Regulation of the United Kingdom biotechnology industry and global competitiveness

100 Pages·1993·9.3 MB·English

by  Great Britain. Parliament. House of Lords. Science and Technology Committee

HOU/L
HOUSE OF LORDS SESSION 1992—93
. 7th REPORT
SELECT COMMITTEE ON
SCIENCE AND TECHNOLOGY
REGULATION OF THE
UNITED KINGDOM
BIOTECHNOLOGY INDUSTRY AND
GLOBAL COMPETITIVENESS
Ordered by The House of Lords to be printed 13 July 1993
LONDON : HMSO
Reprinted (with corrections) October 1993
£21.00 net

HOUSE OF LORDS SESSION 1992—93
7th REPORT
SELECT COMMITTEE ON
SCIENCE AND TECHNOLOGY
REGULATION OF THE
UNITED KINGDOM
BIOTECHNOLOGY INDUSTRY AND
GLOBAL COMPETITIVENESS
Ordered by The House of Lords to be printed 13 July 1993
INEQP MATION CENTRE
xPA grep i994 49°*
Wellcome Venire for Medical Science
LONDON : HMSO
Reprinted (with corrections) October 1993
£21.00 net
HL Paper 80
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CONTENTS
Paragraph Page
CHAPTER 1 INTRODUCTION AND EXECUTIVE SUMMARY ........... iH 9
CHAPTER?2+ WHATIS: BIOTECHNOLOGY? «..2 902C.UPS2. 0Ane9, G4et a i 12
PS liswmeins MOWONA ASS AeA AAA Sie sd nt 42. SOI Tae f 2.3 12
PP UAMELeMICHCONOOSICST -NAAAAMAA RAS AR AGA SA Le Kad Lah 2.7 14
REL tansPe eve hetta te ttFe RENCHY eee os -sdi ee ead peat kak caveyapsiva ngea rvocsaovecsanse 2.8 15
CHAPTER 3 APPLICATIONS OF BIOTECHNOLOGY ................... 3. 16
Prarmacenticalsswrrs, Hisnakecwe seer eee. Cee, OF DOUBT YG 32 16
PACAMMATICUTICALINEM eepire ss tee ste tote een serene ts ee Eee ee ees Nat, « aS 16
PAPLICHitire Syren! edocs ts he A: Bees 4.33. PEP ARAM 3.4 17
Foodie! {xmeanoen< nines: 23 “SUR Vase dnes Handsndscaons. aSOnAaRd,. 3.5 18
Ghemicalindusty- won «4 Selina: Weles. ccc ncaa e nce oo CA.. 3.6 19
Environmental-applicationsicali 144s. s2cncahc.ia aPnOOnRn nIRes . 3 19
ORST hC oen MRM MN ooo oin yc sb ye h whey veo k3 pa no hs uo nceyc sm ye ho ys gh Udy ley Spapiny tugsa gn ee, ps 3.8 20
MareO TAPCERIVETINICAUISUEY PRON ASC Te| KURT oso o 0co cou icnS ian enes sucho so caeey tyess csss phina mneyn ayo ie 8s« 3.9 20
MCOMOMIICRASSERSITIOM oo.e ps o ecco ass hes, Senin, 55ss sscnce cE Oe, POOR, Bate 2 3.10 20
Biotechnology and the United Kingdom economy ....................06- 3.16 21
CHAPIERKy CHE, REGULATIONS 0... cin. csce ss slecey SES ot LARA 4. 22
Beckground to the regulations oo... gs ess epics el geet e aoe Bee et RR, 4.1 22
eR SPECS BING 0 osp c) ees) 5 ogy sas bondoc ec sissy Sons, evs HH Aiea 4.9 23
Pm NCEE CIL TONI Be clos co oh avis oy ohs pss A asl yee yeenean en Ge aed 4.14 24
Contained isle gulations® 55.7. 2G e, Y.0). 98 QF POR PET. 4.19 25
ineihermie Re leasenccul ations): (droainepi let. asec sles, sips asec eee 4.28 26
Commercially confidential information ............0.. e.ee. ee.e .ee. ee e 4.35 27
Administrative arrangements for the regulations ....................006. 4.36 27
Horiventalond-vertical regulations: s,« JPEG tor, 208 DOMME, PUNE... 4.39 28
Pneiphslosophy ofreculation «<..i sts gcki ge caaeaaganVIeR.n sA 4.41 28
inemvaviahnade Veeaiiary: Suter isms es ceed it aagr gecesi ness area 4.44 28
heibourtty Murdlorers Recpedterts <leiewills sags 6s 45,00P4O,R 4OO6PE3DS. Th 4.47 29
