Table Of ContentMOLECULAR ASPECTS OF PAPOVA VIRUSES
Yechiel Becker, Series Editor
Julia Hadar, Managing Editor
DEVELOPMENTS IN MOLECULAR VIROLOGY
Becker, Y. (ed.) Herpesvirus DNA (1981)
Becker, Y. (ed.) Replication of Viral and Cellular Genomes (1983)
Becker, Y. (ed.) Antiviral Drugs and Interferon: the Molecular Basis of Their
Activity (1983)
Kohn, A. and Fuchs, P. (eds.) Mechanisms of Viral Pathogenesis from Gene
to Pathogen (1983)
Becker, Y. (ed.) Recombinant DNA Research and Viruses. Cloning and
Expression of Viral Genes (1985)
Feitelson, M. (author) Molecular Components of Hepatitis B Virus (1985)
Becker, Y. (ed.) Viral messenger RNA: Transcription, Processing, Splicing and
Molecular Structure (1985)
Doerfler, W. (ed.) Adenovirus DNA: the Viral Genome and Its Expression
(1986)
DEVELOPMENTS IN VETERINARY VIROLOGY
Payne, L.N. (ed.) Marek's Disease (1985)
Burny, A. and Mammerickx, M. Enzootic Bovine Leukosis and Bovine
Leukemia Virus (1987)
Becker, Y. (ed.) African Swine Fever (1987)
De Boer, a.F. (ed.) Avian Leukosis (1987)
DEVELOPMENTS IN MEDICAL VIROLOGY
Levine, P.H. (ed.) Epstein-Barr Virus and Associated Diseases (1985)
Becker, Y. (ed.) Virus Infections and Diabetes Mellitus (1987)
MOLECULAR ASPECTS OF
P APOV AV IRUSES
edited by
Yosef Aloni
The Weizmann Institute of Science
Rehovot, Israel
~.
"
Martinus Nijhoff Publishing
a member of the Kluwer Academic Publishers Group
Boston/Dordrecht/Lancaster
Distributors for the United States and Canada:
Kluwer Academic Publishers
101 Philip Drive
Assinippi Park
Norwell, Massachusetts 02061, USA
Distributors for the UK and Ireland:
Kluwer Academic Publishers
MTP Press Limited
Falcon House, Queen Square
Lancaster LAI IRN, UNITED KINGDOM
Distributors for all other countries:
Kluwer Academic Publishers Group
Distribution Centre
Post Office Box 322
3300 AH Dordrecht, THE NETHERLANDS
Library of Congress Cataloging-in-Publication Data
Molecular aspects of pap ova viruses .
(Developments in molecular virology; 9)
Bibliography: p.
Includes index.
l. Papovaviruses. 2. Molecular biology.
I. Aloni, Yosef. II. Series.
QR406.M65 1987 576'.6484 87-19103
ISBN-\3: 978-1-4612-9237-1 e-ISBN-\3: 978-1-46\3-2087-6
DOl: 10.1007/978-1-46\3-2087-6
The figure on the cover is from DePamphilis M.L. "Replication of Simian Virus 40 and Polyoma
Virus Chromosomes". The figure appears on page 3 of this book.
Copyright © 1988 by Martinus Nijhoff Publishing, Boston.
Softcover reprint of the hardcover 1st edition 1988
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or
transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise,
without the prior written permission of the publishers, Martinus Nijhoff Publishing, 101 Philip Drive,
Assinippi Park, Norwell, Massachusetts 02061.
CONTENTS
Contributors vii
Preface xiii
Replication of simian virus 40 and polyoma virus chromosomes
M.L. DePamphilis
2
Polyomavirus sequences affecting the initiation of transcription and
DNA replication
W.R. Folk, W.J. Tang, M. Martin, J. Lednicky, S. Berger, and
R.H. Adams 41
3
The SV 40 early promoter
M. Zenke, A. Wildeman and P. Chambon 53
4
The polyoma enhancer
J. Piette, M.-H. Kryszke and M. Yaniv 85
5
In vitro polyadenylation of SV40 early pre-mRNA
L.C. Ryner, M. Chaudhuri and J.L. Manley 101
6
Regulation of viral transcription units by SV40 T-antigen
J. Brady, M. Loeken, M.A. Thompson, J. Duvall and G. Khoury 119
7
Regulation of gene expression from the polyoma late promoter
F.G. Kern, P. Delli-Bovi, S. Pellegrini and C. Basilico 137
8
Characterization of an immunologically distinct population of simian virus 40
large tumor antigen
L. Covey, P. Kwok and C. Prives 163
9
The simian virus 40 agnoprotein
S. Carswell and J.C. Alwine 185
10
SV40 chromatin structure
W.A. Scott 199
vi
11
SV40 chromatin structure and virus assembly
V. Blasquez, C. Ambrose, H. Lowman and M. Bina 219
12
The complex cellular networks in the control of SV40 gene expression
A. Ben-Ze'ev 239
13
Molecular biology of papilloma virus
H. Pfister, E. Kleiner, G. Lang, G. Sagner, W. Dietrich and P.G. Fuchs 269
Index 289
CONTRIBUTORS
Raquel H. Adams
Department of Microbiology
The University of Tens at Austin
Austin, Tens 78712
U.S.A.
