Chapter 2 Computer Simulation and Analysis of
Three-Dimensional Tumor Geometry in Radiotherapy 29
Seishin Takao, Shigeru Tadano, Hiroshi Taguchi and Hiroki Shirato
Chapter 3 Frequency-Domain Objective Response Detection
Techniques Applied to Evoked Potentials: A Review 47
Danilo Barbosa Melges,
Antonio Mauricio Ferreira Leite Miranda de Sá
and Antonio Fernando Catelli Infantosi
Chapter 4 Extraction of 3D Geometrical Features of Biological
Objects with 3D PCA Analysis and Applications of Results 85
Michal Rychlik and Witold Stankiewicz
Chapter 5 Mathematical Modelling of Gene Regulatory Networks 113
Ana Tušek and Želimir Kurtanjek
Chapter 6 Modern Methods Used in the Complex
Analysis of the Phonocardiography Signal 133
Nicolae Marius Roman and Stefan Gergely
Chapter 7 Osteocytes Characterization Using
Synchrotron Radiation CT and Finite Element Analysis 165
Zully Ritter, Andreas Staude, Steffen Prohaska and Dieter Felsenberg
Chapter 8 Specific Absorption Rate Analysis of Heterogeneous
Head Models with EEG Electrodes/Leads at 7T MRI 191
Leonardo M. Angelone and Giorgio Bonmassar
VI Contents
Chapter 9 Simulating Idiopathic Parkinson’s
Disease by In Vitro and Computational Models 209
Tjitske Heida, Jan Stegenga, Marcel Lourens, Hil Meijer,
Stephan van Gils, Nikolai Lazarov and Enrico Marani
Chapter 10 Vascular Stent Design Optimisation
Using Numerical Modelling Techniques 237
Houman Zahedmanesh, Paul A. Cahill and Caitríona Lally
Part 2 Biomechanical Engineering Methods and Applications 259
Chapter 11 Functional Significance of Force
Fluctuation During Voluntary Muscle Contraction 261
Kazushige Oshita and Sumio Yano
Chapter 12 The Influence of Different Elbow
Angles on the Twitch Response of the Biceps Brachii
Muscle Between Intermittent Electrical Stimulations 283
Srdjan Djordjevič, Sašo Tomažič,
Gregor Zupančič, Rado Pišot and Raja Dahmane
Chapter 13 Experimental Examination
on the Effects and Adaptation Condition
of the Fibula Excision Method Using the Stress
Freezing Method on the Osteoarthritis of the Knee 297
Nobutaka Maezaki, Tsutomu Ezumi and Masashi Hachiya
Chapter 14 Motor Unit Potential Train Validation and
Its Application in EMG Signal Decomposition 321
Hossein Parsaei and Daniel W. Stashuk
Chapter 15 Role of Biomechanical Parameters in Hip
Osteoarthritis and Avascular Necrosis of Femoral Head 347
Veronika Kralj - Iglič, Drago Dolinar,
Matic Ivanovski, Ivo List and Matej Daniel
Chapter 16 Development and Clinical Application
of Instruments to Measure Orofacial Structures 365
Amanda Freitas Valentim, Renata Maria Moreira Moraes Furlan,
Tatiana Vargas de Castro Perilo,
Andréa Rodrigues Motta, Monalise Costa Batista Berbert,
Márcio Falcão Santos Barroso, Cláudio Gomes da Costa,
Iracema Maria Utsch Braga and Estevam Barbosa de Las Casas
Part 3 Biochemical Engineering Methods and Applications 391
Chapter 17 In Vitro Blood Flow Behaviour in
Microchannels with Simple and Complex Geometries 393
Valdemar Garcia, Ricardo Dias and Rui Lima
Contents VII
Chapter 18 Electroporation of Kluyveromyces
marxianus and -D-galactosidase Extraction 417
Airton Ramos and Andrea Lima Schneider
Chapter 19 Physiological Analysis
of Yeast Cell by Intelligent Signal Processing 435
Andrei Doncescu, Sebastien Regis,
Katsumi Inoue and Nathalie Goma
Chapter 20 Protocol of a Seamless
Recombination with Specific Selection
Cassette in PCR-Based Site-Directed Mutagenesis 461
Qiyi Tang, Benjamin Silver and Hua Zhu
Chapter 21 Extraction of Drug from the Biological Matrix: A Review 479
S. Lakshmana Prabu and T. N. K. Suriyaprakash
Part 4 E-Health and Educational Aspects of Bioengineering 507
Chapter 22 Quality Assessment of E-Health
Solutions in Primary Health Care –
Approach Based on User Experience 509
Damir Kralj
Chapter 23 Psychomagnetobiology 529
José María De la Roca Chiapas
Chapter 24 Study on the Mechanism of Traumatic Brain Injury 549
Yuelin Zhang, Shigeru Aomura,
Hiromichi Nakadate and Satoshi Fujiwara
Chapter 25 Residual Stresses and Cracking