CHAPTER 5 REVIEW OF THE EVIDENCE. .....:......0s00055. IEEE £, 5. 30
The need to regulate and the perception of risk: general comments .......... wz 30
The need to regulate and the perception of risk: contained use ............. 5.15 33
The need to regulate and the perception of risk: deliberate release .......... 5.17 33
Contained use: classification of activities .........cc. ee.e e.e.e .ee.n s 5.25 35
Contained use: administrative issues and delay ...............ce.c.e 0ee e 5.33 37
Contained use: fees and associated CostS.0. .ce.e c.ec.e .ee.e .ee e 5.37 38
Contained use; disclosure of information, sirsic wack Vie op ieee lee ee ee eel 5.40 38
Deliberate release: bureaucracy and risk assessment ...............00000- 5.43 39
Deliberate releasedelays,and:costs» frads donuliidss iit.. i. DiSnU 5.46 39
Deliberate release: disclosure of information .................e.eee eee s 5.49 40
Deliberate release: novel foods and labelling ...........0.0s.e.c. e.en s 5.01 40
Process.regulation.and product-regulation «oi... i ce cece RL 5:55 41
Overseas comparisons: is there a “level playing field”? ................... 5.62. 43
The regelations and-competitiveness . i vrwWi. ici ee eee es COOOL Pat Sil 45
Non-regulatory factors and competitiveness ......0..... e.e ee. ee.e .ee e 5.79 47
Regulation and public understanding ......0..2 .cc e.ce .ee .eee. ee. ee e ee 5.91 50
CHAPTER 6 OPINION OF THE COMMITTEE ................00000 0000 - 6. 53
eH OS PIOLECRUOION V4 5:5.5.0.5.4 4.045.400 4 9 cain a's a8 os, 5 SI A, 6.1 a
Veroritions Obnishsh Pi fias ss 0546.04 ais eis POO SPAR NOEL, Joo 6.6 53
The background to the regulations ............... tNBi.)E ciom.vararl que 6.14 55
The contained use regulations ........... Rah Fe 24 ny 2a» sn EOL ED 6.17 56
125703 A*2
The deliberate release regulations 235/04 44;.c ns ee as ee O.2e 56
Process regulation and product regulation” 2s ays wa as ae 6.27 58
Regulation and competitiveness : .: Po \iWaciaae eo. es woe eau cee eee ees 6.32 59
Public understanding -.:.o.c5.0% 5.ge azie «'- varns Se rere ee ae oe 6.42 60
CHAPTER 7 SUMMARY OF CONCLUSIONS AND RECOMMENDATIONS . 7. 62
Gomera is. siaeis ss nie Sle eee oa sense wre ae at em i os a dal 62
Contained use ......... WRADAAL EE TASER See Oct F. . ora sheer aa 7.8 62
Deliberate release (32. ofa cet ale» eee ee Oe ee eee ae 62
Process regulation and product regulation ..........e.ee. ce.ce.ee.ee.es 7.17 63
Regulation and competitiveness .... 6.6. .0us. +6. <= +6 5 ee oe 7.20 63
Publictunderstanding 20 Jiu. van ute ee oe nada, & RNp aialehanieda a nt 7.24 63
APPENDIX 1 Membership of Sub-Committee TT... 1.1... weeee eens 65
APPENDIX 2 Invitation to submit written evidence (United Kingdom) ............ 65
APPENDIX 3 Invitation to submit written evidence (Foreign) ................2-. 67
APPENDIX 4 Comparison of regulation of new biotechnologies in major
industrialised countries |v o.'.3% . . a. o< 4 on ee ee ee
APPENDIX 5 Acronyms ...... TCE Ce Fe ee a ee 87
APPENDES6, Glossary, ooo06 sigs <5 39 44% cee» ella ors Mine rene eee a
APPENDIX:7, List of witnesses ... . 0222.2 +4tss acs 5 oe Centre le iernnl 91
References in the text are as follows:
(Q) refers to a question in oral evidence.