1ames C. Alwine
Department of Microbiology
School of Medicine
University of Penn~lvania
Philadelphia, PA 19104
U.S.A.
Christine Ambrose
Department of Chemistry
Purdue University
West Lafayette, IN 47907
U.S.A.
Claudio Basilico
Department of Pathology
New York University School of Medicine
550 First Avenue, Rm 551
New York, N.Y. 10016
U.S.A.
Avri Ben-Ze'ev
Department of Genetics
Weizmann Institue of Science
Rehovot 76100
Israel
Shelley Berger
Department of Microbiology
The University of Tens at Austin
Austin, Tens 78712
U.S.A.
Minou Bina
Department of Chemistry
Purdue University
West Lafayette, IN .. 7907
U.S.A.
Veronica Blasquez
Department of Chemistry
Purdue University
West Lafayette, IN 47907
U.S.A.
John Brady
Laboratory of Molecular Virology
cancer
National Institute
National Institutes of Health
Bethesda, Maryland 20892
U.S.A.
viii
Susan Carswell
Department of Microbiology
School of Medicine
University of Pennsylvania
Philadelphia, PA 191 04
U.S. A.
Pierre Chambon
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS
Unite 184 de Biologie Moleculaire et
de Genie Genetique de L'INSERM
Faculte de Medecine
11, rue Humann
67086 Strasbourg-cedeI
France
Murari Chaudhuri
Department of Biological Sciences
Columbia University
New York. N.Y. 10027
U.S. A.
Lori Covey
Department of Biological Sciences
Columbia University
New York. N.Y. 10027
U.S. A.
Pasquale DeUi-Bovi
Department of Pathology
New York University School of Medicine
SSO First Avenue. Rm ))4
New York, N.Y. 10016
U.S. A.
Melvin L. DePamphilis
Department of Cell Biology
Roche Institute of Molecular Biology
Nutley, N.J. 07110
U.S.A.
Walter Dietrich
Institut fOr Klinische Virologie
Universitat Erlangen-NOrnberg
0-8520 Erlangen
Federal Republic of Germany
Janet Duvall
Laboratory of Molecular Virology
National Cancer Institute
National Institutes of Health
Bethesda, Maryland 20892
U.S. A.
ix
WiHiam R. Folk
Department of Microbiology
The University of Teus at Austin
Austin, Tens 78712
U.S. A.
Pawel G. Fuchs
Institut for Klinische Virologie
UniversiHtt Erlangen-Nornberg
D-8520 Erlangen
Federal Republic of Germany
Francis G. Kern
Breast Cancer Section/Medicine Branch
National Cancer Institute
National Institutes of Health
Building 10, Rm 12N 266
Bethesda, Maryland 20982
U.S.A.
George Khoury
Laboratory of Molecular Virology
National Cancer Institute
National Institutes of Health
Bethesda, Maryland 20892
U.S. A.
Eva Kleiner
Institut fOr Klinische Virologie
Universitat Erlangen-Nornberg
D-8520 Srlangen
Federal Republic of Germany
Marie-Helene Kryszke
Department of Molecular Biology
Pasteur Institute
25, rue du Dr. ROUI
75724 Paris, Cedel 15
France
Perry Kwok
Department of Biological Sciences
Columbia University
New York, N.Y. 10027
U.S.A.
Gerlinde Lang
Institut fOr Klinische Virologie
Universitat Erlangen-Nornberg
D-8520 Erlangen
Federal Republic of Germany
John Lednicky
Department of Microbiology
The University of Tens at Austin
Austin, Texas 78712
U.S. A.
x
Mary Loeken
Laboratory of Molecular Virology
National Cancer Institute
National Institutes of Health
Bethesda, Maryland 20892
U.S.A.
Henry Lowman
Department of Chemistry
Purdue University
West Lafayette, IN 47907
U.S. A.
James L. Manley
Department of Biological Sciences
Columbia University
New York, N.Y. 10027
U.S. A.
Mark Martin
Department of Microbiology
The University of Texas at Austin
Austin, Tens 78712
U.S.A.
Sandra Pellegrini
I.C.R.F. Laboratories
P.O. 801 123
Lincoln's Fields
London, WC 2A 3PX
England
Jacques Piette
Department of Molecular Biology
Pasteur Institute
25, rue du Dr. ROUI
75724 Paris, Cedel 15
France
Herbert Pfister
Institut fOr Klinische und Molekulare Virologie
Universitat Erlangen-Nornberg
D-8520 Erlangen
Federal Republic of Germany
Carol Prives
Department of Biological Sciences
Columbia University
New York, N.Y. 10027
U.S.A.
Lisa C. Ryner
Department of Biological Sciences
Columbia University
New York, N.Y. 10027
U.S.A.
