Pathophysiology: The Biologic Basis for Disease in Adults and Children Kathryn L McCance, Sue E. Huether 2019 8th ed

6328 Pages·2019·53.24 MB·english

by  Pathophysiology: The Biologic Basis for Disease in Adults and Children Kathryn L McCance

Pathophysiology
THE BIOLOGIC BASIS FOR
DISEASE IN ADULTS AND
CHILDREN
EIGHTH EDITION
KATHRYN L. McCANCE, MS, PhD
Professor Emeritus
College of Nursing
University of Utah
Salt Lake City, Utah
SUE E. HUETHER, MS, PhD
Professor Emeritus
College of Nursing
University of Utah
Salt Lake City, Utah
SECTION EDITORS
VALENTINA L. BRASHERS, MD, FACP,
FNAP
Professor of Nursing and Woodard Clinical Scholar
Attending Physician in Internal Medicine
University of Virginia Health System
Charlottesville, Virginia
NEAL S. ROTE, PhD
Academic Vice-Chair and Director of Research, Department of Obstetrics
and Gynecology
University Hospitals Case Medical Center
William H. Weir, MD Professor of Reproductive Biology and Pathology
Case Western Reserve University, School of Medicine
Cleveland, Ohio
with more than 1200 illustrations
Table of Contents
Cover image
Title Page
What's New?
About the Cover Image
Copyright
Contributors
Reviewers
Preface
Organization and Content: What's New in the Eighth Edition
Features to Promote Learning
Art Program
Ancillaries
Acknowledgments
Introduction to Pathophysiology
References
Part One Central Concepts of Pathophysiology:
Cells and Tissues
Unit I The Cell
Chapter 1 Cellular Biology
Prokaryotes and Eukaryotes
Cellular Functions
Structure and Function of Cellular Components
Cell-to-Cell Adhesions
Cellular Communication and Signal Transduction
Cellular Metabolism
Membrane Transport: Cellular Intake and Output
Cellular Reproduction: the Cell Cycle
Tissues
Summary Review
Key Terms
References
Chapter 2 Altered Cellular and Tissue Biology
Cellular Adaptation
Cellular Injury
Manifestations of Cellular Injury
Cellular Death
Aging and Altered Cellular and Tissue Biology
Somatic Death
Summary Review
Key Terms
References
Chapter 3 The Cellular Environment
Distribution of Body Fluids
Aging and Distribution of Body Fluids
Alterations in Water Movement
Sodium, Chloride, and Water Balance
Alterations in Sodium, Water, and Chloride Balance
Alterations in Potassium, Calcium, Phosphate, and Magnesium Balance
Acid-Base Balance
Summary Review
Key Terms
References
Unit II Genes, Gene-Environment Interaction, and
Epigenetics
Chapter 4 Genes and Genetic Diseases
DNA, RNA, and Proteins: Heredity at the Molecular Level
Chromosomes
Elements of Formal Genetics
Transmission of Genetic Diseases
Linkage Analysis and Gene Identification
Summary Review
Key Terms
References
Chapter 5 Genes, Environment-Lifestyle, and Common Diseases
Factors Influencing Incidence of Disease in Populations
Principles of Multifactorial Inheritance
Nature and Nurture: Disentangling the Effects of Genes and Environment
Genetics of Common Diseases
Summary Review
Key Terms
References
Chapter 6 Epigenetics and Disease
Overview of Epigenetic Mechanisms
Epigenetics and Human Development
Genomic Imprinting
Epigenetics in Cognitive Development and Mental Health
Exploring the Possible Multigenerational Persistence of Epigenetic States That
Arise in Response to Environmental Factors
Epigenetic Change Over the Life Span
Molecular and Computational Tools for Exploring Epigenetic States
Epigenetics and Cancer
Emerging Strategies for the Treatment of Epigenetic Disease
Future Directions
Summary Review
Key Terms
References
Unit III Mechanisms of Self-Defense
Chapter 7 Innate Immunity
Human Defense Mechanisms
First Line of Defense: Physical, Mechanical, and Biochemical Barriers and
Normal Microbiome
Second Line of Defense: Inflammation
Local Manifestations of Inflammation
Systemic Manifestations of Acute Inflammation
Chronic Inflammation
Wound Healing
Pediatrics: Innate Immunity in the Newborn Child
Aging: Innate Immunity in the Older Adult Population
Summary Review
Key Terms
References
Chapter 8 Adaptive Immunity
General Characteristics of Adaptive Immunity
Recognition and Response
Generation of Clonal Diversity
Induction of an Immune Response: Clonal Selection
Effector Mechanisms
Fetal and Neonatal Immune Function
Aging and Immune Function
Summary Review
Key Terms
References
Chapter 9 Alterations in Immunity and Inflammation
Hypersensitivity: Allergy, Autoimmunity, and Alloimmunity
References:
Deficiencies in Immunity
Summary Review
Key Terms
References