(p) refers to a page in HL Paper 80-I.
(P) refers to a page in HL Paper 80-II.
Written evidence received up to 30 April 1993 - HL Paper 80-I
Agricultural and Food Research Council ......2.c c.ec.e e.ee e.ee. ee .ee e
Agricultural Genetics Company Ltd . . . snijciamees ae dat eee eee eso
Bayer AG, Pharma Research and Development ..................00eeeeeeee
Professor D R Berry .. .. is ss nesses ene th ersshs caus s eae oe > peeled
Biocatalysts Utd ovate o's iris Ba 8 heat 4 el ee ee ces oie
Biolidustry Association visi: sve none es vba ag nelceiea pale: a es cs OI ee
Proféssor D Boulter jifo.c Siciaie ss ae ee ees eee eae are ene
The Brewers’ Society wasicwm:s loweue .deo-eeasama-oontetlv-eehs aats b as
British Bio-technology Group plenisiis:). teado.aicitshe hwim ssaneleeeesr o-f b os
The British Society of Plant Breeders Ltd ............ 00. c cece cece eee eees
The British Sugar Beet Seed Producers’ Association .................eeeeeee
Proféssér D C Burke, ...¢ 55 is: e272 «WEED Bab paddal eviterdelieehe sca bank
Cantab Pharmaceuticals... .. .is5 esd pee +500 > Ript eeiione Sut ened kor ane
Celltecht Ltd... oss nececn scans esn sas 5 5 oR ORI 1h Shei eneh Jone Ban
Chemucal Industries Association ... . smoresastes dere ees susie <oenelens Gime
CibaPhiarmaceuticals. .... 6454 sees 2504554 e 7064 aD DOR eUnIND eee sie ete
Confederation of British Industry ,....,. -aGidnteae til. We suse eal Bier
Dr Yi Cripps... ss ces gegen sa scee's os yy GEC Gmeenbne teven! as eaten mtn
Proféssor J.E Dale... >i ice scecb ser ssh oss ROMS di drigelenes af
Denton ‘Hall, Burgin, &/Warrens , "Iie? ontvsies beyel? a-epesi 23 seoemese an
Department of Health... , 65.55.50 525+5 s:04 6 v oan HRD STEED EMER SeeonmiemEe
Dupontide Nemours (France) S.A. ....... aasae¥ilbeGseomnee nVleaesn
JohniDuirant. .6245 4 cca ease seen ess vibe e449 seenaNO ie! gtd deee.rpien
Gerard Fairtloupt a. dij»i4.5 e54 n«b.ee s Wty vet Tite olka,d h ges a atl end eaen rem ate
Farm Animal. Welfare Council (FAWC). . AYTTAEEE LBt GMOTOHIRS-S « a
Food and Drink Federation. ....5..+555<ss3e|0 H+ME0OE2 sO4O7S aa0masl e
French Ministry of Agriculture and Fisheries ..........+e. ce.ee.se.cv.ce.ee
Glaxo Group Research Ltd (Microbiology Division) (supplementary evidence) ...
