Management of Hematological Cancer in Older People

338 Pages·2015·5.995 MB·English

by  Ulrich Wedding, Riccardo A. Audisio (eds.)

Management of
Hematological Cancer
in Older People
Ulrich Wedding
Riccardo A. Audisio
Editors
123
Management of Hematological Cancer
in Older People

Ulrich Wedding (cid:129) Riccardo A. Audisio
Editors
Management of
Hematological Cancer
in Older People
Editors
Ulrich Wedding Riccardo A. Audisio
Department of Palliative Care St Helens Teaching Hospital
University Hospital Jena University of Liverpool
Jena , Thüringen St Helens
Germany United Kingdom
ISBN 978-1-4471-2836-6 ISBN 978-1-4471-2837-3 (eBook)
DOI 10.1007/978-1-4471-2837-3
Springer London Heidelberg New York Dordrecht
Library of Congress Control Number: 2014956864
© Springer-Verlag London 2015
T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of
the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation,
broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information
storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology
now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection
with reviews or scholarly analysis or material supplied specifi cally for the purpose of being entered and
executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this
publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's
location, in its current version, and permission for use must always be obtained from Springer.
Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations
are liable to prosecution under the respective Copyright Law.
T he use of general descriptive names, registered names, trademarks, service marks, etc. in this publication
does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant
protective laws and regulations and therefore free for general use.
While the advice and information in this book are believed to be true and accurate at the date of
publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for
any errors or omissions that may be made. The publisher makes no warranty, express or implied, with
respect to the material contained herein.
Printed on acid-free paper
Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1 Hematological Malignancies in the Elderly:
The Epidemiological Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Alberto Quaglia†, Marina Vercelli, and Roberto Lillini,
AIRTUM Working Group
2 Anemia, Fatigue and Aging. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
Lodovico Balducci
3 Myelodysplastic Syndromes in Older Patients . . . . . . . . . . . . . . . . . . 49
Reinhard Stauder
4 Acute Myeloid Leukemia. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
Heidi D. Klepin and Timothy S. Pardee
5 Chronic Myelogeneous Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Andreas Hochhaus and Susanne Saussele
6 Myeloproliferative Neoplasms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101
Farah Shariff and Claire Harrison
7 Chronic Lymphocytic Leukemia (CLL) . . . . . . . . . . . . . . . . . . . . . . . 113
Valentin Goede and Michael Hallek
8 Indolent Lymphomas in Older Patients. . . . . . . . . . . . . . . . . . . . . . . . 129
Andreas Viardot and Christian Buske
9 The Challenge of Treating Elderly Patients with Mantle
Cell Lymphoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143
Simone Ferrero and Martin Dreyling
10 Hodgkin Lymphoma in the Elderly . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Paul Fields
11 Diffuse Large B-Cell Non-Hodgkin’s Lymphoma
(DLBCL- NHL) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Nils Winkelmann and Ulrich Wedding
v
vi Contents
12 Multiple Myeloma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
Roberto Mina and Antonio Palumbo
13 Geriatric Assessment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219
Martine Extermann
14 Nursing Issues. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239
Corien M. Eeltink, Angelina Beumer-Grootenhuis,
and Carolien Burghout
15 General Considerations on Treatment in Older Patients
with Hematological Malignancies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253
Pierre Soubeyran, Camille Chakiba, and Anne-Sophie Michallet
16 General Consideration on Radiotherapy in Older Patients
with Hematological Malignancies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
Youlia M. Kirova
17 Supportive Care in Older Patients with
Hematological Malignancies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
Karin Jordan, Berit Jordan, Camilla Leithold, and Jörn Rüssel
18 Patients Reported Outcome/Quality of Life . . . . . . . . . . . . . . . . . . . . 297
Barbara Deschler
19 Palliative Care in Elderly Patients with Hematological
Malignancies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313
Ulrich Wedding
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325
Contributors
Riccardo A. Audisio , MD, FRCS St Helens Teaching Hospital,
University of Liverpool , St Helens , UK
Lodovico Balducci , MD H. Lee Moffi tt Cancer Center and Research Institute,
University of South Florida College of Medicine , Tampa , FL , USA
Angelina Beumer , MD Department of Oncology , Deventer Ziekenhuis ,
Ziekenhuis , The Netherlands