in Dental Restorations due to Resin Contraction
Considering In-Depth Young’s Modulus Variation 571
Estevam Barbosa de Las Casas, João Batista Novaes Jr.,
Elissa Talma, Willian Henrique Vasconcelos,
Tulimar P. Machado Cornacchia, Iracema Maria Utsch Braga,
Carlos Alberto Cimini Jr. and Rodrigo Guerra Peixoto
Chapter 26 Genetic Engineering in a Computer Science Curriculum 589
Nevena Ackovska, Liljana Bozinovska and Stevo Bozinovski
Chapter 27 Design of a PC-Based
Electrocardiogram (ECG) Recorder as - Internet Appliance 607
Mahmud Hasan
Chapter 28 Implications of Corporate Yoga: A Review 635
Rudra B. Bhandari, Churna B. Bhandari, Balkrishna Acharya,
Pranav Pandya, Kartar Singh, Vinod K. Katiyar and Ganesh D. Sharma
Preface
Background and Motivation
Biological and medical phenomena are complex and intelligent. Our observations and
understanding of some of these phenomena have inspired the development of creative
theories and technologies in science. Biological engineering (also known as
bioengineering) represents an exciting, broad-based discipline that ties together the
engineering, medical and biological sciences, with slight help from physics, chemistry,
mathematics and computer science. The key objective is to benefit human-kind, animal
and plant life - in other words, it is “engineering for life”.
In all different areas of biological engineering, the ultimate objectives in research and
education are to improve the quality life, reduce the impact of disease on the everyday
life of individuals, and provide an appropriate infrastructure to promote and enhance
the interaction of biomedical engineering researchers. Biological engineering has a
base that applies the principles of engineering to a wide range of systems and
complexities including the molecular level such as biochemistry, molecular biology,
pharmacology, microbiology, cytology, protein chemistry and neurobiology.
The most important trend in biological engineering is the dynamic range of scales at
which biotechnology is now able to integrate with biological processes. An explosion
in micro/nanoscale technology is allowing the manufacture of nanoparticles for drug
delivery into cells, miniaturized implantable microsensors for medical diagnostics, and
micro-engineered robots for on-board tissue repairs. This book aims to provide an up-
to-date overview of the recent developments in biological engineering from diverse
aspects and various applications in clinical and experimental research.
Intended Readership
This book covers some of the most important current research related to biological
engineering. It is partly a textbook and partly a monograph. It is a textbook because it
gives a detailed introduction to biological engineering techniques and applications. It
is simultaneously a monograph because it presents and brings together several new
results, concepts and further developments. Furthermore, the research results
previously scattered throughout many scientific journals and conference papers
worldwide, are methodically collected and presented in the book in a unified form.
X Preface
As a result of its twofold character the book is likely to be of interest to graduate and
postgraduate students, engineers and scientists in the field of biomedical and
biological engineering. This book can also be used as handbook for students and
professionals seeking to gain a better understanding of where bioengineering stands
today. One can read this book through sequentially but it is not necessary since each
chapter is essentially self-contained, with as few cross-references as possible. So,
browsing is encouraged.
As an editor and also an author in this field, I am honoured to be editing a book with
such fascinating and exciting content, written by a select group of gifted researchers. I
would like to thank the authors, who have committed so much effort to the
publication of this work.
Dr Ganesh R. Naik
RMIT University, Melbourne
Australia