Professor G Goldspink\'... 0... 5.050: ners ckeue ne vines 1 eOeO, GU Wosipitsic
PTOICRRITM IOU RUTIOLSCMER < Wy Lah u ak & yaw 4s rico aae waa! Wa wake vgn v vce0 OTR 98
PIOLGSsii lO SEAQUTISY, cy ass gee es cvs bv vis ks nen anna veg OO ee I.. oot 100
Roger tra Rae Reser ee UC os os ve a keels oe bec saveceeewes’s 101
HGeciabes Ge Rie PR a es sca canna wan nas USMDOE Don Sheth ta a 103
PeAULUBigI an OCUCHLAG Ie Sate sn ty ss eee ee kee ke cease Soe 105
Institution of Professionals, Managers and Specialists .................000008 106
Rea CuneT aS WS ak a ge en ak Li ke weeiean wave naecs 111
Japan Bioindustry Association '.....Soo%. b.an..sera.des.. .ecwa.thes.ite d,s 112
Pot UM aneener lererjeetio At eG. os ees cade dsc ondeses 0's SG 113
Profensorgyit Bally AOS oat nsw dnlac nanan nvsinanane EOC) Habs OS. nosis 119
DyARstyecIVICESONIAIL I Scots | Vye iee he fone ey RON re me eat ete Ana Til Nerd PEC. 120
MedicnuRescarch iG Ouncilins Yer ue EAA NGERE oo iio ove ec vac ecucaeass 122
Medical Technology Assessment and Policy Centre (MEDTAP),
BOE PUTING so thre Ge cee ssa re ee eed ase e eae yo ECCT Ire To es 124
Ministry of Agriculture, Fisheries and Food (MAFF)
POIUOI TEH P at aeMCNeUE Vises nae We, See el cae CE eB eb 125
Professor M Wright and Professor C FA Bryce .............cccccececeuces 126
National dennsumenCotncilasenieise Jitsew, oa ooo eves » FOR) fied. Ls sans 128
National Farmers’ Union of England and Wales ...........00. e.ee.eu.ee.es 132
National Office of Animal Health Ltd...............«.9bt.auevtdwenlentss).c 133
MGHONBURIVETSPOUINOLIVEe 4 ious acces ses apecaeconss ROOT ined, t! e219 136
Naturakeavirbniment Research Council i. as ccc celine cee ecusceages 137
PI OVP ALOIS PAS Brus oie clie lsw iser esas OS a Saale Ga EE Rs oe ewes RE ON 139
NemetuConncilon Rioethics nu c.ccessccerxeKrOOe) eDoieod rOfe .secn s 140
Tite MaMa Pree ISEE ead is 4 serra ds dash Ge aaa cohol ay aed WAS bears 140
BS OVI Beis oe ai ss aielc lave aaryin 3 iy wx Od ole oe RR OL tater st) lon 145
epessOU LOVE aISONS oo goer ccbburvvisacoese rUvGE raaed uOfy o es 146
Peeee ere HOOI B ores a a ak aeai evs, occ hepa dum ue Gauls wod uabaddanwds 147
PU ZeP MANE Fee la ca sled a 6s bod sas oles e vee bss ee Deen) -cetlandsetes 147
POLIO MOtKehNS BOSTO ia oui dc oo wdtw onk one osucow e MOL Linh. Of conn 151
Processors & Growers Research Organisation .....0..0 .cc .ece. ce.ce .ee ns 153
PHC aca AOOLALOLY SEITVICES iii aiscs ads nk bed de by enlcb Ne dee. ae COM 154
RovabAcalemyvonineiicering dy. Ccncwstk) ABR ke ass ccasc BRL AeA 8 vanes 156
RoyabAencultural Society ofEnglandicat Jc. CABPES occ ce ccntwn ees 161
Bee CCS OW acta osw iser scien awaiesa nia hah dace Awe 165
Royal. Gollece of Veterinary, Surgeons ite.tyciclaieyer | .-,0,<,0,040.0,0 Boe bee Moke « ararees 166