Angelina Beumer-Grootenhuis , RN Department of Oncology ,
Deventer Ziekenhuis , Deventer , The Netherlands
Carolien Burghout , RN, M ANP Department of Haematology ,
Jeroen Bosch Hospital , ‘s-Hertogenbosch , The Netherlands
Christian Buske , MD Comprehensive Cancer Center Ulm, Institute of
Experimental Cancer Research, University Hospital Ulm , Ulm , Germany
Camille Chakiba , MD Department of Medical Oncology , Institut Bergonié ,
Bordeaux Cedex , France
Site de Recherche Intégrée sur le Cancer, BRIO (Bordeaux Recherche
Intégrée Oncologie) , Bordeaux Cedex , France
Barbara Deschler , MD Interdisciplinary Clinical Trials Offi ce , Comprehensive
Cancer Center Mainfranken, University Hospital Würzburg , Würzburg , Germany
Department of Hematology/Oncology , University of Freiburg Medical Center ,
Freiburg , Germany
Martin Dreyling , MD, PhD Department of Medicine III , University Hospital
Großhadern/LMU München , Munich , Germany
Corien M. Eeltink , RN, MA, ANP Department of Haematology , VU University
Medical Center , Amsterdam , Netherlands
vii
viii Contributors
Martine Extermann Moffi tt Cancer Center, University of South Florida ,
Tampa , FL , USA
Simone Ferrero , MD Division of Hematology, Department of Molecular
Biotechnologies and Health Sciences , University of Torino , Torino , Italy
Paul Fields , MD Department of Haematology, Guy’s and St Thomas’, and Kings
College Hospitals, Kings Health Partners AHSC , London , UK
Valentin Goede , MD German CLL Study Group (GCLLSG),
Department of Internal Medicine , Center of Integrated Oncology
Cologne-Bonn, University Hospital Cologne , Cologne , Germany
Department of Geriatric Medicine and Research, St. Marien Hospital
and University of Cologne , Cologne , Germany
Michael Hallek , MD, PhD German CLL Study Group (GCLLSG),
Department I of Internal Medicine , Center of Integrated Oncology
Cologne-Bonn, University of Cologne , Cologne , Germany
Cluster of Excellence ‘Cellular Stress Responses in Aging Associated Diseases’
(CECAD), University of Cologne , Cologne , Germany
Claire Harrison , MD, DM, FRCP, FRCPath Department of Haematology ,
Guy’s and St Thomas’ NHS Foundation Trust , Great Maze Pond, London , UK
Andreas Hochhaus , Prof. Dr Abteilung Hämatologie/Onkologie, Klinik für
Innere Medizin II , Universitätsklinikum Jena , Jena , Germany
Berit Jordan , MD Department of Neurology , University Hospital Halle (Saale) ,
Halle (Saale) , Germany
Karin Jordan , MD Department of Hematology/Oncology , Universitätsklinikum
Halle (Saale) , Halle (Saale) , Germany
Youlia M. Kirova , MD Radiation Oncology , Institut Curie , Paris , France
Heidi D. Klepin , MD, MS Department of Internal Medicine, Section on
Hematology and Oncology , Wake Forest School of Medicine , Winston-Salem ,
NC , USA
Camilla Leithold , MSc Department of Hematology and Oncology ,
University Hospital Halle (Saale) , Halle (Saale) , Germany
Roberto Lillini , PHD , AIRTUM Working Group IRCCS Azienda Ospedaliera
Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro ,
Genoa , Italy
Department of Sociology , University of Milan-Bicocca , Milan , Italy
Anne-Sophie Michallet , MD Department of Hematology , Hôpital Lyon-Sud,
Hospices Civils de Lyon , Lyon , France
Contributors ix
Roberto Mina , MD Myeloma Unit, Division of Hematology,
University of Torino, Azienda Ospedaliera Città della Salute e della
Scienza di Torino , Torino , Italy
Antonio Palumbo , MD Myeloma Unit, Division of Hematology,
University of Torino, Azienda Ospedaliera Città della Salute e della
Scienza di Torino , Torino , Italy
Timothy S. Pardee , MD, PhD Department of Internal Medicine, Section on
Hematology and Oncology , Wake Forest School of Medicine , Winston-Salem ,
NC , USA
Alberto Quaglia† , MD Liguria Region Cancer Registry, Descriptive
Epidemiology Unit , IRCCS Azienda Ospedaliera Universitaria San Martino – IST
Istituto Nazionale per la Ricerca sul Cancro , Genoa , Italy
Jörn Rüssel , MD Department of Hematology and Oncology , University Hospital
Halle (Saale) , Halle (Saale) , Germany
Susanne Saussele , MD III. Medizinische Universitätsklinik, Medizinische
Fakultät Mannheim , der Universität Heidelberg , Mannheim , Germany
Farah Shariff , MD, MBBS, BSc (Hons), MRCP Department of Haematology ,
Guy’s and St Thomas’ NHS Foundation Trust , Great Maze Pond, London , UK
Pierre Soubeyran , MD Department of Medical Oncology , Institut Bergonié ,
Bordeaux Cedex , France
Site de Recherche Intégrée sur le Cancer, BRIO (Bordeaux Recherche Intégrée
Oncologie) , Bordeaux Cedex , France
Université Bordeaux , Segalen , France
Reinhard Stauder , MD, MSc Department of Internal Medicine V (Haematology
and Oncology) , Innsbruck Medical University , Innsbruck , Austria
Marina Vercelli , PHD Department of Health Sciences, University of Genoa ,
Genoa , Italy
Andreas Viardot , MD Department of Internal Medicine III ,
Universitätsklinikum Ulm , Ulm , Germany
Ulrich Wedding , MD Department of Palliative Care , University Hospital Jena ,
Jena , Thüringen , Germany
Nils Winkelmann , MD Department of Internal Medicine II,
Department of Hematology and Medical Oncology , Jena University Hospital ,
Jena , Germany