organic synthesis the disconnection approach

342 Pages·2009·7.38 MB·English

by  Stuart Warren

Organic
Synth岱is:
The Disconnection Approach
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Organic
Synth臼is;
The Disconnection Approach
Edition
2日d
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Stuart 飞毛Tarre室主
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Department, llu瓦
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and
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Paul Wyatet
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Schoolof c of Bristol, U瓦
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⑧WIL盯
AJohn飞iVìleyand Sons, Ltd" Publication
This edition first published 2008
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LibraηI 0/ Congress C.αtaloging-in-Pl￥blication Data
Warren哩 Stuart G.
Organic synthesís : the disconnection approach I Stuart Warren and Paul Wyatt.一一2nded.
p. cm.
Includes biblíographical references and index.
ISBN 978-0-470-71237-5 (cloth)一-ISBN 978-0斗70-71236-8 (pbk. :
alk. paper)
1. O~mic L 百yatt， PauL n. 在tle.
QD262.W2842008
547'.2-dc22
2008033269
A catalogue record for this book is available from the British
ISl日-l' 978-0-470-7份12375 (HIB) 978-0-470平12368 (P!B)
τypeset in 10/12 Times-Roman by Laserwords Private Limited, Chennai, India
Printed and bound in Great Britain by CPI Antony Rowe, Chippenham, Wiltshire
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Co吕立f盟ts
Preface lX
General References XI
7730J55310J733i751Q/30/
2. Basic and Synthesis of Aromatic
li233458678QJAVG12233
3. Strategy 1: The Order of Events n
4. One-Group C-X Dìsconnections v
5. Strate2:v II: l.
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6. C-X DisconnectÎons a
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7. III: Reversal of Polarity, of
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8. Arnìn已
生 Strategy IV: Protecting e
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10. One Group C C Disconnections 1: Alcohols
… c
11. General St栩如前r A: a Disconnect.ion
12. Strate玄v V: w
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w 2
1
2
15. Alkene // i$1·
16. Strategy VII: 盯se of p: (Alkynes) EAli
17.τwo-Group C…C Disconntections 1: Diels-Ald时 Reactions 2·
t
18. Strate2:v VIII: Introduchtion to
19. 在isconnections II: Compounds 豆
20. IX: Control in Car柱。nvl Condensations '1
21. C-C Disconnections III: Compounds
Conjugate (Michael) Addîtion and Robinson Annelation 151
22. X: 技itro 161
23. 在NφGroup Disconnections IV: Compounds 167
24. 177
25. Disconnections V: 185
26. Strategy XII: Reconnection 193
27. Two-Group C…C Disconn巳ctions VI: 199
28. General B: Strategy of Car七onyl Disconnections 207
29. XIII: Introduction to Synthesis: Saturated 217
30. Three品lernbered 229
31. XIV: 237
245
VH呈 Contents
33. XV:τhe U se of Ketenes in 251
34. Five-Mem如ered 255
35. StrateQ.v XVI: Special Methods
2岳1
36. Six-Membered Rings 269
37. General Strategy C: Synthesis 279
38. XVII: 289
39. AromatÍC 301
40. General D:A母vanced 313
Index 325
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Preface
In the 26 years since 有iley publìshed Organic 1于ze Disconnection Approach 色y Stuart
Warren，由自 approach to the learning of synthesis has become while the book Ìtself
is now dated in content and appearance‘ In 唱Tiley published Organic
and Control by Paul Wyatt and Stuart 轧Tarren. Thís muc如柱。okís as a
fourth year und巳rgradu时es and research workers in universities and industry. The
workbook was published ìn 2008.τ如is new book made thεold one look very dated ín
and content and gaps between what students were expectεd to nunderstand in the 1980s
and what are to understand now. This second editionv is intended to fill some of
.
those gaps. l
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The of the book is the same in the second edítioan. It alternates chapters
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new concepts wÌth strategy chapters that put 出e new work in the context of overall planning.
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丁he 40 chapters have the same titles: some have hardly been changed whíle others
have a revision with considerabele amounts of new m剖erial. In most cases
from recent years are included. h
One source of new material is the courses 出actthe authors in the pharmaceutical
.
Our 色asic course is 'The Disconnection Apwproach' and the 削aterial we have for this
course has reinforced our attempts to reasons for the of the various compounds
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which we 忧lieve enlivens the 加ok and makes it more for students. We to
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a second edítíon of the workbook after the publication of the
The 民rstedition of th巳 textbo/o/kwas in fact thεthird in a series of品。oks on
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by 乳 The firspt: The an lntroduction to
如 1974， is a t book asking for a of interaction with the reader who
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was to solve prho剖ems while rarely use now as the
method has 岳阳n suplersedt~d 七y interactive programmes on computers. Paul Wyatt is writín革 an
electronic book to replace The Cαrbonyl Group which will a of an electronic
七ook and 七ooks with associated workbooks in a uniform format that we hope will prove of
value as students of organic develop their careers.
Stuart 飞可arren and Paul 研rya生在
March 2008.
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