Science and Engineering Research Council ......... MEE es 54 hare, is 168
SOOMISNMStICUIMITAlESCICNCEZA PENCY 5.6. ni. 5.o c5.0 :s ine esc are Aileon care: « ote ateth oa 170
SCOtishiBigisennolGsve Task lore coc. o.nccascestceceurseRaetu ePgRRn AyRoSn es0,0e8 171
Senior Advisory Group Biotechnology (SAGB) ............ce.ce. e.e0e eeae e 173
ShelliR esearch cd toni ak Geet ort, Vache ety CORSE). he JOR vende » 176
PEO SES SIAR RS ADES PENIS oo ecge cstl thi dnencisasarutiearatCaOcOnL t(oArRnAiBeSi euennc,e ! 178
SmithKline Beecham Pharinaccuticalasice .ieradine TMvautoe) .. 0. e 180
soctetyfonGenerali Microbiologyviicionte Yomi: «aoe ee ss gaged 185
Swiss Federal Office for Education and Science, Berne ..............-2--005- 186
Professor Joyce Tait, on behalf of the Economic and Social Research
(Jouibotdl BSR asctee hs.8 iy 6 chic cece « ei pos ces «so,o c OA ato -coscend unenast 187
United Kingdom Agricultural Supply Trade Association Ltd.................. 197
Pepe PE RSTR ETA “aura desea rm AeA oN Oo gO ae oe 199
ProtessamSir David Weatherall FRS (0 foi ee ie enc sin sss, «0 Bao Awe 200
AVOUT THOUNOANON FIG 2. « acta snp osss etae sans te ORL GRO 4). Dott 202
Peo SG PACTaTn C' s ig Palm cess mersealr le 5 aS Oy OPE 206
Oral and written evidence - HL Paper 80-II
Health and Safety Executive
WV Tite OTe aaah (se. RS Is Soca sso lalene. Se vt s cide wieicissese.cccnaaeeanees 1
Oral sey tenet Marcel 19939) ics LRA alates aoe Se dah 86 tee 11
Department of the Environment
Written Evidence’ 7.0. SIS rere ea dadevealde2e Sceiei gOeee:Le 18
Oral Evidence11. March’ 19930)". gcc ccd reed id te. cticers 330) eee ee 24
Department of Trade and Industry
Written Evidence: pes re a reek eben we snl sats Gd Lens een cE 31
Oral Evidence,'25 March: 1993: : : : : : 2i20Rpere cate PRR wetaneeaheoee 35
Ministry of Agriculture, Fisheries and Food
Written’ Evidence 25 foo. PUD ae Roo eo bets 2 LL Ee 5 Bei cs oe 43
Oral Evidence,-25 March 1993 vrs tics c8sc dt ai es cbs 8k Cie. Cay eee 48
Zeneca
Written Evidence’ 2 oo. sch Bei natch dt che atetave f Stan a alti, RR ONO EEN: & SOHNE saa, 55
Oral Evidence, 1 ApriPl99ser.y sss ss ss te ees cae tes oe een Te. él: See 60
Glaxo
Written Evidence’... ese Ct oa ee ee ee 67
Oral Evidence, }’April’19932 6.06025 05 608 004 6 Ook 15.08 CRE 71
British Bio-technology Group plc
Oral Evidence, 15 April 1993-5 casi... .snnsnunc5 es seus Weis Seem Raney ne oe AL
Celltech Biologics plc
Oral Evidence, 15 April 1993-65... s45 ww sue wenn ns se eee ENP te tne ee 77
Agricultural Genetics Co Ltd
Oral Evidence, 15 ‘April 1993) oc. Ss. snccanah anh sca sienna: BORNE oe wenn 83
Animal Biotechnology Cambs Ltd
Oral Evidence, 1TS"April 1993. vi 5. cc tece e's a te ore otat s ln ily tem le ABN Oty Skee 83
Hoechst AG
Oral Evidence, 22 April 19937 00.105. (0:6 esis fate re emis taselote nsM EPEIeRCt eis tats, Ke SeerP enne 9 90
Hoechst UK Ltd
Oral Evidence, 22*April 19936 2% iu.ces. cease cysradete rarale soe erc l Pee MnaNaa GaP mE 9 90
SmithKline Beecham
Oral Evidence; 22*April 1993) <5. (8+.5:./arsce-andte tase wivl ahana ge OMI se nerahe ones alge 97
Sir Walter Bodmer FRS
Oral Evidence; 29 April 19S ior. i5.-5- ics. oknns lahate nadavele latehs taale \oetete su' oM MENST Rasi gtchet cRtRO 104
Green Alliance
Oral Evidence; 29 ‘April 1993) tei) Pe, SR TE a ais ee ata Cee 111
Senior Advisory Group Biotechnology
Oral Evidence, 6 May 1993. ../. 254. QWU CHE. SO, ER, CME i ete ee 119
Biolndustry Association
Oral Evidence; 6 May 1993 ° 0)f oo foo ue le via w hapa ae tele: alc lei giesey EIRDR Ic RanaNR en. Ota ae 125
British Society of Plant Breeders Ltd
Oral Evidence, TS May logge et ate ae sta tly sinleta neats catata esther rs catenin ety ee re ire
Food and Drink Federation ;
Oral Evidence, 135 May logs not ataty crwie's p's a wees ete ent phe alaed oii ens MeRatE EnB OE 136
Confederation of British Industry |
Oral Evidence. TS May tags or cs cteeiete ss a tote ae tena IDe eT ote ce aty a een 140
Advisory Board for the Research Councils
Oral Evidence?20)Mayshovs Gs it. ai. 2. ara. ba 4 eee. DES. Be es i44
oo © e250
Agricultural and Food Research Council
RITA MIACIGaICE UVa Uo Sue ee a Gare bet aiat ae: fein Sate ewe Pavel. Ocala FO 149
“eee
Science and Engineering Research Council
CRP aed VIG VetoA OE eee Een est hata deta tehs woes, & aida da. bidvbyeiaw wie e © 157
O,8) Ww care
Advisory Committee on Genetic Modification
CIPO MI ei CeNOCMT ANIAV L SOA Mote e esC et ais dlh ires 5 g0) mic Ries aS od bon 0% e 4a ot otG 6 161
es Ss « 2
Advisory Committee on Releases to the Environment
RH AUISVIOCOCE ET IVIAY LOSS Fen cae tM E Ce gts Cin Ret N's! ags ie tid wiece Fhe. fees 161
eevee
Medical Research Council
DOTA VICCNICO ALU TUNG 10 8c ase ice io areas is alo eeeee le eve ate Chae arera lea ithe 169
eevee
Association of the British Pharmaceutical Industry
CATEPSO C SOr 4D RT Pope 8 st2 kB N coo ey soe Pa AL eA 0 Ue 174
Chemical Industries Association
PAE VICCNCOTS OFS NOT Le eae ee crete etre ee ee ee ee ae eis 178
EC Commission
eR CrAGENCG m SeNIE LOUD ai be eas la ain aah CPA Sine eee ees 183
Greenpeace
CITA VIGNE ee UE LOO re ee ee te ee BY EES I PE es 189
eo Sea
Written evidence from witnesses as from Ist May 1993:
Advisory Board for the Research Councils (ABRC) ................05. 195
o..0 © 10; 2
Association of the British Pharmaceutical Industry (ABPI) .............. 196
ee ee
PCA CCAR es eae BE i Ml ald ou. vanleeidinss (pain 203
Biolndustry Association (supplementary evidence) ..................4- 205
British Bio-technology Group plc (supplementary evidence) ............. 207
ar eae eC PROC ACION nee ce nares PA ada rs vhs eta 63 214
6 0. (ae ace
STURT SiS pret aya [ee VAC 0)M Se a agai ti i daa a hare a a A PR ae 215
Centre for Exploitation of Science and Technology (CEST) (Dr John Savin) 217
eee ee
Centre for Exploitation of Science and Technology (CEST) (Dr John Savin)
(sipplementary evidence) SI a. SSS O05 aS IS URL SEI 221
eeeee
Cobb Breeding Company Ltd (J Hunnable, Managing Director) .......... 221
oeeeve
Department of the Environment (supplementary evidence) .............. 222
oeeee
Peter Dunnill, Advanced Centre for Biochemical Engineering, University
RCO UICRe LON ee Le Aes knw Bie bint g «inn ale eo
PLEA TTTESA TET 0) Lie eR ray 8 eS SRST a PR ey Ol nD 229
SalW e A CL OCC VRE ee Eva et a es oF s oh ek cies ous
SPLe oMCEMCEICH SIS etre ee MT eee Sere eee es oo iv dlavn eho ols wd bea eee 234
aR CeNIDERCG Lee ney eateon Cuticric neti ie Aoe eee «o s's ee aha o 236
oereee
RDA SCLANUASSN EE Ce cre ee TOF ce cm eo ses eae ks es hoe es 238
SOP Reet YVLLLICS Peete eee ee ee ne TEE ane Pe ee ke de ee ees Zoo
ae 1 6€ 6
Monsanto Europe (Dr K M Baker, Director, Public Policy) .............. 241
alps difere reitta heSa trel10a5 ena) saat ae ie AN aren ee ee eer ee 244
Ce ee ee
Organisation for Economic Co-operation and Development (OECD) ......
Pharmaceutical Proteins Ltd (Ron James, Managing Director) ........... 250
RE ECOPIR AUC le Soci a ceriecpsid Sapstaate Wiri ats ie:R oaels \sco<lelounys GO gad G10ESS Aon 4 253
Margaret Sharp and Gimon Shackley:cus ween oe eos rade Pe 255
Bog pagP y Seager eye cones Sei diet purnapatien asa As haeditnaeets areata helene tae ate 260
EGS OR ISS100) TAU DOICIMETILALY CV MICTICE) 5 oe. lgcmssbais ein ieee Wine’ s eheiwwilg wiegsls ie 262
+ nasaandslnaiihac:f ear “area en obtain tele
ee ee revf ab sd vias ” hd pistes sacle, partaly
Orai Evideavs, Ti Maren 1993 veh sea 7 se oe enW onbbie (yh +
De al trend of ody ty thew rye tes eel eae ae af vei | a .
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Oral Bvidienco, 24M anch (95 sob alba vA .
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MiniIs try oFee aees hicilbure1 Fuaies heriReARsD P GaMdd aFn ooObds valdn ee Eeeh oobNi heBe 7 | Sas ea ENviTe ’
Wri a E vihence i’ { i avewe's , Rotasiboth ni. » ey 4 Pig vet
dint |, vide, +e S Mauls ws. RIe Seni eossnbowe sheng henegt . eas 7 ; =a
Zeneco THMAACMIVoAdtS o l 28
Tek: cet rEA T) det * ote 1. ~ 7 selec ubaoddak trim bbb i'a oe : -
Orel Evidense, 1A pel (43 SNE AWY vos cae
Pod - ee @ ee ee * PPT raat ee ots « a re et eee ae » © he %
Wi coh ey ence ‘ ” ep-e ib' * guy
Oral Evidence, 7 Apr = ld qual
et i ‘eave eee * *- , iFat at «a He beeen
Drsrsails iof-vti drlecnteem1,a6 l% Aosgcyh 61 9a9a4p jek (iid adn esta 6 ve Hey witwohna h le: vip es :
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eB! a! ¢ , We h " ry"e di ihe baa i ois waa ‘ i‘ leeks ae Li*f cat a er ‘es pp yi O : me—-e
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